TDR Targets

Basic information

Technical information

TDR Targets ID: 1619712
Name: MOLI000005
MW: 367.49 | Formula: C23H29FN2O
H donors: 1 H acceptors: 1 LogP: 3.71 Rotable bonds: 4
Rule of 5 violations (Lipinski): 1
SMILES: O[C@@H]1CCN(C[C@H]1N1CCC(CC1)c1ccccc1)Cc1ccc(cc1)[18F]
InChi: 1S/C23H29FN2O/c24-21-8-6-18(7-9-21)16-25-13-12-23(27)22(17-25)26-14-10-20(11-15-26)19-4-2-1-3-5-19/h1-9,20,22-23,27H,10-17H2/t22-,23-/m1/s1/i24-1
InChiKey: HPZHSYBCGLDRCT-YRPGOWEVSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	solute carrier family 18 (vesicular acetylcholine transporter), member 3	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Schistosoma mansoni	vesicular acetylcholine transporter	Get druggable targets OG5_133283	All targets in OG5_133283
Echinococcus multilocularis	vesicular acetylcholine transporter	Get druggable targets OG5_133283	All targets in OG5_133283
Brugia malayi	vesicular acetylcholine transporter unc-17	Get druggable targets OG5_133283	All targets in OG5_133283
Loa Loa (eye worm)	vesicular acetylcholine transporter unc-17	Get druggable targets OG5_133283	All targets in OG5_133283
Schistosoma japonicum	ko:K08155 MFS transporter, DHA1 family, solute carrier family 18 (vesicular, putative	Get druggable targets OG5_133283	All targets in OG5_133283
Onchocerca volvulus	Vesicular acetylcholine transporter homolog	Get druggable targets OG5_133283	All targets in OG5_133283
Echinococcus granulosus	vesicular acetylcholine transporter	Get druggable targets OG5_133283	All targets in OG5_133283

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Brugia malayi	Abnormal catecholamine distribution protein 1	solute carrier family 18 (vesicular acetylcholine transporter), member 3	532 aa	504 aa	34.3 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	TK/ACK protein kinase	0.0258	0.144	0.2606
Schistosoma mansoni	nck2/grb4	0.0428	0.2538	0.6029
Schistosoma mansoni	tensin-related	0.0428	0.2538	0.6029
Brugia malayi	Nuclear hormone receptor-like 1	0.004	0.0031	0.0056
Echinococcus multilocularis	epidermal growth factor receptor	0.0258	0.144	0.3422
Trichomonas vaginalis	conserved hypothetical protein	0.0258	0.144	1
Echinococcus granulosus	neuropeptides capa receptor	0.004	0.0028	0.0028
Echinococcus granulosus	tyrosine protein kinase Lyn	0.0686	0.4209	0.4209
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.004	0.0028	0.0051
Trichomonas vaginalis	TKL family protein kinase	0.0258	0.144	1
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.004	0.0028	0.0067
Onchocerca volvulus		0.0258	0.144	0.3422
Echinococcus multilocularis	protein kinase	0.0258	0.144	0.3422
Schistosoma mansoni	hypothetical protein	0.004	0.0028	0.0067
Trichomonas vaginalis	TKL family protein kinase	0.0258	0.144	1
Brugia malayi	Protein kinase domain containing protein	0.0258	0.144	0.2606
Schistosoma mansoni	tyrosine-protein kinase fps85d	0.0258	0.144	0.3422
Loa Loa (eye worm)	hypothetical protein	0.0428	0.2538	0.4592
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.004	0.0031	0.0056
Brugia malayi	Protein kinase domain containing protein	0.0686	0.4209	0.7617
Trichomonas vaginalis	conserved hypothetical protein	0.0258	0.144	1
Echinococcus multilocularis	protein kinase	0.0258	0.144	0.3422
Echinococcus multilocularis	neuropeptides capa receptor	0.004	0.0028	0.0067
Loa Loa (eye worm)	hypothetical protein	0.0428	0.2538	0.4592
Brugia malayi	SH2 domain containing protein	0.0428	0.2538	0.4592
Loa Loa (eye worm)	TK/FER protein kinase	0.0258	0.144	0.2606
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.004	0.0031	0.0056
Trypanosoma cruzi	C-8 sterol isomerase, putative	0.0889	0.5526	1
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.004	0.0028	0.0067
Onchocerca volvulus		0.004	0.0028	0.0067
Brugia malayi	nuclear receptor NHR-88	0.004	0.0031	0.0056
Schistosoma mansoni	serine/threonine protein kinase	0.0258	0.144	0.3422
Loa Loa (eye worm)	TK protein kinase	0.0258	0.144	0.2606
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.004	0.0028	0.0067
Echinococcus granulosus	expressed conserved protein	0.0428	0.2538	0.2538
Echinococcus granulosus	retinal guanylyl cyclase 2	0.0258	0.144	0.144
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.004	0.0028	0.0067
Brugia malayi	ephrin receptor 1 precursor	0.0258	0.144	0.2606
Schistosoma mansoni	tyrosine kinase	0.0258	0.144	0.3422
Brugia malayi	SH2 domain containing protein	0.0428	0.2538	0.4592
Trichomonas vaginalis	TKL family protein kinase	0.0258	0.144	1
Echinococcus multilocularis	neuropeptide receptor	0.004	0.0028	0.0067
Echinococcus granulosus	retinal guanylyl cyclase 2	0.0258	0.144	0.144
Entamoeba histolytica	hypothetical protein	0.0268	0.1507	0.024
Loa Loa (eye worm)	TK protein kinase	0.0258	0.144	0.2606
Echinococcus multilocularis	tyrosine protein kinase ABL1	0.0686	0.4209	1
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.004	0.0031	0.0073
Echinococcus granulosus	alpha 1A adrenergic receptor	0.004	0.0028	0.0028
Echinococcus granulosus	G protein coupled receptor 139	0.004	0.0028	0.0028
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.004	0.0028	0.0067
Loa Loa (eye worm)	TK/FER protein kinase	0.0258	0.144	0.2606
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.004	0.0031	0.0073
Loa Loa (eye worm)	TK/FER protein kinase	0.0258	0.144	0.2606
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.004	0.0028	0.0067
Entamoeba histolytica	protein kinase, putative	0.0428	0.2538	0.3964
Brugia malayi	Protein kinase domain containing protein	0.0258	0.144	0.2606
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.004	0.0028	0.0028
Loa Loa (eye worm)	hypothetical protein	0.004	0.0028	0.0051
Schistosoma mansoni	biogenic amine (5HT) receptor	0.004	0.0028	0.0067
Loa Loa (eye worm)	TK/FER protein kinase	0.0686	0.4209	0.7617
Schistosoma mansoni	neuropeptide receptor	0.004	0.0028	0.0067
Brugia malayi	Protein kinase domain containing protein	0.0686	0.4209	0.7617
Brugia malayi	Protein kinase domain containing protein	0.0258	0.144	0.2606
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.004	0.0028	0.0051
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.004	0.0028	0.0067
Schistosoma mansoni	suppressor of cytokine signaling	0.0428	0.2538	0.6029
Plasmodium falciparum	protein kinase, putative	0.0258	0.144	0.5
Loa Loa (eye worm)	STAT protein	0.0428	0.2538	0.4592
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.004	0.0028	0.0067
Schistosoma mansoni	protein kinase	0.0258	0.144	0.3422
Trichomonas vaginalis	TKL family protein kinase	0.0258	0.144	1
Loa Loa (eye worm)	TK/RYK protein kinase	0.0258	0.144	0.2606
Loa Loa (eye worm)	SH2 domain-containing protein	0.0428	0.2538	0.4592
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.004	0.0028	0.0067
Loa Loa (eye worm)	TK/ALK protein kinase	0.0258	0.144	0.2606
Echinococcus multilocularis	receptor type guanylyl cyclase	0.0258	0.144	0.3422
Loa Loa (eye worm)	hypothetical protein	0.004	0.0028	0.0051
Trichomonas vaginalis	TKL family protein kinase	0.0258	0.144	1
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.004	0.0028	0.0067
Echinococcus granulosus	tyrosine kinase	0.0686	0.4209	0.4209
Loa Loa (eye worm)	TK/FER protein kinase	0.0258	0.144	0.2606
Schistosoma mansoni	protein kinase	0.0258	0.144	0.3422
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.004	0.0031	0.0056
Trichomonas vaginalis	TKL family protein kinase	0.0258	0.144	1
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0686	0.4209	0.4209
Echinococcus multilocularis	tyrosine protein kinase transmembrane receptor	0.0258	0.144	0.3422
Echinococcus multilocularis	SH2 motif	0.0428	0.2538	0.6029
Echinococcus granulosus	hypothetical protein	0.004	0.0028	0.0028
Loa Loa (eye worm)	TKL/RAF/KSR protein kinase	0.0258	0.144	0.2606
