TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 466.48 | Formula: C25H24F2N4O3
H donors: 1 H acceptors: 2 LogP: 3.45 Rotable bonds: 5
Rule of 5 violations (Lipinski): 1
SMILES: OCC1(ON=C2N1CCC/C/2=C\c1ccc(c(c1)OC)n1cnc(c1)C)c1cc(F)cc(c1)F
InChi: 1S/C25H24F2N4O3/c1-16-13-30(15-28-16)22-6-5-17(9-23(22)33-2)8-18-4-3-7-31-24(18)29-34-25(31,14-32)19-10-20(26)12-21(27)11-19/h5-6,8-13,15,32H,3-4,7,14H2,1-2H3/b18-8+
InChiKey: IVHPMGRSWKGUQU-QGMBQPNBSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	APH1B gamma secretase subunit	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Echinococcus multilocularis	gamma secretase subunit aph 1	Get druggable targets OG5_130831	All targets in OG5_130831
Schistosoma mansoni	gamma-secretase subunit aph-1	Get druggable targets OG5_130831	All targets in OG5_130831
Loa Loa (eye worm)	gamma-secretase subunit aph-1	Get druggable targets OG5_130831	All targets in OG5_130831
Brugia malayi	gamma-secretase subunit aph-1	Get druggable targets OG5_130831	All targets in OG5_130831
Echinococcus granulosus	gamma secretase subunit aph 1	Get druggable targets OG5_130831	All targets in OG5_130831
Schistosoma japonicum	ko:K06172 anterior pharynx defective 1, putative	Get druggable targets OG5_130831	All targets in OG5_130831

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	lozenge	0.0054	0.0329	0.0389
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.0179	0.1977	0.2339
Giardia lamblia	Aldose reductase	0.0179	0.1977	0.5
Schistosoma mansoni	sex comb on midleg homolog	0.0046	0.0229	0.027
Brugia malayi	oxidoreductase, aldo/keto reductase family protein	0.0179	0.1977	0.3739
Mycobacterium leprae	Possible oxidoreductase	0.0052	0.0301	0.1343
Echinococcus granulosus	histone acetyltransferase MYST2	0.0053	0.0313	0.037
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0179	0.1977	0.1977
Trichomonas vaginalis	aldo-keto reductase, putative	0.0179	0.1977	0.737
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0049	0.0261	0.0493
Echinococcus granulosus	aldo keto reductase	0.0179	0.1977	0.2339
Loa Loa (eye worm)	hypothetical protein	0.0053	0.0313	0.0592
Schistosoma mansoni	hypothetical protein	0.0033	0.0057	0.0068
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0179	0.1977	0.1977
Schistosoma mansoni	inositol monophosphatase	0.0036	0.0091	0.0107
Brugia malayi	hypothetical protein	0.0429	0.5289	1
Trypanosoma brucei	serine peptidase, Clan SC, Family S10	0.0272	0.321	1
Trypanosoma brucei	aldo-keto reductase, putative	0.0179	0.1977	0.6049
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0162	0.0307
Brugia malayi	Inositol-1	0.0036	0.0091	0.0171
Loa Loa (eye worm)	oxidoreductase	0.0179	0.1977	0.3739
Trichomonas vaginalis	aldo-keto reductase, putative	0.0179	0.1977	0.737
Echinococcus multilocularis	aldo keto reductase	0.0179	0.1977	0.1977
Schistosoma mansoni	scm-relatedprotein containing 4 mbt domains (sfmbt)	0.0046	0.0229	0.027
Loa Loa (eye worm)	matrixin family protein	0.0075	0.0609	0.1152
Onchocerca volvulus		0.0179	0.1977	0.3739
Brugia malayi	C2-HC type zinc finger protein C.e-MyT1	0.0053	0.0313	0.0592
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0202	0.2282	0.4316
Brugia malayi	Matrixin family protein	0.0034	0.0065	0.0123
Onchocerca volvulus		0.0179	0.1977	0.3739
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0065	0.0123
Entamoeba histolytica	aldose reductase, putative	0.0179	0.1977	1
Loa Loa (eye worm)	glutamate-cysteine ligase modifier subunit	0.0052	0.0301	0.057
