TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 349.354 | Formula: C17H18F3N5
H donors: 1 H acceptors: 3 LogP: 4.88 Rotable bonds: 5
Rule of 5 violations (Lipinski): 1
SMILES: CC(Cc1nn2c(n1)nc(cc2Nc1ccc(cc1)C(F)(F)F)C)C
InChi: 1S/C17H18F3N5/c1-10(2)8-14-23-16-21-11(3)9-15(25(16)24-14)22-13-6-4-12(5-7-13)17(18,19)20/h4-7,9-10,22H,8H2,1-3H3
InChiKey: BCLWOCAQCDGMFL-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Plasmodium falciparum	dihydroorotate dehydrogenase	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Neospora caninum	dihydroorotate dehydrogenase, putative	Get druggable targets OG5_127289	All targets in OG5_127289
Plasmodium falciparum	dihydroorotate dehydrogenase	Get druggable targets OG5_127289	All targets in OG5_127289
Candida albicans	likely dihydroorotate oxidase similar to S. pombe ura3 (SPAC57A10.12c) and to S. cerevisiae URA1 (YKL216W) involved in pyrimidin	Get druggable targets OG5_127289	All targets in OG5_127289
Mycobacterium tuberculosis	Probable dihydroorotate dehydrogenase PyrD	Get druggable targets OG5_127289	All targets in OG5_127289
Trypanosoma brucei gambiense	dihydroorotate dehydrogenase, putative	Get druggable targets OG5_127289	All targets in OG5_127289
Trypanosoma congolense	dihydroorotate dehydrogenase, putative	Get druggable targets OG5_127289	All targets in OG5_127289
Leishmania mexicana	dihydroorotate dehydrogenase, putative	Get druggable targets OG5_127289	All targets in OG5_127289
Theileria parva	dihydroorotate dehydrogenase, putative	Get druggable targets OG5_127289	All targets in OG5_127289
Leishmania infantum	dihydroorotate dehydrogenase;with=GeneDB:LmjF16.0530	Get druggable targets OG5_127289	All targets in OG5_127289
Plasmodium vivax	dihydroorotate dehydrogenase, mitochondrial precursor, putative	Get druggable targets OG5_127289	All targets in OG5_127289
Leishmania major	dihydroorotate dehydrogenase	Get druggable targets OG5_127289	All targets in OG5_127289
Mycobacterium ulcerans	dihydroorotate dehydrogenase 2	Get druggable targets OG5_127289	All targets in OG5_127289
Schistosoma mansoni	dihydroorotate dehydrogenase	Get druggable targets OG5_127289	All targets in OG5_127289
Brugia malayi	Dihydroorotate dehydrogenase, mitochondrial precursor, putative	Get druggable targets OG5_127289	All targets in OG5_127289
Leishmania braziliensis	dihydroorotate dehydrogenase	Get druggable targets OG5_127289	All targets in OG5_127289
Wolbachia endosymbiont of Brugia malayi	dihydroorotate dehydrogenase 2	Get druggable targets OG5_127289	All targets in OG5_127289
Candida albicans	likely dihydroorotate oxidase similar to S. pombe ura3 (SPAC57A10.12c) and to S. cerevisiae URA1 (YKL216W) involved in pyrimidin	Get druggable targets OG5_127289	All targets in OG5_127289
Trypanosoma cruzi	dihydroorotate dehydrogenase, putative	Get druggable targets OG5_127289	All targets in OG5_127289
Trypanosoma cruzi	dihydroorotate dehydrogenase (fumarate), putative	Get druggable targets OG5_127289	All targets in OG5_127289
Mycobacterium leprae	Probable dihydroorotate dehydrogenase PyrD	Get druggable targets OG5_127289	All targets in OG5_127289
Schistosoma japonicum	ko:K00226 dihydroorotate oxidase [EC1.3.3.1], putative	Get druggable targets OG5_127289	All targets in OG5_127289
Babesia bovis	dihydroorotate dehydrogenase	Get druggable targets OG5_127289	All targets in OG5_127289
