Detailed information for compound 1615357

Basic information

Technical information
  • TDR Targets ID: 1615357
  • Name: (10Z)-10-[(4-methoxyphenyl)hydrazinylidene]-2 ,2-dimethyl-3,4-dihydrobenzo[g]chromen-5-one
  • MW: 362.422 | Formula: C22H22N2O3
  • H donors: 1 H acceptors: 1 LogP: 4.77 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc(cc1)N/N=C/1\C2=C(CCC(O2)(C)C)C(=O)c2c1cccc2
  • InChi: 1S/C22H22N2O3/c1-22(2)13-12-18-20(25)17-7-5-4-6-16(17)19(21(18)27-22)24-23-14-8-10-15(26-3)11-9-14/h4-11,23H,12-13H2,1-3H3/b24-19-
  • InChiKey: HYPYJBHFHUVFAE-CLCOLTQESA-N  


Substructure search Similarity search

Network

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Synonyms

  • (10Z)-10-[(4-methoxyphenyl)hydrazono]-2,2-dimethyl-3,4-dihydrobenzo[g]chromen-5-one
  • NSC716758

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis tyrosine kinase 0.0011 0.0001 0.0003
Loa Loa (eye worm) hypothetical protein 0.0011 0.0001 0.0002
Echinococcus multilocularis sex peptide receptor 0.0023 0.0018 0.0073
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0023 0.0018 0.0068
Loa Loa (eye worm) hypothetical protein 0.0023 0.0018 0.0068
Onchocerca volvulus Glucosylceramidase homolog 0.0168 0.0221 0.0828
Brugia malayi larval opioid receptor 0.0023 0.0018 0.0066
Trypanosoma cruzi UDP-galactopyranose mutase 0.0749 0.104 0.6876
Echinococcus granulosus rhodopsin orphan GPCR 0.0023 0.0018 0.0073
Loa Loa (eye worm) hypothetical protein 0.0023 0.0018 0.0068
Echinococcus granulosus Ribosomal protein S1 RNA binding domain 0.0021 0.0015 0.006
Echinococcus granulosus allatostatin A receptor 0.0023 0.0018 0.0073
Loa Loa (eye worm) hypothetical protein 0.1906 0.2667 1
Echinococcus granulosus nmda type glutamate receptor 0.0044 0.0047 0.0189
Loa Loa (eye worm) hypothetical protein 0.0023 0.0018 0.0068
Echinococcus multilocularis rhodopsin orphan GPCR 0.0023 0.0018 0.0073
Echinococcus multilocularis neuropeptides capa receptor 0.0023 0.0018 0.0073
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0016 0.0008 0.0033
Echinococcus multilocularis glutamate receptor 2 0.0057 0.0065 0.026
Trichomonas vaginalis glucosylceramidase, putative 0.0256 0.0345 1
Schistosoma mansoni neuropeptide F-like receptor 0.0023 0.0018 0.007
Echinococcus multilocularis neuropeptide Y receptor 0.0023 0.0018 0.0073
Onchocerca volvulus 0.0023 0.0018 0.0066
Echinococcus granulosus rhodopsin orphan GPCR 0.0023 0.0018 0.0073
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0032 0.0031 0.012
Brugia malayi MH2 domain containing protein 0.0016 0.0008 0.0029
Echinococcus granulosus receptor type guanylyl cyclase 0.0011 0.0001 0.0003
Echinococcus multilocularis g-protein coupled receptor 0.0023 0.0018 0.0073
Echinococcus multilocularis NMDA receptor 0.0021 0.0015 0.006
Brugia malayi Calcitonin receptor-like protein seb-1 0.0251 0.0338 0.1266
Onchocerca volvulus 0.0023 0.0018 0.0066
Echinococcus multilocularis g protein coupled receptor 0.0023 0.0018 0.0073
Loa Loa (eye worm) RGC/RGC protein kinase 0.0011 0.0001 0.0002
Brugia malayi Isocitrate dehydrogenase 0.0032 0.0031 0.0113
Onchocerca volvulus 0.0023 0.0018 0.0066
Loa Loa (eye worm) hypothetical protein 0.0011 0.0001 0.0002
Schistosoma mansoni hypothetical protein 0.0197 0.0262 0.1043
Entamoeba histolytica SWIRM domain protein 0.0111 0.0142 1
Loa Loa (eye worm) hypothetical protein 0.0023 0.0018 0.0068
Echinococcus granulosus rhodopsin orphan GPCR 0.0023 0.0018 0.0073
Loa Loa (eye worm) hypothetical protein 0.0023 0.0018 0.0068
Echinococcus multilocularis rhodopsin orphan GPCR 0.0023 0.0018 0.0073
Plasmodium falciparum protoporphyrinogen oxidase 0.0749 0.104 1
Loa Loa (eye worm) hypothetical protein 0.0251 0.0338 0.1268
Trypanosoma cruzi C-8 sterol isomerase, putative 0.1085 0.1512 1
Plasmodium vivax lysine-specific histone demethylase 1, putative 0.0749 0.104 1
Loa Loa (eye worm) hypothetical protein 0.0023 0.0018 0.0068
Onchocerca volvulus 0.0023 0.0018 0.0066
Loa Loa (eye worm) hypothetical protein 0.0554 0.0765 0.287
Schistosoma mansoni hypothetical protein 0.0023 0.0018 0.007
Echinococcus multilocularis dro:myosuppressin receptor 0.0023 0.0018 0.0073
Schistosoma mansoni growth hormone secretagogue receptor 0.0023 0.0018 0.007
Loa Loa (eye worm) neuropeptide F receptor 0.0023 0.0018 0.0068
