TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 555.988 | Formula: C26H27ClFN7O4
H donors: 5 H acceptors: 5 LogP: 4.74 Rotable bonds: 9
Rule of 5 violations (Lipinski): 2
SMILES: COC(=O)N[C@@H]1CC(C)(C)c2c(NC1=O)cc(cc2)Nc1ncc(c(n1)Nc1c(F)cccc1C(=O)NC)Cl
InChi: 1S/C26H27ClFN7O4/c1-26(2)11-19(33-25(38)39-4)23(37)32-18-10-13(8-9-15(18)26)31-24-30-12-16(27)21(35-24)34-20-14(22(36)29-3)6-5-7-17(20)28/h5-10,12,19H,11H2,1-4H3,(H,29,36)(H,32,37)(H,33,38)(H2,30,31,34,35)/t19-/m1/s1
InChiKey: XMKAFTZMVDNUII-LJQANCHMSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	insulin receptor	Starlite/ChEMBL	References
Homo sapiens	MET proto-oncogene, receptor tyrosine kinase	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Schistosoma japonicum	IPR000494,EGF receptor, L domain,domain-containing	Get druggable targets OG5_129857	All targets in OG5_129857
Schistosoma japonicum	IPR008957,Fibronectin, type III-like fold,domain-containing	Get druggable targets OG5_129857	All targets in OG5_129857
Schistosoma japonicum	Insulin-like peptide receptor precursor, putative	Get druggable targets OG5_129857	All targets in OG5_129857
Brugia malayi	Protein kinase domain containing protein	Get druggable targets OG5_129857	All targets in OG5_129857
Echinococcus granulosus	insulin receptor	Get druggable targets OG5_129857	All targets in OG5_129857
Schistosoma mansoni	tyrosine kinase	Get druggable targets OG5_129857	All targets in OG5_129857
Echinococcus multilocularis	insulin receptor	Get druggable targets OG5_129857	All targets in OG5_129857
Schistosoma mansoni	tyrosine kinase	Get druggable targets OG5_129857	All targets in OG5_129857
Schistosoma japonicum	ko:K08252 receptor protein-tyrosine kinase [EC2.7.10.1], putative	Get druggable targets OG5_129857	All targets in OG5_129857
Echinococcus multilocularis	insulin growth factor 1 receptor beta	Get druggable targets OG5_129857	All targets in OG5_129857
Brugia malayi	Protein kinase domain containing protein	Get druggable targets OG5_129857	All targets in OG5_129857
Loa Loa (eye worm)	TK/INSR protein kinase	Get druggable targets OG5_129857	All targets in OG5_129857
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_129857	All targets in OG5_129857
Echinococcus granulosus	insulin growth factor 1 receptor beta	Get druggable targets OG5_129857	All targets in OG5_129857
Schistosoma japonicum	ko:K04527 insulin receptor, putative	Get druggable targets OG5_129857	All targets in OG5_129857
Schistosoma japonicum	Insulin-like peptide receptor precursor, putative	Get druggable targets OG5_129857	All targets in OG5_129857

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	tyrosine kinase	0.0071	0.0101	0.0101
Toxoplasma gondii	4'-phosphopantetheinyl transferase superfamily protein	0.0027	0.0018	0.0003
Schistosoma mansoni	cathepsin F (C01 family)	0.0025	0.0015	0.0015
Echinococcus multilocularis	Niemann Pick C1 protein	0.016	0.0267	0.5612
Entamoeba histolytica	acyl-coA synthetase, putative	0.0027	0.0019	0.1068
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0025	0.0015	0.0173
Mycobacterium ulcerans	acyl-CoA synthetase	0.0027	0.0019	1
Echinococcus granulosus	insulin receptor	0.0159	0.0266	0.5661
Mycobacterium ulcerans	acyl-CoA synthetase	0.0027	0.0019	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0025	0.0015	0.0025
Trichomonas vaginalis	Clan CA, family C54, ATG4-like cysteine peptidase	0.0067	0.0094	0.0151
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0027	0.0019	1
Brugia malayi	Protein kinase domain containing protein	0.0159	0.0266	0.5661
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0025	0.0015	0.0025
Entamoeba histolytica	peptidase, C54 family	0.0026	0.0017	0.0983
Echinococcus multilocularis	plexin a4	0.0025	0.0015	0.0162
Loa Loa (eye worm)	cysteine protease	0.0025	0.0015	0.0173
