Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | expressed conserved protein | 0.0087 | 0.0874 | 0.2933 |
Loa Loa (eye worm) | hypothetical protein | 0.0225 | 0.2739 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0225 | 0.2739 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0225 | 0.2739 | 1 |
Onchocerca volvulus | Nuclear receptor subfamily 6 group A member 1 homolog | 0.0106 | 0.1133 | 0.4136 |
Schistosoma mansoni | nuclear hormone receptor | 0.0106 | 0.1133 | 0.3915 |
Schistosoma mansoni | hypothetical protein | 0.0034 | 0.0156 | 0.0213 |
Loa Loa (eye worm) | hypothetical protein | 0.0106 | 0.1133 | 0.4136 |
Onchocerca volvulus | 0.0045 | 0.0312 | 0.1137 | |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0225 | 0.2739 | 1 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0034 | 0.0156 | 0.0213 |
Brugia malayi | Niemann-Pick C1 protein precursor | 0.0093 | 0.095 | 0.3466 |
Loa Loa (eye worm) | hypothetical protein | 0.0119 | 0.1305 | 0.4764 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0225 | 0.2739 | 0.2666 |
Echinococcus granulosus | nuclear receptor nhr 48 | 0.0106 | 0.1133 | 0.3915 |
Brugia malayi | CHE-14 protein | 0.004 | 0.0236 | 0.086 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0225 | 0.2739 | 1 |
Schistosoma mansoni | nuclear receptor | 0.0106 | 0.1133 | 0.3915 |
Brugia malayi | nuclear receptor NHR-88 | 0.0106 | 0.1133 | 0.4136 |
Schistosoma mansoni | coup transcription factor | 0.0225 | 0.2739 | 1 |
Echinococcus granulosus | FTZ F1 alpha | 0.0225 | 0.2739 | 1 |
Schistosoma mansoni | niemann-pick C1 (NPC1) | 0.0094 | 0.0969 | 0.3293 |
Onchocerca volvulus | 0.0106 | 0.1133 | 0.4136 | |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0225 | 0.2739 | 1 |
Onchocerca volvulus | 0.0225 | 0.2739 | 1 | |
Trichomonas vaginalis | conserved hypothetical protein | 0.004 | 0.0236 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0225 | 0.2739 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor | 0.0106 | 0.1133 | 0.4136 |
Echinococcus granulosus | sterol regulatory element binding protein | 0.004 | 0.0236 | 0.0515 |
Brugia malayi | nuclear receptor RXR | 0.0106 | 0.1133 | 0.4136 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0094 | 0.0965 | 0.3524 |
Brugia malayi | Latrophilin receptor protein 2 | 0.003 | 0.01 | 0.0363 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0225 | 0.2739 | 0.2666 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0094 | 0.0965 | 0.3524 |
Brugia malayi | ecdysteroid receptor | 0.0225 | 0.2739 | 1 |
Brugia malayi | hypothetical protein | 0.0222 | 0.2703 | 0.9867 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0225 | 0.2739 | 1 |
Loa Loa (eye worm) | helix-loop-helix DNA-binding domain-containing protein | 0.0101 | 0.1063 | 0.3882 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0119 | 0.1305 | 0.4764 |
Loa Loa (eye worm) | hypothetical protein | 0.0222 | 0.2703 | 0.9867 |
Echinococcus multilocularis | Nuclear hormone receptor HR96 | 0.0106 | 0.1133 | 0.1044 |
Entamoeba histolytica | hypothetical protein | 0.0034 | 0.0156 | 0.1641 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0225 | 0.2739 | 1 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0119 | 0.1305 | 0.4567 |
Brugia malayi | hypothetical protein | 0.0106 | 0.1133 | 0.4136 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0112 | 0.1215 | 0.4437 |
Brugia malayi | nuclear hormone receptor family member odr-7 | 0.0106 | 0.1133 | 0.4136 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0225 | 0.2739 | 1 |
Onchocerca volvulus | Nuclear receptor subfamily 6 group A member 1 homolog | 0.0106 | 0.1133 | 0.4136 |
Echinococcus multilocularis | expressed conserved protein | 0.0087 | 0.0874 | 0.0782 |
Loa Loa (eye worm) | hypothetical protein | 0.0106 | 0.1133 | 0.4136 |