Toxoplasma gondii histone lysine methyltransferase SET1 0.0063 0.0074 0.0432
Loa Loa (eye worm) G-protein coupled receptor 0.0023 0.0018 0.0068
Echinococcus granulosus sex peptide receptor 0.0023 0.0018 0.0073
Echinococcus multilocularis somatostatin receptor 0.0023 0.0018 0.0073
Loa Loa (eye worm) hypothetical protein 0.0023 0.0018 0.0068
Echinococcus granulosus GPCR family 2 0.0079 0.0097 0.0387
Brugia malayi hypothetical protein 0.0023 0.0018 0.0066
Loa Loa (eye worm) MH1 domain-containing protein 0.0016 0.0008 0.0031
Onchocerca volvulus 0.0023 0.0018 0.0066
Schistosoma mansoni biogenic amine (5HT) receptor 0.0023 0.0018 0.007
Onchocerca volvulus 0.0023 0.0018 0.0066
Loa Loa (eye worm) isocitrate dehydrogenase 0.0032 0.0031 0.0115
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0256 0.0345 0.1292
Loa Loa (eye worm) hypothetical protein 0.0023 0.0018 0.0068
Trypanosoma brucei C-8 sterol isomerase, putative 0.1085 0.1512 1
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0079 0.0097 0.0362
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0049 0.0196
Echinococcus granulosus transcription factor eb 0.0107 0.0136 0.0541
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0068 0.008 0.0321
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0032 0.0031 0.0014
Echinococcus granulosus orexin receptor type 2 0.0023 0.0018 0.0073
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0023 0.0018 0.0073
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0023 0.0018 0.0073
Brugia malayi GnHR receptor homolog 0.0023 0.0018 0.0066
Brugia malayi Dopamine receptor 0.0023 0.0018 0.0066
Echinococcus granulosus mothers against decapentaplegic 5 0.0016 0.0008 0.0033
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0256 0.0345 0.1294
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0023 0.0018 0.0073
Trichomonas vaginalis glucosylceramidase, putative 0.0256 0.0345 1
Brugia malayi Smad1 0.0016 0.0008 0.0029
Trichomonas vaginalis glucosylceramidase, putative 0.0177 0.0234 0.4544
Schistosoma mansoni smad 0.0016 0.0008 0.0031
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0023 0.0018 0.0073
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0032 0.0031 0.0122
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0023 0.0018 0.0073
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0023 0.0018 0.0066
Echinococcus granulosus glutamate receptor ionotropic kainate 0.0021 0.0015 0.006
Echinococcus multilocularis metabotropic glutamate receptor 2 0.0011 0.0001 0.0003
Loa Loa (eye worm) CXXC zinc finger family protein 0.0033 0.0032 0.0122
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0068 0.008 0.0321
Loa Loa (eye worm) hypothetical protein 0.0749 0.104 0.3898
Schistosoma mansoni hypothetical protein 0.0079 0.0097 0.0384
Brugia malayi MH1 domain containing protein 0.0016 0.0008 0.0029
Loa Loa (eye worm) hypothetical protein 0.0023 0.0018 0.0068
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0251 0.0338 0.1266
Loa Loa (eye worm) hypothetical protein 0.0011 0.0001 0.0002
Echinococcus granulosus biogenic amine 5HT receptor 0.0023 0.0018 0.0073
Echinococcus multilocularis glutamate receptor subunit protein glur 0.0021 0.0015 0.006
Echinococcus multilocularis atrial natriuretic peptide receptor 0.0011 0.0001 0.0003
Echinococcus multilocularis fmrfamide receptor 0.0023 0.0018 0.0073
Echinococcus multilocularis rhodopsin orphan GPCR 0.0023 0.0018 0.0073
Echinococcus multilocularis smad 0.0016 0.0008 0.0033
Schistosoma mansoni Smad4 0.0016 0.0008 0.0031
Loa Loa (eye worm) hypothetical protein 0.0023 0.0018 0.0068
Echinococcus multilocularis rhodopsin orphan GPCR 0.0023 0.0018 0.0073
Schistosoma mansoni adenoreceptor 0.0023 0.0018 0.007
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0079 0.0097 0.0387
Echinococcus granulosus metabotropic glutamate receptor 2 0.0011 0.0001 0.0003
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0049 0.0196
Brugia malayi Dopamine receptor protein 1 0.0023 0.0018 0.0066
Echinococcus multilocularis isocitrate dehydrogenase 0.0032 0.0031 0.0122
Echinococcus multilocularis rhodopsin orphan GPCR 0.0023 0.0018 0.0073
Schistosoma mansoni myosin xvIII 0.0023 0.0018 0.007
Loa Loa (eye worm) hypothetical protein 0.0023 0.0018 0.0068
Brugia malayi hypothetical protein 0.0023 0.0018 0.0066