Echinococcus multilocularis	sterol regulatory element binding protein	0.0048	0.0058	0.1101
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0025	0.0015	0.0025
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0025	0.0015	0.0025
Echinococcus multilocularis	L aminoadipate semialdehyde	0.0094	0.0145	0.2975
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.3331	0.6197	1
Onchocerca volvulus		0.0025	0.0015	0.0173
Schistosoma mansoni	aminoadipate-semialdehyde dehydrogenase	0.0094	0.0145	0.0145
Schistosoma mansoni	niemann-pick C1 (NPC1)	0.0113	0.0181	0.0181
Trypanosoma brucei	cysteine peptidase, Clan CA, family C54, putative	0.0026	0.0017	0.0253
Plasmodium vivax	dipeptidyl aminopeptidase 1, putative	0.5365	1	1
Echinococcus granulosus	plexin a4	0.0025	0.0015	0.0315
Echinococcus multilocularis	cathepsin L cysteine protease	0.0025	0.0015	0.0177
Loa Loa (eye worm)	TK/EGFR protein kinase	0.0073	0.0105	0.1173
Brugia malayi	AMP-binding enzyme family protein	0.0027	0.0019	0.0403
Plasmodium vivax	holo-[acyl-carrier-protein] synthase, putative	0.0027	0.0018	0.0012
Plasmodium vivax	dipeptidyl aminopeptidase 3, putative	0.2039	0.378	0.3776
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0025	0.0015	0.0025
Trypanosoma brucei	hypothetical protein, conserved	0.0027	0.0018	0.0358
Entamoeba histolytica	cysteine protease, putative	0.0025	0.0015	0.0872
Loa Loa (eye worm)	hypothetical protein	0.0067	0.0094	0.1047
Brugia malayi	AMP-binding enzyme family protein	0.0027	0.0019	0.0403
Brugia malayi	Plexin repeat family protein	0.0021	0.0008	0.0163
Toxoplasma gondii	preprocathepsin c precursor, putative	0.5365	1	1
Echinococcus multilocularis	epidermal growth factor receptor	0.0073	0.0105	0.2112
Plasmodium vivax	vivapain-2	0.0025	0.0015	0.0009
Schistosoma mansoni	plexin	0.0021	0.0008	0.0008
Plasmodium vivax	dipeptidyl aminopeptidase 2, putative	0.5365	1	1
Mycobacterium ulcerans	long-chain-fatty-acid-CoA ligase	0.0027	0.0019	1
Echinococcus granulosus	expressed conserved protein	0.0105	0.0165	0.3505
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0027	0.0019	0.1068
Echinococcus granulosus	insulin growth factor 1 receptor beta	0.0159	0.0266	0.5661
Mycobacterium ulcerans	long-chain fatty-acid CoA ligase	0.0027	0.0019	1
Mycobacterium tuberculosis	Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase)	0.002	0.0006	0.139
Brugia malayi	AMP-binding enzyme family protein	0.0027	0.0019	0.0403
Trypanosoma cruzi	AUT2/APG4/ATG4 cysteine peptidase, putative	0.0026	0.0017	0.1862
Schistosoma mansoni	tyrosine kinase	0.0071	0.0101	0.0101
Trypanosoma cruzi	cysteine peptidase, putative	0.0025	0.0015	0.165
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0025	0.0015	0.0025
Plasmodium falciparum	cysteine proteinase falcipain 3	0.0025	0.0015	0.0009
Brugia malayi	Niemann-Pick C1 protein precursor	0.0112	0.0178	0.3775
Entamoeba histolytica	peptidase, C54 family	0.0026	0.0017	0.0983
Onchocerca volvulus	Cathepsin L homolog	0.0025	0.0015	0.0173
Mycobacterium ulcerans	acyl-CoA synthetase	0.0027	0.0019	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0025	0.0015	0.0025
Brugia malayi	Protein kinase domain containing protein	0.0089	0.0134	0.2852
Echinococcus granulosus	melanoma receptor tyrosine protein kinase	0.0073	0.0105	0.2234
Echinococcus granulosus	Protein patched homolog 1	0.0048	0.0058	0.124
Plasmodium falciparum	dipeptidyl aminopeptidase 3	0.2039	0.378	0.3776
Loa Loa (eye worm)	hypothetical protein	0.0268	0.047	0.525
Schistosoma mansoni	tyrosine kinase	0.0073	0.0105	0.0105
Loa Loa (eye worm)	ctsf protein	0.0025	0.0015	0.0173
Schistosoma mansoni	hypothetical protein	0.0046	0.0055	0.0055
Loa Loa (eye worm)	hypothetical protein	0.0059	0.0078	0.0876
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.0025	0.0015	0.0009
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0025	0.0015	0.0025