Trichomonas vaginalis	aldo-keto reductase, putative	0.0179	0.1977	0.737
Echinococcus multilocularis	histone acetyltransferase MYST2	0.0053	0.0313	0.0313
Trichomonas vaginalis	conserved hypothetical protein	0.0052	0.0301	0.0822
Mycobacterium ulcerans	hydrolase	0.0041	0.0162	0.038
Echinococcus multilocularis	family S10 non peptidase ue (S10 family)	0.0245	0.2855	0.2855
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0229	0.0432
Onchocerca volvulus		0.0179	0.1977	0.3739
Trypanosoma brucei	prostaglandin f synthase	0.0179	0.1977	0.6049
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.0179	0.1977	0.2339
Trypanosoma cruzi	serine peptidase, Clan SC, Family S10, putative	0.0272	0.321	1
Entamoeba histolytica	Acid sphingomyelinase-like phosphodiesterase, putative	0.008	0.0675	0.3098
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.0179	0.1977	0.2339
Trypanosoma brucei	aldo/keto reductase, putative	0.0052	0.0301	0.0675
Echinococcus granulosus	aldo keto reductase family 1, member B4	0.0052	0.0301	0.0356
Mycobacterium tuberculosis	Probable oxidoreductase	0.0179	0.1977	1
Loa Loa (eye worm)	oxidoreductase	0.0179	0.1977	0.3739
Echinococcus multilocularis	Protein lozenge	0.0054	0.0329	0.0329
Trichomonas vaginalis	aldo-keto reductase, putative	0.0179	0.1977	0.737
Onchocerca volvulus		0.0048	0.0252	0.0476
Schistosoma mansoni	matrix metallopeptidase-7 (M10 family)	0.0034	0.0065	0.0077
Onchocerca volvulus	Matrix metalloproteinase homolog	0.0075	0.0609	0.1152
Trypanosoma cruzi	Aph-1 protein, putative	0.0115	0.1141	0.3366
Entamoeba histolytica	aldose reductase, putative	0.0179	0.1977	1
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0049	0.0261	0.0493
Schistosoma mansoni	inositol monophosphatase	0.0036	0.0091	0.0107
Brugia malayi	mbt repeat family protein	0.0046	0.0229	0.0432
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0179	0.1977	0.1977
Loa Loa (eye worm)	MBCTL1	0.0053	0.0313	0.0592
Trichomonas vaginalis	aldo-keto reductase, putative	0.0179	0.1977	0.737
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0049	0.0261	0.0493
Toxoplasma gondii	inositol(myo)-1(or 4)-monophosphatase 2, putative	0.0036	0.0091	0.0459
Trypanosoma cruzi	aldo/keto reductase, putative	0.0052	0.0301	0.0675
Echinococcus multilocularis	suppression of tumorigenicity 18 protein	0.0053	0.0313	0.0313
Giardia lamblia	Aldose reductase	0.0179	0.1977	0.5
Brugia malayi	oxidoreductase, aldo/keto reductase family protein	0.0179	0.1977	0.3739
Echinococcus granulosus	matrix metallopeptidase 7 M10 family	0.0123	0.1243	0.1471
Schistosoma mansoni	family S10 non-peptidase homologue (S10 family)	0.0272	0.321	0.3797
Onchocerca volvulus		0.0179	0.1977	0.3739
Echinococcus multilocularis	lysosomal protective protein	0.0272	0.321	0.321
Echinococcus multilocularis	inositol monophosphatase 1	0.0036	0.0091	0.0091
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0179	0.1977	0.1977
Onchocerca volvulus		0.023	0.2651	0.5012
Trichomonas vaginalis	aldo-keto reductase, putative	0.0179	0.1977	0.737
Mycobacterium leprae	PROBABLE OXIDOREDUCTASE	0.0179	0.1977	1
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0179	0.1977	0.1977
Echinococcus granulosus	gamma secretase subunit aph 1	0.0296	0.3526	0.4171
Trichomonas vaginalis	aldo-keto reductase, putative	0.0052	0.0301	0.0822
Echinococcus granulosus	polycomb protein SCMH1	0.0046	0.0229	0.027
Loa Loa (eye worm)	oxidoreductase	0.0179	0.1977	0.3739
Trypanosoma cruzi	aldo-keto reductase	0.0179	0.1977	0.6049
Schistosoma mansoni	aldo-keto reductase	0.0179	0.1977	0.2339
