Detailed information for compound 1609377

Basic information

Technical information
  • TDR Targets ID: 1609377
  • Name: 1-[4-(3-amino-1-methylpyrazolo[5,4-b]pyridin- 4-yl)phenyl]-3-[3-(trifluoromethyl)phenyl]ure a
  • MW: 426.394 | Formula: C21H17F3N6O
  • H donors: 3 H acceptors: 3 LogP: 3.56 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(Nc1cccc(c1)C(F)(F)F)Nc1ccc(cc1)c1ccnc2c1c(N)nn2C
  • InChi: 1S/C21H17F3N6O/c1-30-19-17(18(25)29-30)16(9-10-26-19)12-5-7-14(8-6-12)27-20(31)28-15-4-2-3-13(11-15)21(22,23)24/h2-11H,1H3,(H2,25,29)(H2,27,28,31)
  • InChiKey: KROLCVQARUUHNV-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 1-[4-(3-amino-1-methyl-pyrazolo[5,4-b]pyridin-4-yl)phenyl]-3-[3-(trifluoromethyl)phenyl]urea
  • 1-[4-(3-amino-1-methyl-4-pyrazolo[5,4-b]pyridinyl)phenyl]-3-[3-(trifluoromethyl)phenyl]urea

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog Starlite/ChEMBL No references
Homo sapiens LYN proto-oncogene, Src family tyrosine kinase Starlite/ChEMBL No references
Homo sapiens fms-related tyrosine kinase 1 Starlite/ChEMBL No references
Homo sapiens colony stimulating factor 1 receptor Starlite/ChEMBL No references
Homo sapiens BLK proto-oncogene, Src family tyrosine kinase Starlite/ChEMBL No references
Homo sapiens fms-related tyrosine kinase 3 Starlite/ChEMBL No references
Homo sapiens SRC proto-oncogene, non-receptor tyrosine kinase Starlite/ChEMBL No references
Homo sapiens LCK proto-oncogene, Src family tyrosine kinase Starlite/ChEMBL No references
Homo sapiens FYN proto-oncogene, Src family tyrosine kinase Starlite/ChEMBL No references
Homo sapiens kinase insert domain receptor Starlite/ChEMBL No references
Homo sapiens ABL proto-oncogene 1, non-receptor tyrosine kinase Starlite/ChEMBL No references
Homo sapiens fms-related tyrosine kinase 4 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus multilocularis tyrosine protein kinase Abl Get druggable targets OG5_131234 All targets in OG5_131234
Loa Loa (eye worm) TK protein kinase Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus multilocularis tyrosine protein kinase Fyn Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus multilocularis tyrosine protein kinase Fyn Get druggable targets OG5_127750 All targets in OG5_127750
Loa Loa (eye worm) TK/KIN16 protein kinase Get druggable targets OG5_130320 All targets in OG5_130320
Loa Loa (eye worm) TK/ABL protein kinase Get druggable targets OG5_131234 All targets in OG5_131234
Schistosoma japonicum ko:K05703 proto-oncogene tyrosine-protein kinase Fyn, putative Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus multilocularis tyrosine protein kinase Srms Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus granulosus tyrosine protein kinase Src42A Get druggable targets OG5_127750 All targets in OG5_127750
Schistosoma mansoni tyrosine kinase Get druggable targets OG5_127750 All targets in OG5_127750
Schistosoma mansoni tyrosine kinase Get druggable targets OG5_131234 All targets in OG5_131234
Schistosoma japonicum ko:K08892 fyn-related kinase, putative Get druggable targets OG5_127750 All targets in OG5_127750
Loa Loa (eye worm) TK protein kinase Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus granulosus tyrosine protein kinase Src64B Get druggable targets OG5_127750 All targets in OG5_127750
Schistosoma japonicum Tyrosine-protein kinase transforming protein Abl, putative Get druggable targets OG5_131234 All targets in OG5_131234
Schistosoma japonicum Proto-oncogene tyrosine-protein kinase FYN, putative Get druggable targets OG5_127750 All targets in OG5_127750
Brugia malayi Tyrosine-protein kinase abl-1 Get druggable targets OG5_131234 All targets in OG5_131234
Echinococcus granulosus tyrosine protein kinase ABL1 Get druggable targets OG5_131234 All targets in OG5_131234
Echinococcus granulosus tyrosine protein kinase Fyn Get druggable targets OG5_127750 All targets in OG5_127750