Loa Loa (eye worm) | hypothetical protein | 0.0106 | 0.1133 | 0.4136 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0225 | 0.2739 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0119 | 0.1305 | 0.4764 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0225 | 0.2739 | 1 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0225 | 0.2739 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0225 | 0.2739 | 1 |
Brugia malayi | nuclear receptor subfamily 1, group D, member 1, putative | 0.0106 | 0.1133 | 0.4136 |
Schistosoma mansoni | zinc finger protein | 0.0106 | 0.1133 | 0.3915 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0225 | 0.2739 | 0.2666 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0225 | 0.2739 | 0.2666 |
Echinococcus granulosus | Nuclear hormone receptor HR96 | 0.0106 | 0.1133 | 0.3915 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0225 | 0.2739 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0225 | 0.2739 | 1 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0225 | 0.2739 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0093 | 0.095 | 0.3466 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0225 | 0.2739 | 1 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0225 | 0.2739 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0034 | 0.0156 | 0.1641 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0225 | 0.2739 | 0.2666 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.003 | 0.01 | 0.0363 |
Loa Loa (eye worm) | nuclear receptor NHR-67 | 0.0106 | 0.1133 | 0.4136 |
Brugia malayi | steroid hormone receptor | 0.0225 | 0.2739 | 1 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0094 | 0.0965 | 0.3524 |
Echinococcus multilocularis | Nuclear hormone receptor HR96 | 0.0106 | 0.1133 | 0.1044 |
Schistosoma mansoni | patched 1 | 0.004 | 0.0236 | 0.0515 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0225 | 0.2739 | 1 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0225 | 0.2739 | 1 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0225 | 0.2739 | 1 |
Echinococcus granulosus | Niemann Pick C1 protein | 0.0093 | 0.095 | 0.322 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0225 | 0.2739 | 1 |
Echinococcus multilocularis | nuclear receptor subfamily 4 group A | 0.0106 | 0.1133 | 0.1044 |
Echinococcus multilocularis | protein patched | 0.004 | 0.0236 | 0.0137 |
Schistosoma mansoni | nuclear hormone receptor | 0.0225 | 0.2739 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0038 | 0.0216 | 0.0442 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.0356 | 0.1301 |
Echinococcus multilocularis | protein dispatched 1 | 0.0045 | 0.0311 | 0.0214 |
Echinococcus granulosus | Nuclear hormone receptor HR96 | 0.0106 | 0.1133 | 0.3915 |
Loa Loa (eye worm) | hypothetical protein | 0.0101 | 0.1063 | 0.3882 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0225 | 0.2739 | 1 |
Echinococcus multilocularis | nuclear receptor nhr 48 | 0.0106 | 0.1133 | 0.1044 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0119 | 0.1305 | 0.4764 |
Schistosoma mansoni | thyroid hormone receptor | 0.0225 | 0.2739 | 1 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0225 | 0.2739 | 1 |
Schistosoma mansoni | survival motor neuron protein | 0.0045 | 0.0312 | 0.0803 |
Loa Loa (eye worm) | hypothetical protein | 0.0225 | 0.2739 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0225 | 0.2739 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0064 | 0.0565 | 0.2061 |
Loa Loa (eye worm) | abnormal chemotaxis protein 14 | 0.004 | 0.0236 | 0.086 |
Loa Loa (eye worm) | hypothetical protein | 0.0106 | 0.1133 | 0.4136 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0225 | 0.2739 | 1 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0225 | 0.2739 | 0.2666 |