Schistosoma mansoni neuropeptide receptor 0.0023 0.0018 0.007
Schistosoma mansoni smad1 5 8 and 0.0016 0.0008 0.0031
Echinococcus granulosus tachykinin peptides receptor 99D 0.0023 0.0018 0.0073
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0023 0.0018 0.0073
Echinococcus multilocularis nmda type glutamate receptor 0.0044 0.0047 0.0189
Mycobacterium tuberculosis Conserved hypothetical protein 0.0749 0.104 0.1144
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0023 0.0018 0.007
Loa Loa (eye worm) hypothetical protein 0.0011 0.0001 0.0002
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0068 0.008 0.0321
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0023 0.0018 0.0066
Echinococcus multilocularis orexin receptor type 2 0.0023 0.0018 0.0073
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0023 0.0018 0.0073
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0023 0.0018 0.007
Brugia malayi Serotonin receptor 0.0023 0.0018 0.0066
Echinococcus granulosus neuropeptide FF receptor 2 0.0023 0.0018 0.0073
Schistosoma mansoni opsin-like receptor 0.0023 0.0018 0.007
Echinococcus granulosus cpg binding protein 0.0035 0.0035 0.014
Onchocerca volvulus 0.0023 0.0018 0.0066
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0079 0.0097 0.0387
Loa Loa (eye worm) hypothetical protein 0.0023 0.0018 0.0068
Schistosoma mansoni cpg binding protein 0.0035 0.0035 0.0137
Chlamydia trachomatis protoporphyrinogen oxidase 0.0749 0.104 1
Brugia malayi ERG2 and Sigma1 receptor like protein 0.1085 0.1512 0.5667
Echinococcus granulosus lysine specific histone demethylase 1A 0.0749 0.104 0.414
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0023 0.0018 0.0066
Loa Loa (eye worm) Smad1 0.0016 0.0008 0.0031
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0023 0.0018 0.007
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0023 0.0018 0.0073
Loa Loa (eye worm) hypothetical protein 0.0023 0.0018 0.0068
Loa Loa (eye worm) hypothetical protein 0.0023 0.0018 0.0068
Echinococcus granulosus g protein coupled receptor 0.0023 0.0018 0.0073
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0079 0.0097 0.0387
Echinococcus granulosus neuropeptides capa receptor 0.0023 0.0018 0.0073
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0023 0.0018 0.007
Onchocerca volvulus 0.0023 0.0018 0.0066
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0749 0.104 1
Schistosoma mansoni hypothetical protein 0.0079 0.0097 0.0384
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0023 0.0018 0.007
Toxoplasma gondii histone lysine-specific demethylase 0.0749 0.104 0.9972
Loa Loa (eye worm) hypothetical protein 0.0106 0.0135 0.0506
Echinococcus multilocularis lysine specific histone demethylase 1A 0.1795 0.2511 1
Schistosoma mansoni neuropeptide F-like receptor 0.0023 0.0018 0.007
Loa Loa (eye worm) hypothetical protein 0.0023 0.0018 0.0068
Brugia malayi neuropeptide F receptor 0.0023 0.0018 0.0066
Trichomonas vaginalis glucosylceramidase, putative 0.0168 0.0221 0.392
Brugia malayi neuropeptide F receptor 0.0023 0.0018 0.0066
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0023 0.0018 0.0066
Schistosoma mansoni amine oxidase 0.0749 0.104 0.4139
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0023 0.0018 0.0066
Brugia malayi CXXC zinc finger family protein 0.0033 0.0032 0.0119
Onchocerca volvulus 0.0023 0.0018 0.0066
Loa Loa (eye worm) hypothetical protein 0.0023 0.0018 0.0068
Schistosoma mansoni alpha-1 adrenergic receptor 0.0023 0.0018 0.007
Loa Loa (eye worm) TYRA-2 protein 0.0023 0.0018 0.0068
Schistosoma mansoni cpg binding protein 0.0035 0.0035 0.0137
Schistosoma mansoni opsin-like receptor 0.0023 0.0018 0.007
Echinococcus granulosus nmda type glutamate receptor 0.0011 0.0001 0.0003
Brugia malayi MH1 domain containing protein 0.0016 0.0008 0.0029
Plasmodium falciparum lysine-specific histone demethylase 1, putative 0.0749 0.104 1
Echinococcus multilocularis glutamate receptor, ionotrophic, AMPA 3 0.0068 0.008 0.0321
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0023 0.0018 0.007
Echinococcus granulosus neuropeptides capa receptor 0.0023 0.0018 0.0073
Mycobacterium ulcerans dehydrogenase 0.0749 0.104 0.1023
Schistosoma mansoni Lysine-specific histone demethylase 1 0.1795 0.2511 1