Toxoplasma gondii	dihydroorotate dehydrogenase reveal, putative	Get druggable targets OG5_127289	All targets in OG5_127289
Leishmania donovani	dihydroorotate dehydrogenase	Get druggable targets OG5_127289	All targets in OG5_127289
Plasmodium yoelii	dihydroorotate dehydrogenase, putative	Get druggable targets OG5_127289	All targets in OG5_127289
Trypanosoma cruzi	dihydroorotate dehydrogenase, putative	Get druggable targets OG5_127289	All targets in OG5_127289
Plasmodium berghei	dihydroorotate dehydrogenase, putative	Get druggable targets OG5_127289	All targets in OG5_127289
Brugia malayi	Dihydroorotate dehydrogenase, mitochondrial precursor, putative	Get druggable targets OG5_127289	All targets in OG5_127289
Plasmodium knowlesi	dihydroorotate dehydrogenase, putative	Get druggable targets OG5_127289	All targets in OG5_127289
Trypanosoma brucei	dihydroorotate dehydrogenase (fumarate)	Get druggable targets OG5_127289	All targets in OG5_127289

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus granulosus	short transient receptor potential channel 6	0.0269	0.049	0.0505
Echinococcus granulosus	potassium channel KvQLT family member kqt 1	0.0269	0.049	0.0505
Echinococcus multilocularis	potassium voltage gated channel subfamily D	0.0269	0.049	0.0505
Echinococcus granulosus	fibroblast growth factor receptor 4	0.3027	0.9699	1
Schistosoma mansoni	voltage-gated potassium channel	0.0269	0.049	0.0497
Echinococcus granulosus	potassium voltage gated channel subfamily C	0.0269	0.049	0.0505
Loa Loa (eye worm)	hypothetical protein	0.0125	0.0008	0.0008
Schistosoma mansoni	transient receptor potential channel 4	0.0269	0.049	0.0497
Echinococcus multilocularis	potassium voltage gated channel subfamily H	0.0269	0.049	0.0505
Brugia malayi	voltage-dependent calcium channel	0.0269	0.049	0.0482
Loa Loa (eye worm)	hypothetical protein	0.0269	0.049	0.049
Echinococcus granulosus	TRP transient receptor potential channel	0.0269	0.049	0.0505
Echinococcus multilocularis	fibroblast growth factor receptor 4	0.3027	0.9699	1
Schistosoma mansoni	voltage-dependent calcium channel	0.0269	0.049	0.0497
Echinococcus multilocularis	neurotracting:lsamp:neurotrimin:obcam	0.0125	0.0008	0.0008
Toxoplasma gondii	hypothetical protein	0.0269	0.049	0.0698
Brugia malayi	Large-conductance calcium-activated potassium channel Slo-1 (KCNMA) alpha subunit. C. elegans slo-1 ortholog	0.0269	0.049	0.0482
Schistosoma mansoni	calcium-activated potassium channel	0.0269	0.049	0.0497
Echinococcus multilocularis	calcium activated potassium channel	0.0269	0.049	0.0505
Echinococcus multilocularis	voltage dependent calcium channel	0.0269	0.049	0.0505
Schistosoma mansoni	voltage-gated potassium channel	0.0269	0.049	0.0497
Brugia malayi	Voltage-gated calcium channel, T-type, alpha subunit. C. elegans cca-1 ortholog	0.0269	0.049	0.0482
Echinococcus granulosus	transient receptor potential cation channel	0.0269	0.049	0.0505
Loa Loa (eye worm)	CAMK/MLCK protein kinase	0.0125	0.0008	0.0008
Schistosoma mansoni	cyclic-nucleotide-gated cation channel	0.0269	0.049	0.0497
Echinococcus granulosus	voltage dependent calcium channel type d subunit\|voltage dependent calcium channel\|voltage dependent L type calcium channel subu	0.0269	0.049	0.0505
Schistosoma mansoni	voltage-gated potassium channel	0.0269	0.049	0.0497
Loa Loa (eye worm)	hypothetical protein	0.0125	0.0008	0.0008
Echinococcus multilocularis	voltage gated potassium channel	0.0269	0.049	0.0505
