Detailed information for compound 1613207

Basic information

Technical information
  • TDR Targets ID: 1613207
  • Name: 1,3-bis(phenylmethyl)pyrrolo[3,4-d]imidazole- 2,4,6-trione
  • MW: 333.341 | Formula: C19H15N3O3
  • H donors: 1 H acceptors: 3 LogP: 1.71 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=c1n(Cc2ccccc2)c2c(n1Cc1ccccc1)c(=O)[nH]c2=O
  • InChi: 1S/C19H15N3O3/c23-17-15-16(18(24)20-17)22(12-14-9-5-2-6-10-14)19(25)21(15)11-13-7-3-1-4-8-13/h1-10H,11-12H2,(H,20,23,24)
  • InChiKey: MGFIMCFURALMFZ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 1,3-bis(benzyl)pyrrolo[3,4-d]imidazole-2,4,6-trione
  • NCI60_013753
  • 1,3-Dibenzyl-1,3-dihydropyrrolo[3,4-d]imidazole-2,4,6(5H)-trione
  • AIDS-137229
  • AIDS137229
  • NSC641061

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0036 0.0221 0.0517
Schistosoma mansoni biogenic amine receptor 0.0036 0.0221 0.0216
Onchocerca volvulus 0.0036 0.0221 0.3063
Schistosoma mansoni neuropeptide receptor 0.0036 0.0221 0.0216
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0041 0.0286 0.0281
Echinococcus granulosus g-protein coupled receptor 0.0036 0.0221 0.0216
Brugia malayi neuropeptide F receptor 0.0036 0.0221 0.0287
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0036 0.0221 0.0216
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0036 0.0221 0.3063
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0036 0.0221 0.0287
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0036 0.0221 0.0216
Brugia malayi hypothetical protein 0.0036 0.0221 0.0287
Brugia malayi Dopamine receptor protein 1 0.0036 0.0221 0.0287
Loa Loa (eye worm) hypothetical protein 0.0027 0.0103 0.0237
Echinococcus multilocularis rhodopsin orphan GPCR 0.0036 0.0221 0.0216
Echinococcus granulosus neuropeptide Y receptor 0.0036 0.0221 0.0216
Loa Loa (eye worm) hypothetical protein 0.0044 0.0321 0.0758
Onchocerca volvulus 0.0036 0.0221 0.3063
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0027 0.0103 0.5
Schistosoma mansoni amine GPCR 0.0036 0.0221 0.0216
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0036 0.0221 0.0287
Schistosoma mansoni microtubule-associated protein tau 0.0793 1 1
Loa Loa (eye worm) hypothetical protein 0.0027 0.0103 0.0237
Echinococcus granulosus rhodopsin orphan GPCR 0.0036 0.0221 0.0216
Brugia malayi hypothetical protein 0.0036 0.0221 0.0287
Loa Loa (eye worm) hypothetical protein 0.0036 0.0221 0.0517
Loa Loa (eye worm) hypothetical protein 0.0036 0.0221 0.0517
Echinococcus multilocularis serotonin receptor 0.0036 0.0221 0.0216
Onchocerca volvulus 0.0057 0.0486 1
Echinococcus multilocularis allatostatin A receptor 0.0036 0.0221 0.0216
Loa Loa (eye worm) hypothetical protein 0.0036 0.0221 0.0517
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0041 0.0285 0.0281
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0036 0.0221 0.0216
Onchocerca volvulus 0.0036 0.0221 0.3063
Echinococcus granulosus alpha 1A adrenergic receptor 0.0036 0.0221 0.0216
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0036 0.0221 0.0216
Echinococcus multilocularis neuropeptide s receptor 0.0036 0.0221 0.0216
Echinococcus granulosus rhodopsin orphan GPCR 0.0036 0.0221 0.0216
Loa Loa (eye worm) TYRA-2 protein 0.0036 0.0221 0.0517
Schistosoma mansoni amine GPCR 0.0036 0.0221 0.0216
Echinococcus multilocularis g protein coupled receptor 0.0036 0.0221 0.0216
Brugia malayi hypothetical protein 0.0036 0.0221 0.0287
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0027 0.0103 1
Loa Loa (eye worm) hypothetical protein 0.0036 0.0221 0.0517
Schistosoma mansoni growth hormone secretagogue receptor 0.0036 0.0221 0.0216
Brugia malayi AKH receptor 0.0036 0.0221 0.0287