Loa Loa (eye worm) hypothetical protein 0.0023 0.0018 0.0068
Brugia malayi latrophilin 2 splice variant baaae 0.0171 0.0227 0.0847
Schistosoma mansoni neuropeptide receptor 0.0023 0.0018 0.007
Loa Loa (eye worm) hypothetical protein 0.0023 0.0018 0.0068
Echinococcus granulosus g protein coupled receptor 0.0023 0.0018 0.0073
Echinococcus granulosus atrial natriuretic peptide receptor 0.0011 0.0001 0.0003
Echinococcus granulosus lysine specific histone demethylase 1A 0.1795 0.2511 1
Echinococcus granulosus g-protein coupled receptor 0.0023 0.0018 0.0073
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0023 0.0018 0.007
Loa Loa (eye worm) hypothetical protein 0.1795 0.2511 0.9414
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0023 0.0018 0.007
Loa Loa (eye worm) hypothetical protein 0.0023 0.0018 0.0068
Echinococcus granulosus rhodopsin orphan GPCR 0.0023 0.0018 0.0073
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0049 0.0196
Echinococcus granulosus neuropeptide Y receptor 0.0023 0.0018 0.0073
Loa Loa (eye worm) hypothetical protein 0.0023 0.0018 0.0068
Schistosoma mansoni glutamate receptor AMPA 0.0057 0.0065 0.0258
Loa Loa (eye worm) RGC/RGC protein kinase 0.0011 0.0001 0.0002
Echinococcus granulosus neuropeptide receptor A26 0.0485 0.0668 0.266
Brugia malayi putative neuropeptide receptor NPR1 0.0023 0.0018 0.0066
Schistosoma mansoni biogenic amine (5HT) receptor 0.0023 0.0018 0.007
Loa Loa (eye worm) hypothetical protein 0.0023 0.0018 0.0068
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0023 0.0018 0.0068
Echinococcus granulosus somatostatin receptor 0.0023 0.0018 0.0073
Trichomonas vaginalis glucosylceramidase, putative 0.0256 0.0345 1
Loa Loa (eye worm) hypothetical protein 0.0011 0.0001 0.0002
Echinococcus multilocularis receptor type guanylyl cyclase 0.0011 0.0001 0.0003
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0023 0.0018 0.007
Loa Loa (eye worm) hypothetical protein 0.0023 0.0018 0.0068
Brugia malayi G-protein coupled receptor 0.0023 0.0018 0.0066
Echinococcus granulosus fmrfamide receptor 0.0023 0.0018 0.0073
Schistosoma mansoni neuropeptide receptor 0.0023 0.0018 0.007
Brugia malayi isocitrate dehydrogenase 0.0032 0.0031 0.0113
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0032 0.0031 0.0122
Brugia malayi Serotonin receptor 0.0023 0.0018 0.0066
Loa Loa (eye worm) hypothetical protein 0.1795 0.2511 0.9414
Echinococcus multilocularis protoporphyrinogen oxidase 0.0749 0.104 0.414
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0032 0.0031 0.0199
Echinococcus granulosus glutamate receptor subunit protein glur 0.0021 0.0015 0.006
Mycobacterium tuberculosis Probable flavin-containing monoamine oxidase AofH (amine oxidase) (MAO) 0.6369 0.8946 1
Schistosoma mansoni glutamate receptor kainate 0.0057 0.0065 0.0258
Echinococcus multilocularis geminin 0.0197 0.0262 0.1045
Brugia malayi putative neuropeptide receptor 0.0023 0.0018 0.0066
Echinococcus granulosus glutamate receptor ionotropic kainate 3 0.0021 0.0015 0.006
Schistosoma mansoni glutamate receptor kainate 0.0057 0.0065 0.0258
Entamoeba histolytica SWIRM domain protein 0.0111 0.0142 1
Trichomonas vaginalis glucosylceramidase, putative 0.0168 0.0221 0.392
Loa Loa (eye worm) hypothetical protein 0.0023 0.0018 0.0068
Brugia malayi ORL1-like opioid receptor 0.0023 0.0018 0.0066
Loa Loa (eye worm) hypothetical protein 0.0023 0.0018 0.0068
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0068 0.008 0.0321
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0023 0.0018 0.0073
Brugia malayi sulfakinin receptor protein 0.0023 0.0018 0.0066
Echinococcus multilocularis neuropeptide s receptor 0.0485 0.0668 0.266
Echinococcus multilocularis g protein coupled receptor 0.0023 0.0018 0.0073
Echinococcus multilocularis serotonin receptor 0.0023 0.0018 0.0073
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0023 0.0018 0.007
Loa Loa (eye worm) helix-loop-helix DNA-binding domain-containing protein 0.0106 0.0135 0.0506
Trypanosoma cruzi UDP-galactopyranose mutase 0.0749 0.104 0.6876
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0023 0.0018 0.0073
Schistosoma mansoni cpg binding protein 0.0033 0.0032 0.0127
Echinococcus granulosus glutamate receptor 2 0.0068 0.008 0.0321
