Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0058 | 0.0402 | 0.039 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase 1 | 0.0954 | 0.9828 | 0.9827 |
Leishmania major | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase-1-like protein | 0.0414 | 0.4151 | 0.4132 |
Mycobacterium ulcerans | fatty-acid-CoA ligase | 0.0027 | 0.0084 | 0.0125 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0042 | 0.0234 | 1 |
Onchocerca volvulus | 0.0042 | 0.0234 | 0.015 | |
Mycobacterium tuberculosis | Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) | 0.0027 | 0.0084 | 0.0326 |
Leishmania major | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.0954 | 0.9828 | 0.9827 |
Mycobacterium ulcerans | long-chain-fatty-acid--CoA ligase | 0.0027 | 0.0084 | 0.0125 |
Mycobacterium tuberculosis | Probable hydrolase | 0.0042 | 0.0234 | 0.0903 |
Mycobacterium ulcerans | DNA polymerase IV | 0.0022 | 0.0031 | 0.0033 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0058 | 0.0402 | 1 |
Leishmania major | DNA polymerase eta, putative | 0.0036 | 0.0179 | 0.0148 |
Mycobacterium tuberculosis | Probable lipase LipD | 0.0042 | 0.0234 | 0.0903 |
Loa Loa (eye worm) | beta-lactamase | 0.0042 | 0.0234 | 0.0222 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0053 | 0.0352 | 0.0322 |
Mycobacterium tuberculosis | Probable esterase LipL | 0.0042 | 0.0234 | 0.0903 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0058 | 0.0402 | 1 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0027 | 0.0084 | 0.0125 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0042 | 0.0234 | 1 |
Plasmodium vivax | hypothetical protein, conserved | 0.0042 | 0.0234 | 1 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.0971 | 1 | 1 |
Brugia malayi | beta-lactamase | 0.0042 | 0.0234 | 0.5468 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.0084 | 0.0073 |
Trichomonas vaginalis | esterase, putative | 0.0042 | 0.0234 | 1 |
Mycobacterium tuberculosis | Conserved protein | 0.0042 | 0.0234 | 0.0903 |
Mycobacterium ulcerans | lipase LipD | 0.0042 | 0.0234 | 0.0382 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0053 | 0.0352 | 0.0322 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.0234 | 0.0222 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.0971 | 1 | 1 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0027 | 0.0084 | 0.0125 |
Chlamydia trachomatis | acylglycerophosphoethanolamine acyltransferase | 0.002 | 0.0012 | 0.5 |
Giardia lamblia | Hypothetical protein | 0.0573 | 0.5818 | 1 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0027 | 0.0084 | 0.0326 |
Mycobacterium tuberculosis | Conserved protein | 0.0042 | 0.0234 | 0.0903 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.0234 | 0.0222 |
Entamoeba histolytica | acyl-CoA synthetase, putative | 0.0027 | 0.0084 | 0.0092 |
Loa Loa (eye worm) | hypothetical protein | 0.0971 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.0234 | 0.0222 |
Trypanosoma brucei | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.0971 | 1 | 1 |
Entamoeba histolytica | acyl-CoA synthetase, putative | 0.0027 | 0.0084 | 0.0092 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0042 | 0.0234 | 1 |
Leishmania major | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.0971 | 1 | 1 |
Mycobacterium tuberculosis | Conserved protein | 0.0042 | 0.0234 | 0.0903 |
Leishmania major | hypothetical protein, conserved | 0.0042 | 0.0234 | 0.0203 |
Mycobacterium tuberculosis | Possible conserved lipoprotein LpqK | 0.0042 | 0.0234 | 0.0903 |
Echinococcus multilocularis | 6 phosphofructo 2 kinase:fructose 2 | 0.0971 | 1 | 1 |
Echinococcus multilocularis | dna polymerase eta | 0.0052 | 0.034 | 0.031 |
Schistosoma mansoni | DNA polymerase eta | 0.0052 | 0.034 | 0.031 |
Mycobacterium leprae | conserved hypothetical protein | 0.0042 | 0.0234 | 1 |
Toxoplasma gondii | ABC1 family protein | 0.0042 | 0.0234 | 1 |
Mycobacterium ulcerans | long-chain-fatty-acid-CoA ligase | 0.0027 | 0.0084 | 0.0125 |
Brugia malayi | AMP-binding enzyme family protein | 0.0027 | 0.0084 | 0.1443 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0053 | 0.0352 | 0.0322 |
Schistosoma mansoni | 6-phosphofructokinase | 0.0971 | 1 | 1 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0042 | 0.0234 | 0.0203 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.0414 | 0.4151 | 0.4132 |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.0042 | 0.0234 | 0.5468 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0053 | 0.0352 | 0.0322 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.0234 | 0.0222 |
Loa Loa (eye worm) | hypothetical protein | 0.0954 | 0.9828 | 0.9828 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0027 | 0.0084 | 0.0125 |
Trypanosoma cruzi | DNA polymerase eta, putative | 0.0052 | 0.034 | 0.031 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0053 | 0.0352 | 0.0322 |
Leishmania major | DNA polymerase eta, putative | 0.0052 | 0.034 | 0.031 |
Onchocerca volvulus | 0.0042 | 0.0234 | 0.015 | |
Mycobacterium ulcerans | hypothetical protein | 0.0027 | 0.0084 | 0.0125 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0027 | 0.0084 | 0.0054 |
Mycobacterium tuberculosis | Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) | 0.0022 | 0.0031 | 0.012 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0042 | 0.0234 | 0.0203 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0053 | 0.0352 | 0.0322 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.021 | 0.0199 |