Echinococcus multilocularis	suppressor of cytokine signaling 7	0.0428	0.2538	0.6029
Onchocerca volvulus		0.0686	0.4209	1
Loa Loa (eye worm)	TKL/RAF/RAF protein kinase	0.0258	0.144	0.2606
Echinococcus granulosus	tyrosine protein kinase shark	0.0686	0.4209	0.4209
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0686	0.4209	0.4209
Echinococcus granulosus	sex peptide receptor	0.004	0.0028	0.0028
Echinococcus granulosus	SH2 motif	0.0428	0.2538	0.2538
Echinococcus granulosus	3'partial\|retinal guanylyl cyclase 2	0.0258	0.144	0.144
Schistosoma mansoni	tyrosine kinase	0.0258	0.144	0.3422
Echinococcus granulosus	rhodopsin orphan GPCR	0.004	0.0028	0.0028
Schistosoma mansoni	tyrosine kinase	0.0258	0.144	0.3422
Trichomonas vaginalis	TKL family protein kinase	0.0258	0.144	1
Echinococcus granulosus	neuropeptides capa receptor	0.004	0.0028	0.0028
Loa Loa (eye worm)	hypothetical protein	0.004	0.0028	0.0051
Loa Loa (eye worm)	hypothetical protein	0.0428	0.2538	0.4592
Brugia malayi	proto-oncogene tyrosine-protein kinase FER	0.0258	0.144	0.2606
Trichomonas vaginalis	conserved hypothetical protein	0.0258	0.144	1
Brugia malayi	STAT protein, DNA binding domain containing protein	0.0428	0.2538	0.4592
Loa Loa (eye worm)	TK/EGFR protein kinase	0.0258	0.144	0.2606
Onchocerca volvulus		0.004	0.0028	0.0067
Trichomonas vaginalis	TKL family protein kinase	0.0258	0.144	1
Schistosoma mansoni	nuclear hormone receptor	0.004	0.0031	0.0073
Echinococcus multilocularis	neuropeptide Y receptor	0.004	0.0028	0.0067
Echinococcus multilocularis	rhodopsin orphan GPCR	0.004	0.0028	0.0067
Brugia malayi	Protein kinase domain containing protein	0.0258	0.144	0.2606
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.004	0.0031	0.0031
Schistosoma mansoni	neuropeptide f receptor 76f	0.004	0.0028	0.0067
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.004	0.0028	0.0067
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.004	0.0028	0.0028
Onchocerca volvulus		0.004	0.0028	0.0067
Loa Loa (eye worm)	hypothetical protein	0.0428	0.2538	0.4592
Echinococcus multilocularis	tyrosine protein kinase lyn tyrosine protein kinase blk	0.0686	0.4209	1
Loa Loa (eye worm)	hypothetical protein	0.004	0.0031	0.0056
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.004	0.0028	0.0067
Toxoplasma gondii	Tyrosine kinase-like (TKL) protein	0.0258	0.144	1
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.004	0.0028	0.0067
Echinococcus multilocularis	allatostatin A receptor	0.004	0.0028	0.0067
Loa Loa (eye worm)	hypothetical protein	0.004	0.0028	0.0051
Brugia malayi	Sex muscle abnormal protein 5	0.0428	0.2538	0.4592
Toxoplasma gondii	calcium dependent protein kinase CDPK8	0.0258	0.144	1
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.004	0.0031	0.0073
Echinococcus multilocularis	FL cytokine receptor	0.0258	0.144	0.3422
Loa Loa (eye worm)	hypothetical protein	0.0258	0.144	0.2606
Schistosoma mansoni	neuropeptide F-like receptor	0.004	0.0028	0.0067
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.004	0.0028	0.0067
Brugia malayi	Protein kinase domain containing protein	0.0258	0.144	0.2606
Echinococcus multilocularis	proto oncogene tyrosine protein kinase LCK	0.0686	0.4209	1
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.004	0.0031	0.0056
Echinococcus granulosus	protein kinase	0.0258	0.144	0.144
Loa Loa (eye worm)	TK/ABL protein kinase	0.0686	0.4209	0.7617
Echinococcus granulosus	signal transduction protein lnk realted	0.0428	0.2538	0.2538
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.004	0.0031	0.0031
Trichomonas vaginalis	conserved hypothetical protein	0.0258	0.144	1
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase src	0.0686	0.4209	1
Onchocerca volvulus		0.004	0.0028	0.0067
Echinococcus multilocularis	tyrosine protein kinase csk	0.0258	0.144	0.3422
Loa Loa (eye worm)	TK/EPH protein kinase	0.0258	0.144	0.2606
Schistosoma mansoni	amine GPCR	0.004	0.0028	0.0067
Trichomonas vaginalis	TK family protein kinase	0.0258	0.144	1
Schistosoma mansoni	tyrosine kinase	0.0258	0.144	0.3422
Brugia malayi	Protein kinase domain containing protein	0.0258	0.144	0.2606
Loa Loa (eye worm)	hypothetical protein	0.004	0.0028	0.0051
Trichomonas vaginalis	TKL family protein kinase	0.0258	0.144	1
Schistosoma mansoni	tensin	0.0428	0.2538	0.6029
Echinococcus granulosus	c src tyrosine kinase	0.0686	0.4209	0.4209
Loa Loa (eye worm)	hypothetical protein	0.0455	0.2711	0.4907
Echinococcus multilocularis	mitogen activated protein kinase kinase kinase	0.0258	0.144	0.3422
Plasmodium vivax	tyrosine kinase-like protein, putative	0.0258	0.144	1
Schistosoma mansoni	tyrosine kinase	0.0258	0.144	0.3422
Schistosoma mansoni	serine/threonine protein kinase	0.0258	0.144	0.3422
Loa Loa (eye worm)	hypothetical protein	0.0428	0.2538	0.4592
Echinococcus granulosus	tm gpcr rhodopsin	0.004	0.0028	0.0028
Onchocerca volvulus		0.0428	0.2538	0.6029
Echinococcus granulosus	tyrosine protein kinase Fps85D	0.0686	0.4209	0.4209
Trichomonas vaginalis	protein tyrosine kinase, putative	0.0258	0.144	1
Brugia malayi	Adenylate and Guanylate cyclase catalytic domain containing protein	0.0258	0.144	0.2606
Trichomonas vaginalis	TKL family protein kinase	0.0258	0.144	1
Echinococcus granulosus	neuropeptide s receptor	0.004	0.0028	0.0028
Loa Loa (eye worm)	hypothetical protein	0.004	0.0028	0.0051
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase src	0.0258	0.144	0.3422
Loa Loa (eye worm)	hypothetical protein	0.004	0.0028	0.0051
Schistosoma mansoni	growth hormone secretagogue receptor	0.004	0.0028	0.0067
Echinococcus granulosus	tyrosine protein kinase csk	0.0258	0.144	0.144
Schistosoma mansoni	coup transcription factor	0.004	0.0031	0.0073
Loa Loa (eye worm)	hypothetical protein	0.004	0.0028	0.0051
Loa Loa (eye worm)	hypothetical protein	0.004	0.0028	0.0051
Onchocerca volvulus		0.004	0.0028	0.0067
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.004	0.0031	0.0031
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.004	0.0028	0.0067
Echinococcus granulosus	biogenic amine 5HT receptor	0.004	0.0028	0.0028
Onchocerca volvulus	Tyrosine kinase homolog	0.0258	0.144	0.3422
Echinococcus multilocularis	fmrfamide receptor	0.004	0.0028	0.0067
Trichomonas vaginalis	TKL family protein kinase	0.0258	0.144	1
Loa Loa (eye worm)	TYRA-2 protein	0.004	0.0028	0.0051
Loa Loa (eye worm)	serine/threonine protein kinase	0.0258	0.144	0.2606
Trypanosoma brucei	AGC/RSK family serine/threonine kinase, putative	0.0258	0.144	0.2606
Schistosoma mansoni	hypothetical protein	0.004	0.0028	0.0067
Brugia malayi	larval opioid receptor	0.004	0.0028	0.0051
Loa Loa (eye worm)	hypothetical protein	0.004	0.0028	0.0051
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.004	0.0028	0.0028
Schistosoma mansoni	tensin	0.0428	0.2538	0.6029
Brugia malayi	nuclear hormone receptor	0.004	0.0031	0.0056
Echinococcus granulosus	g-protein coupled receptor	0.004	0.0028	0.0028
Echinococcus multilocularis	tyrosine protein kinase Src64B	0.0686	0.4209	1
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.004	0.0028	0.0067
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.0258	0.144	0.2606
Loa Loa (eye worm)	TK/KIN16 protein kinase	0.0258	0.144	0.2606
Schistosoma mansoni	tyrosine kinase	0.0686	0.4209	1
Brugia malayi	photoreceptor-specific nuclear receptor	0.004	0.0031	0.0056
Schistosoma mansoni	adenoreceptor	0.004	0.0028	0.0067
Echinococcus multilocularis	activated cdc42 kinase 1	0.0258	0.144	0.3422
Schistosoma mansoni	tyrosine kinase	0.0258	0.144	0.3422
Brugia malayi	Tyrosine-protein kinase F09A5.2 in chromosome X, putative	0.0258	0.144	0.2606
Echinococcus granulosus	tyrosine kinase	0.0686	0.4209	0.4209
Loa Loa (eye worm)	hypothetical protein	0.004	0.0028	0.0051
