Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | neurogenic locus protein delta | 0.0017 | 0.0108 | 0.0108 |
Trypanosoma cruzi | NADPH-dependent FMN/FAD containing oxidoreductase, putative | 0.0026 | 0.2857 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.0108 | 0.0108 |
Brugia malayi | EGF-like domain containing protein | 0.0017 | 0.0108 | 0.0108 |
Echinococcus multilocularis | fat cadherin tumor suppressor | 0.0017 | 0.0108 | 0.0108 |
Echinococcus multilocularis | neurogenic locus notch protein | 0.0017 | 0.0108 | 0.0108 |
Onchocerca volvulus | 0.0051 | 1 | 1 | |
Schistosoma mansoni | peroxidasin | 0.0051 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.0108 | 0.0108 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0051 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.0108 | 0.0108 |
Chlamydia trachomatis | sulfite reductase | 0.0016 | 0 | 0.5 |
Onchocerca volvulus | Peroxidasin homolog | 0.0051 | 1 | 1 |
Trypanosoma brucei | NADPH-dependent diflavin oxidoreductase 1 | 0.0026 | 0.2857 | 0.5 |
Echinococcus multilocularis | neural cadherin | 0.0017 | 0.0108 | 0.0108 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.0108 | 0.0108 |
Brugia malayi | Delta serrate ligand family protein | 0.0017 | 0.0108 | 0.0108 |
Brugia malayi | EGF-like domain containing protein | 0.0017 | 0.0108 | 0.0108 |
Echinococcus multilocularis | protein jagged 1 | 0.0017 | 0.0108 | 0.0108 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.0108 | 0.0108 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.0108 | 0.0108 |
Trypanosoma brucei | NADPH--cytochrome P450 reductase, putative | 0.0026 | 0.2857 | 0.5 |
Brugia malayi | Animal haem peroxidase family protein | 0.0051 | 1 | 1 |
Brugia malayi | Animal haem peroxidase family protein | 0.0051 | 1 | 1 |
Echinococcus multilocularis | protein jagged 1 | 0.0017 | 0.0108 | 0.0108 |
Brugia malayi | Calcium binding EGF domain containing protein | 0.0017 | 0.0108 | 0.0108 |
Onchocerca volvulus | 0.0051 | 1 | 1 | |
Brugia malayi | EGF-like domain containing protein | 0.0017 | 0.0108 | 0.0108 |
Trypanosoma cruzi | cytochrome P450 reductase, putative | 0.0026 | 0.2857 | 0.5 |
Brugia malayi | Calcium binding EGF domain containing protein | 0.0017 | 0.0108 | 0.0108 |
Echinococcus multilocularis | fibropellin Ia | 0.0017 | 0.0108 | 0.0108 |
Brugia malayi | FAD binding domain containing protein | 0.0026 | 0.2857 | 0.2857 |
Loa Loa (eye worm) | hypothetical protein | 0.0051 | 1 | 1 |
Echinococcus granulosus | fibropellin Ia | 0.0017 | 0.0108 | 0.0108 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.0108 | 0.0108 |
Trypanosoma brucei | NADPH-cytochrome p450 reductase, putative | 0.0026 | 0.2857 | 0.5 |
Echinococcus multilocularis | neurogenic locus notch protein 4 | 0.0017 | 0.0108 | 0.0108 |
Brugia malayi | Animal haem peroxidase family protein | 0.0051 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0051 | 1 | 1 |
Brugia malayi | Peroxidasin | 0.0051 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0017 | 0.0108 | 0.0108 |
Brugia malayi | Animal haem peroxidase family protein | 0.0051 | 1 | 1 |
Echinococcus granulosus | neurogenic locus notch protein 4 | 0.0017 | 0.0108 | 0.0108 |
Schistosoma mansoni | hypothetical protein | 0.0017 | 0.0108 | 0.0108 |
Echinococcus multilocularis | NADPH dependent diflavin oxidoreductase 1 | 0.0026 | 0.2857 | 0.2857 |
Schistosoma mansoni | peroxidasin | 0.0051 | 1 | 1 |
Brugia malayi | Muscle positioning protein 4 | 0.0017 | 0.0108 | 0.0108 |
Brugia malayi | Cadherin domain containing protein | 0.0017 | 0.0108 | 0.0108 |
Trypanosoma cruzi | cytochrome P450 reductase, putative | 0.0026 | 0.2857 | 0.5 |
Echinococcus multilocularis | peroxidasin | 0.0051 | 1 | 1 |
Brugia malayi | EGF-like domain containing protein | 0.0017 | 0.0108 | 0.0108 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.0108 | 0.0108 |