Echinococcus multilocularis neuropeptides capa receptor 0.0036 0.0221 0.0216
Echinococcus granulosus fmrfamide receptor 0.0036 0.0221 0.0216
Loa Loa (eye worm) hypothetical protein 0.0036 0.0221 0.0517
Schistosoma mansoni adenoreceptor 0.0036 0.0221 0.0216
Echinococcus multilocularis fmrfamide receptor 0.0036 0.0221 0.0216
Loa Loa (eye worm) hypothetical protein 0.0036 0.0221 0.0517
Echinococcus granulosus peptide allatostatin:somatostatin 0.0036 0.0221 0.0216
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0036 0.0221 0.0216
Schistosoma mansoni serine/threonine protein kinase 0.0343 0.418 0.4177
Echinococcus multilocularis tumor protein p63 0.0388 0.477 0.4767
Echinococcus granulosus neuropeptide receptor 0.0036 0.0221 0.0216
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0036 0.0221 0.0216
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0036 0.0221 0.0216
Loa Loa (eye worm) hypothetical protein 0.0036 0.0221 0.0517
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0041 0.0285 0.0281
Echinococcus granulosus tm gpcr rhodopsin 0.0036 0.0221 0.0216
Onchocerca volvulus 0.0036 0.0221 0.3063
Echinococcus granulosus neuropeptide FF receptor 2 0.0036 0.0221 0.0216
Brugia malayi Serotonin receptor 0.0036 0.0221 0.0287
Loa Loa (eye worm) hypothetical protein 0.0036 0.0221 0.0517
Loa Loa (eye worm) hypothetical protein 0.0036 0.0221 0.0517
Brugia malayi map kinase activated protein kinase protein 2 0.0343 0.418 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0036 0.0221 0.0216
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0036 0.0221 0.0216
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0036 0.0221 0.0517
Schistosoma mansoni opsin-like receptor 0.0036 0.0221 0.0216
Loa Loa (eye worm) hypothetical protein 0.0036 0.0221 0.0517
Brugia malayi Melatonin receptor type 1A 0.0036 0.0221 0.0287
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0036 0.0221 0.0216
Loa Loa (eye worm) hypothetical protein 0.0036 0.0221 0.0517
Loa Loa (eye worm) G-protein coupled receptor 0.0036 0.0221 0.0517
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0036 0.0221 0.0216
Echinococcus granulosus neuropeptide s receptor 0.0036 0.0221 0.0216
Brugia malayi Dopamine receptor protein 2 0.0036 0.0221 0.0287
Onchocerca volvulus 0.0036 0.0221 0.3063
Echinococcus granulosus sex peptide receptor 0.0036 0.0221 0.0216
Echinococcus multilocularis g protein coupled receptor 0.0036 0.0221 0.0216
Echinococcus multilocularis neuropeptide receptor A26 0.0036 0.0221 0.0216
Entamoeba histolytica hypothetical protein 0.0041 0.0286 1
Echinococcus multilocularis neuropeptide receptor 0.0036 0.0221 0.0216
Loa Loa (eye worm) hypothetical protein 0.0036 0.0221 0.0517
Plasmodium falciparum acyl-CoA synthetase 0.002 0.0014 0.5
Schistosoma mansoni zinc finger protein 0.0023 0.0042 0.0037
Loa Loa (eye worm) hypothetical protein 0.0036 0.0221 0.0517
Loa Loa (eye worm) hypothetical protein 0.0036 0.0221 0.0517
Loa Loa (eye worm) PHD-finger family protein 0.0024 0.0058 0.0127
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0036 0.0221 0.0216
Loa Loa (eye worm) hypothetical protein 0.0036 0.0221 0.0517
Schistosoma mansoni neuropeptide receptor 0.0036 0.0221 0.0216
Loa Loa (eye worm) hypothetical protein 0.0036 0.0221 0.0517
Schistosoma mansoni hypothetical protein 0.0041 0.0286 0.0281
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0036 0.0221 0.0216
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0027 0.0103 1
Brugia malayi Tachykinin-like peptides receptor 99D 0.0036 0.0221 0.0287
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0036 0.0221 0.0216
Onchocerca volvulus 0.0036 0.0221 0.3063
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0036 0.0221 0.0216