Loa Loa (eye worm)	hypothetical protein	0.004	0.0028	0.0051
Brugia malayi	sulfakinin receptor protein	0.004	0.0028	0.0051
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.004	0.0028	0.0067
Schistosoma mansoni	tensin	0.0428	0.2538	0.6029
Onchocerca volvulus		0.004	0.0028	0.0067
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.004	0.0031	0.0073
Trichomonas vaginalis	TKL family protein kinase	0.0258	0.144	1
Echinococcus granulosus	hypothetical protein	0.0428	0.2538	0.2538
Onchocerca volvulus	Dopamine\/Ecdysteroid receptor homolog	0.004	0.0028	0.0067
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.004	0.0031	0.0056
Echinococcus multilocularis	tyrosine protein kinase Btk29A	0.0686	0.4209	1
Loa Loa (eye worm)	TK/ROR protein kinase	0.0258	0.144	0.2606
Brugia malayi	Protein kinase domain containing protein	0.0258	0.144	0.2606
Plasmodium vivax	protein kinase, putative	0.0258	0.144	1
Loa Loa (eye worm)	neuropeptide F receptor	0.004	0.0028	0.0051
Brugia malayi	Variant SH3 domain containing protein	0.0428	0.2538	0.4592
Onchocerca volvulus		0.004	0.0028	0.0067
Echinococcus multilocularis	somatostatin receptor	0.004	0.0028	0.0067
Echinococcus granulosus	raf serine:threonine protein kinase	0.0258	0.144	0.144
Schistosoma mansoni	retinoic acid receptor RXR	0.004	0.0031	0.0073
Echinococcus multilocularis	tyrosine protein kinase csk	0.0258	0.144	0.3422
Trichomonas vaginalis	TKL family protein kinase	0.0258	0.144	1
Echinococcus multilocularis	g protein coupled receptor	0.004	0.0028	0.0067
Echinococcus multilocularis	N chimaerin	0.0428	0.2538	0.6029
Schistosoma mansoni	amine GPCR	0.004	0.0028	0.0067
Echinococcus multilocularis	raf serine:threonine protein kinase	0.0258	0.144	0.3422
Loa Loa (eye worm)	hypothetical protein	0.004	0.0028	0.0051
Trichomonas vaginalis	TKL family protein kinase	0.0258	0.144	1
Schistosoma mansoni	protein kinase	0.0258	0.144	0.3422
Onchocerca volvulus		0.004	0.0028	0.0067
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0428	0.2538	0.6029
Loa Loa (eye worm)	hypothetical protein	0.0428	0.2538	0.4592
Echinococcus granulosus	neuropeptide FF receptor 2	0.004	0.0028	0.0028
Brugia malayi	hypothetical protein	0.004	0.0028	0.0051
Echinococcus multilocularis	neuropeptide s receptor	0.004	0.0028	0.0067
Onchocerca volvulus		0.004	0.0031	0.0073
Echinococcus granulosus	protein tyrosine kinase	0.0258	0.144	0.144
Loa Loa (eye worm)	hypothetical protein	0.004	0.0028	0.0051
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.004	0.0028	0.0067
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.004	0.0028	0.0028
Loa Loa (eye worm)	hypothetical protein	0.0258	0.144	0.2606
Schistosoma mansoni	tyrosine kinase	0.0258	0.144	0.3422
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0428	0.2538	0.2538
Echinococcus granulosus	activated cdc42 kinase 1	0.0258	0.144	0.144
Brugia malayi	Protein kinase domain containing protein	0.0686	0.4209	0.7617
Brugia malayi	Probable tyrosine-protein kinase kin-31	0.0258	0.144	0.2606
Schistosoma mansoni	thyroid hormone receptor	0.004	0.0031	0.0073
Onchocerca volvulus		0.004	0.0028	0.0067
Trichomonas vaginalis	TKL family protein kinase	0.0258	0.144	1
Onchocerca volvulus	Neuropeptide F receptor homolog	0.004	0.0028	0.0067
Echinococcus granulosus	tyrosine protein kinase	0.0258	0.144	0.144
Trichomonas vaginalis	TKL family protein kinase	0.0258	0.144	1
Loa Loa (eye worm)	hypothetical protein	0.0258	0.144	0.2606
Echinococcus granulosus	basic fibroblast growth factor receptor 1 A	0.0258	0.144	0.144
Loa Loa (eye worm)	hypothetical protein	0.004	0.0028	0.0051
Loa Loa (eye worm)	hypothetical protein	0.0258	0.144	0.2606
Schistosoma mansoni	serine/threonine protein kinase	0.0258	0.144	0.3422
Brugia malayi	Tensin	0.0428	0.2538	0.4592
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0258	0.144	0.2606
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.004	0.0028	0.0067
Echinococcus multilocularis	tensin	0.0428	0.2538	0.6029
Brugia malayi	ORL1-like opioid receptor	0.004	0.0028	0.0051
Plasmodium falciparum	protein kinase, putative	0.0258	0.144	0.5
Schistosoma mansoni	tyrosine-protein kinase zap-70	0.0428	0.2538	0.6029
Loa Loa (eye worm)	TK/FER protein kinase	0.0686	0.4209	0.7617
Loa Loa (eye worm)	SH2 domain-containing protein	0.0428	0.2538	0.4592
Brugia malayi	Variant SH3 domain containing protein	0.0428	0.2538	0.4592
Schistosoma mansoni	ephrin receptor	0.0258	0.144	0.3422
Brugia malayi	SH2 domain containing protein	0.0686	0.4209	0.7617
Brugia malayi	Protein kinase domain containing protein	0.0258	0.144	0.2606
Trichomonas vaginalis	TKL family protein kinase	0.0258	0.144	1
Loa Loa (eye worm)	hypothetical protein	0.004	0.0031	0.0056
Schistosoma mansoni	protein kinase	0.0258	0.144	0.3422
Brugia malayi	Variant SH3 domain containing protein	0.0428	0.2538	0.4592
Echinococcus multilocularis	orexin receptor type 2	0.004	0.0028	0.0067
Echinococcus multilocularis	macrophage colony stimulating factor 1 receptor	0.0258	0.144	0.3422
Loa Loa (eye worm)	TK protein kinase	0.0258	0.144	0.2606
Loa Loa (eye worm)	TK/KIN6 protein kinase	0.0258	0.144	0.2606
Giardia lamblia	Protein 21.1	0.0258	0.144	0.5
Echinococcus granulosus	ecdysone induced protein 78C	0.004	0.0031	0.0031
Onchocerca volvulus		0.004	0.0028	0.0067
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.004	0.0028	0.0067
Echinococcus granulosus	natriuretic peptide receptor 1	0.0258	0.144	0.144
Brugia malayi	Serotonin receptor	0.004	0.0028	0.0051
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.0428	0.2538	0.4592
Brugia malayi	Protein kinase domain containing protein	0.0258	0.144	0.2606
Loa Loa (eye worm)	hypothetical protein	0.004	0.0028	0.0051
Schistosoma mansoni	tyrosine kinase	0.0258	0.144	0.3422
Brugia malayi	cytokine inducible SH2-containing protein 5	0.0428	0.2538	0.4592
Loa Loa (eye worm)	hypothetical protein	0.0889	0.5526	1
Echinococcus multilocularis	signal transduction protein lnk realted	0.0428	0.2538	0.6029
Echinococcus granulosus	neuropeptide receptor	0.004	0.0028	0.0028
Schistosoma mansoni	neuropeptide F-like receptor	0.004	0.0028	0.0067
Brugia malayi	hypothetical protein	0.004	0.0028	0.0051
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.004	0.0028	0.0051
Loa Loa (eye worm)	hypothetical protein	0.004	0.0028	0.0051
Loa Loa (eye worm)	neuropeptide F receptor	0.004	0.0028	0.0051
Onchocerca volvulus		0.004	0.0028	0.0067
Brugia malayi	Guanylyl cyclase protein 23	0.0258	0.144	0.2606
Brugia malayi	hypothetical protein	0.0258	0.144	0.2606
Loa Loa (eye worm)	hypothetical protein	0.0258	0.144	0.2606
Echinococcus multilocularis	serotonin receptor	0.004	0.0028	0.0067
Echinococcus granulosus	tyrosine protein kinase Blk	0.0686	0.4209	0.4209
Giardia lamblia	Kinase, NEK	0.0258	0.144	0.5
Giardia lamblia	Kinase, NEK	0.0258	0.144	0.5
Loa Loa (eye worm)	hypothetical protein	0.0686	0.4209	0.7617
Trichomonas vaginalis	TKL family protein kinase	0.0258	0.144	1
Onchocerca volvulus		0.0686	0.4209	1
Onchocerca volvulus		0.004	0.0028	0.0067
Brugia malayi	SH2 domain containing protein	0.0428	0.2538	0.4592
Echinococcus multilocularis	tyrosine kinase	0.0686	0.4209	1
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0686	0.4209	1
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.004	0.0028	0.0067
Onchocerca volvulus		0.0428	0.2538	0.6029
Echinococcus granulosus	neuropeptide receptor	0.004	0.0028	0.0028
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.004	0.0031	0.0056
Schistosoma mansoni	hypothetical protein	0.0305	0.1744	0.4144
Echinococcus multilocularis	tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase	0.0686	0.4209	1
Echinococcus granulosus	fmrfamide receptor	0.004	0.0028	0.0028