Schistosoma mansoni	transient receptor potential cation channel subfamily m member	0.0269	0.049	0.0497
Echinococcus granulosus	voltage gated potassium channel	0.0269	0.049	0.0505
Echinococcus multilocularis	sodium channel protein	0.0269	0.049	0.0505
Echinococcus multilocularis	roundabout 2	0.0125	0.0008	0.0008
Echinococcus granulosus	transient receptor potential cation channel	0.0269	0.049	0.0505
Echinococcus multilocularis	transient receptor potential cation channel	0.0269	0.049	0.0505
Schistosoma mansoni	cyclic-nucleotide-gated cation channel	0.0269	0.049	0.0497
Loa Loa (eye worm)	hypothetical protein	0.0125	0.0008	0.0008
Echinococcus multilocularis	potassium voltage gated channel subfamily D	0.0269	0.049	0.0505
Schistosoma mansoni	60S ribosomal protein L21	0.0269	0.049	0.0497
Echinococcus granulosus	voltage dependent calcium channel	0.0269	0.049	0.0505
Echinococcus granulosus	potassium voltage gated channel subfamily A	0.0269	0.049	0.0505
Brugia malayi	Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog	0.0269	0.049	0.0482
Echinococcus granulosus	hemicentin 1	0.0125	0.0008	0.0008
Echinococcus granulosus	potassium voltage gated channel protein	0.0269	0.049	0.0505
Echinococcus granulosus	hyperpolarization activated cyclic	0.0269	0.049	0.0505
Brugia malayi	Voltage-gated potassium channel, Shab-family (KCNB, Kv2-like) alpha-subunit. C. elegans exp-2 ortholog	0.0269	0.049	0.0482
Brugia malayi	Voltage-gated potassium channel, Shab-family (KCNB, Kv2-like) alpha-subunit	0.0269	0.049	0.0482
Echinococcus granulosus	transient receptor potential cation channel	0.0269	0.049	0.0505
Echinococcus granulosus	potassium voltage gated channel protein	0.0269	0.049	0.0505
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0269	0.049	0.0698
Loa Loa (eye worm)	hypothetical protein	0.0269	0.049	0.049
Echinococcus granulosus	Potassium voltage gated channel protein Shaw	0.0269	0.049	0.0505
Loa Loa (eye worm)	voltage-gated calcium channel	0.0269	0.049	0.049
Echinococcus multilocularis	hemicentin 1	0.0125	0.0008	0.0008
Brugia malayi	Voltage-gated calcium channel, alpha subunit	0.0269	0.049	0.0482
Echinococcus granulosus	tyrosine protein kinase otk	0.0125	0.0008	0.0008
Loa Loa (eye worm)	hypothetical protein	0.0125	0.0008	0.0008
Loa Loa (eye worm)	cyclic-nucleotide gated cation channel	0.0269	0.049	0.049
Echinococcus multilocularis	roundabout 2	0.0231	0.0362	0.0373
Echinococcus multilocularis	shaker cognate	0.0269	0.049	0.0505
Echinococcus granulosus	neuroglian	0.0125	0.0008	0.0008
Schistosoma mansoni	hypothetical protein	0.0269	0.049	0.0497
Schistosoma mansoni	two-pore calcium channel	0.0269	0.049	0.0497
Loa Loa (eye worm)	calcium channel	0.0269	0.049	0.049
Echinococcus granulosus	twitchin	0.0196	0.0247	0.0254
Mycobacterium tuberculosis	Probable dihydroorotate dehydrogenase PyrD	0.02	0.0259	0.5
Brugia malayi	Voltage-gated potassium channel, Shaker-family (KCNA, Kv1-like) alpha-subunit	0.0269	0.049	0.0482
Brugia malayi	hypothetical protein	0.0269	0.049	0.0482
Echinococcus multilocularis	peroxidasin	0.0125	0.0008	0.0008
Echinococcus multilocularis	lachesin	0.0125	0.0008	0.0008
Brugia malayi	Dihydroorotate dehydrogenase, mitochondrial precursor, putative	0.02	0.0259	0.0252
Brugia malayi	Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit	0.0269	0.049	0.0482
Brugia malayi	Voltage-gated potassium channel, KCNQ (Kv7-like) alpha-subunit. C. elegans kqt-1 ortholog	0.0269	0.049	0.0482