Echinococcus granulosus glutamate NMDA receptor subunit 0.0057 0.0065 0.026
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0544 0.0751 0.2991
Echinococcus multilocularis Ribosomal protein S1, RNA binding domain 0.0021 0.0015 0.006
Trichomonas vaginalis glucosylceramidase, putative 0.0256 0.0345 1
Schistosoma mansoni glutamate receptor NMDA 0.0057 0.0065 0.0258
Echinococcus multilocularis neuropeptide receptor A26 0.0485 0.0668 0.266
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0023 0.0018 0.0068
Schistosoma mansoni glutamate receptor AMPA 0.0057 0.0065 0.0258
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0023 0.0018 0.0073
Brugia malayi SWIRM domain containing protein 0.0111 0.0142 0.0529
Brugia malayi hypothetical protein 0.0023 0.0018 0.0066
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0045 0.0049 0.0184
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0023 0.0018 0.0073
Loa Loa (eye worm) hypothetical protein 0.0011 0.0001 0.0002
Loa Loa (eye worm) hypothetical protein 0.0011 0.0001 0.0002
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0049 0.0196
Schistosoma mansoni smad1 5 8 and 0.0016 0.0008 0.0031
Entamoeba histolytica hypothetical protein 0.0111 0.0142 1
Loa Loa (eye worm) hypothetical protein 0.0011 0.0001 0.0002
Echinococcus multilocularis rhodopsin orphan GPCR 0.0023 0.0018 0.0073
Plasmodium vivax hypothetical protein, conserved 0.0749 0.104 1
Mycobacterium ulcerans oxidoreductase 0.0749 0.104 0.1023
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0023 0.0018 0.0066
Schistosoma mansoni neuropeptide f receptor 76f 0.0023 0.0018 0.007
Toxoplasma gondii SWIRM domain-containing protein 0.0111 0.0142 0.1097
Trichomonas vaginalis glucosylceramidase, putative 0.0168 0.0221 0.392
Echinococcus multilocularis SWI:SNF complex subunit SMARCC2 0.0111 0.0142 0.0564
Brugia malayi AKH receptor 0.0023 0.0018 0.0066
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0068 0.008 0.0321
Echinococcus multilocularis dnaJ subfamily B 0.0475 0.0654 0.2604
Mycobacterium tuberculosis Possible oxidoreductase 0.0749 0.104 0.1144
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0023 0.0018 0.007
Schistosoma mansoni hypothetical protein 0.0021 0.0015 0.0057
Echinococcus granulosus rhodopsin orphan GPCR 0.0023 0.0018 0.0073
Echinococcus multilocularis glutamate receptor ionotropic kainate 0.0021 0.0015 0.006
Brugia malayi hypothetical protein 0.0023 0.0018 0.0066
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0023 0.0018 0.0073
Leishmania major C-8 sterol isomerase-like protein 0.1085 0.1512 1
Loa Loa (eye worm) melatonin receptor type 1A 0.0023 0.0018 0.0068
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0068 0.008 0.0321
Trichomonas vaginalis glucosylceramidase, putative 0.0177 0.0234 0.4544
Echinococcus granulosus rhodopsin orphan GPCR 0.0023 0.0018 0.0073
Schistosoma mansoni amine GPCR 0.0023 0.0018 0.007
Echinococcus multilocularis glutamate receptor 2 0.0047 0.0051 0.0203
Loa Loa (eye worm) hypothetical protein 0.0171 0.0227 0.0849
Loa Loa (eye worm) hypothetical protein 0.0023 0.0018 0.0068
Loa Loa (eye worm) hypothetical protein 0.0023 0.0018 0.0068
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0023 0.0018 0.007
Loa Loa (eye worm) hypothetical protein 0.0023 0.0018 0.0068
Plasmodium vivax protoporphyrinogen oxidase, putative 0.0749 0.104 1
Brugia malayi G protein-coupled receptor F59B2.13 0.0023 0.0018 0.0066
Brugia malayi RE15519p 0.0023 0.0018 0.0066
Brugia malayi SWIRM domain containing protein 0.1906 0.2667 1
Schistosoma mansoni amine GPCR 0.0023 0.0018 0.007
Loa Loa (eye worm) hypothetical protein 0.0023 0.0018 0.0068
Onchocerca volvulus 0.0023 0.0018 0.0066
Loa Loa (eye worm) MH2 domain-containing protein 0.0016 0.0008 0.0031
Echinococcus granulosus TGF beta signal transducer SmadC 0.0016 0.0008 0.0033
Echinococcus granulosus dro:myosuppressin receptor 0.0023 0.0018 0.0073
Echinococcus multilocularis neuropeptide receptor 0.0023 0.0018 0.0073
Mycobacterium leprae PROBABLE PROTOPORPHYRINOGEN OXIDASE HEMY (PROTOPORPHYRINOGEN-IX OXIDASE) (PROTOPORPHYRINOGENASE) (PPO) 0.0749 0.104 0.5
Loa Loa (eye worm) G-protein coupled receptor 0.0023 0.0018 0.0068
Schistosoma mansoni opsin-like receptor 0.0023 0.0018 0.007
Trichomonas vaginalis glucosylceramidase, putative 0.0168 0.0221 0.392