Echinococcus granulosus	Peptidase C54	0.0067	0.0094	0.1994
Leishmania major	4-coumarate:coa ligase-like protein	0.0027	0.0019	0.0446
Plasmodium vivax	vivapain-2	0.0025	0.0015	0.0009
Echinococcus granulosus	cathepsin L cysteine proteinase	0.0025	0.0015	0.0329
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0025	0.0015	0.0025
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0025	0.0015	0.0025
Onchocerca volvulus		0.0025	0.0015	0.0173
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0008	0.0086
Loa Loa (eye worm)	plexin A	0.0025	0.0015	0.0165
Loa Loa (eye worm)	hypothetical protein	0.0094	0.0145	0.1619
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0058	0.0651
Leishmania major	AUT2/APG4/ATG4 cysteine peptidase, putative	0.0026	0.0017	0.0253
Loa Loa (eye worm)	hypothetical protein	0.0104	0.0164	0.1829
Trypanosoma cruzi	cysteine peptidase, putative	0.0025	0.0015	0.165
Schistosoma mansoni	tyrosine kinase	0.0159	0.0266	0.0266
Mycobacterium ulcerans	long-chain-fatty-acid--CoA ligase	0.0027	0.0019	1
Trypanosoma cruzi	cysteine peptidase, putative	0.0025	0.0015	0.165
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.0025	0.0015	0.0009
Onchocerca volvulus		0.0025	0.0015	0.0173
Onchocerca volvulus		0.0025	0.0015	0.0173
Schistosoma mansoni	survival motor neuron protein	0.0055	0.0071	0.0071
Entamoeba histolytica	cysteine proteinase, putative	0.0025	0.0015	0.0872
Mycobacterium ulcerans	phosphopantetheinyl transferase, PptII	0.0027	0.0018	0.9458
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0015	0.0173
Echinococcus granulosus	survival motor neuron protein 1	0.0268	0.047	1
Loa Loa (eye worm)	fibroinase	0.0025	0.0015	0.0173
Brugia malayi	aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase	0.0094	0.0145	0.3084
Entamoeba histolytica	peptidase, C54 family	0.0026	0.0017	0.0983
Echinococcus multilocularis	insulin growth factor 1 receptor beta	0.0159	0.0266	0.5593
Trichomonas vaginalis	Clan CA, family C54, ATG4-like cysteine peptidase	0.0067	0.0094	0.0151
Echinococcus multilocularis	cysteine protease atg4b	0.0067	0.0094	0.1868
Echinococcus multilocularis	Peptidase C54	0.0067	0.0094	0.1868
Echinococcus multilocularis	insulin receptor	0.0159	0.0266	0.5593
Brugia malayi	plexin A	0.0025	0.0015	0.0315
Schistosoma mansoni	hypothetical protein	0.0046	0.0055	0.0055
Schistosoma mansoni	family C54 unassigned peptidase (C54 family)	0.0067	0.0094	0.0094
Brugia malayi	Cathepsin L-like precursor	0.0025	0.0015	0.0329
Brugia malayi	Cathepsin L-like precursor	0.0025	0.0015	0.0329
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0025	0.0015	0.0025
Toxoplasma gondii	autophagy-related cysteine peptidase atg4, putative	0.0026	0.0017	0.0002
Trichomonas vaginalis	Clan CA, family C54, ATG4-like cysteine peptidase	0.0067	0.0094	0.0151
Brugia malayi	Cathepsin L-like precursor	0.0025	0.0015	0.0329
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0025	0.0015	0.0177
Schistosoma mansoni	tyrosine kinase	0.0159	0.0266	0.0266
Echinococcus granulosus	epidermal growth factor receptor	0.0073	0.0105	0.2234
Schistosoma mansoni	tyrosine kinase	0.0071	0.0101	0.0101
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0025	0.0015	0.0025
Echinococcus granulosus	Niemann Pick C1 protein	0.016	0.0267	0.568
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0025	0.0015	0.0025
Mycobacterium ulcerans	hypothetical protein	0.0027	0.0019	1
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0027	0.0019	0.1068
Brugia malayi	Papain family cysteine protease containing protein	0.0025	0.0015	0.0329
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0025	0.0015	0.0025
Loa Loa (eye worm)	hypothetical protein	0.0086	0.013	0.1449
Onchocerca volvulus		0.0027	0.0019	0.0212
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C54, putative	0.0026	0.0017	0.1862