Echinococcus multilocularis	voltage dependent calcium channel	0.0269	0.049	0.0505
Loa Loa (eye worm)	voltage-gated potassium channel	0.0269	0.049	0.049
Echinococcus multilocularis	hemicentin 1	0.0125	0.0008	0.0008
Schistosoma mansoni	calcium channel voltage-dependent p/q type alpha 1a-related	0.0269	0.049	0.0497
Leishmania major	hypothetical protein, unknown function	0.0269	0.049	1
Echinococcus multilocularis	voltage gated hydrogen channel 1	0.0269	0.049	0.0505
Loa Loa (eye worm)	hypothetical protein	0.0125	0.0008	0.0008
Schistosoma mansoni	transient receptor potential cation channel subfamily m member	0.0269	0.049	0.0497
Loa Loa (eye worm)	cyclic-nucleotide gated cation channel	0.0269	0.049	0.049
Leishmania major	hypothetical protein, conserved	0.0269	0.049	1
Echinococcus granulosus	contactin	0.0125	0.0008	0.0008
Trypanosoma brucei	inositol 1,4,5-trisphosphate receptor	0.0269	0.049	1
Echinococcus multilocularis	voltage dependent calcium channel type d subunit	0.0269	0.049	0.0505
Echinococcus multilocularis	potassium voltage gated channel subfamily KQT	0.0269	0.049	0.0505
Loa Loa (eye worm)	voltage-dependent calcium channel	0.0269	0.049	0.049
Brugia malayi	Voltage-gated calcium channel, L-type, alpha subunit. C. elegans egl-19 ortholog	0.0269	0.049	0.0482
Brugia malayi	ion channel NompC	0.0269	0.049	0.0482
Echinococcus granulosus	potassium voltage gated channel subfamily D	0.0269	0.049	0.0505
Schistosoma mansoni	hyperpolarization activated cyclic nucleotide-gated potassium channel	0.0269	0.049	0.0497
Echinococcus multilocularis	voltage gated potassium channel	0.0269	0.049	0.0505
Schistosoma mansoni	voltage-gated potassium channel	0.0269	0.049	0.0497
Echinococcus granulosus	two pore calcium channel protein 2	0.0269	0.049	0.0505
Schistosoma mansoni	voltage-gated potassium channel	0.0269	0.049	0.0497
Echinococcus granulosus	cyclic nucleotide gated cation channel alpha 3	0.0269	0.049	0.0505
Loa Loa (eye worm)	hypothetical protein	0.0269	0.049	0.049
Echinococcus granulosus	potassium voltage gated channel protein	0.0269	0.049	0.0505
Loa Loa (eye worm)	hypothetical protein	0.0231	0.0362	0.0362
Echinococcus multilocularis	short transient receptor potential channel 6	0.0269	0.049	0.0505
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0173	0.0168	0.016
Schistosoma mansoni	tyrosine kinase	0.0157	0.0115	0.0111
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0269	0.049	0.5
Loa Loa (eye worm)	hypothetical protein	0.0269	0.049	0.049
Echinococcus multilocularis	transfer RNA-Gly	0.0269	0.049	0.0505
Onchocerca volvulus	Basement membrane proteoglycan homolog	0.0125	0.0008	0.0167
Loa Loa (eye worm)	hypothetical protein	0.0269	0.049	0.049
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0125	0.0008	0.0008
Brugia malayi	cation channel family protein	0.0269	0.049	0.0482
Loa Loa (eye worm)	TK/KIN16 protein kinase	0.0173	0.0168	0.0168
Echinococcus multilocularis	roundabout 2	0.0125	0.0008	0.0008
Echinococcus multilocularis	potassium voltage gated channel subfamily A	0.0269	0.049	0.0505
Echinococcus multilocularis	transient receptor potential cation channel	0.0269	0.049	0.0505
Echinococcus granulosus	neuroglian	0.0196	0.0247	0.0254
Loa Loa (eye worm)	hypothetical protein	0.0269	0.049	0.049
Brugia malayi	Voltage-gated calcium channel, P/Q-type, alpha subunit. C. elegans unc-2 ortholog	0.0269	0.049	0.0482
Echinococcus multilocularis	cyclic nucleotide gated cation channel alpha 3	0.0269	0.049	0.0505