Loa Loa (eye worm) hypothetical protein 0.0036 0.0221 0.0517
Schistosoma mansoni biogenic amine (5HT) receptor 0.0036 0.0221 0.0216
Mycobacterium ulcerans acyl-CoA synthetase 0.0027 0.0103 1
Echinococcus granulosus neuropeptides capa receptor 0.0036 0.0221 0.0216
Echinococcus granulosus orexin receptor type 2 0.0036 0.0221 0.0216
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0036 0.0221 0.0216
Schistosoma mansoni biogenic amine (5HT) receptor 0.0036 0.0221 0.0216
Echinococcus granulosus neuropeptide receptor A26 0.0036 0.0221 0.0216
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0027 0.0103 1
Entamoeba histolytica hypothetical protein 0.0041 0.0286 1
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0036 0.0221 0.0287
Echinococcus granulosus biogenic amine 5HT receptor 0.0036 0.0221 0.0216
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0036 0.0221 0.0216
Entamoeba histolytica hypothetical protein 0.0041 0.0286 1
Schistosoma mansoni myosin xvIII 0.0036 0.0221 0.0216
Mycobacterium ulcerans acyl-CoA synthetase 0.0027 0.0103 1
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0036 0.0221 0.0216
Echinococcus multilocularis g protein coupled receptor 0.0036 0.0221 0.0216
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0036 0.0221 0.0216
Schistosoma mansoni transcription factor LCR-F1 0.0041 0.0286 0.0281
Echinococcus granulosus biogenic amine 5HT receptor 0.0036 0.0221 0.0216
Onchocerca volvulus 0.0036 0.0221 0.3063
Brugia malayi putative neuropeptide receptor 0.0036 0.0221 0.0287
Loa Loa (eye worm) hypothetical protein 0.002 0.0014 0.0024
Echinococcus granulosus tm gpcr rhodopsin 0.0036 0.0221 0.0216
Onchocerca volvulus 0.0036 0.0221 0.3063
Echinococcus granulosus rhodopsin orphan GPCR 0.0036 0.0221 0.0216
Brugia malayi G-protein coupled receptor 0.0036 0.0221 0.0287
Echinococcus granulosus serotonin receptor 0.0036 0.0221 0.0216
Loa Loa (eye worm) hypothetical protein 0.0081 0.0802 0.1909
Loa Loa (eye worm) hypothetical protein 0.0036 0.0221 0.0517
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0036 0.0221 0.0216
Loa Loa (eye worm) hypothetical protein 0.0036 0.0221 0.0517
Schistosoma mansoni hypothetical protein 0.0024 0.0058 0.0053
Echinococcus multilocularis neuropeptide Y receptor 0.0036 0.0221 0.0216
Schistosoma mansoni neuropeptide f receptor 76f 0.0036 0.0221 0.0216
Schistosoma mansoni hypothetical protein 0.0036 0.0221 0.0216
Onchocerca volvulus 0.0036 0.0221 0.3063
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0036 0.0221 0.0216
Loa Loa (eye worm) hypothetical protein 0.0036 0.0221 0.0517
Brugia malayi sulfakinin receptor protein 0.0036 0.0221 0.0287
Brugia malayi Bromodomain containing protein 0.0086 0.0865 0.1869
Brugia malayi hypothetical protein 0.0036 0.0221 0.0287
Echinococcus multilocularis orexin receptor type 2 0.0036 0.0221 0.0216
Loa Loa (eye worm) hypothetical protein 0.0036 0.0221 0.0517
Loa Loa (eye worm) hypothetical protein 0.0036 0.0221 0.0517
Brugia malayi hypothetical protein 0.0036 0.0221 0.0287
Brugia malayi GnHR receptor homolog 0.0036 0.0221 0.0287
Schistosoma mansoni neuropeptide receptor 0.0036 0.0221 0.0216
Echinococcus granulosus rhodopsin orphan GPCR 0.0036 0.0221 0.0216
Onchocerca volvulus 0.0036 0.0221 0.3063
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0036 0.0221 0.0216
Brugia malayi hypothetical protein 0.0036 0.0221 0.0287
Echinococcus granulosus g protein coupled receptor 0.0036 0.0221 0.0216
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0036 0.0221 0.0216
Loa Loa (eye worm) hypothetical protein 0.0036 0.0221 0.0517
Echinococcus granulosus rhodopsin orphan GPCR 0.0036 0.0221 0.0216
Onchocerca volvulus 0.0036 0.0221 0.3063
