Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | GABA-A receptor; anion channel | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | Ankyrin | 0.0076 | 0.0671 | 0.0671 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription factor | 0.0506 | 0.604 | 0.604 |
Schistosoma mansoni | netrin receptor unc5 | 0.0076 | 0.0666 | 0.1373 |
Schistosoma mansoni | hypothetical protein | 0.0076 | 0.0666 | 0.1373 |
Loa Loa (eye worm) | hypothetical protein | 0.0076 | 0.0671 | 0.1144 |
Echinococcus multilocularis | nuclear factor of activated T cells 5 | 0.0823 | 1 | 1 |
Schistosoma mansoni | ankyrin 23/unc44 | 0.0076 | 0.0666 | 0.1373 |
Schistosoma mansoni | retinoblastoma-binding protein 4 (rbbp4) | 0.0076 | 0.0671 | 0.1382 |
Brugia malayi | Death domain containing protein | 0.0076 | 0.0666 | 0.1103 |
Loa Loa (eye worm) | immunoglobulin I-set domain-containing protein | 0.0076 | 0.0666 | 0.1136 |
Onchocerca volvulus | 0.0398 | 0.4682 | 1 | |
Echinococcus multilocularis | netrin receptor unc 5 | 0.0076 | 0.0666 | 0.0666 |
Brugia malayi | bZIP transcription factor family protein | 0.0506 | 0.604 | 1 |
Brugia malayi | Protein kinase domain containing protein | 0.0076 | 0.0666 | 0.1103 |
Loa Loa (eye worm) | hypothetical protein | 0.0492 | 0.5867 | 1 |
Echinococcus granulosus | death domain containing protein | 0.0076 | 0.0666 | 0.0666 |
Echinococcus multilocularis | Ankyrin | 0.0076 | 0.0671 | 0.0671 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0076 | 0.0666 | 0.1103 |
Echinococcus granulosus | netrin receptor unc 5 | 0.0076 | 0.0666 | 0.0666 |
Schistosoma mansoni | jun-related protein | 0.0411 | 0.4856 | 1 |
Echinococcus multilocularis | ankyrin repeat and death domain containing protein | 0.0076 | 0.0666 | 0.0666 |
Brugia malayi | Uncoordinated protein 44 | 0.0076 | 0.0666 | 0.1103 |
Brugia malayi | hypothetical protein | 0.0398 | 0.4682 | 0.7752 |
Echinococcus granulosus | ankyrin repeat and death domain containing protein | 0.0076 | 0.0666 | 0.0666 |
Onchocerca volvulus | Netrin receptor homolog | 0.0076 | 0.0666 | 0.1423 |
Echinococcus granulosus | jun protein | 0.0506 | 0.604 | 0.604 |
Loa Loa (eye worm) | hypothetical protein | 0.0076 | 0.0666 | 0.1136 |
Schistosoma mansoni | hypothetical protein | 0.0411 | 0.4856 | 1 |
Echinococcus multilocularis | jun protein | 0.0506 | 0.604 | 0.604 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription factor | 0.0506 | 0.604 | 0.604 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | > 1000 nM | Binding affinity at Benzodiazepine receptor of rat forebrain by [3H]- flunitrazepam displacement. | ChEMBL. | 1846920 |
IC50 (binding) | > 1000 nM | Binding affinity at Benzodiazepine receptor of rat forebrain by [3H]- flunitrazepam displacement. | ChEMBL. | 1846920 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.