Echinococcus granulosus	voltage gated potassium channel	0.0269	0.049	0.0505
Schistosoma mansoni	cell adhesion molecule	0.0141	0.0061	0.0054
Echinococcus granulosus	voltage dependent calcium channel	0.0269	0.049	0.0505
Echinococcus multilocularis	voltage dependent L type calcium channel subunit	0.0269	0.049	0.0505
Echinococcus multilocularis	basic fibroblast growth factor receptor 1 A	0.3027	0.9699	1
Echinococcus multilocularis	transient receptor potential cation channel	0.0269	0.049	0.0505
Schistosoma mansoni	transient receptor potential cation channel subfamily m member	0.0269	0.049	0.0497
Echinococcus granulosus	ryanodine receptor 44f	0.0269	0.049	0.0505
Loa Loa (eye worm)	hypothetical protein	0.0125	0.0008	0.0008
Echinococcus multilocularis	receptor type tyrosine protein phosphatase F	0.0125	0.0008	0.0008
Schistosoma mansoni	voltage-gated potassium channel	0.0269	0.049	0.0497
Brugia malayi	olfactory channel protein osm-9	0.0269	0.049	0.0482
Echinococcus granulosus	cyclic nucleotide gated cation channel	0.0269	0.049	0.0505
Schistosoma mansoni	voltage-gated potassium channel	0.0269	0.049	0.0497
Echinococcus granulosus	potassium:sodium hyperpolarization activated	0.0269	0.049	0.0505
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0269	0.049	0.0698
Toxoplasma gondii	transporter, cation channel family protein	0.0269	0.049	0.0698
Echinococcus multilocularis	contactin neuroglian septate junction protein	0.0125	0.0008	0.0008
Echinococcus granulosus	roundabout 2	0.0125	0.0008	0.0008
Schistosoma mansoni	ryanodine receptor related	0.0269	0.049	0.0497
Schistosoma mansoni	voltage-gated cation channel	0.0269	0.049	0.0497
Brugia malayi	Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit	0.0269	0.049	0.0482
Schistosoma mansoni	tyrosine kinase	0.3027	0.9699	1
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0269	0.049	0.5
Schistosoma mansoni	transient receptor potential channel	0.0269	0.049	0.0497
Schistosoma mansoni	high voltage-activated calcium channel Cav2A	0.0269	0.049	0.0497
Echinococcus granulosus	potassium voltage gated channel subfamily D	0.0269	0.049	0.0505
Mycobacterium ulcerans	dihydroorotate dehydrogenase 2	0.02	0.0259	0.5
Echinococcus granulosus	transient receptor potential cation channel	0.0269	0.049	0.0505
Loa Loa (eye worm)	voltage and ligand gated potassium channel	0.0269	0.049	0.049
Schistosoma mansoni	voltage-gated potassium channel	0.0269	0.049	0.0497
Schistosoma mansoni	inositol 145-trisphosphate receptor	0.0269	0.049	0.0497
Echinococcus multilocularis	transient receptor potential gamma protein	0.0269	0.049	0.0505
Schistosoma mansoni	hyperpolarization activated cyclic nucleotide-gated potassium channel	0.0269	0.049	0.0497
Schistosoma mansoni	hyperpolarization activated cyclic nucleotide-gated potassium channel	0.0269	0.049	0.0497
Schistosoma mansoni	voltage-gated potassium channel KCNQ	0.0269	0.049	0.0497
Loa Loa (eye worm)	hypothetical protein	0.0269	0.049	0.049
Loa Loa (eye worm)	hypothetical protein	0.0269	0.049	0.049
Echinococcus granulosus	voltage gated hydrogen channel 1	0.0269	0.049	0.0505
Echinococcus granulosus	potassium voltage gated channel subfamily D	0.0269	0.049	0.0505
Echinococcus multilocularis	TRP (transient receptor potential) channel	0.0269	0.049	0.0505
Echinococcus multilocularis	two pore calcium channel protein 2	0.0269	0.049	0.0505
Echinococcus multilocularis	potassium voltage gated channel subfamily H	0.0269	0.049	0.0505
