Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium tuberculosis | Phenolpthiocerol synthesis type-I polyketide synthase PpsA | 0.0776 | 0.4383 | 0.5856 |
Mycobacterium tuberculosis | Polyketide synthetase MbtD (polyketide synthase) | 0.0239 | 0.0039 | 0.0052 |
Toxoplasma gondii | type I fatty acid synthase, putative | 0.0552 | 0.2576 | 0.3708 |
Mycobacterium tuberculosis | Phenolpthiocerol synthesis type-I polyketide synthase PpsC | 0.0776 | 0.4383 | 0.5856 |
Toxoplasma gondii | type I fatty acid synthase, putative | 0.0824 | 0.4773 | 1 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSD | 0.0776 | 0.4383 | 0.581 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks1 | 0.0557 | 0.2616 | 0.3495 |
Mycobacterium tuberculosis | Phenolpthiocerol synthesis type-I polyketide synthase PpsD | 0.0776 | 0.4383 | 0.5856 |
Mycobacterium ulcerans | polyketide synthase Pks13 | 0.116 | 0.7486 | 1 |
Mycobacterium ulcerans | Type I modular polyketide synthase | 0.0776 | 0.4383 | 0.5834 |
Onchocerca volvulus | 0.135 | 0.9028 | 0.9285 | |
Giardia lamblia | Methyltransferase like 2 | 0.0234 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable multifunctional mycocerosic acid synthase membrane-associated Mas | 0.0824 | 0.4773 | 0.6376 |
Mycobacterium tuberculosis | Probable fatty acid synthase Fas (fatty acid synthetase) | 0.0244 | 0.0081 | 0.0108 |
Mycobacterium tuberculosis | Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) | 0.0725 | 0.3971 | 0.5305 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks15 | 0.0314 | 0.0647 | 0.0864 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsE | 0.0513 | 0.2258 | 0.2981 |
Mycobacterium leprae | Polyketide synthase Pks13 | 0.116 | 0.7486 | 1 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks9 | 0.0441 | 0.1676 | 0.224 |
Mycobacterium tuberculosis | Probable membrane bound polyketide synthase Pks6 | 0.116 | 0.7486 | 1 |
Mycobacterium leprae | Probable multifunctional mycocerosic acid synthase membrane associated enzyme Mas | 0.0824 | 0.4773 | 0.6337 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks5 | 0.0752 | 0.4191 | 0.5599 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsC | 0.0824 | 0.4773 | 0.6357 |
Mycobacterium ulcerans | polyketide synthase Pks9 | 0.0513 | 0.2258 | 0.2981 |
Loa Loa (eye worm) | hypothetical protein | 0.0435 | 0.1625 | 0.0823 |
Mycobacterium ulcerans | multifunctional mycocerosic acid synthase membrane-associated Mas | 0.0824 | 0.4773 | 0.6357 |
Mycobacterium tuberculosis | Polyketide synthase Pks12 | 0.0824 | 0.4773 | 0.6376 |
Loa Loa (eye worm) | AMP-binding enzyme family protein | 0.0725 | 0.3971 | 0.3889 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks8 | 0.0635 | 0.324 | 0.4329 |
Mycobacterium tuberculosis | Polyketide synthase Pks2 | 0.0752 | 0.4191 | 0.5599 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSB | 0.0624 | 0.3157 | 0.4155 |
Mycobacterium leprae | Probable polyketide synthase Pks1 | 0.0824 | 0.4773 | 0.6337 |
Brugia malayi | AMP-binding enzyme family protein | 0.0725 | 0.3971 | 0.3971 |
Mycobacterium ulcerans | thioesterase TesA | 0.0647 | 0.3337 | 0.443 |
Mycobacterium tuberculosis | Polyketide synthase Pks13 | 0.116 | 0.7486 | 1 |
Mycobacterium ulcerans | polyketide synthase | 0.0776 | 0.4383 | 0.5834 |
Mycobacterium ulcerans | Type I modular polyketide synthase | 0.0776 | 0.4383 | 0.5834 |
Brugia malayi | Beta-ketoacyl synthase, N-terminal domain containing protein | 0.0776 | 0.4383 | 0.4383 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSA | 0.0776 | 0.4383 | 0.581 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0234 | 0 | 0.5 |
Mycobacterium tuberculosis | Polyketide synthetase MbtC (polyketide synthase) | 0.0267 | 0.0267 | 0.0356 |
Loa Loa (eye worm) | fatty acid synthase | 0.0766 | 0.43 | 0.4318 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSE | 0.0513 | 0.2258 | 0.2941 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsB | 0.0624 | 0.3157 | 0.4188 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsD | 0.0776 | 0.4383 | 0.5834 |
Toxoplasma gondii | beta-ketoacyl synthase, N-terminal domain-containing protein | 0.0503 | 0.218 | 0.2574 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsA | 0.0624 | 0.3157 | 0.4188 |
Mycobacterium tuberculosis | Probable thioesterase TesA | 0.0647 | 0.3337 | 0.4459 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks7 | 0.0824 | 0.4773 | 0.6376 |
Mycobacterium ulcerans | polyketide synthase | 0.0824 | 0.4773 | 0.6357 |
Brugia malayi | AMP-binding enzyme family protein | 0.0239 | 0.0039 | 0.0039 |
Onchocerca volvulus | Fatty acid synthase homolog | 0.1399 | 0.9418 | 1 |
Leishmania major | hypothetical protein, conserved | 0.0234 | 0 | 0.5 |
Mycobacterium ulcerans | thioesterase | 0.0647 | 0.3337 | 0.443 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSC | 0.0824 | 0.4773 | 0.6337 |
Loa Loa (eye worm) | hypothetical protein | 0.1303 | 0.8648 | 1 |
Schistosoma mansoni | methyltransferase-related | 0.0234 | 0 | 0.5 |
Mycobacterium leprae | PROBABLE THIOESTERASE TESA | 0.0647 | 0.3337 | 0.4398 |
Mycobacterium ulcerans | fatty acid synthase Fas | 0.0244 | 0.0081 | 0.0056 |
Mycobacterium ulcerans | Type I modular polyketide synthase | 0.0776 | 0.4383 | 0.5834 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.