Loa Loa (eye worm) | hypothetical protein | 0.0225 | 0.2739 | 1 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0225 | 0.2739 | 0.2666 |
Brugia malayi | tailless protein | 0.0106 | 0.1133 | 0.4136 |
Entamoeba histolytica | Niemann-Pick C1 protein, putative | 0.0093 | 0.095 | 1 |
Loa Loa (eye worm) | DR-78 | 0.0106 | 0.1133 | 0.4136 |
Brugia malayi | nuclear receptor RXR | 0.0119 | 0.1305 | 0.4764 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0034 | 0.0156 | 0.0213 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0225 | 0.2739 | 1 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0225 | 0.2739 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0225 | 0.2739 | 1 |
Echinococcus granulosus | thyroid hormone receptor alpha | 0.0106 | 0.1133 | 0.3915 |
Schistosoma mansoni | nuclear hormone receptor superfamily protein-related | 0.0106 | 0.1133 | 0.3915 |
Loa Loa (eye worm) | hypothetical protein | 0.0106 | 0.1133 | 0.4136 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0225 | 0.2739 | 1 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0034 | 0.0156 | 0.0057 |
Schistosoma mansoni | hepatocyte nuclear factor 4-alpha (hnf-4-alpha) | 0.0106 | 0.1133 | 0.3915 |
Brugia malayi | Helix-loop-helix DNA-binding domain containing protein | 0.0101 | 0.107 | 0.3906 |
Loa Loa (eye worm) | hypothetical protein | 0.0225 | 0.2739 | 1 |
Schistosoma mansoni | nuclear receptor nhr-48 | 0.0106 | 0.1133 | 0.3915 |
Echinococcus multilocularis | Niemann Pick C1 protein | 0.0093 | 0.095 | 0.0858 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0225 | 0.2739 | 0.2666 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0064 | 0.0565 | 0.2061 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0225 | 0.2739 | 1 |
Brugia malayi | nuclear hormone receptor | 0.0225 | 0.2739 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0106 | 0.1133 | 0.4136 |
Loa Loa (eye worm) | hypothetical protein | 0.0106 | 0.1133 | 0.4136 |
Brugia malayi | hypothetical protein | 0.0119 | 0.1305 | 0.4764 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0225 | 0.2739 | 1 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0225 | 0.2739 | 0.2666 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.003 | 0.01 | 0.0363 |
Entamoeba histolytica | hypothetical protein | 0.0034 | 0.0156 | 0.1641 |
Loa Loa (eye worm) | hypothetical protein | 0.0119 | 0.1305 | 0.4764 |
Loa Loa (eye worm) | hypothetical protein | 0.0106 | 0.1133 | 0.4136 |
Echinococcus granulosus | nuclear receptor subfamily 1 group D | 0.0119 | 0.1305 | 0.4567 |
Echinococcus granulosus | Niemann Pick C1 protein | 0.0132 | 0.1486 | 0.5253 |
Brugia malayi | nuclear receptor NHR-88 | 0.0225 | 0.2739 | 1 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0106 | 0.1133 | 0.1044 |
Schistosoma mansoni | nuclear hormone receptor | 0.0106 | 0.1133 | 0.3915 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0225 | 0.2739 | 1 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0225 | 0.2739 | 1 |
Brugia malayi | nuclear hormone receptor | 0.0106 | 0.1133 | 0.4136 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0112 | 0.1215 | 0.4437 |
Loa Loa (eye worm) | hypothetical protein | 0.0119 | 0.1305 | 0.4764 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0225 | 0.2739 | 1 |
Brugia malayi | ecdysone receptor | 0.0106 | 0.1133 | 0.4136 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0225 | 0.2739 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0106 | 0.1133 | 0.4136 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0225 | 0.2739 | 1 |
Onchocerca volvulus | 0.0106 | 0.1133 | 0.4136 | |
Loa Loa (eye worm) | hypothetical protein | 0.0106 | 0.1133 | 0.4136 |
Schistosoma mansoni | hypothetical protein | 0.0045 | 0.0312 | 0.0803 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.01 | 0.0363 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0225 | 0.2739 | 1 |