Brugia malayi Immunoglobulin I-set domain containing protein Get druggable targets OG5_130320 All targets in OG5_130320
Echinococcus multilocularis tyrosine protein kinase HCK Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus multilocularis tyrosine protein kinase Src42A Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus granulosus tyrosine protein kinase Fyn Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus multilocularis tyrosine protein kinase Src64B Get druggable targets OG5_127750 All targets in OG5_127750
Loa Loa (eye worm) SRC-1 Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus granulosus tyrosine kinase Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus granulosus macrophage colony stimulating factor 1 receptor Get druggable targets OG5_132967 All targets in OG5_132967
Echinococcus granulosus tyrosine protein kinase Lyn Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn Get druggable targets OG5_127750 All targets in OG5_127750
Brugia malayi SRC-1 Get druggable targets OG5_127750 All targets in OG5_127750
Schistosoma mansoni tyrosine kinase Get druggable targets OG5_127750 All targets in OG5_127750
Schistosoma japonicum Tyrosine-protein kinase transforming protein Abl, putative Get druggable targets OG5_131234 All targets in OG5_131234
Echinococcus granulosus tyrosine protein kinase Fyn Get druggable targets OG5_127750 All targets in OG5_127750
Onchocerca volvulus Get druggable targets OG5_130320 All targets in OG5_130320
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK Get druggable targets OG5_127750 All targets in OG5_127750
Schistosoma japonicum Proto-oncogene tyrosine-protein kinase FYN, putative Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus granulosus tyrosine protein kinase HCK Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk Get druggable targets OG5_127750 All targets in OG5_127750
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131234 All targets in OG5_131234
Echinococcus granulosus tyrosine protein kinase Blk Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus multilocularis tyrosine protein kinase Fgr Get druggable targets OG5_127750 All targets in OG5_127750
Schistosoma japonicum Proto-oncogene tyrosine-protein kinase FGR, putative Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus multilocularis tyrosine protein kinase Fyn Get druggable targets OG5_127750 All targets in OG5_127750
Schistosoma japonicum expressed protein Get druggable targets OG5_131234 All targets in OG5_131234
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus granulosus tyrosine protein kinase Src42A Get druggable targets OG5_127750 All targets in OG5_127750
Brugia malayi protein-tyrosine kinase Get druggable targets OG5_127750 All targets in OG5_127750
Schistosoma japonicum Proto-oncogene tyrosine-protein kinase ABL1, putative Get druggable targets OG5_131234 All targets in OG5_131234
Schistosoma japonicum Proto-oncogene tyrosine-protein kinase Yrk, putative Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus multilocularis tyrosine protein kinase Blk Get druggable targets OG5_127750 All targets in OG5_127750
Entamoeba histolytica protein kinase, putative Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK Get druggable targets OG5_127750 All targets in OG5_127750
Schistosoma japonicum expressed protein Get druggable targets OG5_131234 All targets in OG5_131234
Echinococcus multilocularis tyrosine protein kinase Src42A Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus multilocularis tyrosine protein kinase ABL1 Get druggable targets OG5_131234 All targets in OG5_131234
Onchocerca volvulus Tyrosine kinase homolog Get druggable targets OG5_130320 All targets in OG5_130320
Echinococcus multilocularis tyrosine protein kinase Fyn Get druggable targets OG5_127750 All targets in OG5_127750
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus ring and YY1 binding protein 0.0244 0.1701 0.1701