Brugia malayi	oxidoreductase, aldo/keto reductase family protein	0.0179	0.1977	0.3739
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.0179	0.1977	0.2339
Brugia malayi	glutamate-cysteine ligase modifier subunit	0.0052	0.0301	0.057
Trypanosoma brucei	Aph-1 protein, putative	0.0115	0.1141	0.3366
Schistosoma mansoni	hypothetical protein	0.0285	0.3379	0.3997
Mycobacterium tuberculosis	Conserved protein	0.0052	0.0301	0.1343
Onchocerca volvulus	Polycomb protein Sfmbt homolog	0.0046	0.0229	0.0432
Mycobacterium ulcerans	hypothetical protein	0.0052	0.0301	0.1116
Schistosoma mansoni	hypothetical protein	0.0164	0.1787	0.2114
Loa Loa (eye worm)	matrixin family protein	0.0082	0.0699	0.1321
Loa Loa (eye worm)	gamma-secretase subunit aph-1	0.0296	0.3526	0.6667
Schistosoma mansoni	aldo-keto reductase	0.0179	0.1977	0.2339
Brugia malayi	Hemopexin family protein	0.0048	0.0252	0.0476
Echinococcus multilocularis	polycomb protein SCMH1	0.0046	0.0229	0.0229
Leishmania major	aldo-keto reductase-like protein	0.0179	0.1977	0.6049
Schistosoma mansoni	myelin transcription factor 1 myt1	0.0053	0.0313	0.037
Loa Loa (eye worm)	hypothetical protein	0.0272	0.321	0.6069
Toxoplasma gondii	aldo/keto reductase family oxidoreductase	0.0052	0.0301	0.1523
Trichomonas vaginalis	aldo-keto reductase, putative	0.0179	0.1977	0.737
Echinococcus granulosus	aldo keto reductase	0.0179	0.1977	0.2339
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0065	0.0123
Leishmania major	prostaglandin f2-alpha synthase/D-arabinose dehydrogenase	0.0179	0.1977	0.6049
Echinococcus granulosus	aldehyde reductase	0.0127	0.1294	0.1531
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0179	0.1977	0.1977
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.0179	0.1977	0.2339
Echinococcus granulosus	suppression of tumorigenicity 18 protein	0.0053	0.0313	0.037
Onchocerca volvulus		0.0052	0.0301	0.057
Trichomonas vaginalis	aldo/keto reductase, putative	0.0179	0.1977	0.737
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0179	0.1977	0.1977
Brugia malayi	Matrixin family protein	0.0082	0.0699	0.1321
Plasmodium vivax	aldehyde reductase, putative	0.0052	0.0301	1
Echinococcus multilocularis	aldo keto reductase	0.0179	0.1977	0.1977
Trypanosoma cruzi	serine carboxypeptidase (CBP1), putative	0.0272	0.321	1
Schistosoma mansoni	family S10 unassigned peptidase (S10 family)	0.0272	0.321	0.3797
Plasmodium vivax	oxidoreductase, aldo/keto reductase domain containing protein	0.0052	0.0301	1
Brugia malayi	gamma-secretase subunit aph-1	0.0296	0.3526	0.6667
Leishmania major	serine carboxypeptidase (CBP1), putative,serine peptidase, Clan SC, Family S10	0.0272	0.321	1
Schistosoma mansoni	matrix metallopeptidase-9 (M10 family)	0.008	0.068	0.0804
Mycobacterium tuberculosis	Probable peptidoglycan hydrolase	0.0041	0.0162	0.0626
Brugia malayi	Matrix metalloprotease, N-terminal domain containing protein	0.0041	0.0162	0.0307
Loa Loa (eye worm)	mbt repeat family protein	0.0046	0.0229	0.0432
Onchocerca volvulus		0.0179	0.1977	0.3739
Brugia malayi	mbt repeat family protein	0.0046	0.0229	0.0432
Trypanosoma cruzi	serine carboxypeptidase (CBP1), putative	0.0272	0.321	1
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0179	0.1977	0.1977
Brugia malayi	Matrixin family protein	0.0034	0.0065	0.0123
Toxoplasma gondii	oxidoreductase, aldo/keto reductase family protein	0.0052	0.0301	0.1523
Brugia malayi	NADH-dependent xylose reductase	0.0052	0.0301	0.057
Schistosoma mansoni	hypothetical protein	0.0048	0.0252	0.0298
Brugia malayi	Matrixin family protein	0.0034	0.0065	0.0123
