Detailed information for compound 1596555

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 406.501 | Formula: C22H22N4O2S
  • H donors: 2 H acceptors: 3 LogP: 4.03 Rotable bonds: 0
    Rule of 5 violations (Lipinski): 1
  • SMILES: Nc1nc2Sc3cccc(c3)OCCCNC(=O)c3cc(c(n1)c2)c(C)cc3C
  • InChi: 1S/C22H22N4O2S/c1-13-9-14(2)18-11-17(13)19-12-20(26-22(23)25-19)29-16-6-3-5-15(10-16)28-8-4-7-24-21(18)27/h3,5-6,9-12H,4,7-8H2,1-2H3,(H,24,27)(H2,23,25,26)
  • InChiKey: HDKDXSZAJVZYLD-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens heat shock protein 90kDa alpha (cytosolic), class A member 1 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Leishmania mexicana lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma brucei heat shock protein, putative Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania mexicana heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Plasmodium knowlesi heat shock protein 90, putative Get druggable targets OG5_126623 All targets in OG5_126623
Candida albicans heat shock protein Get druggable targets OG5_126623 All targets in OG5_126623
Schistosoma mansoni heat shock protein Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania braziliensis heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma brucei gambiense heat shock protein 83,heat shock protein Get druggable targets OG5_126623 All targets in OG5_126623
Loa Loa (eye worm) heat shock protein 90 Get druggable targets OG5_126623 All targets in OG5_126623
Echinococcus granulosus heat shock protein Get druggable targets OG5_126623 All targets in OG5_126623
Plasmodium knowlesi endoplasmin, putative Get druggable targets OG5_126623 All targets in OG5_126623
Toxoplasma gondii heat shock protein 90, putative Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania mexicana heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Loa Loa (eye worm) endoplasmin Get druggable targets OG5_126623 All targets in OG5_126623
Plasmodium berghei heat shock protein 90, putative Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Schistosoma mansoni endoplasmin Get druggable targets OG5_126623 All targets in OG5_126623
Brugia malayi Endoplasmin precursor Get druggable targets OG5_126623 All targets in OG5_126623
Echinococcus multilocularis heat shock protein 90 Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma brucei heat shock protein, putative Get druggable targets OG5_126623 All targets in OG5_126623
Schistosoma japonicum ko:K09487 heat shock protein 90kDa beta, putative Get druggable targets OG5_126623 All targets in OG5_126623
Plasmodium falciparum heat shock protein 90 Get druggable targets OG5_126623 All targets in OG5_126623
Babesia bovis hsp90 protein Get druggable targets OG5_126623 All targets in OG5_126623
Plasmodium yoelii heat shock 90 kDa protein homolog Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma brucei heat shock protein, putative Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Cryptosporidium parvum Hsp90 Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma brucei Heat shock protein 83, putative Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma brucei gambiense Heat shock protein 83, putative Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania braziliensis heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Giardia lamblia Heat shock protein HSP 90-alpha Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma cruzi heat shock protein 85, putative Get druggable targets OG5_126623 All targets in OG5_126623
Plasmodium vivax heat shock protein 86, putative Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Theileria parva heat shock protein 90 Get druggable targets OG5_126623 All targets in OG5_126623
Mycobacterium ulcerans heat shock protein 90 Get druggable targets OG5_126623 All targets in OG5_126623
Trichomonas vaginalis heat shock protein, putative Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma brucei gambiense Heat shock protein 83, putative Get druggable targets OG5_126623 All targets in OG5_126623
Wolbachia endosymbiont of Brugia malayi heat shock protein 90 Get druggable targets OG5_126623 All targets in OG5_126623
Trichomonas vaginalis heat shock protein, putative Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania infantum heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma brucei heat shock protein, putative Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma congolense Heat shock protein 83, putative Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma congolense heat shock protein 90, putative Get druggable targets OG5_126623 All targets in OG5_126623