Brugia malayi	Protein kinase domain containing protein	0.0258	0.144	0.2606
Echinococcus multilocularis	snurportin 1	0.0305	0.1744	0.4144
Brugia malayi	Protein kinase domain containing protein	0.0258	0.144	0.2606
Brugia malayi	putative neuropeptide receptor NPR1	0.004	0.0028	0.0051
Brugia malayi	protein-tyrosine kinase	0.0686	0.4209	0.7617
Echinococcus granulosus	dual specificity testis-specific protein kinase	0.0258	0.144	0.144
Echinococcus multilocularis	thyroid hormone receptor alpha	0.004	0.0031	0.0073
Brugia malayi	SH2 domain containing protein	0.0428	0.2538	0.4592
Onchocerca volvulus		0.0686	0.4209	1
Loa Loa (eye worm)	TK/DDR protein kinase	0.0258	0.144	0.2606
Entamoeba histolytica	hypothetical protein	0.0268	0.1507	0.024
Echinococcus multilocularis	dual specificity testis specific protein kinase	0.0258	0.144	0.3422
Toxoplasma gondii	protein kinase domain-containing protein	0.0258	0.144	1
Brugia malayi	Protein kinase domain containing protein	0.0686	0.4209	0.7617
Echinococcus multilocularis	rhodopsin orphan GPCR	0.004	0.0028	0.0067
Onchocerca volvulus	Tyrosine kinase receptor Cad96Ca homolog	0.0258	0.144	0.3422
Loa Loa (eye worm)	TK protein kinase	0.0258	0.144	0.2606
Loa Loa (eye worm)	TK protein kinase	0.0258	0.144	0.2606
Schistosoma mansoni	hypothetical protein	0.004	0.0028	0.0067
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.0258	0.144	0.3422
Trichomonas vaginalis	TKL family protein kinase	0.0258	0.144	1
Schistosoma mansoni	protein kinase	0.0258	0.144	0.3422
Brugia malayi	Protein kinase domain containing protein	0.0258	0.144	0.2606
Loa Loa (eye worm)	protein kinase domain-containing protein	0.0258	0.144	0.2606
Schistosoma mansoni	neuropeptide receptor	0.004	0.0028	0.0067
Schistosoma mansoni	tyrosine kinase	0.0686	0.4209	1
Loa Loa (eye worm)	hypothetical protein	0.004	0.0028	0.0051
Trichomonas vaginalis	TKL family protein kinase	0.0258	0.144	1
Loa Loa (eye worm)	hypothetical protein	0.004	0.0028	0.0051
Echinococcus granulosus	mitogen-activated protein kinase kinase kinase 9	0.0258	0.144	0.144
Brugia malayi	hypothetical protein	0.004	0.0028	0.0051
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.004	0.0028	0.0051
Brugia malayi	Protein kinase domain containing protein	0.0258	0.144	0.2606
Loa Loa (eye worm)	TK protein kinase	0.0258	0.144	0.2606
Echinococcus granulosus	epidermal growth factor receptor	0.0258	0.144	0.144
Trichomonas vaginalis	TKL family protein kinase	0.0258	0.144	1
Echinococcus multilocularis	neuropeptides capa receptor	0.004	0.0028	0.0067
Schistosoma mansoni	tyrosine kinase	0.0258	0.144	0.3422
Brugia malayi	Protein kinase domain containing protein	0.0258	0.144	0.2606
Echinococcus granulosus	SH2 domain containing adapter protein F	0.0428	0.2538	0.2538
Giardia lamblia	Kinase	0.0258	0.144	0.5
Echinococcus granulosus	somatostatin receptor	0.004	0.0028	0.0028
Schistosoma mansoni	growth factor receptor-bound protein	0.0428	0.2538	0.6029
Trichomonas vaginalis	TKL family protein kinase	0.0258	0.144	1
Loa Loa (eye worm)	hypothetical protein	0.004	0.0031	0.0056
Brugia malayi	hypothetical protein	0.0686	0.4209	0.7617
Echinococcus granulosus	dro:myosuppressin receptor	0.004	0.0028	0.0028
Brugia malayi	Protein kinase domain containing protein	0.0258	0.144	0.2606
Loa Loa (eye worm)	sex muscle abnormal protein 5	0.0428	0.2538	0.4592
Echinococcus multilocularis	suppressor of cytokine signaling 6	0.0428	0.2538	0.6029
Brugia malayi	Adenylate and Guanylate cyclase catalytic domain containing protein	0.0258	0.144	0.2606
Brugia malayi	hypothetical protein	0.004	0.0028	0.0051
Onchocerca volvulus	Suppressor of cytokine signaling at 36E homolog	0.0428	0.2538	0.6029
Echinococcus multilocularis	transfer RNA-Thr	0.0258	0.144	0.3422
Trichomonas vaginalis	conserved hypothetical protein	0.0258	0.144	1
Onchocerca volvulus	Bile acid receptor homolog	0.004	0.0031	0.0073
Schistosoma mansoni	tyrosine kinase	0.0258	0.144	0.3422
Onchocerca volvulus		0.004	0.0028	0.0067
Schistosoma mansoni	protein tyrosine phosphatase n11 (shp2)	0.0428	0.2538	0.6029
Onchocerca volvulus	Atrial natriuretic peptide receptor 3 homolog	0.0258	0.144	0.3422
Brugia malayi	Tachykinin-like peptides receptor 99D	0.004	0.0028	0.0051
Trichomonas vaginalis	TKL family protein kinase	0.0258	0.144	1
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0428	0.2538	0.4592
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0686	0.4209	1
Loa Loa (eye worm)	hypothetical protein	0.004	0.0031	0.0056
Echinococcus multilocularis	guanine nucleotide exchange factor VAV2	0.0428	0.2538	0.6029
Schistosoma mansoni	hypothetical protein	0.0428	0.2538	0.6029
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.004	0.0031	0.0073
Echinococcus multilocularis	fibroblast growth factor receptor 4	0.0258	0.144	0.3422
Echinococcus multilocularis	tyrosine protein kinase csk	0.0258	0.144	0.3422
Trichomonas vaginalis	TKL family protein kinase	0.0258	0.144	1
Entamoeba histolytica	SH2 domain containing protein	0.0428	0.2538	0.3964
Echinococcus granulosus	g protein coupled receptor	0.004	0.0028	0.0028
Loa Loa (eye worm)	nucleolar RNA-associated protein alpha	0.0305	0.1744	0.3157
Trichomonas vaginalis	TKL family protein kinase	0.0258	0.144	1
Schistosoma mansoni	tyrosine kinase	0.0258	0.144	0.3422
Echinococcus multilocularis	neuropeptide Y receptor	0.004	0.0028	0.0067
Schistosoma mansoni	tyrosine kinase	0.0686	0.4209	1
Brugia malayi	SH2 domain containing protein	0.0428	0.2538	0.4592
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.004	0.0031	0.0056
Trichomonas vaginalis	TKL family protein kinase	0.0258	0.144	1
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.004	0.0028	0.0028
Loa Loa (eye worm)	TKL/MLK/HH498 protein kinase	0.0258	0.144	0.2606
Toxoplasma gondii	STE kinase	0.0258	0.144	1
Trichomonas vaginalis	TKL family protein kinase	0.0258	0.144	1
Trichomonas vaginalis	TKL family protein kinase	0.0258	0.144	1
Trichomonas vaginalis	TKL family protein kinase	0.0258	0.144	1
Leishmania major	protein kinase, putative	0.0258	0.144	0.2606
Loa Loa (eye worm)	hypothetical protein	0.004	0.0028	0.0051
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.004	0.0031	0.0073
Schistosoma mansoni	tyrosine kinase	0.0258	0.144	0.3422
Loa Loa (eye worm)	hypothetical protein	0.0428	0.2538	0.4592
Echinococcus multilocularis	tyrosine protein kinase Fes:Fps	0.0258	0.144	0.3422
Echinococcus multilocularis		0.0428	0.2538	0.6029
Echinococcus multilocularis	SH2 domain containing protein 7	0.0428	0.2538	0.6029
Trichomonas vaginalis	TKL family protein kinase	0.0258	0.144	1
Echinococcus granulosus	SH2 motif	0.0428	0.2538	0.2538
Echinococcus multilocularis	tensin	0.0428	0.2538	0.6029
Entamoeba histolytica	hypothetical protein	0.0268	0.1507	0.024
Brugia malayi	hypothetical protein	0.0428	0.2538	0.4592
Brugia malayi	neuropeptide F receptor	0.004	0.0028	0.0051
Schistosoma mansoni	tyrosine kinase	0.0686	0.4209	1
Entamoeba histolytica	leucine-rich repeat domain-containing protein	0.0268	0.1507	0.024
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.004	0.0031	0.0073
Brugia malayi	Dopamine receptor	0.004	0.0028	0.0051
Schistosoma mansoni	tensin-related	0.0428	0.2538	0.6029
Echinococcus multilocularis	tyrosine kinase	0.0258	0.144	0.3422
Schistosoma mansoni	amine GPCR	0.004	0.0028	0.0067
Loa Loa (eye worm)	hypothetical protein	0.004	0.0031	0.0056
Echinococcus granulosus	mitogen activated protein kinase kinase kinase	0.0258	0.144	0.144
Trichomonas vaginalis	AGC family protein kinase	0.0258	0.144	1
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.004	0.0031	0.0056
Onchocerca volvulus	Protein ultraspiracle homolog	0.004	0.0031	0.0073
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.004	0.0028	0.0051
Trichomonas vaginalis	TKL family protein kinase	0.0258	0.144	1