Echinococcus granulosus | protein jagged 1 | 0.0017 | 0.0108 | 0.0108 |
Echinococcus granulosus | delta-like protein 1 | 0.0017 | 0.0108 | 0.0108 |
Schistosoma mansoni | hypothetical protein | 0.0017 | 0.0108 | 0.0108 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.0108 | 0.0108 |
Loa Loa (eye worm) | hypothetical protein | 0.0051 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.0108 | 0.0108 |
Schistosoma mansoni | notch | 0.0017 | 0.0108 | 0.0108 |
Trypanosoma brucei | NADPH--cytochrome P450 reductase, putative | 0.0026 | 0.2857 | 0.5 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0051 | 1 | 1 |
Brugia malayi | Calcium binding EGF domain containing protein | 0.0017 | 0.0108 | 0.0108 |
Brugia malayi | Animal haem peroxidase family protein | 0.0051 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.0108 | 0.0108 |
Schistosoma mansoni | notch | 0.0017 | 0.0108 | 0.0108 |
Schistosoma mansoni | hypothetical protein | 0.0017 | 0.0108 | 0.0108 |
Echinococcus granulosus | neurogenic locus notch protein | 0.0017 | 0.0108 | 0.0108 |
Leishmania major | p450 reductase, putative | 0.0026 | 0.2857 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0051 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0051 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.2857 | 0.2857 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.0108 | 0.0108 |
Schistosoma mansoni | notch | 0.0017 | 0.0108 | 0.0108 |
Loa Loa (eye worm) | hypothetical protein | 0.0051 | 1 | 1 |
Loa Loa (eye worm) | Notch2 | 0.0017 | 0.0108 | 0.0108 |
Schistosoma mansoni | cytochrome P450 reductase | 0.0026 | 0.2857 | 0.2857 |
Echinococcus granulosus | protein jagged 1 | 0.0017 | 0.0108 | 0.0108 |
Loa Loa (eye worm) | hypothetical protein | 0.0051 | 1 | 1 |
Echinococcus granulosus | notch | 0.0017 | 0.0108 | 0.0108 |
Brugia malayi | Blistered cuticle protein 3 | 0.0051 | 1 | 1 |
Echinococcus granulosus | neural cadherin | 0.0017 | 0.0108 | 0.0108 |
Toxoplasma gondii | EGF family domain-containing protein | 0.0017 | 0.0108 | 0.5 |
Plasmodium vivax | NADPH-cytochrome p450 reductase, putative | 0.0026 | 0.2857 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.0108 | 0.0108 |
Leishmania major | NADPH-cytochrome p450 reductase-like protein | 0.0026 | 0.2857 | 1 |
Onchocerca volvulus | Peroxidasin homolog | 0.0051 | 1 | 1 |
Echinococcus multilocularis | protein jagged 2 | 0.0017 | 0.0108 | 0.0108 |
Echinococcus multilocularis | neurogenic locus notch protein | 0.0017 | 0.0108 | 0.0108 |
Onchocerca volvulus | Dual oxidase homolog | 0.0051 | 1 | 1 |
Schistosoma mansoni | notch | 0.0017 | 0.0108 | 0.0108 |
Loa Loa (eye worm) | hypothetical protein | 0.0051 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0051 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.0108 | 0.0108 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.0108 | 0.0108 |
Onchocerca volvulus | Peroxidase homolog | 0.0051 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0017 | 0.0108 | 0.0108 |
Echinococcus granulosus | slit 2 protein | 0.0017 | 0.0108 | 0.0108 |
Trypanosoma cruzi | p450 reductase, putative | 0.0026 | 0.2857 | 0.5 |
Brugia malayi | GCC2 and GCC3 family protein | 0.0017 | 0.0108 | 0.0108 |
Loa Loa (eye worm) | hypothetical protein | 0.0051 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.0108 | 0.0108 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.0108 | 0.0108 |
Loa Loa (eye worm) | blistered cuticle protein 3 | 0.0051 | 1 | 1 |
Schistosoma mansoni | laminin gamma-3 chain | 0.0017 | 0.0108 | 0.0108 |
Schistosoma mansoni | septate junction protein | 0.0017 | 0.0108 | 0.0108 |
Loa Loa (eye worm) | notch protein | 0.0017 | 0.0108 | 0.0108 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.0108 | 0.0108 |
Echinococcus granulosus | NADPH cytochrome P450 reductase | 0.0026 | 0.2857 | 0.2857 |
Echinococcus multilocularis | slit 2 protein | 0.0017 | 0.0108 | 0.0108 |