Brugia malayi	hypothetical protein	0.0268	0.047	1
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0019	0.0212
Toxoplasma gondii	4'-phosphopantetheinyl transferase domain-containing protein	0.0027	0.0018	0.0003
Wolbachia endosymbiont of Brugia malayi	4'-phosphopantetheinyl transferase	0.0027	0.0018	0.5
Leishmania major	phosphopantetheinyl transferase-like protein	0.0027	0.0018	0.0358
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0027	0.0019	1
Echinococcus granulosus	cathepsin l cysteine peptidase	0.0025	0.0015	0.0329
Onchocerca volvulus		0.0025	0.0015	0.0173
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0025	0.0015	0.0025
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0019	0.0212
Entamoeba histolytica	peptidase, C54 family	0.0067	0.0094	0.5282
Echinococcus multilocularis	cysteine protease	0.0025	0.0015	0.0177
Echinococcus multilocularis	protein dispatched 1	0.0055	0.0071	0.1375
Onchocerca volvulus		0.0025	0.0015	0.0173
Brugia malayi	Peptidase family C54 containing protein	0.0067	0.0094	0.1994
Trypanosoma cruzi	AUT2/APG4/ATG4 cysteine peptidase, putative	0.0067	0.0094	1
Schistosoma mansoni	family C54 unassigned peptidase (C54 family)	0.0067	0.0094	0.0094
Mycobacterium tuberculosis	Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase)	0.0027	0.0019	1
Echinococcus granulosus	epidermal growth factor receptor	0.0073	0.0105	0.2234
Echinococcus multilocularis	expressed conserved protein	0.0105	0.0165	0.3403
Loa Loa (eye worm)	hypothetical protein	0.0496	0.0896	1
Loa Loa (eye worm)	TK/INSR protein kinase	0.0159	0.0266	0.2972
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0027	0.0019	1
Toxoplasma gondii	cathepsin CPC1	0.5365	1	1
Schistosoma mansoni	hypothetical protein	0.0055	0.0071	0.0071
Schistosoma mansoni	tyrosine kinase	0.0073	0.0105	0.0105
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0025	0.0015	0.0025
Mycobacterium tuberculosis	holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie	0.0027	0.0018	0.9534
Loa Loa (eye worm)	hypothetical protein	0.002	0.0006	0.007
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0025	0.0015	0.0025
Trypanosoma brucei	AUT2/APG4/ATG4 cysteine peptidase, putative	0.0067	0.0094	1
Entamoeba histolytica	hypothetical protein	0.0027	0.0018	0.1029
Leishmania major	AUT2/APG4/ATG4 cysteine peptidase, putative	0.0067	0.0094	1
Brugia malayi	Phospholipase A2 family protein	0.0104	0.0164	0.3484
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0025	0.0015	0.0025
Plasmodium falciparum	holo-[acyl-carrier-protein] synthase, putative	0.0027	0.0018	0.0012
Loa Loa (eye worm)	hypothetical protein	0.002	0.0006	0.007
Brugia malayi	CHE-14 protein	0.0048	0.0058	0.124
Echinococcus granulosus	L aminoadipate semialdehyde	0.0094	0.0145	0.3084
Onchocerca volvulus		0.0055	0.0071	0.0792
Loa Loa (eye worm)	abnormal chemotaxis protein 14	0.0048	0.0058	0.0651
Schistosoma mansoni	dipeptidyl-peptidase I (C01 family)	0.5365	1	1
Loa Loa (eye worm)	hypothetical protein	0.002	0.0006	0.007
Echinococcus multilocularis	survival motor neuron protein 1	0.0268	0.047	1
Trypanosoma cruzi	cysteine peptidase, putative	0.0025	0.0015	0.165
Trypanosoma cruzi	cruzipain precursor, putative	0.0025	0.0015	0.165
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0025	0.0015	0.0025
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0025	0.0015	0.0025
Echinococcus granulosus	sterol regulatory element binding protein	0.0048	0.0058	0.124
Echinococcus multilocularis	cathepsin L cysteine protease	0.0025	0.0015	0.0177
Brugia malayi	Furin-like cysteine rich region family protein	0.0073	0.0105	0.2234
Treponema pallidum	4'-phosphopantetheinyl transferase	0.0027	0.0018	0.5
Leishmania major	4-coumarate:coa ligase-like protein	0.0027	0.0019	0.0446
Onchocerca volvulus		0.0025	0.0015	0.0173