Schistosoma mansoni	neuropeptide receptor	0.004	0.0028	0.0067
Echinococcus granulosus	proto oncogene tyrosine protein kinase LCK	0.0686	0.4209	0.4209
Brugia malayi	Steroid receptor seven-up type 2	0.004	0.0031	0.0056
Loa Loa (eye worm)	hypothetical protein	0.0258	0.144	0.2606
Loa Loa (eye worm)	TK/FER protein kinase	0.0686	0.4209	0.7617
Echinococcus multilocularis	basic fibroblast growth factor receptor 1 A	0.0258	0.144	0.3422
Schistosoma mansoni	tyrosine protein kinase	0.0258	0.144	0.3422
Loa Loa (eye worm)	TK/INSR protein kinase	0.0258	0.144	0.2606
Loa Loa (eye worm)	hypothetical protein	0.0258	0.144	0.2606
Loa Loa (eye worm)	hypothetical protein	0.004	0.0028	0.0051
Echinococcus granulosus	neuropeptide Y receptor	0.004	0.0028	0.0028
Brugia malayi	RE15519p	0.004	0.0028	0.0051
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.004	0.0031	0.0056
Entamoeba histolytica	protein kinase, putative	0.0268	0.1507	0.024
Loa Loa (eye worm)	hypothetical protein	0.004	0.0028	0.0051
Loa Loa (eye worm)	vesicular acetylcholine transporter unc-17	0.0267	0.1497	0.2709
Loa Loa (eye worm)	hypothetical protein	0.004	0.0028	0.0051
Echinococcus multilocularis	serotonin receptor	0.004	0.0028	0.0067
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0258	0.144	0.2606
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.004	0.0028	0.0067
Onchocerca volvulus		0.0258	0.144	0.3422
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.0258	0.144	0.2606
Echinococcus multilocularis	FTZ F1 alpha	0.004	0.0031	0.0073
Loa Loa (eye worm)	TK/FER protein kinase	0.0686	0.4209	0.7617
Plasmodium falciparum	tyrosine kinase-like protein	0.0258	0.144	0.5
Loa Loa (eye worm)	hypothetical protein	0.004	0.0028	0.0051
Echinococcus granulosus	melanoma receptor tyrosine protein kinase	0.0258	0.144	0.144
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.004	0.0031	0.0073
Echinococcus granulosus	snurportin 1	0.0305	0.1744	0.1744
Loa Loa (eye worm)	TK/FER protein kinase	0.0686	0.4209	0.7617
Echinococcus granulosus	activated cdc42 kinase 1	0.0258	0.144	0.144
Loa Loa (eye worm)	hypothetical protein	0.004	0.0028	0.0051
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.004	0.0031	0.0073
Brugia malayi	RNA, U transporter 1	0.0081	0.0295	0.0534
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0258	0.144	1
Echinococcus multilocularis	phosphatidylinositol 3 kinase regulatory subunit	0.0428	0.2538	0.6029
Echinococcus granulosus	atrial natriuretic peptide receptor 1	0.0258	0.144	0.144
Brugia malayi	Protein kinase domain containing protein	0.0258	0.144	0.2606
Echinococcus granulosus	tachykinin peptides receptor 99D	0.004	0.0028	0.0028
Trichomonas vaginalis	TKL family protein kinase	0.0258	0.144	1
Brugia malayi	hypothetical protein	0.004	0.0028	0.0051
Trichomonas vaginalis	TKL family protein kinase	0.0258	0.144	1
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.004	0.0031	0.0031
Schistosoma mansoni	vesicular acetylcholine transporter	0.0267	0.1497	0.3557
Loa Loa (eye worm)	hypothetical protein	0.004	0.0028	0.0051
Echinococcus multilocularis	tyrosine protein kinase	0.0258	0.144	0.3422
Loa Loa (eye worm)	hypothetical protein	0.004	0.0031	0.0056
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.004	0.0028	0.0067
Brugia malayi	hypothetical protein	0.004	0.0028	0.0051
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.004	0.0028	0.0051
Schistosoma mansoni	tyrosine kinase	0.0258	0.144	0.3422
Brugia malayi	SRC-1	0.0686	0.4209	0.7617
Brugia malayi	Protein kinase domain containing protein	0.0258	0.144	0.2606
Loa Loa (eye worm)	hypothetical protein	0.004	0.0028	0.0051
Trichomonas vaginalis	TKL family protein kinase	0.0258	0.144	1
Loa Loa (eye worm)	hypothetical protein	0.004	0.0028	0.0051
Echinococcus granulosus	suppressor of cytokine signaling 7	0.0428	0.2538	0.2538
Trichomonas vaginalis	TKL family protein kinase	0.0258	0.144	1
Loa Loa (eye worm)	TK/CSK protein kinase	0.0258	0.144	0.2606
Schistosoma mansoni	tyrosine kinase	0.0686	0.4209	1
Trichomonas vaginalis	TKL family protein kinase	0.0258	0.144	1
Loa Loa (eye worm)	hypothetical protein	0.0428	0.2538	0.4592
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.004	0.0028	0.0067
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.004	0.0031	0.0056
Schistosoma mansoni	hypothetical protein	0.0428	0.2538	0.6029
Loa Loa (eye worm)	steroid hormone receptor	0.004	0.0031	0.0056
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.004	0.0031	0.0056
Schistosoma mansoni	protein kinase	0.0258	0.144	0.3422
Trichomonas vaginalis	TKL family protein kinase	0.0258	0.144	1
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.0258	0.144	0.144
Schistosoma mansoni	myosin xvIII	0.004	0.0028	0.0067
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0428	0.2538	0.6029
Schistosoma mansoni	chimerin-related rho-gtpase-activating protein	0.0428	0.2538	0.6029
Echinococcus granulosus	phosphatidylinositol 3 kinase regulatory subunit	0.0428	0.2538	0.2538
Echinococcus multilocularis	mitogen activated protein kinase kinase kinase	0.0258	0.144	0.3422
Echinococcus multilocularis	rhodopsin orphan GPCR	0.004	0.0028	0.0067
Schistosoma mansoni	steroid hormone receptor ad4bp	0.004	0.0031	0.0073
Brugia malayi	GnHR receptor homolog	0.004	0.0028	0.0051
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0428	0.2538	0.2538
Schistosoma mansoni	thyroid hormone receptor	0.004	0.0031	0.0073
Brugia malayi	neuropeptide F receptor	0.004	0.0028	0.0051
Echinococcus granulosus	rhodopsin orphan GPCR	0.004	0.0028	0.0028
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.004	0.0031	0.0056
Toxoplasma gondii	protein kinase	0.0258	0.144	1
Onchocerca volvulus		0.0428	0.2538	0.6029
Trichomonas vaginalis	TKL family protein kinase	0.0258	0.144	1
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.004	0.0031	0.0056
Schistosoma mansoni	tyrosine kinase	0.0258	0.144	0.3422
Echinococcus granulosus	tm gpcr rhodopsin	0.004	0.0028	0.0028
Entamoeba histolytica	SH2-protein kinase domain containing protein	0.0686	0.4209	1
Loa Loa (eye worm)	hypothetical protein	0.004	0.0028	0.0051
Echinococcus granulosus	tyrosine protein kinase Srms	0.0686	0.4209	0.4209
Trichomonas vaginalis	serine/threonine-protein kinase wnk, putative	0.0258	0.144	1
Loa Loa (eye worm)	hypothetical protein	0.004	0.0028	0.0051
Trichomonas vaginalis	TKL family protein kinase	0.0258	0.144	1
Echinococcus granulosus	tyrosine protein kinase csk	0.0258	0.144	0.144
Brugia malayi	hypothetical protein	0.004	0.0028	0.0051
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.004	0.0028	0.0067
Echinococcus multilocularis	protein tyrosine kinase	0.0258	0.144	0.3422
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0686	0.4209	0.4209
Loa Loa (eye worm)	hypothetical protein	0.004	0.0028	0.0051
Trichomonas vaginalis	TKL family protein kinase	0.0258	0.144	1
Echinococcus multilocularis	neuropeptide receptor A26	0.004	0.0028	0.0067
Schistosoma mansoni	tyrosine kinase	0.0258	0.144	0.3422
Schistosoma mansoni	tyrosine kinase	0.0258	0.144	0.3422
Schistosoma mansoni	hypothetical protein	0.0258	0.144	0.3422
Echinococcus granulosus	tyrosine kinase	0.0258	0.144	0.144
Brugia malayi	hypothetical protein	0.004	0.0028	0.0051
Echinococcus multilocularis	tyrosine protein kinase HCK	0.0258	0.144	0.3422
Brugia malayi	ERG2 and Sigma1 receptor like protein	0.0889	0.5526	1
Loa Loa (eye worm)	TK protein kinase	0.0258	0.144	0.2606
Echinococcus multilocularis	SH2 domain containing adapter protein F	0.0428	0.2538	0.6029
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.004	0.0031	0.0073
Brugia malayi	Serotonin receptor	0.004	0.0028	0.0051
Echinococcus multilocularis	tyrosine protein kinase Abl	0.0686	0.4209	1