Echinococcus multilocularis heat shock protein Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma cruzi heat shock protein 90, putative Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania infantum heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Treponema pallidum heat shock protein 90 Get druggable targets OG5_126623 All targets in OG5_126623
Schistosoma mansoni heat shock protein Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma cruzi heat shock protein 85, putative Get druggable targets OG5_126623 All targets in OG5_126623
Trichomonas vaginalis heat shock protein, putative Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma cruzi heat shock protein 85, putative Get druggable targets OG5_126623 All targets in OG5_126623
Giardia lamblia Heat shock protein HSP 90-alpha Get druggable targets OG5_126623 All targets in OG5_126623
Entamoeba histolytica heat shock protein 90, putative Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma brucei heat shock protein, putative Get druggable targets OG5_126623 All targets in OG5_126623
Neospora caninum HSP90, related Get druggable targets OG5_126623 All targets in OG5_126623
Toxoplasma gondii heat shock protein HSP90 Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania major lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative Get druggable targets OG5_126623 All targets in OG5_126623
Trichomonas vaginalis heat shock protein, putative Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Giardia lamblia Grp94/Hsp90 Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma brucei heat shock protein, putative Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania donovani heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Schistosoma mansoni endoplasmin Get druggable targets OG5_126623 All targets in OG5_126623
Schistosoma japonicum Heat shock protein HSP 90-beta, putative Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania donovani heat shock protein 90, putative Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma brucei gambiense lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative Get druggable targets OG5_126623 All targets in OG5_126623
Candida albicans heat shock protein Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania braziliensis heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Echinococcus granulosus heat shock protein 90 Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma cruzi heat shock protein 90, putative Get druggable targets OG5_126623 All targets in OG5_126623
Echinococcus granulosus heat shock protein heat shock protein 90 alpha Get druggable targets OG5_126623 All targets in OG5_126623
Candida albicans hypothetical protein Get druggable targets OG5_126623 All targets in OG5_126623
Echinococcus granulosus endoplasmin Get druggable targets OG5_126623 All targets in OG5_126623
Plasmodium yoelii putative heat shock protein 81-2 Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma brucei heat shock protein 90, putative Get druggable targets OG5_126623 All targets in OG5_126623
Mycobacterium tuberculosis Probable chaperone protein HtpG (heat shock protein) (HSP90 family protein) (high temperature protein G) Get druggable targets OG5_126623 All targets in OG5_126623
Echinococcus multilocularis heat shock protein 90 Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma cruzi heat shock protein 85, putative Get druggable targets OG5_126623 All targets in OG5_126623
Schistosoma japonicum ko:K04079 molecular chaperone HtpG, putative Get druggable targets OG5_126623 All targets in OG5_126623
Brugia malayi heat shock protein 90 Get druggable targets OG5_126623 All targets in OG5_126623
Entamoeba histolytica heat shock protein 90, putative Get druggable targets OG5_126623 All targets in OG5_126623
Echinococcus granulosus heat shock protein 90 Get druggable targets OG5_126623 All targets in OG5_126623
Plasmodium yoelii heat shock protein 90 Get druggable targets OG5_126623 All targets in OG5_126623
Schistosoma japonicum Heat shock protein HSP 90-alpha, putative Get druggable targets OG5_126623 All targets in OG5_126623
Mycobacterium leprae PROBABLE CHAPERONE PROTEIN HTPG (HEAT SHOCK PROTEIN) (HSP90 FAMILY PROTEIN) (HIGH TEMPERATURE PROTEIN G) Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma cruzi Heat shock protein 83, putative Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma brucei heat shock protein 90, putative Get druggable targets OG5_126623 All targets in OG5_126623
Schistosoma japonicum Heat shock protein 83, putative Get druggable targets OG5_126623 All targets in OG5_126623