Mycobacterium ulcerans | beta-lactamase | 0.0042 | 0.0234 | 0.0382 |
Trypanosoma brucei | 6-phosphofructo-2-kinase 2 | 0.0954 | 0.9828 | 0.9827 |
Entamoeba histolytica | acyl-coA synthetase, putative | 0.0027 | 0.0084 | 0.0092 |
Schistosoma mansoni | hypothetical protein | 0.0039 | 0.021 | 0.018 |
Brugia malayi | AMP-binding enzyme family protein | 0.0027 | 0.0084 | 0.1443 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0027 | 0.0084 | 0.0054 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.0084 | 0.0073 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0042 | 0.0234 | 0.0203 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0042 | 0.0234 | 0.0203 |
Brugia malayi | AMP-binding enzyme family protein | 0.0027 | 0.0084 | 0.1443 |
Entamoeba histolytica | phosphoglycerate mutase family protein, putative | 0.0573 | 0.5818 | 1 |
Plasmodium falciparum | acyl-CoA synthetase | 0.002 | 0.0012 | 0.5 |
Mycobacterium ulcerans | hypothetical protein | 0.0042 | 0.0234 | 0.0382 |
Trypanosoma cruzi | DNA polymerase eta, putative | 0.0036 | 0.0179 | 0.0148 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0053 | 0.0352 | 0.8655 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0042 | 0.0234 | 1 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0039 | 0.021 | 0.4837 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0042 | 0.0234 | 0.0203 |
Trypanosoma brucei | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.0414 | 0.4151 | 0.4132 |
Mycobacterium tuberculosis | Probable conserved lipoprotein | 0.0042 | 0.0234 | 0.0903 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0042 | 0.0234 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0556 | 0.5646 | 0.5641 |
Echinococcus multilocularis | beta LACTamase domain containing family member | 0.0042 | 0.0234 | 0.0203 |
Trypanosoma brucei | DNA polymerase eta, putative | 0.0052 | 0.034 | 0.031 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.0234 | 0.0222 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0053 | 0.0352 | 0.0341 |
Mycobacterium ulcerans | fructose-2,6-bisphosphatase GpmB | 0.0573 | 0.5818 | 1 |
Brugia malayi | ImpB/MucB/SamB family protein | 0.0052 | 0.034 | 0.8338 |
Mycobacterium tuberculosis | Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) | 0.002 | 0.0012 | 0.0045 |
Brugia malayi | beta-lactamase family protein | 0.0042 | 0.0234 | 0.5468 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0266 | 0.2588 | 1 |
Mycobacterium ulcerans | fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE | 0.0042 | 0.0234 | 0.0382 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.0084 | 0.0073 |
Mycobacterium tuberculosis | Probable esterase/lipase LipP | 0.0042 | 0.0234 | 0.0903 |
Onchocerca volvulus | 0.0042 | 0.0234 | 0.015 | |
Mycobacterium ulcerans | esterase/lipase LipP | 0.0042 | 0.0234 | 0.0382 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0058 | 0.0402 | 0.039 |
Mycobacterium tuberculosis | Probable lipase LipE | 0.0042 | 0.0234 | 0.0903 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0022 | 0.0031 | 0.012 |
Mycobacterium ulcerans | hypothetical protein | 0.0573 | 0.5818 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0053 | 0.0352 | 0.0322 |
Onchocerca volvulus | 0.0971 | 1 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.0234 | 0.0222 |
Giardia lamblia | Hypothetical protein | 0.0573 | 0.5818 | 1 |
Echinococcus granulosus | beta LACTamase domain containing family member | 0.0042 | 0.0234 | 0.0203 |
Mycobacterium leprae | Probable lipase LipE | 0.0042 | 0.0234 | 1 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase 1 | 0.0954 | 0.9828 | 0.9827 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0027 | 0.0084 | 0.0054 |
Trypanosoma cruzi | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative | 0.0414 | 0.4151 | 0.4132 |
Echinococcus granulosus | dna polymerase eta | 0.0052 | 0.034 | 0.031 |
Loa Loa (eye worm) | ImpB/MucB/SamB family protein | 0.0022 | 0.0031 | 0.0019 |
Brugia malayi | beta-lactamase family protein | 0.0042 | 0.0234 | 0.5468 |
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.0042 | 0.0234 | 0.0222 |
Loa Loa (eye worm) | hypothetical protein | 0.0052 | 0.034 | 0.0329 |
Mycobacterium ulcerans | long-chain fatty-acid CoA ligase | 0.0027 | 0.0084 | 0.0125 |
Mycobacterium ulcerans | DNA polymerase IV | 0.0022 | 0.0031 | 0.0033 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
GI50 (functional) | -6.73 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MDA-N Breast cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -6.68 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -6.665 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MALME-3M Melanoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -6.567 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -6.532 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-5 Melanoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -6.455 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -6.319 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the DU-145 Prostate cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -6.158 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -6.114 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -6.028 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -5.869 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.