Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium tuberculosis | Phenolpthiocerol synthesis type-I polyketide synthase PpsD | 0.0796 | 0.4383 | 0.5856 |
Toxoplasma gondii | type I fatty acid synthase, putative | 0.0845 | 0.4773 | 1 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsD | 0.0796 | 0.4383 | 0.5834 |
Mycobacterium ulcerans | polyketide synthase | 0.0796 | 0.4383 | 0.5834 |
Brugia malayi | Beta-ketoacyl synthase, N-terminal domain containing protein | 0.0796 | 0.4383 | 0.4383 |
Toxoplasma gondii | beta-ketoacyl synthase, N-terminal domain-containing protein | 0.0516 | 0.218 | 0.2574 |
Brugia malayi | AMP-binding enzyme family protein | 0.0743 | 0.3971 | 0.3971 |
Mycobacterium ulcerans | thioesterase TesA | 0.0663 | 0.3337 | 0.443 |
Brugia malayi | AMP-binding enzyme family protein | 0.0245 | 0.0039 | 0.0039 |
Mycobacterium ulcerans | polyketide synthase Pks13 | 0.1189 | 0.7486 | 1 |
Mycobacterium tuberculosis | Phenolpthiocerol synthesis type-I polyketide synthase PpsC | 0.0796 | 0.4383 | 0.5856 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsE | 0.0526 | 0.2258 | 0.2981 |
Giardia lamblia | Methyltransferase like 2 | 0.024 | 0 | 0.5 |
Onchocerca volvulus | 0.1385 | 0.9028 | 0.9285 | |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSD | 0.0796 | 0.4383 | 0.581 |
Loa Loa (eye worm) | hypothetical protein | 0.0446 | 0.1625 | 0.0823 |
Mycobacterium tuberculosis | Polyketide synthase Pks12 | 0.0845 | 0.4773 | 0.6376 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks1 | 0.0572 | 0.2616 | 0.3495 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks5 | 0.0771 | 0.4191 | 0.5599 |
Leishmania major | hypothetical protein, conserved | 0.024 | 0 | 0.5 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSA | 0.0796 | 0.4383 | 0.581 |
Mycobacterium ulcerans | Type I modular polyketide synthase | 0.0796 | 0.4383 | 0.5834 |
Mycobacterium leprae | Probable polyketide synthase Pks1 | 0.0845 | 0.4773 | 0.6337 |
Mycobacterium ulcerans | Type I modular polyketide synthase | 0.0796 | 0.4383 | 0.5834 |
Mycobacterium ulcerans | polyketide synthase | 0.0845 | 0.4773 | 0.6357 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks8 | 0.0651 | 0.324 | 0.4329 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks9 | 0.0452 | 0.1676 | 0.224 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks15 | 0.0322 | 0.0647 | 0.0864 |
Mycobacterium tuberculosis | Phenolpthiocerol synthesis type-I polyketide synthase PpsA | 0.0796 | 0.4383 | 0.5856 |
Schistosoma mansoni | microtubule-associated protein tau | 0.0803 | 0.4439 | 1 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0268 | 0.022 | 0.0294 |
Mycobacterium leprae | PROBABLE THIOESTERASE TESA | 0.0663 | 0.3337 | 0.4398 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSE | 0.0526 | 0.2258 | 0.2941 |
Mycobacterium tuberculosis | Polyketide synthase Pks13 | 0.1189 | 0.7486 | 1 |
Echinococcus granulosus | microtubule associated protein 2 | 0.0803 | 0.4439 | 0.5 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSB | 0.064 | 0.3157 | 0.4155 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks7 | 0.0845 | 0.4773 | 0.6376 |
Mycobacterium ulcerans | fatty acid synthase Fas | 0.025 | 0.0081 | 0.0056 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsC | 0.0845 | 0.4773 | 0.6357 |
Mycobacterium ulcerans | thioesterase | 0.0663 | 0.3337 | 0.443 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsA | 0.064 | 0.3157 | 0.4188 |
Mycobacterium ulcerans | polyketide synthase Pks9 | 0.0526 | 0.2258 | 0.2981 |
Trichomonas vaginalis | conserved hypothetical protein | 0.024 | 0 | 0.5 |
Toxoplasma gondii | type I fatty acid synthase, putative | 0.0566 | 0.2576 | 0.3708 |
Mycobacterium tuberculosis | Probable fatty acid synthase Fas (fatty acid synthetase) | 0.025 | 0.0081 | 0.0108 |
Mycobacterium leprae | Probable multifunctional mycocerosic acid synthase membrane associated enzyme Mas | 0.0845 | 0.4773 | 0.6337 |
Mycobacterium tuberculosis | Polyketide synthase Pks2 | 0.0771 | 0.4191 | 0.5599 |
Mycobacterium ulcerans | multifunctional mycocerosic acid synthase membrane-associated Mas | 0.0845 | 0.4773 | 0.6357 |
Loa Loa (eye worm) | AMP-binding enzyme family protein | 0.0743 | 0.3971 | 0.3889 |
Mycobacterium tuberculosis | Probable thioesterase TesA | 0.0663 | 0.3337 | 0.4459 |
Mycobacterium tuberculosis | Probable multifunctional mycocerosic acid synthase membrane-associated Mas | 0.0845 | 0.4773 | 0.6376 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsB | 0.064 | 0.3157 | 0.4188 |
Loa Loa (eye worm) | fatty acid synthase | 0.0785 | 0.43 | 0.4318 |
Loa Loa (eye worm) | hypothetical protein | 0.1337 | 0.8648 | 1 |
Mycobacterium ulcerans | Type I modular polyketide synthase | 0.0796 | 0.4383 | 0.5834 |
Mycobacterium tuberculosis | Polyketide synthetase MbtC (polyketide synthase) | 0.0274 | 0.0267 | 0.0356 |
Mycobacterium tuberculosis | Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) | 0.0743 | 0.3971 | 0.5305 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSC | 0.0845 | 0.4773 | 0.6337 |
Onchocerca volvulus | Fatty acid synthase homolog | 0.1434 | 0.9418 | 1 |
Mycobacterium tuberculosis | Polyketide synthetase MbtD (polyketide synthase) | 0.0245 | 0.0039 | 0.0052 |
Echinococcus multilocularis | microtubule associated protein 2 | 0.0803 | 0.4439 | 0.5 |
Mycobacterium leprae | Polyketide synthase Pks13 | 0.1189 | 0.7486 | 1 |
Mycobacterium tuberculosis | Probable membrane bound polyketide synthase Pks6 | 0.1189 | 0.7486 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
GI50 (functional) | -4.539 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MDA-N Breast cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.534 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.515 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.41 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.295 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.119 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the DU-145 Prostate cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-5 Melanoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.