Cryptosporidium hominis heat shock protein 83 Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma cruzi heat shock protein 90, putative Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Schistosoma japonicum IPR003367,Thrombospondin type 3 repeat;IPR002048,Calcium-binding EF-hand,domain-containing Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma congolense heat shock protein 90, putative Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma brucei heat shock protein, putative Get druggable targets OG5_126623 All targets in OG5_126623
Neospora caninum HSP90-like protein, related Get druggable targets OG5_126623 All targets in OG5_126623
Echinococcus multilocularis endoplasmin Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania braziliensis lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative Get druggable targets OG5_126623 All targets in OG5_126623
Trypanosoma brucei heat shock protein, putative Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania infantum heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Plasmodium vivax endoplasmin, putative Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania major heat shock protein 83-1 Get druggable targets OG5_126623 All targets in OG5_126623
Leishmania infantum lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative Get druggable targets OG5_126623 All targets in OG5_126623
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis Diacylglycerol kinase zeta 0.0036 0.0144 0.0056
Toxoplasma gondii heat shock protein HSP90 0.0039 0.0177 1
Trypanosoma cruzi diacylglycerol kinase-like protein, putative 0.0036 0.0144 0.8136
Leishmania major heat shock protein 83-1 0.0039 0.0177 1
Schistosoma mansoni endoplasmin 0.0039 0.0177 0.0034
Schistosoma mansoni sphingoid long chain base kinase 0.0931 1 1
Trichomonas vaginalis diacylglycerol kinase, epsilon, putative 0.0036 0.0144 0.8024
Plasmodium vivax heat shock protein 86, putative 0.0039 0.0177 1
Schistosoma mansoni endoplasmin 0.0039 0.0177 0.0034
Echinococcus multilocularis heat shock protein 90 0.0039 0.0177 0.0089
Leishmania major heat shock protein 83-1 0.0039 0.0177 1
Loa Loa (eye worm) hypothetical protein 0.0931 1 1
Leishmania major heat shock protein 83-1 0.0039 0.0177 1
Giardia lamblia Heat shock protein HSP 90-alpha 0.0039 0.0177 1
Trypanosoma cruzi heat shock protein 90, putative 0.0031 0.0089 0.503
Entamoeba histolytica heat shock protein 90, putative 0.0039 0.0177 0.0034
Mycobacterium ulcerans diacylglycerol kinase 0.0036 0.0144 0.0056
Echinococcus multilocularis ceramide kinase 0.0036 0.0144 0.0056
Trypanosoma cruzi Sphingosine kinase 0.0036 0.0144 0.8136
Trypanosoma cruzi diacylglycerol kinase, putative 0.0036 0.0144 0.8136
Trypanosoma brucei heat shock protein 90, putative 0.0039 0.0177 1
Leishmania major heat shock protein 83-1 0.0039 0.0177 1
Trypanosoma brucei heat shock protein, putative 0.0039 0.0177 1
Trypanosoma brucei heat shock protein, putative 0.0039 0.0177 1
Trichomonas vaginalis bmru protein, putative 0.0036 0.0144 0.8024
Brugia malayi heat shock protein 90 0.0039 0.0177 1
Leishmania major hypothetical protein, conserved 0.0036 0.0144 0.6249
Trypanosoma cruzi heat shock protein 85, putative 0.0039 0.0177 1
Echinococcus granulosus heat shock protein 90 0.0039 0.0177 0.0089
Leishmania major heat shock protein 83-1 0.0039 0.0177 1
Leishmania major heat shock protein 83-1 0.0039 0.0177 1
Trypanosoma brucei heat shock protein, putative 0.0039 0.0177 1
Trypanosoma brucei heat shock protein, putative 0.0039 0.0177 1
Trichomonas vaginalis conserved hypothetical protein 0.0036 0.0144 0.8024
Leishmania major heat shock protein 83-1 0.0039 0.0177 1
Loa Loa (eye worm) heat shock protein 90 0.0039 0.0177 0.0034
Trypanosoma cruzi diacylglycerol kinase-like protein, putative 0.0036 0.0144 0.8136
Leishmania major heat shock protein 83-1 0.0039 0.0177 1
Plasmodium vivax endoplasmin, putative 0.0039 0.0177 1
Echinococcus granulosus ceramide kinase 0.0036 0.0144 0.0056
Wolbachia endosymbiont of Brugia malayi heat shock protein 90 0.0031 0.0089 0.5
Trypanosoma brucei heat shock protein, putative 0.0039 0.0177 1
Onchocerca volvulus Ceramide kinase 1 homolog 0.0036 0.0144 0.5
Echinococcus multilocularis acylglycerol kinase, mitochondrial 0.0036 0.0144 0.0056
Schistosoma mansoni sphingosine kinase A B 0.0931 1 1
Plasmodium falciparum diacylglycerol kinase, putative 0.0036 0.0144 0.8024
Leishmania major heat shock protein 83-1 0.0039 0.0177 1
Leishmania major diacylglycerol kinase-like protein 0.0036 0.0144 0.6249
Trichomonas vaginalis sphingosine kinase, putative 0.0036 0.0144 0.8024