Echinococcus multilocularis	aldo keto reductase	0.0179	0.1977	0.1977
Leishmania major	aldo/keto reductase, putative,aldo/keto reductase family-like protein	0.0052	0.0301	0.0675
Echinococcus multilocularis	aldehyde reductase	0.0127	0.1294	0.1294
Schistosoma mansoni	sex comb on midleg homolog	0.0046	0.0229	0.027
Loa Loa (eye worm)	matrix metalloproteinase	0.0034	0.0065	0.0123
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0179	0.1977	0.1977
Plasmodium falciparum	aldehyde reductase, putative	0.0052	0.0301	0.5
Echinococcus granulosus	inositol monophosphatase 1	0.0036	0.0091	0.0107
Schistosoma mansoni	potassium channel beta	0.0052	0.0301	0.0356
Trichomonas vaginalis	aldo/keto reductase, putative	0.0179	0.1977	0.737
Onchocerca volvulus		0.0429	0.5289	1
Loa Loa (eye worm)	inositol-1	0.0036	0.0091	0.0171
Echinococcus multilocularis	gamma secretase subunit aph 1	0.0296	0.3526	0.3526
Echinococcus multilocularis	microtubule associated protein 2	0.0669	0.8453	0.8453
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0065	0.0123
Echinococcus granulosus	lysosomal protective protein	0.0272	0.321	0.3797
Toxoplasma gondii	aldo-keto reductase	0.0052	0.0301	0.1523
Schistosoma mansoni	gamma-secretase subunit aph-1	0.0296	0.3526	0.4171
Toxoplasma gondii	aldose reductase, putative	0.0179	0.1977	1
Echinococcus multilocularis	geminin	0.0164	0.1787	0.1787
Loa Loa (eye worm)	hypothetical protein	0.008	0.0675	0.1277
Brugia malayi	oxidoreductase, aldo/keto reductase family protein	0.0179	0.1977	0.3739
Trichomonas vaginalis	aldo-keto reductase, putative	0.0179	0.1977	0.737
Echinococcus multilocularis	SAM and MBT domain containing protein	0.0046	0.0229	0.0229
Leishmania major	prostaglandin f synthase, putative	0.0179	0.1977	0.6049
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.0179	0.1977	0.2339
Echinococcus granulosus	endonuclease exonuclease phosphatase	0.0186	0.2073	0.2452
Loa Loa (eye worm)	hypothetical protein	0.0429	0.5289	1
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.0179	0.1977	0.2339
Schistosoma mansoni	microtubule-associated protein tau	0.0669	0.8453	1
Trypanosoma brucei	serine peptidase, Clan SC, Family S10	0.0272	0.321	1
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0179	0.1977	0.1977
Echinococcus multilocularis	endonuclease exonuclease phosphatase	0.0186	0.2073	0.2073
Trichomonas vaginalis	aldo-keto reductase, putative	0.0052	0.0301	0.0822
Trichomonas vaginalis	set domain proteins, putative	0.023	0.2651	1
Echinococcus multilocularis	aldo keto reductase	0.0179	0.1977	0.1977
Loa Loa (eye worm)	hypothetical protein	0.0179	0.1977	0.3739
Echinococcus granulosus	voltage gated potassium channel subunit	0.0052	0.0301	0.0356
Trypanosoma cruzi	aldo/keto reductase, putative	0.0179	0.1977	0.6049
Leishmania major	aldehyde reductase, putative,oxidoreductase, putative	0.0179	0.1977	0.6049
Echinococcus granulosus	family S10 non peptidase ue S10 family	0.0245	0.2855	0.3377
Trichomonas vaginalis	alcohol dehydrogenase, putative	0.0052	0.0301	0.0822
Schistosoma mansoni	pol-related	0.0179	0.1977	0.2339
Brugia malayi	latrophilin 2 splice variant baaae	0.0033	0.0057	0.0108
Trichomonas vaginalis	aldo-keto reductase, putative	0.0179	0.1977	0.737
Echinococcus granulosus	SAM and MBT domain containing protein	0.0046	0.0229	0.027
Onchocerca volvulus		0.0046	0.0229	0.0432
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0179	0.1977	0.1977
Echinococcus granulosus	hypothetical protein	0.0179	0.1977	0.2339