Plasmodium falciparum	dihydroorotate dehydrogenase	0.02	0.0259	0.5
Echinococcus granulosus	transient receptor potential cation channel	0.0269	0.049	0.0505
Trypanosoma cruzi	inositol 1,4,5-trisphosphate receptor, putative	0.0269	0.049	1
Echinococcus granulosus	basic fibroblast growth factor receptor 1 A	0.3027	0.9699	1
Trypanosoma brucei	Voltage-dependent calcium channel subunit, putative	0.0269	0.049	1
Echinococcus granulosus	sodium channel protein	0.0269	0.049	0.0505
Schistosoma mansoni	voltage-gated potassium channel	0.0269	0.049	0.0497
Toxoplasma gondii	MAPEG family protein	0.1191	0.3567	1
Echinococcus multilocularis	ryanodine receptor 44f	0.0269	0.049	0.0505
Loa Loa (eye worm)	hypothetical protein	0.0269	0.049	0.049
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0125	0.0008	0.0008
Schistosoma mansoni	membrane associated proteins in eicosanoid and glutathione metabolism family member	0.1191	0.3567	0.3672
Echinococcus multilocularis	short transient receptor potential channel 6	0.0269	0.049	0.0505
Echinococcus multilocularis	neuroglian	0.0125	0.0008	0.0008
Leishmania major	calcium channel protein, putative,ion transporter, putative	0.0269	0.049	1
Echinococcus granulosus	neurotracting:lsamp:neurotrimin:obcam	0.0141	0.0061	0.0063
Loa Loa (eye worm)	immunoglobulin I-set domain-containing protein	0.0125	0.0008	0.0008
Schistosoma mansoni	voltage-gated potassium channel	0.0269	0.049	0.0497
Echinococcus multilocularis	potassium voltage gated channel subfamily D	0.0269	0.049	0.0505
Echinococcus granulosus	transient receptor potential cation channel	0.0269	0.049	0.0505
Mycobacterium leprae	Probable dihydroorotate dehydrogenase PyrD	0.02	0.0259	0.5
Echinococcus multilocularis	hyperpolarization activated cyclic	0.0269	0.049	0.0505
Schistosoma mansoni	voltage-gated potassium channel	0.0269	0.049	0.0497
Schistosoma mansoni	voltage-gated potassium channel	0.0269	0.049	0.0497
Wolbachia endosymbiont of Brugia malayi	dihydroorotate dehydrogenase 2	0.02	0.0259	0.5
Brugia malayi	Dihydroorotate dehydrogenase, mitochondrial precursor, putative	0.02	0.0259	0.0252
Schistosoma mansoni	transient receptor potential channel	0.0269	0.049	0.0497
Schistosoma mansoni	voltage-gated ion channel	0.0269	0.049	0.0497
Schistosoma mansoni	high voltage-activated calcium channel Cav1	0.0269	0.049	0.0497
Loa Loa (eye worm)	hypothetical protein	0.0269	0.049	0.049
Loa Loa (eye worm)	hypothetical protein	0.0269	0.049	0.049
Loa Loa (eye worm)	hypothetical protein	0.0269	0.049	0.049
Loa Loa (eye worm)	hypothetical protein	0.0269	0.049	0.049
Schistosoma mansoni	voltage-gated potassium channel	0.0269	0.049	0.0497
Echinococcus granulosus	potassium large conductance calcium activated	0.0269	0.049	0.0505
Schistosoma mansoni	voltage-gated potassium channel	0.0269	0.049	0.0497
Echinococcus multilocularis	cyclic nucleotide gated cation channel	0.0269	0.049	0.0505
Loa Loa (eye worm)	ryanodine receptor	0.0269	0.049	0.049
Onchocerca volvulus	Transient receptor potential cation channel trpm homolog	0.0269	0.049	1
Loa Loa (eye worm)	hypothetical protein	0.0141	0.0061	0.0061
Echinococcus multilocularis	transient receptor potential cation channel	0.0269	0.049	0.0505
Schistosoma mansoni	vesicular amine transporter	0.0375	0.0844	0.0863
Echinococcus multilocularis	potassium:sodium hyperpolarization activated	0.0269	0.049	0.0505
Echinococcus granulosus	hypothetical protein	0.0269	0.049	0.0505