Loa Loa (eye worm) metabotropic glutamate receptor 8 0.0011 0.0001 0.0002
Brugia malayi hypothetical protein 0.0023 0.0018 0.0066
Trichomonas vaginalis glucosylceramidase, putative 0.0256 0.0345 1
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0079 0.0097 0.0387
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0023 0.0018 0.0073
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0023 0.0018 0.007
Brugia malayi hypothetical protein 0.0023 0.0018 0.0066
Onchocerca volvulus 0.0023 0.0018 0.0066
Leishmania major UDP-galactopyranose mutase 0.0749 0.104 0.6876
Echinococcus multilocularis allatostatin A receptor 0.0023 0.0018 0.0073
Loa Loa (eye worm) hypothetical protein 0.0023 0.0018 0.0068
Echinococcus multilocularis G-protein coupled receptor, putative 0.0023 0.0018 0.0073
Brugia malayi MH2 domain containing protein 0.0016 0.0008 0.0029
Onchocerca volvulus 0.0023 0.0018 0.0066
Loa Loa (eye worm) hypothetical protein 0.0023 0.0018 0.0068
Echinococcus granulosus biogenic amine 5HT receptor 0.0023 0.0018 0.0073
Echinococcus multilocularis G protein coupled receptor 139 0.0023 0.0018 0.0073
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0023 0.0018 0.007
Schistosoma mansoni neuropeptide receptor 0.0023 0.0018 0.007
Echinococcus multilocularis 0.0749 0.104 0.414
Loa Loa (eye worm) latrophilin receptor protein 2 0.0079 0.0097 0.0364
Schistosoma mansoni biogenic amine receptor 0.0023 0.0018 0.007
Schistosoma mansoni hypothetical protein 0.0079 0.0097 0.0384
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0023 0.0018 0.0073
Brugia malayi hypothetical protein 0.0023 0.0018 0.0066
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0023 0.0018 0.007
Onchocerca volvulus 0.0023 0.0018 0.0066
Onchocerca volvulus 0.0023 0.0018 0.0066
Loa Loa (eye worm) hypothetical protein 0.0023 0.0018 0.0068
Toxoplasma gondii histone lysine-specific demethylase LSD1/BHC110/KDMA1A 0.0751 0.1042 1
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0023 0.0018 0.0068
Loa Loa (eye worm) hypothetical protein 0.086 0.1196 0.4483
Loa Loa (eye worm) hypothetical protein 0.0079 0.0097 0.0364
Echinococcus granulosus Smad4 0.0016 0.0008 0.0033
Echinococcus multilocularis neuropeptide Y receptor 0.0023 0.0018 0.0073
Echinococcus multilocularis g protein coupled receptor 0.0023 0.0018 0.0073
Loa Loa (eye worm) hypothetical protein 0.0023 0.0018 0.0068
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0251 0.0338 0.1268
Loa Loa (eye worm) neuropeptide F receptor 0.0023 0.0018 0.0068
Loa Loa (eye worm) hypothetical protein 0.0023 0.0018 0.0068
Loa Loa (eye worm) hypothetical protein 0.0111 0.0142 0.0531
Onchocerca volvulus 0.0023 0.0018 0.0066
Schistosoma mansoni hypothetical protein 0.0475 0.0654 0.2603
Echinococcus granulosus rhodopsin orphan GPCR 0.0023 0.0018 0.0073
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0023 0.0018 0.0073
Schistosoma mansoni ATP-binding cassette transporter 0.0057 0.0065 0.0258
Echinococcus multilocularis rhodopsin orphan GPCR 0.0023 0.0018 0.0073
Echinococcus granulosus serotonin receptor 0.0023 0.0018 0.0073
Echinococcus granulosus smad 0.0016 0.0008 0.0033
Brugia malayi Melatonin receptor type 1A 0.0023 0.0018 0.0066
Schistosoma mansoni glutamate receptor NMDA 0.0068 0.008 0.0318
Onchocerca volvulus 0.0023 0.0018 0.0066
Onchocerca volvulus 0.0023 0.0018 0.0066
Loa Loa (eye worm) hypothetical protein 0.0023 0.0018 0.0068
Echinococcus granulosus g protein coupled receptor 0.0023 0.0018 0.0073
Schistosoma mansoni biogenic amine receptor 0.0023 0.0018 0.007
Echinococcus multilocularis nmda type glutamate receptor 0.0011 0.0001 0.0003
Onchocerca volvulus 0.1906 0.2667 1
Loa Loa (eye worm) hypothetical protein 0.0023 0.0018 0.0068
Loa Loa (eye worm) hypothetical protein 0.0023 0.0018 0.0068
Brugia malayi Glutamate receptor 1 precursor 0.0057 0.0065 0.0243
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0023 0.0018 0.0073
Echinococcus multilocularis neuropeptide FF receptor 2 0.0023 0.0018 0.0073
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0049 0.0193
Schistosoma mansoni hypothetical protein 0.0197 0.0262 0.1043
Loa Loa (eye worm) hypothetical protein 0.1085 0.1512 0.5668
Echinococcus granulosus peptide allatostatin:somatostatin 0.0023 0.0018 0.0073