Schistosoma mansoni cellular tumor antigen P53 0.0057 0.0486 0.0481
Brugia malayi ORL1-like opioid receptor 0.0036 0.0221 0.0287
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0026 0.0086 0.0082
Echinococcus granulosus 7TM GPCR rhodopsin 0.0036 0.0221 0.0216
Entamoeba histolytica hypothetical protein 0.0041 0.0286 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0036 0.0221 0.0216
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0036 0.0221 0.0216
Brugia malayi Serotonin receptor 0.0036 0.0221 0.0287
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0036 0.0221 0.0517
Brugia malayi hypothetical protein 0.0036 0.0221 0.0287
Echinococcus granulosus neuropeptide Y receptor 0.0036 0.0221 0.0216
Echinococcus granulosus rhodopsin orphan GPCR 0.0036 0.0221 0.0216
Onchocerca volvulus 0.0036 0.0221 0.3063
Echinococcus multilocularis serotonin receptor 0.0036 0.0221 0.0216
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0036 0.0221 0.0216
Loa Loa (eye worm) hypothetical protein 0.0036 0.0221 0.0517
Echinococcus multilocularis rhodopsin orphan GPCR 0.0036 0.0221 0.0216
Echinococcus multilocularis dro:myosuppressin receptor 0.0036 0.0221 0.0216
Leishmania major 4-coumarate:coa ligase-like protein 0.0027 0.0103 0.5
Onchocerca volvulus 0.0036 0.0221 0.3063
Schistosoma mansoni opsin-like receptor 0.0036 0.0221 0.0216
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0036 0.0221 0.0216
Echinococcus granulosus neuropeptide receptor 0.0036 0.0221 0.0216
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0036 0.0221 0.0216
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0036 0.0221 0.0216
Brugia malayi G protein-coupled receptor 0.0036 0.0221 0.0287
Loa Loa (eye worm) hypothetical protein 0.002 0.0014 0.0024
Schistosoma mansoni histamine h1 receptor 0.0036 0.0221 0.0216
Loa Loa (eye worm) hypothetical protein 0.0036 0.0221 0.0517
Echinococcus granulosus rhodopsin orphan GPCR 0.0036 0.0221 0.0216
Echinococcus granulosus tm gpcr rhodopsin 0.0036 0.0221 0.0216
Loa Loa (eye worm) hypothetical protein 0.0036 0.0221 0.0517
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0036 0.0221 0.0517
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0036 0.0221 0.0216
Echinococcus granulosus tumor protein p63 0.0388 0.477 0.4767
Loa Loa (eye worm) G-protein coupled receptor 0.0036 0.0221 0.0517
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0036 0.0221 0.0216
Echinococcus granulosus G protein coupled receptor 139 0.0036 0.0221 0.0216
Schistosoma mansoni neuropeptide F-like receptor 0.0036 0.0221 0.0216
Loa Loa (eye worm) hypothetical protein 0.0036 0.0221 0.0517
Loa Loa (eye worm) bromodomain containing protein 0.002 0.0014 0.0022
Schistosoma mansoni hypothetical protein 0.0036 0.0221 0.0216
Schistosoma mansoni amine GPCR 0.0036 0.0221 0.0216
Echinococcus multilocularis sex peptide receptor 0.0036 0.0221 0.0216
Mycobacterium ulcerans hypothetical protein 0.0027 0.0103 1
Loa Loa (eye worm) hypothetical protein 0.0036 0.0221 0.0517
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0027 0.0103 1
Loa Loa (eye worm) neuropeptide F receptor 0.0036 0.0221 0.0517
Schistosoma mansoni neuropeptide receptor 0.0036 0.0221 0.0216
Brugia malayi larval opioid receptor 0.0036 0.0221 0.0287
Loa Loa (eye worm) hypothetical protein 0.0036 0.0221 0.0517
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0036 0.0221 0.0216
Echinococcus granulosus hypothetical protein 0.0036 0.0221 0.0216
Echinococcus multilocularis rhodopsin orphan GPCR 0.0036 0.0221 0.0216
Leishmania major 4-coumarate:coa ligase-like protein 0.0027 0.0103 0.5
Brugia malayi G protein-coupled receptor F59B2.13 0.0036 0.0221 0.0287
Onchocerca volvulus 0.0036 0.0221 0.3063