Onchocerca volvulus	Transient receptor potential cation channel trpm homolog	0.0269	0.049	1
Loa Loa (eye worm)	hypothetical protein	0.0269	0.049	0.049
Schistosoma mansoni	dihydroorotate dehydrogenase	0.02	0.0259	0.0259
Brugia malayi	Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog	0.0269	0.049	0.0482
Echinococcus granulosus	voltage gated sodium channel Nav1 alpha subunit	0.0269	0.049	0.0505
Brugia malayi	Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit. C. elegans egl-36 ortholog	0.0269	0.049	0.0482
Echinococcus multilocularis	potassium voltage gated channel protein	0.0269	0.049	0.0505
Echinococcus granulosus	microsomal glutathione S transferase 3	0.1191	0.3567	0.3678
Loa Loa (eye worm)	hypothetical protein	0.0125	0.0008	0.0008
Echinococcus granulosus	potassium voltage gated channel protein	0.0269	0.049	0.0505
Echinococcus granulosus	lachesin	0.0125	0.0008	0.0008
Loa Loa (eye worm)	hypothetical protein	0.0269	0.049	0.049
Schistosoma mansoni	voltage-gated potassium channel	0.0269	0.049	0.0497
Schistosoma mansoni	cyclic-nucleotide-gated cation channel	0.0269	0.049	0.0497
Echinococcus multilocularis	voltage dependent calcium channel type d subunit	0.0269	0.049	0.0505
Echinococcus multilocularis	neuroglian	0.0196	0.0247	0.0254
Loa Loa (eye worm)	hypothetical protein	0.0269	0.049	0.049
Toxoplasma gondii	hypothetical protein	0.0269	0.049	0.0698
Trypanosoma cruzi	Voltage-dependent calcium channel subunit, putative	0.0269	0.049	1
Echinococcus multilocularis	potassium voltage gated channel protein	0.0269	0.049	0.0505
Echinococcus multilocularis	potassium large conductance calcium activated	0.0269	0.049	0.0505
Echinococcus multilocularis	transient receptor potential cation channel	0.0269	0.049	0.0505
Schistosoma mansoni	microsomal glutathione s-transferase	0.1191	0.3567	0.3672
Schistosoma mansoni	voltage-gated potassium channel	0.0269	0.049	0.0497
Brugia malayi	Cyclic-nucleotide gated cation channel	0.0269	0.049	0.0482
Loa Loa (eye worm)	hypothetical protein	0.0269	0.049	0.049
Loa Loa (eye worm)	hypothetical protein	0.0269	0.049	0.049
Echinococcus multilocularis	sodium leak channel non selective protein	0.0269	0.049	0.0505
Loa Loa (eye worm)	hypothetical protein	0.0231	0.0362	0.0362
Loa Loa (eye worm)	immunoglobulin I-set domain-containing protein	0.0125	0.0008	0.0008
Echinococcus multilocularis	potassium voltage gated channel subfamily C	0.0269	0.049	0.0505
Brugia malayi	Ryanodine Receptor TM 4-6 family protein	0.0269	0.049	0.0482
Echinococcus multilocularis	microsomal glutathione S transferase 3	0.1191	0.3567	0.3678
Schistosoma mansoni	cyclic-nucleotide-gated cation channel	0.0269	0.049	0.0497
Echinococcus granulosus	potassium voltage gated channel subfamily H	0.0269	0.049	0.0505
Echinococcus multilocularis	tyrosine protein kinase otk	0.0125	0.0008	0.0008
Echinococcus granulosus	roundabout 2	0.0125	0.0008	0.0008
Echinococcus granulosus	sodium leak channel non selective protein	0.0269	0.049	0.0505
Echinococcus granulosus	cyclic nucleotide gated cation channel	0.0269	0.049	0.0505
Echinococcus multilocularis	transient receptor potential cation channel	0.0269	0.049	0.0505
Echinococcus granulosus	voltage dependent L type calcium channel subunit\|voltage dependent calcium channel	0.0269	0.049	0.0505
Echinococcus granulosus	short transient receptor potential channel 6	0.0269	0.049	0.0505
Echinococcus multilocularis	potassium voltage gated channel protein	0.0269	0.049	0.0505