Trypanosoma cruzi Zn-finger in Ran binding protein and others/FYVE zinc finger, putative 0.0244 0.1701 0.5
Loa Loa (eye worm) hypothetical protein 0.0077 0.0219 0.0386
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0137 0.0751 0.1337
Echinococcus granulosus Zinc finger RanBP2 type 0.0244 0.1701 0.1701
Echinococcus multilocularis basement membrane specific heparan sulfate 0.0077 0.0219 0.039
Trypanosoma brucei Zn-finger in Ran binding protein and others/FYVE zinc finger, putative 0.0244 0.1701 0.5
Echinococcus multilocularis tyrosine protein kinase ABL1 0.029 0.2106 0.375
Loa Loa (eye worm) hypothetical protein 0.0077 0.0219 0.0386
Schistosoma mansoni nephrin 0.0087 0.0308 0.0548
Loa Loa (eye worm) TK/ABL protein kinase 0.029 0.2106 0.3716
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0137 0.0751 0.1337
Leishmania major hypothetical protein, conserved 0.0244 0.1701 0.5
Brugia malayi Zn-finger in Ran binding protein and others containing protein 0.0244 0.1701 0.3001
Brugia malayi hypothetical protein 0.0077 0.0219 0.0386
Trypanosoma cruzi hypothetical protein, conserved 0.0244 0.1701 0.5
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0137 0.0751 0.1337
Brugia malayi protein-tyrosine kinase 0.0111 0.0523 0.0924
Echinococcus multilocularis tyrosine protein kinase Srms 0.0111 0.0523 0.0932
Echinococcus multilocularis Immunoglobulin 0.0077 0.0219 0.039
Echinococcus granulosus tyrosine kinase 0.0111 0.0523 0.0523
Trypanosoma cruzi WLM domain containing protein, putative 0.0244 0.1701 0.5
Schistosoma mansoni tyrosine kinase 0.0066 0.0127 0.0227
Brugia malayi brahma associated protein 60 kDa 0.0686 0.5616 0.991
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0111 0.0523 0.0523
Echinococcus multilocularis Upstream activation factor subunit UAF30 0.0686 0.5616 1
Schistosoma mansoni Neurotrimin precursor (hNT) 0.0077 0.0219 0.039
Brugia malayi SWIB/MDM2 domain containing protein 0.0686 0.5616 0.991
Schistosoma mansoni RNA binding protein 0.0244 0.1701 0.3028
Trypanosoma cruzi Zn-finger in Ran binding protein and others, putative 0.0244 0.1701 0.5
Loa Loa (eye worm) hypothetical protein 0.0077 0.0219 0.0386
Brugia malayi Zn-finger in Ran binding protein and others containing protein 0.0244 0.1701 0.3001
Trichomonas vaginalis conserved hypothetical protein 0.0686 0.5616 0.5
Brugia malayi SRC-1 0.0137 0.0751 0.1325
Echinococcus granulosus tyrosine protein kinase HCK 0.0085 0.029 0.029
Loa Loa (eye worm) hypothetical protein 0.0104 0.0462 0.0815
Brugia malayi Zn-finger in Ran binding protein and others containing protein 0.0244 0.1701 0.3001
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0137 0.0751 0.1337
Echinococcus granulosus SWI:SNF matrix associated 0.0686 0.5616 0.5616
Brugia malayi brahma associated protein 60 kDa 0.0686 0.5616 0.991
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.0066 0.0127 0.0227
Brugia malayi Tyrosine-protein kinase abl-1 0.0162 0.0971 0.1713
Brugia malayi Tyrosine-protein kinase abl-1 0.0154 0.0901 0.1591
Echinococcus multilocularis ring and YY1 binding protein 0.0244 0.1701 0.3028
Trypanosoma cruzi Zn-finger in Ran binding protein and others, putative 0.0244 0.1701 0.5
Echinococcus granulosus tyrosine protein kinase Src42A 0.0097 0.0396 0.0396
Toxoplasma gondii SWIB/MDM2 domain-containing protein 0.0686 0.5616 1
Trypanosoma cruzi mitochondrial RNA binding complex 1 subunit, putative 0.0244 0.1701 0.5
Loa Loa (eye worm) hypothetical protein 0.0077 0.0219 0.0386
Schistosoma mansoni hypothetical protein 0.0686 0.5616 1
Loa Loa (eye worm) hypothetical protein 0.0077 0.0219 0.0386
Schistosoma mansoni defective proboscis extension response (dpr)-related 0.0077 0.0219 0.039
Plasmodium vivax hypothetical protein, conserved 0.0686 0.5616 0.5
Schistosoma mansoni tyrosine kinase 0.0066 0.0127 0.0227
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0137 0.0751 0.1337
Echinococcus granulosus defective proboscis extension response 0.0077 0.0219 0.0219