Mycobacterium ulcerans	4'-phosphopantetheinyl transferase	0.0027	0.0018	0.9458
Echinococcus multilocularis	protein patched	0.0048	0.0058	0.1101
Schistosoma mansoni	patched 1	0.0048	0.0058	0.0058
Brugia malayi	Cathepsin L-like precursor	0.0025	0.0015	0.0329
Onchocerca volvulus		0.0094	0.0145	0.1619
Entamoeba histolytica	peptidase, C54 family	0.0026	0.0017	0.0983
Echinococcus multilocularis	epidermal growth factor receptor	0.0073	0.0105	0.2112
Toxoplasma gondii	cathepsin CPC2	0.2039	0.378	0.3771
Loa Loa (eye worm)	hypothetical protein	0.0112	0.0178	0.1982
Chlamydia trachomatis	holo [acyl-carrier protein] synthase	0.0027	0.0018	1
Echinococcus granulosus	cysteine protease atg4b	0.0067	0.0094	0.1994
Trichomonas vaginalis	Clan CA, family C54, ATG4-like cysteine peptidase	0.0067	0.0094	0.0151
Echinococcus granulosus	cathepsin l1	0.0025	0.0015	0.0329
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0019	0.0212
Schistosoma mansoni	hypothetical protein	0.0046	0.0055	0.0055
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0025	0.0015	0.0025
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0025	0.0015	0.0025
Brugia malayi	Cathepsin L-like precursor	0.0025	0.0015	0.0329
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0027	0.0019	1
Echinococcus multilocularis	cysteine protease	0.0025	0.0015	0.0177
Onchocerca volvulus	Cathepsin L homolog	0.0025	0.0015	0.0173
Onchocerca volvulus	Cathepsin F homolog	0.0025	0.0015	0.0173
Schistosoma mansoni	autophagin-1 (C54 family)	0.0067	0.0094	0.0094
Entamoeba histolytica	Niemann-Pick C1 protein, putative	0.0112	0.0178	1
Echinococcus multilocularis	Niemann Pick C1 protein	0.0112	0.0178	0.3676
Schistosoma mansoni	cathepsin F (C01 family)	0.0025	0.0015	0.0015
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0025	0.0015	0.0177
Loa Loa (eye worm)	hypothetical protein	0.002	0.0006	0.007
Schistosoma mansoni	hypothetical protein	0.0046	0.0055	0.0055
Trichomonas vaginalis	conserved hypothetical protein	0.0048	0.0058	0.0094
Onchocerca volvulus		0.0021	0.0008	0.0086
Entamoeba histolytica	cysteine proteinase, putative	0.0025	0.0015	0.0872
Brugia malayi	Cathepsin L-like precursor	0.0025	0.0015	0.0329
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0025	0.0015	0.0025
Leishmania major	4-coumarate:coa ligase-like protein	0.0027	0.0019	0.0446
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0025	0.0015	0.0025
Plasmodium falciparum	dipeptidyl aminopeptidase 1	0.5365	1	1
Brugia malayi	Iron-sulfur cluster assembly accessory protein	0.0055	0.0071	0.1509
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.0025	0.0015	0.0173
Loa Loa (eye worm)	hypothetical protein	0.002	0.0006	0.007
Onchocerca volvulus	Phospholipase A2 homolog	0.0104	0.0164	0.1829
Schistosoma mansoni	tyrosine kinase	0.0073	0.0105	0.0105
Onchocerca volvulus	Phospholipase A2 homolog	0.0496	0.0896	1
Trichomonas vaginalis	Clan CA, family C54, ATG4-like cysteine peptidase	0.0067	0.0094	0.0151
Plasmodium falciparum	cysteine protease ATG4, putative	0.0026	0.0017	0.0011
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0025	0.0015	0.0025
Plasmodium falciparum	dipeptidyl aminopeptidase 2	0.5365	1	1
Echinococcus granulosus	Niemann Pick C1 protein	0.0112	0.0178	0.3775

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 7 nM	Inhibition of c-Met phosphorylation in human GTL16 cells after 2 hrs by immunoassay	ChEMBL.	21967808
IC50 (binding)	= 78 nM	Inhibition of GST-tagged c-Met expressed in baculovirus system using phospholipase C-gamma as substrate after 30 mins by time-resolved fluorescence assay	ChEMBL.	21967808
IC50 (binding)	= 273 nM	Inhibition of insulin receptor after 20 mins by time-resolved fluorescence assay	ChEMBL.	21967808

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1939493

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 1589955