Mycobacterium leprae	PROBABLE HYDROLASE	0.0041	0.0162	0.0626
Trypanosoma cruzi	Aph-1 protein, putative	0.0115	0.1141	0.3366
Echinococcus granulosus	geminin	0.0164	0.1787	0.2114
Plasmodium falciparum	aldo-keto reductase, putative	0.0052	0.0301	0.5
Entamoeba histolytica	aldose reductase, putative	0.0179	0.1977	1
Trichomonas vaginalis	aldo-keto reductase, putative	0.0179	0.1977	0.737
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0057	0.0108
Brugia malayi	Pre-SET motif family protein	0.0202	0.2282	0.4316
Schistosoma mansoni	hypothetical protein	0.0164	0.1787	0.2114
Onchocerca volvulus		0.0179	0.1977	0.3739
Onchocerca volvulus	Matrilysin homolog	0.0075	0.0609	0.1152
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0261	0.0493
Entamoeba histolytica	alcohol dehydrogenase, putative	0.0052	0.0301	0.1116
Loa Loa (eye worm)	hypothetical protein	0.0429	0.5289	1
Entamoeba histolytica	Acid sphingomyelinase-like phosphodiesterase, putative	0.008	0.0675	0.3098
Echinococcus multilocularis	matrix metallopeptidase 7 (M10 family)	0.0123	0.1243	0.1243
Trichomonas vaginalis	aldo/keto reductase, putative	0.0179	0.1977	0.737
Trichomonas vaginalis	dihydrodiol dehydrogenase, putative	0.0179	0.1977	0.737
Trichomonas vaginalis	aldo-keto reductase, putative	0.0179	0.1977	0.737
Wolbachia endosymbiont of Brugia malayi	fructose-1,6-bisphosphatase	0.0036	0.0091	0.5
Trichomonas vaginalis	aldo-keto reductase, putative	0.0179	0.1977	0.737
Mycobacterium leprae	Conserved hypothetical protein	0.0127	0.1294	0.647
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.0179	0.1977	0.2339
Trichomonas vaginalis	aldo-keto reductase, putative	0.0052	0.0301	0.0822
Echinococcus multilocularis	voltage gated potassium channel subunit	0.0052	0.0301	0.0301
Brugia malayi	Serine carboxypeptidase F41C3.5 precursor	0.0272	0.321	0.6069
Brugia malayi	Matrixin family protein	0.0034	0.0065	0.0123
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.0179	0.1977	0.2339
Trypanosoma cruzi	serine peptidase, Clan SC, Family S10, putative	0.0272	0.321	1
Trichomonas vaginalis	dihydrodiol dehydrogenase, putative	0.0179	0.1977	0.737
Loa Loa (eye worm)	oxidoreductase	0.0179	0.1977	0.3739
Trypanosoma brucei	serine peptidase, Clan SC, Family S10	0.0272	0.321	1
Onchocerca volvulus	Uncharacterized serine carboxypeptidase homolog	0.0272	0.321	0.6069
Mycobacterium ulcerans	oxidoreductase	0.0179	0.1977	1
Onchocerca volvulus	Matrilysin homolog	0.0034	0.0065	0.0123
Loa Loa (eye worm)	runx1	0.0054	0.0329	0.0622
Onchocerca volvulus		0.0034	0.0065	0.0123
Echinococcus granulosus	aldo keto reductase	0.0179	0.1977	0.2339
Trichomonas vaginalis	dihydrodiol dehydrogenase, putative	0.0179	0.1977	0.737
Entamoeba histolytica	alcohol dehydrogenase, putative	0.0052	0.0301	0.1116
Echinococcus granulosus	microtubule associated protein 2	0.0669	0.8453	1
Loa Loa (eye worm)	oxidoreductase	0.0179	0.1977	0.3739

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 21 nM	Modulation of gamma-secretase-mediated cleavage of human APP Swedish and London mutation expressed in HEK293 cells assessed as inhibition of amyloid beta42 production after 5 hrs by sandwich immunoassay	ChEMBL.	22098494
IC50 (binding)	= 6750 nM	Modulation of gamma-secretase-mediated cleavage of human APP Swedish and London mutation expressed in HEK293 cells assessed as reduction of total amyloid beta level after 5 hrs by sandwich immunoassay	ChEMBL.	22098494

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1950523

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 1602374