Echinococcus granulosus SWI:SNF complex subunit SMARCC2 0.0111 0.0142 0.0564
Schistosoma mansoni histamine h1 receptor 0.0023 0.0018 0.007
Echinococcus granulosus metabotropic glutamate receptor 5 0.0011 0.0001 0.0003
Trichomonas vaginalis glucosylceramidase, putative 0.0256 0.0345 1
Schistosoma mansoni amine GPCR 0.0023 0.0018 0.007
Loa Loa (eye worm) metabotropic GABA-B receptor subtype 2 0.0011 0.0001 0.0002
Schistosoma mansoni glutamate receptor kainate 0.0057 0.0065 0.0258
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0032 0.0031 0.0122
Trichomonas vaginalis glucosylceramidase, putative 0.0168 0.0221 0.392
Schistosoma mansoni Protoporphyrinogen oxidase chloroplast/mitochondrial precursor 0.0749 0.104 0.4139
Brugia malayi amine oxidase, flavin-containing family protein 0.086 0.1196 0.4482
Schistosoma mansoni hypothetical protein 0.0079 0.0097 0.0384
Echinococcus granulosus tm gpcr rhodopsin 0.0023 0.0018 0.0073
Echinococcus multilocularis mothers against decapentaplegic 5 0.0016 0.0008 0.0033
Echinococcus granulosus G protein coupled receptor 139 0.0023 0.0018 0.0073
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0016 0.0008 0.0031
Schistosoma mansoni hypothetical protein 0.0023 0.0018 0.007
Echinococcus granulosus hypothetical protein 0.0023 0.0018 0.0073
Brugia malayi G-protein coupled receptor 0.0023 0.0018 0.0066
Loa Loa (eye worm) receptor family ligand binding region containing protein 0.0011 0.0001 0.0002
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0032 0.0031 0.0199
Echinococcus multilocularis glutamate receptor 2 0.0068 0.008 0.0321
Onchocerca volvulus 0.0033 0.0032 0.0119
Echinococcus granulosus neuropeptide Y receptor 0.0023 0.0018 0.0073
Plasmodium vivax hypothetical protein, conserved 0.0749 0.104 1
Brugia malayi MH2 domain containing protein 0.0238 0.032 0.1199
Loa Loa (eye worm) hypothetical protein 0.0023 0.0018 0.0068
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0023 0.0018 0.007
Loa Loa (eye worm) glutamate receptor 2 0.0057 0.0065 0.0245
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0049 0.0193
Loa Loa (eye worm) glutamate receptor 0.0011 0.0001 0.0002
Brugia malayi G protein-coupled receptor 0.0023 0.0018 0.0066
Schistosoma mansoni amine oxidase 0.0749 0.104 0.4139
Schistosoma mansoni hypothetical protein 0.0023 0.0018 0.007
Brugia malayi Helix-loop-helix DNA-binding domain containing protein 0.0107 0.0136 0.0507
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0032 0.0031 0.0122
Loa Loa (eye worm) hypothetical protein 0.0023 0.0018 0.0068
Echinococcus multilocularis rhodopsin orphan GPCR 0.0023 0.0018 0.0073
Treponema pallidum amino acid ABC transporter, periplasmic binding protein 0.0023 0.0018 0.5
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 3 0.0044 0.0047 0.0189
Brugia malayi hypothetical protein 0.0749 0.104 0.3896
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0023 0.0018 0.0073
Mycobacterium ulcerans monoamine oxidase 0.0749 0.104 0.1023
Mycobacterium ulcerans protoporphyrinogen oxidase 0.0749 0.104 0.1023
Schistosoma mansoni biogenic amine receptor 0.0023 0.0018 0.007
Echinococcus granulosus glutamate receptor 2 0.0047 0.0051 0.0203
Loa Loa (eye worm) hypothetical protein 0.0023 0.0018 0.0068
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0049 0.0193
Echinococcus granulosus tyrosine kinase 0.0011 0.0001 0.0003
Echinococcus granulosus 7TM GPCR rhodopsin 0.0023 0.0018 0.0073
Brugia malayi Latrophilin receptor protein 2 0.0079 0.0097 0.0362
Echinococcus multilocularis glutamate (NMDA) receptor subunit 0.0057 0.0065 0.026
Brugia malayi hypothetical protein 0.0023 0.0018 0.0066
Echinococcus granulosus 7tm_1 domain containing protein 0.0023 0.0018 0.0073
Echinococcus multilocularis fmrfamide receptor 0.0023 0.0018 0.0073
Schistosoma mansoni smad1 5 8 and 0.0016 0.0008 0.0031
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0023 0.0018 0.007
Giardia lamblia hypothetical protein 0.0111 0.0142 0.5
Loa Loa (eye worm) MH2 domain-containing protein 0.0238 0.032 0.1201
Echinococcus granulosus alpha 1A adrenergic receptor 0.0023 0.0018 0.0073
Loa Loa (eye worm) hypothetical protein 0.0023 0.0018 0.0068
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0023 0.0018 0.0073
Brugia malayi hypothetical protein 0.0023 0.0018 0.0066