Mycobacterium ulcerans | formate dehydrogenase H FdhF | 0.0026 | 0.2857 | 0.5 |
Schistosoma mansoni | cell polarity protein | 0.0017 | 0.0108 | 0.0108 |
Giardia lamblia | Hypothetical protein | 0.0023 | 0.2008 | 1 |
Brugia malayi | Transmembrane cell adhesion receptor mua-3 precursor, putative | 0.0017 | 0.0108 | 0.0108 |
Brugia malayi | flavodoxin family protein | 0.0026 | 0.2857 | 0.2857 |
Loa Loa (eye worm) | hypothetical protein | 0.0051 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0017 | 0.0108 | 0.0108 |
Brugia malayi | EGF-like domain containing protein | 0.0017 | 0.0108 | 0.0108 |
Schistosoma mansoni | hypothetical protein | 0.0017 | 0.0108 | 0.0108 |
Loa Loa (eye worm) | FAD binding domain-containing protein | 0.0026 | 0.2857 | 0.2857 |
Brugia malayi | Cadherin domain containing protein | 0.0017 | 0.0108 | 0.0108 |
Schistosoma mansoni | slit | 0.0017 | 0.0108 | 0.0108 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.0108 | 0.0108 |
Echinococcus multilocularis | neurogenic locus protein delta | 0.0017 | 0.0108 | 0.0108 |
Echinococcus granulosus | NADPH dependent diflavin oxidoreductase 1 | 0.0026 | 0.2857 | 0.2857 |
Brugia malayi | EGF-like domain containing protein | 0.0017 | 0.0108 | 0.0108 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0051 | 1 | 1 |
Schistosoma mansoni | notch | 0.0017 | 0.0108 | 0.0108 |
Onchocerca volvulus | Chorion peroxidase homolog | 0.0051 | 1 | 1 |
Echinococcus multilocularis | notch | 0.0017 | 0.0108 | 0.0108 |
Trichomonas vaginalis | sulfite reductase, putative | 0.0026 | 0.2857 | 1 |
Echinococcus granulosus | protein jagged 2 | 0.0017 | 0.0108 | 0.0108 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.0108 | 0.0108 |
Onchocerca volvulus | Peroxidase homolog | 0.0051 | 1 | 1 |
Plasmodium falciparum | nitric oxide synthase, putative | 0.0026 | 0.2857 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0051 | 1 | 1 |
Brugia malayi | EGF-like domain containing protein | 0.0017 | 0.0108 | 0.0108 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.0108 | 0.0108 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0051 | 1 | 1 |
Schistosoma mansoni | Pro-neuregulin-4 membrane-bound isoform (Pro-NRG4) [Contains: Neuregulin-4 (NRG-4)] | 0.0017 | 0.0108 | 0.0108 |
Giardia lamblia | Nitric oxide synthase, inducible | 0.0023 | 0.2008 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0051 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.0108 | 0.0108 |
Echinococcus multilocularis | NADPH cytochrome P450 reductase | 0.0026 | 0.2857 | 0.2857 |
Echinococcus multilocularis | neurogenic locus protein delta | 0.0017 | 0.0108 | 0.0108 |
Echinococcus granulosus | neurogenic locus notch protein | 0.0017 | 0.0108 | 0.0108 |
Loa Loa (eye worm) | hypothetical protein | 0.0051 | 1 | 1 |
Schistosoma mansoni | notch | 0.0017 | 0.0108 | 0.0108 |
Echinococcus granulosus | protein jagged 2 | 0.0017 | 0.0108 | 0.0108 |
Onchocerca volvulus | 0.0051 | 1 | 1 | |
Echinococcus granulosus | peroxidasin | 0.0051 | 1 | 1 |
Brugia malayi | notch-like transmembrane receptor | 0.0017 | 0.0108 | 0.0108 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
GI50 (functional) | -5.318 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.904 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.757 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.742 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-5 Melanoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.626 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MALME-3M Melanoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.606 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.558 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the DU-145 Prostate cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.452 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MDA-N Breast cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.