Echinococcus multilocularis	G protein coupled receptor 139	0.004	0.0028	0.0067
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.004	0.0031	0.0056
Loa Loa (eye worm)	cytokine inducible SH2-containing protein 5	0.0428	0.2538	0.4592
Loa Loa (eye worm)	hypothetical protein	0.004	0.0028	0.0051
Echinococcus granulosus	serotonin receptor	0.004	0.0028	0.0028
Trichomonas vaginalis	TKL family protein kinase	0.0258	0.144	1
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.004	0.0028	0.0067
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.004	0.0031	0.0073
Echinococcus multilocularis	activin receptor type	0.0258	0.144	0.3422
Brugia malayi	G-protein coupled receptor	0.004	0.0028	0.0051
Trichomonas vaginalis	TKL family protein kinase	0.0258	0.144	1
Echinococcus multilocularis	SH2 motif	0.0428	0.2538	0.6029
Loa Loa (eye worm)	TK protein kinase	0.0686	0.4209	0.7617
Echinococcus multilocularis	NCK adaptor protein	0.0428	0.2538	0.6029
Schistosoma mansoni	protein kinase	0.0258	0.144	0.3422
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.004	0.0031	0.0056
Schistosoma mansoni	protein kinase	0.0258	0.144	0.3422
Echinococcus granulosus	tyrosine kinase\|tyrosine protein kinase Fyn	0.0686	0.4209	0.4209
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.004	0.0031	0.0056
Echinococcus multilocularis	tyrosine protein kinase shark	0.0686	0.4209	1
Echinococcus multilocularis	integrin linked protein kinase	0.0258	0.144	0.3422
Schistosoma mansoni	SH2A	0.0428	0.2538	0.6029
Loa Loa (eye worm)	TK/FER protein kinase	0.0686	0.4209	0.7617
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.004	0.0028	0.0067
Echinococcus multilocularis	G-protein coupled receptor, putative	0.004	0.0028	0.0067
Trypanosoma cruzi	protein kinase, putative	0.0258	0.144	0.2606
Echinococcus granulosus	rhodopsin orphan GPCR	0.004	0.0028	0.0028
Trichomonas vaginalis	TKL family protein kinase	0.0258	0.144	1
Brugia malayi	Dopamine receptor protein 2	0.004	0.0028	0.0051
Onchocerca volvulus		0.0258	0.144	0.3422
Echinococcus granulosus	receptor type guanylyl cyclase	0.0258	0.144	0.144
Onchocerca volvulus		0.0428	0.2538	0.6029
Loa Loa (eye worm)	hypothetical protein	0.0258	0.144	0.2606
Loa Loa (eye worm)	TK/FER protein kinase	0.0258	0.144	0.2606
Schistosoma mansoni	tyrosine kinase	0.0258	0.144	0.3422
Loa Loa (eye worm)	hypothetical protein	0.0428	0.2538	0.4592
Schistosoma mansoni	chimerin-related rho-gtpase-activating protein	0.0428	0.2538	0.6029
Schistosoma mansoni	serine/threonine RGC	0.0258	0.144	0.3422
Trichomonas vaginalis	protein kinase atn1, putative	0.0258	0.144	1
Echinococcus granulosus	retinal guanylyl cyclase 2	0.0258	0.144	0.144
Onchocerca volvulus		0.004	0.0028	0.0067
Echinococcus multilocularis	fmrfamide receptor	0.004	0.0028	0.0067
Trichomonas vaginalis	TKL family protein kinase	0.0258	0.144	1
Brugia malayi	G protein-coupled receptor F59B2.13	0.004	0.0028	0.0051
Echinococcus multilocularis	growth factor receptor bound protein 2	0.0428	0.2538	0.6029
Echinococcus multilocularis	rhodopsin orphan GPCR	0.004	0.0028	0.0067
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase abl1	0.0428	0.2538	0.6029
Brugia malayi	G protein-coupled receptor	0.004	0.0028	0.0051
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.0258	0.144	0.3422
Brugia malayi	SH2 domain containing protein	0.0428	0.2538	0.4592
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0686	0.4209	1
Schistosoma mansoni	tyrosine kinase	0.0258	0.144	0.3422
Onchocerca volvulus		0.0258	0.144	0.3422
Loa Loa (eye worm)	G-protein coupled receptor	0.004	0.0028	0.0051
Brugia malayi	hypothetical protein	0.0258	0.144	0.2606
Trypanosoma brucei	Flagellum attachment zone protein 20	0.0258	0.144	0.2606
Brugia malayi	tRNA modification GTPase TrmE family protein	0.0428	0.2538	0.4592
Schistosoma mansoni	amine GPCR	0.004	0.0028	0.0067
Loa Loa (eye worm)	hypothetical protein	0.0428	0.2538	0.4592
Onchocerca volvulus		0.0686	0.4209	1
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.004	0.0031	0.0031
Loa Loa (eye worm)	hypothetical protein	0.0428	0.2538	0.4592
Plasmodium falciparum	tyrosine kinase-like protein	0.0258	0.144	0.5
Schistosoma mansoni	tyrosine protein kinase fes (fps) (ptk group IV)	0.0258	0.144	0.3422
Echinococcus multilocularis	heat shock protein 70	0.0258	0.144	0.3422
Echinococcus multilocularis	tyrosine protein kinase Blk	0.0686	0.4209	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.004	0.0028	0.0067
Plasmodium falciparum	protein kinase, putative	0.0258	0.144	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0258	0.144	1
Brugia malayi	Protein kinase domain containing protein	0.0258	0.144	0.2606
Onchocerca volvulus		0.0428	0.2538	0.6029
Echinococcus granulosus	tensin C1 domain containing phosphatase	0.0428	0.2538	0.2538
Echinococcus multilocularis	epidermal growth factor receptor	0.0258	0.144	0.3422
Echinococcus multilocularis	atrial natriuretic peptide receptor 1	0.0258	0.144	0.3422
Loa Loa (eye worm)	TK/FER protein kinase	0.0258	0.144	0.2606
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.004	0.0028	0.0067
Trichomonas vaginalis	TKL family protein kinase	0.0258	0.144	1
Schistosoma mansoni	vav2	0.0428	0.2538	0.6029
Loa Loa (eye worm)	TK/FAK protein kinase	0.0258	0.144	0.2606
Loa Loa (eye worm)	TKL/STKR/TYPE1 protein kinase	0.0258	0.144	0.2606
Trichomonas vaginalis	conserved hypothetical protein	0.0258	0.144	1
Loa Loa (eye worm)	hypothetical protein	0.0258	0.144	0.2606
Schistosoma mansoni	biogenic amine receptor	0.004	0.0028	0.0067
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.004	0.0031	0.0073
Schistosoma mansoni	tyrosine kinase	0.0686	0.4209	1
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.0428	0.2538	0.4592
Echinococcus granulosus	neuropeptide Y receptor	0.004	0.0028	0.0028
Echinococcus multilocularis	g protein coupled receptor	0.004	0.0028	0.0067
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.004	0.0028	0.0067
Schistosoma mansoni	biogenic amine (5HT) receptor	0.004	0.0028	0.0067
Echinococcus granulosus	SHC transforming protein 3	0.0428	0.2538	0.2538
Echinococcus granulosus	tyrosine protein kinase Fes:Fps	0.0258	0.144	0.144
Schistosoma mansoni	alpha-1 adrenergic receptor	0.004	0.0028	0.0067
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.0686	0.4209	0.4209
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0428	0.2538	0.4592
Echinococcus multilocularis	sex peptide receptor	0.004	0.0028	0.0067
Echinococcus granulosus	SH2 domain containing protein 7	0.0428	0.2538	0.2538
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.004	0.0028	0.0067
Brugia malayi	Raf kinase	0.0258	0.144	0.2606
Trichomonas vaginalis	TKL family protein kinase	0.0258	0.144	1
Schistosoma mansoni	tyrosine kinase	0.0258	0.144	0.3422
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0686	0.4209	1
Loa Loa (eye worm)	hypothetical protein	0.004	0.0028	0.0051
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.004	0.0028	0.0051
Loa Loa (eye worm)	hypothetical protein	0.0428	0.2538	0.4592
Echinococcus multilocularis	ephrin type A receptor 4 A	0.0258	0.144	0.3422
Echinococcus granulosus	tyrosine protein kinase HCK	0.0258	0.144	0.144
Schistosoma mansoni	histamine h1 receptor	0.004	0.0028	0.0067
Echinococcus multilocularis	rhodopsin orphan GPCR	0.004	0.0028	0.0067
Echinococcus granulosus	tm gpcr rhodopsin	0.004	0.0028	0.0028
Brugia malayi	Variant SH3 domain containing protein	0.0428	0.2538	0.4592
Echinococcus granulosus	tensin	0.0428	0.2538	0.2538
Schistosoma mansoni	RAR-like nuclear receptor	0.004	0.0031	0.0073
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0228	0.1245	1
Echinococcus multilocularis	vesicular acetylcholine transporter	0.0267	0.1497	0.3557
Trichomonas vaginalis	TKL family protein kinase	0.0258	0.144	1