Loa Loa (eye worm) hypothetical protein 0.0036 0.0221 0.0517
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0036 0.0221 0.0216
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0027 0.0103 1
Onchocerca volvulus Neuropeptide F receptor homolog 0.0036 0.0221 0.3063
Mycobacterium ulcerans acyl-CoA synthetase 0.0027 0.0103 1
Loa Loa (eye worm) camk/mapkapk/mapkapk protein kinase 0.0343 0.418 1
Loa Loa (eye worm) hypothetical protein 0.0036 0.0221 0.0517
Loa Loa (eye worm) hypothetical protein 0.0036 0.0221 0.0517
Loa Loa (eye worm) hypothetical protein 0.0036 0.0221 0.0517
Loa Loa (eye worm) hypothetical protein 0.0057 0.0486 0.1153
Echinococcus multilocularis neuropeptide receptor 0.0036 0.0221 0.0216
Echinococcus multilocularis G protein coupled receptor 139 0.0036 0.0221 0.0216
Schistosoma mansoni biogenic amine receptor 0.0036 0.0221 0.0216
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0036 0.0221 0.0216
Echinococcus multilocularis somatostatin receptor 0.0036 0.0221 0.0216
Onchocerca volvulus 0.0036 0.0221 0.3063
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.002 0.0014 0.5
Schistosoma mansoni neuropeptide F-like receptor 0.0036 0.0221 0.0216
Echinococcus granulosus fetal alzheimer antigen falz 0.0026 0.0086 0.0082
Loa Loa (eye worm) hypothetical protein 0.0036 0.0221 0.0517
Echinococcus multilocularis rhodopsin orphan GPCR 0.0036 0.0221 0.0216
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0041 0.0286 0.0281
Loa Loa (eye worm) hypothetical protein 0.0036 0.0221 0.0517
Brugia malayi G-protein coupled receptor 0.0036 0.0221 0.0287
Echinococcus multilocularis rhodopsin orphan GPCR 0.0036 0.0221 0.0216
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0036 0.0221 0.0216
Brugia malayi Bromodomain containing protein 0.0044 0.032 0.0532
Loa Loa (eye worm) hypothetical protein 0.0027 0.0103 0.0237
Brugia malayi neuropeptide F receptor 0.0036 0.0221 0.0287
Onchocerca volvulus 0.0036 0.0221 0.3063
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0036 0.0221 0.0287
Brugia malayi RE15519p 0.0036 0.0221 0.0287
Loa Loa (eye worm) hypothetical protein 0.002 0.0014 0.0024
Brugia malayi Dopamine receptor 0.0036 0.0221 0.0287
Schistosoma mansoni hypothetical protein 0.0036 0.0221 0.0216
Echinococcus multilocularis rhodopsin orphan GPCR 0.0036 0.0221 0.0216
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0026 0.0086 0.0082
Loa Loa (eye worm) hypothetical protein 0.0036 0.0221 0.0517
Schistosoma mansoni biogenic amine receptor 0.0036 0.0221 0.0216
Schistosoma mansoni alpha-1 adrenergic receptor 0.0036 0.0221 0.0216
Brugia malayi follicle stimulating hormone receptor 0.0036 0.0221 0.0287
Loa Loa (eye worm) hypothetical protein 0.0036 0.0221 0.0517
Echinococcus granulosus MAP kinase activated protein kinase 2 0.0343 0.418 0.4177
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0036 0.0221 0.0216
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0036 0.0221 0.0216
Schistosoma mansoni hypothetical protein 0.0036 0.0221 0.0216
Echinococcus multilocularis neuropeptides capa receptor 0.0036 0.0221 0.0216
Loa Loa (eye worm) hypothetical protein 0.0036 0.0221 0.0517
Schistosoma mansoni amine GPCR 0.0036 0.0221 0.0216
Echinococcus multilocularis rhodopsin orphan GPCR 0.0036 0.0221 0.0216
Loa Loa (eye worm) hypothetical protein 0.0036 0.0221 0.0517
Echinococcus granulosus allatostatin A receptor 0.0036 0.0221 0.0216
Echinococcus multilocularis fmrfamide receptor 0.0036 0.0221 0.0216
Echinococcus granulosus neuropeptides capa receptor 0.0036 0.0221 0.0216
Echinococcus multilocularis microtubule associated protein 2 0.0793 1 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0036 0.0221 0.0216
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0036 0.0221 0.0216