Loa Loa (eye worm) SRC-1 0.0137 0.0751 0.1325
Trypanosoma brucei hypothetical protein, conserved 0.0244 0.1701 0.5
Leishmania major hypothetical protein, conserved 0.0244 0.1701 0.5
Echinococcus granulosus roundabout 2 0.0104 0.0462 0.0462
Echinococcus granulosus Nuclear pore complex protein Nup153 0.0244 0.1701 0.1701
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0097 0.0396 0.0705
Echinococcus granulosus tyrosine protein kinase Fyn 0.0137 0.0751 0.0751
Onchocerca volvulus 0.0686 0.5616 1
Loa Loa (eye worm) TK protein kinase 0.0111 0.0523 0.0924
Trypanosoma cruzi hypothetical protein, conserved 0.0244 0.1701 0.5
Echinococcus granulosus tyrosine protein kinase Src42A 0.0137 0.0751 0.0751
Chlamydia trachomatis DNA topoisomerase I 0.0686 0.5616 0.5
Onchocerca volvulus 0.0583 0.4706 0.7674
Echinococcus multilocularis neuroglian 0.0087 0.0308 0.0548
Echinococcus multilocularis Immunoglobulin 0.0077 0.0219 0.039
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0111 0.0523 0.0932
Echinococcus granulosus Upstream activation factor subunit UAF30 0.0686 0.5616 0.5616
Echinococcus granulosus tyrosine protein kinase Lyn 0.0137 0.0751 0.0751
Loa Loa (eye worm) SWIB/MDM2 domain-containing protein 0.0686 0.5616 0.991
Echinococcus granulosus tyrosine protein kinase Fyn 0.0137 0.0751 0.0751
Echinococcus multilocularis c src tyrosine kinase 0.0066 0.0127 0.0227
Brugia malayi YY1-associated factor 2 0.0244 0.1701 0.3001
Schistosoma mansoni vesicular amine transporter 0.0077 0.0219 0.039
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0137 0.0751 0.1337
Trypanosoma cruzi mitochondrial RNA binding complex 1 subunit, putative 0.0244 0.1701 0.5
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0066 0.0127 0.0227
Echinococcus multilocularis roundabout 2 0.0104 0.0462 0.0822
Echinococcus granulosus zinc finger protein Ran binding 0.0244 0.1701 0.1701
Loa Loa (eye worm) hypothetical protein 0.0244 0.1701 0.3001
Echinococcus multilocularis Zinc finger, RanBP2 type 0.0244 0.1701 0.3028
Leishmania major hypothetical protein, conserved 0.0244 0.1701 0.5
Schistosoma mansoni zinc finger protein 0.0244 0.1701 0.3028
Echinococcus multilocularis SWI:SNF matrix associated 0.0686 0.5616 1
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0137 0.0751 0.0751
Echinococcus granulosus tyrosine protein kinase Src64B 0.0137 0.0751 0.0751
Onchocerca volvulus Tyrosine kinase homolog 0.0608 0.4922 0.8227
Schistosoma mansoni tyrosine kinase 0.0137 0.0751 0.1337
Loa Loa (eye worm) hypothetical protein 0.0244 0.1701 0.3001
Schistosoma mansoni hypothetical protein 0.0686 0.5616 1
Chlamydia trachomatis SWIB complex protein 0.0686 0.5616 0.5
Brugia malayi Fibronectin type III domain containing protein 0.0077 0.0219 0.0386
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0137 0.0751 0.1337
Echinococcus multilocularis tyrosine protein kinase Blk 0.0111 0.0523 0.0932
Loa Loa (eye worm) hypothetical protein 0.011 0.051 0.0899
Schistosoma mansoni tyrosine kinase 0.0137 0.0751 0.1337
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0137 0.0751 0.1337
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0137 0.0751 0.1337
Loa Loa (eye worm) hypothetical protein 0.0094 0.0373 0.0658
Loa Loa (eye worm) hypothetical protein 0.0077 0.0219 0.0386
Brugia malayi Immunoglobulin I-set domain containing protein 0.0692 0.5667 1
Loa Loa (eye worm) brahma associated protein 0.0686 0.5616 0.991
Entamoeba histolytica protein kinase, putative 0.0085 0.029 0.5
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0066 0.0127 0.0127
Echinococcus granulosus c src tyrosine kinase 0.0066 0.0127 0.0127
Echinococcus multilocularis tyrosine protein kinase HCK 0.0085 0.029 0.0516
Echinococcus granulosus neurotracting:lsamp:neurotrimin:obcam 0.0094 0.0373 0.0373
Schistosoma mansoni tyrosine kinase 0.0263 0.1872 0.3334
Schistosoma mansoni cell adhesion molecule 0.0094 0.0373 0.0664