Trichomonas vaginalis	TKL family protein kinase	0.0258	0.144	1
Echinococcus granulosus	activin receptor type	0.0258	0.144	0.144
Loa Loa (eye worm)	hypothetical protein	0.004	0.0028	0.0051
Trichomonas vaginalis	TKL family protein kinase	0.0258	0.144	1
Echinococcus multilocularis	suppressor of cytokine signaling 7	0.0428	0.2538	0.6029
Schistosoma mansoni	opsin-like receptor	0.004	0.0028	0.0067
Loa Loa (eye worm)	TKL/MLK/TAK1 protein kinase	0.0258	0.144	0.2606
Trichomonas vaginalis	TKL family protein kinase	0.0258	0.144	1
Loa Loa (eye worm)	melatonin receptor type 1A	0.004	0.0028	0.0051
Loa Loa (eye worm)	TK/FER protein kinase	0.0686	0.4209	0.7617
Onchocerca volvulus		0.0258	0.144	0.3422
Brugia malayi	Protein kinase domain containing protein	0.0258	0.144	0.2606
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0258	0.144	0.2606
Echinococcus multilocularis	tyrosine protein kinase Srms	0.0686	0.4209	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.004	0.0028	0.0028
Loa Loa (eye worm)	TK/FER protein kinase	0.0686	0.4209	0.7617
Schistosoma mansoni	tyrosine protein kinase fes (fps) (ptk group IV)	0.0258	0.144	0.3422
Schistosoma mansoni	adapter molecule crk	0.0428	0.2538	0.6029
Echinococcus granulosus	epidermal growth factor receptor	0.0258	0.144	0.144
Brugia malayi	Protein kinase domain containing protein	0.0258	0.144	0.2606
Loa Loa (eye worm)	TK protein kinase	0.0258	0.144	0.2606
Echinococcus multilocularis	rhodopsin orphan GPCR	0.004	0.0028	0.0067
Plasmodium vivax	tyrosine kinase-like protein, putative	0.0258	0.144	1
Toxoplasma gondii	Tyrosine kinase-like (TKL) protein	0.0258	0.144	1
Schistosoma mansoni	shc transforming protein	0.0428	0.2538	0.6029
Onchocerca volvulus		0.0428	0.2538	0.6029
Brugia malayi	Melatonin receptor type 1A	0.004	0.0028	0.0051
Schistosoma mansoni	biogenic amine receptor	0.004	0.0028	0.0067
Loa Loa (eye worm)	hypothetical protein	0.0428	0.2538	0.4592
Leishmania major	protein kinase, putative	0.0258	0.144	0.2606
Loa Loa (eye worm)	hypothetical protein	0.004	0.0028	0.0051
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0686	0.4209	1
Trypanosoma brucei	Pseudokinase, putative	0.0258	0.144	0.2606
Schistosoma mansoni	signal transduction protein lnk-related	0.0428	0.2538	0.6029
Echinococcus granulosus	fibroblast growth factor receptor 4	0.0258	0.144	0.144
Brugia malayi	AKH receptor	0.004	0.0028	0.0051
Entamoeba histolytica	SH2-protein kinase domain containing protein	0.0428	0.2538	0.3964
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.004	0.0031	0.0056
Schistosoma mansoni	growth factor receptor-bound protein	0.0428	0.2538	0.6029
Loa Loa (eye worm)	hypothetical protein	0.004	0.0028	0.0051
Echinococcus multilocularis	natriuretic peptide receptor 1	0.0258	0.144	0.3422
Trichomonas vaginalis	TKL family protein kinase	0.0258	0.144	1
Schistosoma mansoni	hypothetical protein	0.004	0.0028	0.0067
Loa Loa (eye worm)	hypothetical protein	0.004	0.0028	0.0051
Echinococcus granulosus	tyrosine protein kinase csk	0.0258	0.144	0.144
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.004	0.0031	0.0056
Echinococcus multilocularis	insulin receptor	0.0258	0.144	0.3422
Trichomonas vaginalis	TKL family protein kinase	0.0258	0.144	1
Loa Loa (eye worm)	hypothetical protein	0.0428	0.2538	0.4592
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0428	0.2538	0.2538
Echinococcus granulosus	7TM GPCR rhodopsin	0.004	0.0028	0.0028
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.004	0.0028	0.0067
Schistosoma mansoni	tyrosine kinase	0.0258	0.144	0.3422
Echinococcus granulosus	peptide allatostatin:somatostatin	0.004	0.0028	0.0028
Echinococcus multilocularis	c src tyrosine kinase	0.0686	0.4209	1
Brugia malayi	bone morphogenetic protein type 1 receptor	0.0258	0.144	0.2606
Brugia malayi	Protein kinase domain containing protein	0.0258	0.144	0.2606
Trichomonas vaginalis	TKL family protein kinase	0.0258	0.144	1
Brugia malayi	G-protein coupled receptor	0.004	0.0028	0.0051
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.004	0.0028	0.0067
Echinococcus granulosus	insulin growth factor 1 receptor beta	0.0258	0.144	0.144
Schistosoma mansoni	serine/threonine protein kinase	0.0258	0.144	0.3422
Echinococcus granulosus	tyrosine protein kinase transmembrane receptor	0.0258	0.144	0.144
Brugia malayi	follicle stimulating hormone receptor	0.004	0.0028	0.0051
Echinococcus granulosus	neuropeptide receptor A26	0.004	0.0028	0.0028
Loa Loa (eye worm)	hypothetical protein	0.004	0.0028	0.0051
Loa Loa (eye worm)	hypothetical protein	0.004	0.0028	0.0051
Echinococcus granulosus	g protein coupled receptor	0.004	0.0028	0.0028
Onchocerca volvulus		0.0686	0.4209	1
Trichomonas vaginalis	br serine/threonine-protein kinase, putative	0.0258	0.144	1
Brugia malayi	Protein kinase domain containing protein	0.0258	0.144	0.2606
Schistosoma mansoni	tyrosine kinase	0.0258	0.144	0.3422
Echinococcus granulosus	ephrin type A receptor 4 A	0.0258	0.144	0.144
Trichomonas vaginalis	TKL family protein kinase	0.0258	0.144	1
Schistosoma mansoni	protein kinase	0.0258	0.144	0.3422
Echinococcus granulosus	NCK adaptor protein	0.0428	0.2538	0.2538
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.004	0.0028	0.0051
Trichomonas vaginalis	TKL family protein kinase	0.0258	0.144	1
Onchocerca volvulus		0.0686	0.4209	1
Schistosoma mansoni	tyrosine kinase	0.0258	0.144	0.3422
Echinococcus granulosus	rhodopsin orphan GPCR	0.004	0.0028	0.0028
Brugia malayi	Protein kinase domain containing protein	0.0258	0.144	0.2606
Trichomonas vaginalis	TKL family protein kinase	0.0258	0.144	1
Brugia malayi	steroid hormone receptor	0.004	0.0031	0.0056
Echinococcus multilocularis	SHC transforming protein 3	0.0428	0.2538	0.6029
Brugia malayi	Protein kinase domain containing protein	0.0258	0.144	0.2606
Trichomonas vaginalis	TKL family protein kinase	0.0258	0.144	1
Brugia malayi	hypothetical protein	0.004	0.0028	0.0051
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.004	0.0031	0.0031
Echinococcus multilocularis	rhodopsin orphan GPCR	0.004	0.0028	0.0067
Trichomonas vaginalis	TKL family protein kinase	0.0258	0.144	1
Brugia malayi	SH2 domain containing protein	0.0686	0.4209	0.7617
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.004	0.0028	0.0067
Echinococcus granulosus	rhodopsin orphan GPCR	0.004	0.0028	0.0028
Brugia malayi	Receptor family ligand binding region containing protein	0.0258	0.144	0.2606
Trichomonas vaginalis	TKL family protein kinase	0.0258	0.144	1
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.004	0.0031	0.0073
Loa Loa (eye worm)	hypothetical protein	0.004	0.0028	0.0051
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.004	0.0031	0.0056
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.004	0.0031	0.0056
Echinococcus multilocularis	tyrosine protein kinase transmembrane receptor	0.0258	0.144	0.3422
Trypanosoma brucei	STE/STE11 serine/threonine-protein kinase, putative	0.0258	0.144	0.2606
Loa Loa (eye worm)	TK/FER protein kinase	0.0686	0.4209	0.7617
Brugia malayi	vesicular acetylcholine transporter unc-17	0.0267	0.1497	0.2709
Brugia malayi	integrin-linked kinase	0.0258	0.144	0.2606
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.004	0.0028	0.0051
Trichomonas vaginalis	TKL family protein kinase	0.0258	0.144	1
Echinococcus granulosus	N chimaerin	0.0428	0.2538	0.2538
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.004	0.0028	0.0028
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0258	0.144	0.2606
Onchocerca volvulus		0.004	0.0028	0.0067
Schistosoma mansoni	tyrosine kinase	0.0258	0.144	0.3422
Brugia malayi	C-terminal src kinase protein 1	0.0258	0.144	0.2606
Trichomonas vaginalis	TKL family protein kinase	0.0258	0.144	1