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0036 0.0221 0.0216
Schistosoma mansoni bromodomain containing protein 0.0073 0.0691 0.0687
Loa Loa (eye worm) hypothetical protein 0.0036 0.0221 0.0517
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0027 0.0103 1
Echinococcus granulosus g protein coupled receptor 0.0036 0.0221 0.0216
Loa Loa (eye worm) hypothetical protein 0.0036 0.0221 0.0517
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0027 0.0103 0.5
Leishmania major 4-coumarate:coa ligase-like protein 0.0027 0.0103 0.5
Echinococcus granulosus tachykinin peptides receptor 99D 0.0036 0.0221 0.0216
Loa Loa (eye worm) hypothetical protein 0.002 0.0014 0.0024
Schistosoma mansoni opsin-like receptor 0.0036 0.0221 0.0216
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0036 0.0221 0.0216
Loa Loa (eye worm) hypothetical protein 0.0036 0.0221 0.0517
Loa Loa (eye worm) hypothetical protein 0.0036 0.0221 0.0517
Plasmodium vivax acyl-CoA synthetase, putative 0.002 0.0014 0.5
Echinococcus multilocularis zinc finger protein 0.0023 0.0042 0.0037
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0036 0.0221 0.0517
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0036 0.0221 0.0216
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0069 0.0638 0.0634
Loa Loa (eye worm) neuropeptide F receptor 0.0036 0.0221 0.0517
Loa Loa (eye worm) hypothetical protein 0.0036 0.0221 0.0517
Echinococcus multilocularis neuropeptide FF receptor 2 0.0036 0.0221 0.0216
Loa Loa (eye worm) hypothetical protein 0.0036 0.0221 0.0517
Echinococcus multilocularis g-protein coupled receptor 0.0036 0.0221 0.0216
Schistosoma mansoni amine GPCR 0.0036 0.0221 0.0216
Echinococcus granulosus 7tm_1 domain containing protein 0.0036 0.0221 0.0216
Brugia malayi hypothetical protein 0.0036 0.0221 0.0287
Loa Loa (eye worm) hypothetical protein 0.002 0.0014 0.0024
Loa Loa (eye worm) hypothetical protein 0.0047 0.0356 0.0842
Echinococcus multilocularis MAP kinase activated protein kinase 2 0.0343 0.418 0.4177
Brugia malayi hypothetical protein 0.0036 0.0221 0.0287
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.002 0.0014 0.139
Echinococcus granulosus zinc finger protein 0.0023 0.0042 0.0037
Brugia malayi putative neuropeptide receptor NPR1 0.0036 0.0221 0.0287
Echinococcus granulosus somatostatin receptor 0.0036 0.0221 0.0216
Onchocerca volvulus 0.0036 0.0221 0.3063
Echinococcus multilocularis neuropeptide Y receptor 0.0036 0.0221 0.0216
Echinococcus multilocularis G-protein coupled receptor, putative 0.0036 0.0221 0.0216
Brugia malayi PHD-finger family protein 0.0029 0.0121 0.0044
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0069 0.0638 0.0634
Brugia malayi hypothetical protein 0.0041 0.0286 0.0447
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0036 0.0221 0.0287
Loa Loa (eye worm) hypothetical protein 0.0049 0.0385 0.091
Brugia malayi hypothetical protein 0.0036 0.0221 0.0287
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0036 0.0221 0.0216
Loa Loa (eye worm) melatonin receptor type 1A 0.0036 0.0221 0.0517
Echinococcus granulosus g protein coupled receptor 0.0036 0.0221 0.0216
Echinococcus granulosus dro:myosuppressin receptor 0.0036 0.0221 0.0216

Activities

Activity type Activity value Assay description Source Reference
GI50 (functional) -4.588 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.444 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.057 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-5 Melanoma cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MALME-3M Melanoma cell line. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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