Brugia malayi Endoplasmin precursor 0.0039 0.0177 1
Trypanosoma brucei heat shock protein, putative 0.0039 0.0177 1
Mycobacterium ulcerans hypothetical protein 0.0931 1 1
Entamoeba histolytica hypothetical protein, conserved 0.0931 1 1
Trichomonas vaginalis sphingosine kinase, putative 0.0036 0.0144 0.8024
Echinococcus granulosus Diacylglycerol kinase theta 0.0036 0.0144 0.0056
Trichomonas vaginalis diacylglycerol kinase, putative 0.0036 0.0144 0.8024
Echinococcus multilocularis Diacylglycerol kinase theta 0.0036 0.0144 0.0056
Leishmania major heat shock protein 83-1 0.0039 0.0177 1
Toxoplasma gondii heat shock protein 90, putative 0.0039 0.0177 1
Trichomonas vaginalis diacylglycerol kinase, zeta, iota, putative 0.0036 0.0144 0.8024
Echinococcus multilocularis sphingosine kinase 1 0.0931 1 1
Leishmania major heat shock protein 83-1 0.0039 0.0177 1
Trypanosoma cruzi heat shock protein 85, putative 0.0039 0.0177 1
Leishmania major heat shock protein 83-1 0.0039 0.0177 1
Trypanosoma cruzi heat shock protein 90, putative 0.0039 0.0177 1
Leishmania major hypothetical protein, conserved 0.0036 0.0144 0.6249
Leishmania major heat shock protein 83-1 0.0039 0.0177 1
Schistosoma mansoni heat shock protein 0.0039 0.0177 0.0034
Trichomonas vaginalis bmru protein, putative 0.0036 0.0144 0.8024
Trichomonas vaginalis heat shock protein, putative 0.0039 0.0177 1
Mycobacterium tuberculosis Diacylglycerol kinase 0.0036 0.0144 0.0056
Trichomonas vaginalis heat shock protein, putative 0.0031 0.0089 0.4732
Trichomonas vaginalis diacylglycerol kinase, zeta, iota, putative 0.0036 0.0144 0.8024
Mycobacterium tuberculosis Conserved protein 0.0931 1 1
Trypanosoma cruzi Heat shock protein 83, putative 0.0039 0.0177 1
Echinococcus granulosus acylglycerol kinase mitochondrial 0.0036 0.0144 0.0056
Plasmodium falciparum heat shock protein 90 0.0039 0.0177 1
Trypanosoma cruzi heat shock protein 85, putative 0.0031 0.0089 0.503
Trypanosoma brucei heat shock protein, putative 0.0039 0.0177 1
Trypanosoma cruzi diacylglycerol kinase, putative 0.0036 0.0144 0.8136
Plasmodium falciparum diacylglycerol kinase, putative 0.0036 0.0144 0.8024
Leishmania major sphingosine kinase A, B, putative 0.0036 0.0144 0.6249
Echinococcus multilocularis heat shock protein 0.0039 0.0177 0.0089
Entamoeba histolytica heat shock protein 90, putative 0.0039 0.0177 0.0034
Trichomonas vaginalis heat shock protein, putative 0.0031 0.0089 0.4732
Echinococcus granulosus heat shock protein 0.0039 0.0177 0.0089
Trypanosoma cruzi Sphingosine kinase 0.0036 0.0144 0.8136
Mycobacterium leprae PROBABLE CHAPERONE PROTEIN HTPG (HEAT SHOCK PROTEIN) (HSP90 FAMILY PROTEIN) (HIGH TEMPERATURE PROTEIN G) 0.0031 0.0089 0.5
Trypanosoma brucei Heat shock protein 83, putative 0.0039 0.0177 1
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0144 0.8136
Leishmania major heat shock protein 83-1 0.0039 0.0177 1
Trichomonas vaginalis heat shock protein, putative 0.0031 0.0089 0.4732
Leishmania major diacylglycerol kinase, putative 0.0036 0.0144 0.6249
Onchocerca volvulus 0.0036 0.0144 0.5
Leishmania major heat shock protein 83-1 0.0039 0.0177 1
Trypanosoma brucei heat shock protein 90, putative 0.0039 0.0177 1
Trichomonas vaginalis diacylglycerol kinase, putative 0.0036 0.0144 0.8024
Trypanosoma brucei heat shock protein, putative 0.0039 0.0177 1
Leishmania major heat shock protein 83-1 0.0039 0.0177 1
Loa Loa (eye worm) endoplasmin 0.0039 0.0177 0.0034
Treponema pallidum heat shock protein 90 0.0031 0.0089 0.5
Echinococcus granulosus Diacylglycerol kinase zeta 0.0036 0.0144 0.0056
Leishmania major heat shock protein 83-1 0.0039 0.0177 1
Trypanosoma cruzi heat shock protein 85, putative 0.0039 0.0177 1
Trypanosoma cruzi Diacylglycerol kinase catalytic domain containing protein, putative 0.0036 0.0144 0.8136
Schistosoma mansoni heat shock protein 0.0039 0.0177 0.0034

Activities

Activity type Activity value Assay description Source Reference
CLH (ADMET) = 93 uL/min Intrinsic clearance in mouse liver microsomes assessed per mg of protein at 5 uM after 60 mins ChEMBL. 22192591
IC50 (functional) = 0.78 uM Antiproliferative activity against human HCT116 cells ChEMBL. 22192591
IC50 (functional) = 0.94 uM Antiproliferative activity against human NCI-N87 cells overexpressing Her-2 ChEMBL. 22192591
Kd (binding) = 1.3 nM Binding affinity to N-terminus biotinylated human Hsp90 alpha by surface plasmon resonance assay ChEMBL. 22192591

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23 22192591

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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