Echinococcus multilocularis tyrosine protein kinase Abl 0.0162 0.0971 0.1729
Trypanosoma brucei mitochondrial RNA binding complex 1 subunit 0.0244 0.1701 0.5
Echinococcus granulosus tyrosine protein kinase ABL1 0.029 0.2106 0.2106
Loa Loa (eye worm) hypothetical protein 0.0104 0.0462 0.0815
Loa Loa (eye worm) hypothetical protein 0.0244 0.1701 0.3001
Echinococcus granulosus twitchin 0.0087 0.0308 0.0308
Plasmodium falciparum SWIB/MDM2 domain-containing protein 0.0686 0.5616 1
Loa Loa (eye worm) TK protein kinase 0.0085 0.029 0.0512
Echinococcus granulosus Immunoglobulin 0.0077 0.0219 0.0219
Echinococcus granulosus tyrosine protein kinase Blk 0.0111 0.0523 0.0523
Trypanosoma cruzi WLM domain containing protein, putative 0.0244 0.1701 0.5
Schistosoma mansoni hypothetical protein 0.0686 0.5616 1
Echinococcus multilocularis SWI:SNF matrix associated 0.0686 0.5616 1
Leishmania major hypothetical protein, conserved 0.0244 0.1701 0.5
Schistosoma mansoni TRABID protein (C64 family) 0.0244 0.1701 0.3028
Loa Loa (eye worm) hypothetical protein 0.0244 0.1701 0.3001
Brugia malayi Zn-finger in Ran binding protein and others containing protein 0.0244 0.1701 0.3001
Schistosoma mansoni hypothetical protein 0.0244 0.1701 0.3028
Toxoplasma gondii DNA topoisomerase domain-containing protein 0.0686 0.5616 1
Loa Loa (eye worm) hypothetical protein 0.0244 0.1701 0.3001
Echinococcus granulosus tyrosine protein kinase Fyn 0.0137 0.0751 0.0751
Plasmodium falciparum SWIB/MDM2 domain-containing protein 0.0686 0.5616 1
Trypanosoma brucei hypothetical protein, conserved 0.0244 0.1701 0.5
Echinococcus multilocularis zinc finger protein Ran binding 0.0244 0.1701 0.3028
Leishmania major hypothetical protein, conserved 0.0244 0.1701 0.5
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0137 0.0751 0.0751
Echinococcus multilocularis Nuclear pore complex protein Nup153 0.0244 0.1701 0.3028
Trypanosoma cruzi hypothetical protein, conserved 0.0244 0.1701 0.5
Schistosoma mansoni brg-1 associated factor 0.0686 0.5616 1
Echinococcus multilocularis SWI:SNF matrix associated 0.0686 0.5616 1
Loa Loa (eye worm) TK/KIN16 protein kinase 0.0692 0.5667 1
Plasmodium vivax SWIB/MDM2 domain-containing protein, putative 0.0686 0.5616 0.5
Schistosoma mansoni fusion 0.0244 0.1701 0.3028
Echinococcus granulosus neuroglian 0.0087 0.0308 0.0308
Brugia malayi Immunoglobulin I-set domain containing protein 0.0077 0.0219 0.0386

Activities

Activity type Activity value Assay description Source Reference
Ki (functional) = 6.1 PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member name: SRC ChEMBL. No reference
Ki (functional) = 6.3 PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member name: FYN ChEMBL. No reference
Ki (functional) = 6.4 PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member name: BLK ChEMBL. No reference
Ki (functional) = 6.5 PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member name: LCK ChEMBL. No reference
Ki (functional) = 6.7 PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member name: ABL1 ChEMBL. No reference
Ki (functional) = 6.9 PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member name: LYN ChEMBL. No reference
Ki (functional) = 8.6 PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member name: CSF1R ChEMBL. No reference
Ki (functional) = 8.8 PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member name: FLT3 ChEMBL. No reference
Ki (functional) = 8.8 PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member name: FLT4 ChEMBL. No reference
Ki (functional) = 9.1 PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member name: KIT ChEMBL. No reference
Ki (functional) = 9.2 PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member name: KDR ChEMBL. No reference
Ki (functional) = 9.5 PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member name: FLT1 ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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