Echinococcus granulosus	insulin receptor	0.0258	0.144	0.144
Trichomonas vaginalis	TKL family protein kinase	0.0258	0.144	1
Leishmania major	hypothetical protein, conserved	0.0258	0.144	0.2606
Echinococcus granulosus	tyrosine protein kinase transmembrane receptor	0.0258	0.144	0.144
Echinococcus granulosus	integrin linked protein kinase	0.0258	0.144	0.144
Brugia malayi	Protein kinase domain containing protein	0.0258	0.144	0.2606
Loa Loa (eye worm)	hypothetical protein	0.004	0.0028	0.0051
Brugia malayi	Tyrosine-protein kinase PR2	0.0258	0.144	0.2606
Onchocerca volvulus		0.004	0.0028	0.0067
Loa Loa (eye worm)	hypothetical protein	0.004	0.0031	0.0056
Onchocerca volvulus		0.0258	0.144	0.3422
Schistosoma mansoni	protein kinase	0.0258	0.144	0.3422
Echinococcus granulosus	guanine nucleotide exchange factor VAV2	0.0428	0.2538	0.2538
Schistosoma mansoni	neuropeptide receptor	0.004	0.0028	0.0067
Onchocerca volvulus	Vesicular acetylcholine transporter homolog	0.0267	0.1497	0.3557
Loa Loa (eye worm)	TK protein kinase	0.0258	0.144	0.2606
Loa Loa (eye worm)	G-protein coupled receptor	0.004	0.0028	0.0051
Echinococcus multilocularis	SH2 motif	0.0428	0.2538	0.6029
Loa Loa (eye worm)	TKL/MLK/ILK protein kinase	0.0258	0.144	0.2606
Brugia malayi	hypothetical protein	0.004	0.0028	0.0051
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0686	0.4209	0.4209
Trypanosoma brucei	protein kinase, putative	0.0258	0.144	0.2606
Echinococcus multilocularis	dro:myosuppressin receptor	0.004	0.0028	0.0067
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.004	0.0028	0.0067
Loa Loa (eye worm)	SRC-1	0.0686	0.4209	0.7617
Schistosoma mansoni	protein kinase	0.0258	0.144	0.3422
Echinococcus granulosus	3'partial\|tyrosine protein kinase Fgr	0.0686	0.4209	0.4209
Echinococcus multilocularis	kinase suppressor of Ras 1	0.0258	0.144	0.3422
Echinococcus granulosus	7tm_1 domain containing protein	0.004	0.0028	0.0028
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0428	0.2538	0.6029
Schistosoma mansoni	tyrosine-protein kinase fps85d	0.0258	0.144	0.3422
Brugia malayi	Tyrosine-protein kinase abl-1	0.0686	0.4209	0.7617
Echinococcus granulosus	biogenic amine 5HT receptor	0.004	0.0028	0.0028
Loa Loa (eye worm)	hypothetical protein	0.004	0.0031	0.0056
Loa Loa (eye worm)	hypothetical protein	0.0258	0.144	0.2606
Brugia malayi	ecdysteroid receptor	0.004	0.0031	0.0056
Echinococcus multilocularis	insulin growth factor 1 receptor beta	0.0258	0.144	0.3422
Schistosoma mansoni	GTPase activating protein	0.0428	0.2538	0.6029
Echinococcus granulosus	growth factor receptor bound protein 2	0.0428	0.2538	0.2538
Loa Loa (eye worm)	hypothetical protein	0.004	0.0028	0.0051
Loa Loa (eye worm)	SH2 domain-containing protein	0.0428	0.2538	0.4592
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0258	0.144	0.2606
Echinococcus multilocularis	rhodopsin orphan GPCR	0.004	0.0028	0.0067
Schistosoma mansoni	protein tyrosine kinase	0.0258	0.144	0.3422
Onchocerca volvulus	Suppressor of cytokine signaling 7 homolog	0.0428	0.2538	0.6029
Leishmania major	C-8 sterol isomerase-like protein	0.0889	0.5526	1
Echinococcus granulosus	g protein coupled receptor	0.004	0.0028	0.0028
Echinococcus granulosus	tyrosine protein kinase ABL1	0.0686	0.4209	0.4209
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.004	0.0028	0.0067
Brugia malayi	Probable tyrosine-protein kinase kin-31	0.0258	0.144	0.2606
Onchocerca volvulus		0.0258	0.144	0.3422
Schistosoma mansoni	src-type protein tyrosine kinase-related	0.0258	0.144	0.3422
Brugia malayi	RhoGAP domain containing protein	0.0428	0.2538	0.4592
Onchocerca volvulus		0.0258	0.144	0.3422
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.004	0.0031	0.0031
Trypanosoma brucei	C-8 sterol isomerase, putative	0.0889	0.5526	1
Brugia malayi	putative neuropeptide receptor	0.004	0.0028	0.0051
Brugia malayi	Protein kinase domain containing protein	0.0686	0.4209	0.7617
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0258	0.144	0.2606
Loa Loa (eye worm)	TK/Met protein kinase	0.0258	0.144	0.2606
Echinococcus granulosus	suppressor of cytokine signaling 6	0.0428	0.2538	0.2538
Echinococcus multilocularis	g-protein coupled receptor	0.004	0.0028	0.0067
Schistosoma mansoni	ephrin receptor	0.0258	0.144	0.3422
Loa Loa (eye worm)	hypothetical protein	0.0258	0.144	0.2606
Echinococcus multilocularis	tyrosine protein kinase pr2	0.0258	0.144	0.3422
Echinococcus granulosus	orexin receptor type 2	0.004	0.0028	0.0028
Brugia malayi	Furin-like cysteine rich region family protein	0.0258	0.144	0.2606
Echinococcus multilocularis	neuropeptide receptor	0.004	0.0028	0.0067
Echinococcus multilocularis	g protein coupled receptor	0.004	0.0028	0.0067
Onchocerca volvulus		0.0258	0.144	0.3422
Echinococcus granulosus	allatostatin A receptor	0.004	0.0028	0.0028
Loa Loa (eye worm)	hypothetical protein	0.004	0.0028	0.0051
Echinococcus multilocularis	neuropeptide FF receptor 2	0.004	0.0028	0.0067
Echinococcus granulosus	rhodopsin orphan GPCR	0.004	0.0028	0.0028
Schistosoma mansoni	biogenic amine receptor	0.004	0.0028	0.0067
Loa Loa (eye worm)	hypothetical protein	0.004	0.0028	0.0051
Echinococcus granulosus	kinase suppressor of Ras 1	0.0258	0.144	0.144
Trichomonas vaginalis	CAMK family protein kinase	0.0258	0.144	1
Schistosoma mansoni	tyrosine kinase	0.0258	0.144	0.3422
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.0258	0.144	0.3422
Trichomonas vaginalis	STE family protein kinase	0.0258	0.144	1
Schistosoma mansoni	tyrosine kinase	0.0258	0.144	0.3422
Brugia malayi	Dopamine receptor protein 1	0.004	0.0028	0.0051
Schistosoma mansoni	opsin-like receptor	0.004	0.0028	0.0067
Echinococcus multilocularis	ecdysone induced protein 78C	0.004	0.0031	0.0073
Loa Loa (eye worm)	hypothetical protein	0.0258	0.144	0.2606
Schistosoma mansoni	opsin-like receptor	0.004	0.0028	0.0067
Trichomonas vaginalis	serine-threonine protein kinase, putative	0.0258	0.144	1
Schistosoma mansoni	amine GPCR	0.004	0.0028	0.0067
Trichomonas vaginalis	TKL family protein kinase	0.0258	0.144	1
Onchocerca volvulus		0.004	0.0028	0.0067
Loa Loa (eye worm)	TK/FER protein kinase	0.0686	0.4209	0.7617
Loa Loa (eye worm)	TK/FER protein kinase	0.0258	0.144	0.2606
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.004	0.0028	0.0051
Loa Loa (eye worm)	hypothetical protein	0.004	0.0028	0.0051
Loa Loa (eye worm)	hypothetical protein	0.0428	0.2538	0.4592
Echinococcus multilocularis	protein KINase family member (kin 25)	0.0258	0.144	0.3422
Echinococcus multilocularis	tyrosine protein kinase Fps85D	0.0686	0.4209	1
Echinococcus multilocularis	tyrosine protein kinase Fgr	0.0686	0.4209	1
Trypanosoma cruzi	protein kinase, putative	0.0258	0.144	0.2606
Echinococcus granulosus	tyrosine protein kinase pr2	0.0258	0.144	0.144
Echinococcus granulosus	vesicular acetylcholine transporter	0.0267	0.1497	0.1497
Trichomonas vaginalis	TKL family protein kinase	0.0258	0.144	1
Trichomonas vaginalis	TKL family protein kinase	0.0258	0.144	1
Echinococcus multilocularis	tyrosine protein kinase csk	0.0258	0.144	0.3422
Loa Loa (eye worm)	RhoGAP domain-containing protein	0.0428	0.2538	0.4592
Schistosoma mansoni	suppressor of cytokine signaling	0.0428	0.2538	0.6029
Echinococcus granulosus	macrophage colony stimulating factor 1 receptor	0.0258	0.144	0.144
Echinococcus granulosus	tyrosine protein kinase Src64B	0.0686	0.4209	0.4209
Brugia malayi	SH2 domain containing protein	0.0428	0.2538	0.4592
Trichomonas vaginalis	TKL family protein kinase	0.0258	0.144	1

Activities

Activity type	Activity value	Assay description	Source	Reference
Ki (binding)	= 0.44 nM	Binding affinity to VAchT	ChEMBL.	22365760

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1956464

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 1619712