Brugia malayi | nuclear receptor NHR-67 | 0.0106 | 0.1133 | 0.4136 |
Brugia malayi | hypothetical protein | 0.0106 | 0.1133 | 0.4136 |
Schistosoma mansoni | hypothetical protein | 0.0038 | 0.0216 | 0.0442 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0106 | 0.1133 | 0.3915 |
Schistosoma mansoni | hypothetical protein | 0.0038 | 0.0216 | 0.0442 |
Echinococcus granulosus | nuclear receptor subfamily 4 group A | 0.0106 | 0.1133 | 0.3915 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0225 | 0.2739 | 1 |
Echinococcus granulosus | survival motor neuron protein 1 | 0.0222 | 0.2703 | 0.9862 |
Schistosoma mansoni | thyroid hormone receptor | 0.0225 | 0.2739 | 1 |
Echinococcus granulosus | transcription factor eb | 0.0101 | 0.107 | 0.3676 |
Echinococcus granulosus | Protein patched homolog 1 | 0.004 | 0.0236 | 0.0515 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0225 | 0.2739 | 1 |
Brugia malayi | hypothetical protein | 0.0119 | 0.1305 | 0.4764 |
Loa Loa (eye worm) | hypothetical protein | 0.0225 | 0.2739 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0034 | 0.0156 | 0.1641 |
Echinococcus multilocularis | Niemann Pick C1 protein | 0.0132 | 0.1486 | 0.1401 |
Brugia malayi | Nuclear hormone receptor E75 | 0.0106 | 0.1133 | 0.4136 |
Brugia malayi | conserved hypotetical protein | 0.0106 | 0.1133 | 0.4136 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0225 | 0.2739 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0119 | 0.1305 | 0.4764 |
Brugia malayi | Nuclear hormone receptor E75 | 0.0106 | 0.1133 | 0.4136 |
Loa Loa (eye worm) | nuclear hormone receptor-like 1 | 0.0119 | 0.1305 | 0.4764 |
Schistosoma mansoni | nuclear receptor | 0.0106 | 0.1133 | 0.3915 |
Echinococcus multilocularis | sterol regulatory element binding protein | 0.004 | 0.0236 | 0.0137 |
Brugia malayi | Iron-sulfur cluster assembly accessory protein | 0.0045 | 0.0312 | 0.1137 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.0236 | 0.086 |
Brugia malayi | hypothetical protein | 0.0034 | 0.0156 | 0.0569 |
Loa Loa (eye worm) | hypothetical protein | 0.0106 | 0.1133 | 0.4136 |
Loa Loa (eye worm) | hypothetical protein | 0.0106 | 0.1133 | 0.4136 |
Loa Loa (eye worm) | hypothetical protein | 0.0094 | 0.0965 | 0.3524 |
Schistosoma mansoni | hypothetical protein | 0.0064 | 0.0565 | 0.1762 |
Schistosoma mansoni | hypothetical protein | 0.0038 | 0.0216 | 0.0442 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0225 | 0.2739 | 1 |
Brugia malayi | orphan nuclear receptor NR2E1 | 0.0106 | 0.1133 | 0.4136 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0225 | 0.2739 | 1 |
Brugia malayi | nuclear hormone receptor family member nhr-6 | 0.0106 | 0.1133 | 0.4136 |
Echinococcus multilocularis | retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha | 0.0106 | 0.1133 | 0.1044 |
Echinococcus multilocularis | nuclear receptor subfamily 1 group D | 0.0119 | 0.1305 | 0.1218 |
Loa Loa (eye worm) | nuclear receptor nhr-7B | 0.0106 | 0.1133 | 0.4136 |
Echinococcus multilocularis | transcription factor eb | 0.0101 | 0.107 | 0.098 |
Loa Loa (eye worm) | hypothetical protein | 0.0106 | 0.1133 | 0.4136 |
Brugia malayi | MH2 domain containing protein | 0.0112 | 0.1215 | 0.4437 |
Schistosoma mansoni | ecdysone-induced protein 78c (dr-78) | 0.0119 | 0.1305 | 0.4567 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0225 | 0.2739 | 1 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0225 | 0.2739 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0225 | 0.2739 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0225 | 0.2739 | 1 |
Echinococcus multilocularis | survival motor neuron protein 1 | 0.0222 | 0.2703 | 0.2629 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.