Treponema pallidum amino acid ABC transporter, periplasmic binding protein (hisJ) 0.0023 0.0018 0.5
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0023 0.0018 0.007
Loa Loa (eye worm) hypothetical protein 0.0023 0.0018 0.0068
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0071 0.0085 0.0336
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0023 0.0018 0.0068
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0023 0.0018 0.007
Loa Loa (eye worm) hypothetical protein 0.0023 0.0018 0.0068
Echinococcus multilocularis transcription factor eb 0.0107 0.0136 0.0541
Echinococcus granulosus neuropeptide receptor 0.0023 0.0018 0.0073
Echinococcus granulosus tm gpcr rhodopsin 0.0544 0.0751 0.2991
Schistosoma mansoni hypothetical protein 0.0023 0.0018 0.007
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0032 0.0031 0.0122
Loa Loa (eye worm) hypothetical protein 0.0023 0.0018 0.0068
Schistosoma mansoni SWI/SNF complex-related 0.0111 0.0142 0.0562
Loa Loa (eye worm) hypothetical protein 0.0023 0.0018 0.0068
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0023 0.0018 0.007
Echinococcus granulosus tm gpcr rhodopsin 0.0023 0.0018 0.0073
Loa Loa (eye worm) hypothetical protein 0.0023 0.0018 0.0068
Brugia malayi follicle stimulating hormone receptor 0.0023 0.0018 0.0066
Echinococcus multilocularis cpg binding protein 0.0035 0.0035 0.014
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0023 0.0018 0.007
Brugia malayi Glutamate receptor 2 precursor 0.0057 0.0065 0.0243
Trichomonas vaginalis glucosylceramidase, putative 0.0168 0.0221 0.392
Schistosoma mansoni hypothetical protein 0.0171 0.0227 0.09
Echinococcus granulosus neuropeptide s receptor 0.0485 0.0668 0.266
Trichomonas vaginalis glucosylceramidase, putative 0.0168 0.0221 0.392
Schistosoma mansoni amine GPCR 0.0023 0.0018 0.007
Loa Loa (eye worm) RGC/RGC protein kinase 0.0011 0.0001 0.0002
Brugia malayi hypothetical protein 0.0023 0.0018 0.0066
Loa Loa (eye worm) hypothetical protein 0.0011 0.0001 0.0002
Loa Loa (eye worm) hypothetical protein 0.0749 0.104 0.3898
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0032 0.0031 0.0199
Onchocerca volvulus Neuropeptide F receptor homolog 0.0023 0.0018 0.0066
Echinococcus multilocularis Smad4 0.0016 0.0008 0.0033
Loa Loa (eye worm) glutamate receptor 1 0.0057 0.0065 0.0245
Echinococcus granulosus geminin 0.0197 0.0262 0.1045
Echinococcus multilocularis GPCR, family 2 0.0079 0.0097 0.0387
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0023 0.0018 0.007
Echinococcus multilocularis neuropeptide receptor 0.0023 0.0018 0.0073
Brugia malayi Dopamine receptor protein 2 0.0023 0.0018 0.0066
Echinococcus granulosus neuropeptide receptor 0.0023 0.0018 0.0073
Loa Loa (eye worm) transcription factor SMAD2 0.0238 0.032 0.1201
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0045 0.0049 0.0182
Brugia malayi Tachykinin-like peptides receptor 99D 0.0023 0.0018 0.0066
Echinococcus granulosus dnaJ subfamily B 0.0475 0.0654 0.2604
Schistosoma mansoni amine GPCR 0.0023 0.0018 0.007
Echinococcus multilocularis metabotropic glutamate receptor 5 0.0011 0.0001 0.0003
Echinococcus multilocularis serotonin receptor 0.0023 0.0018 0.0073
Echinococcus granulosus glutamate receptor ionotrophic AMPA 3 0.0068 0.008 0.0321
Echinococcus multilocularis neuropeptides capa receptor 0.0023 0.0018 0.0073

Activities

Activity type Activity value Assay description Source Reference
GI50 (functional) -4.864 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.815 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.808 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MDA-N Breast cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.747 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.745 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.742 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.68 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MALME-3M Melanoma cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.676 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.613 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.599 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the DU-145 Prostate cell line. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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