Echinococcus multilocularis	conserved hypothetical protein	0.0269	0.049	0.0505
Echinococcus granulosus	calcium activated potassium channel	0.0269	0.049	0.0505
Echinococcus multilocularis	hyperpolarization activated cyclic	0.0269	0.049	0.0505
Echinococcus granulosus	voltage dependent calcium channel type d subunit\|voltage dependent calcium channel alpha 1	0.0269	0.049	0.0505
Echinococcus granulosus	transient receptor potential gamma protein	0.0269	0.049	0.0505
Echinococcus granulosus	peroxidasin	0.0125	0.0008	0.0008
Toxoplasma gondii	transporter, cation channel family protein	0.0269	0.049	0.0698
Loa Loa (eye worm)	hypothetical protein	0.0269	0.049	0.049
Loa Loa (eye worm)	hypothetical protein	0.0269	0.049	0.049
Onchocerca volvulus		0.0269	0.049	1
Loa Loa (eye worm)	immunoglobulin I-set domain-containing protein	0.0125	0.0008	0.0008
Loa Loa (eye worm)	hypothetical protein	0.0269	0.049	0.049
Loa Loa (eye worm)	hypothetical protein	0.0269	0.049	0.049
Echinococcus multilocularis	two pore calcium channel protein 1	0.0269	0.049	0.0505
Echinococcus granulosus	roundabout 2	0.0231	0.0362	0.0373
Plasmodium vivax	dihydroorotate dehydrogenase, mitochondrial precursor, putative	0.02	0.0259	0.5
Echinococcus granulosus	hyperpolarization activated cyclic	0.0269	0.049	0.0505
Loa Loa (eye worm)	ion channel NompC	0.0269	0.049	0.049
Schistosoma mansoni	transient receptor potential cation channel subfamily m member	0.0269	0.049	0.0497
Schistosoma mansoni	nephrin	0.0196	0.0247	0.0246
Echinococcus granulosus	two pore calcium channel protein 1	0.0269	0.049	0.0505
Schistosoma mansoni	voltage-gated potassium channel	0.0269	0.049	0.0497
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0125	0.0008	0.0008
Echinococcus granulosus	shaker cognate	0.0269	0.049	0.0505
Loa Loa (eye worm)	hypothetical protein	0.0125	0.0008	0.0008
Toxoplasma gondii	transporter, cation channel family protein	0.0269	0.049	0.0698
Schistosoma mansoni	transient receptor potential channel	0.0269	0.049	0.0497
Echinococcus granulosus	potassium voltage gated channel protein	0.0269	0.049	0.0505
Brugia malayi	Transient-receptor-potential like protein	0.0269	0.049	0.0482
Brugia malayi	cation channel family protein	0.0269	0.049	0.0482
Echinococcus multilocularis	potassium voltage gated channel protein	0.0269	0.049	0.0505
Schistosoma mansoni	voltage-gated potassium channel	0.0269	0.049	0.0497
Echinococcus multilocularis	voltage dependent L type calcium channel subunit	0.0269	0.049	0.0505
Schistosoma mansoni	transient receptor potential cation channel subfamily m member	0.0269	0.049	0.0497
Echinococcus granulosus	potassium voltage gated channel subfamily H	0.0269	0.049	0.0505
Loa Loa (eye worm)	voltage-gated potassium channel	0.0269	0.049	0.049

Activities

Activity type	Activity value	Assay description	Source	Reference
EC50 (functional)		Antimalarial activity against Plasmodium falciparum 3D7 by [3H]hypoxanthine incorporation assay in presence of human serum	ChEMBL.	21696174
IC50 (binding)		Inhibition of human C-terminal hexa-His tagged DHODH expressed in Escherichia coli by DCIP reduction assay	ChEMBL.	21696174
IC50 (binding)	= 2 uM	Inhibition of Plasmodium falciparum C-terminal hexa-His tagged DHODH expressed in Escherichia coli by DCIP reduction assay	ChEMBL.	21696174

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

ChEMBL: CHEMBL1956270

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 1620136