Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium vivax | hypothetical protein, conserved | 0.0072 | 0.0789 | 1 |
Echinococcus multilocularis | pyruvate kinase | 0.0018 | 0.0058 | 0.0041 |
Mycobacterium tuberculosis | Probable lipase LipE | 0.0072 | 0.0789 | 0.0879 |
Loa Loa (eye worm) | hypothetical protein | 0.0459 | 0.5975 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0136 | 0.1649 | 0.2986 |
Mycobacterium ulcerans | hypothetical protein | 0.0072 | 0.0789 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0072 | 0.0789 | 0.1321 |
Echinococcus multilocularis | pyruvate kinase | 0.0035 | 0.0285 | 0.0269 |
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.0072 | 0.0789 | 0.1321 |
Schistosoma mansoni | hypothetical protein | 0.0032 | 0.0246 | 0.042 |
Schistosoma mansoni | lamin | 0.0025 | 0.0157 | 0.0257 |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.0072 | 0.0789 | 0.1321 |
Loa Loa (eye worm) | hypothetical protein | 0.0047 | 0.0445 | 0.0744 |
Echinococcus granulosus | beta LACTamase domain containing family member | 0.0072 | 0.0789 | 0.1296 |
Schistosoma mansoni | pyruvate kinase | 0.0035 | 0.0285 | 0.0491 |
Echinococcus granulosus | pyruvate kinase | 0.0018 | 0.0058 | 0.0069 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0285 | 0.0477 |
Mycobacterium leprae | conserved hypothetical protein | 0.0072 | 0.0789 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0136 | 0.1649 | 0.1635 |
Mycobacterium tuberculosis | Probable esterase/lipase LipP | 0.0072 | 0.0789 | 0.0879 |
Mycobacterium tuberculosis | Probable hydrolase | 0.0072 | 0.0789 | 0.0879 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0047 | 0.0445 | 0.0744 |
Loa Loa (eye worm) | hypothetical protein | 0.0015 | 0.0017 | 0.0028 |
Mycobacterium ulcerans | fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE | 0.0072 | 0.0789 | 1 |
Mycobacterium tuberculosis | Conserved protein | 0.0072 | 0.0789 | 0.0879 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0136 | 0.1649 | 0.2986 |
Schistosoma mansoni | pyruvate kinase | 0.0035 | 0.0285 | 0.0491 |
Mycobacterium tuberculosis | Probable lipase LipD | 0.0072 | 0.0789 | 0.0879 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0047 | 0.0445 | 0.0744 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0136 | 0.1649 | 0.2739 |
Loa Loa (eye worm) | beta-lactamase | 0.0072 | 0.0789 | 0.1321 |
Mycobacterium tuberculosis | Conserved protein | 0.0072 | 0.0789 | 0.0879 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.0246 | 0.0413 |
Mycobacterium tuberculosis | Probable esterase LipL | 0.0072 | 0.0789 | 0.0879 |
Brugia malayi | Pyruvate kinase, M2 isozyme | 0.0035 | 0.0285 | 0.0477 |
Schistosoma mansoni | lamin | 0.0025 | 0.0157 | 0.0257 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0025 | 0.0157 | 0.0263 |
Loa Loa (eye worm) | hypothetical protein | 0.0072 | 0.0789 | 0.1321 |
Echinococcus granulosus | sodium calcium exchanger | 0.0422 | 0.5483 | 0.9175 |
Mycobacterium tuberculosis | Conserved protein | 0.0072 | 0.0789 | 0.0879 |
Loa Loa (eye worm) | hypothetical protein | 0.0072 | 0.0789 | 0.1321 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0.0157 | 0.0263 |
Chlamydia trachomatis | pyruvate kinase | 0.0035 | 0.0285 | 0.5 |
Mycobacterium ulcerans | lipase LipD | 0.0072 | 0.0789 | 1 |
Entamoeba histolytica | pyruvate kinase, putative | 0.0024 | 0.0144 | 0.5 |
Mycobacterium tuberculosis | Probable conserved lipoprotein | 0.0072 | 0.0789 | 0.0879 |
Echinococcus multilocularis | survival motor neuron protein 1 | 0.0459 | 0.5975 | 0.5968 |
Loa Loa (eye worm) | hypothetical protein | 0.0169 | 0.2084 | 0.3489 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0136 | 0.1649 | 0.2759 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0072 | 0.0789 | 0.9462 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0015 | 0.0017 | 0.0028 |
Giardia lamblia | Pyruvate kinase | 0.0035 | 0.0285 | 1 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0072 | 0.0789 | 0.1413 |
Onchocerca volvulus | Pyruvate kinase homolog | 0.0035 | 0.0285 | 0.1391 |
Onchocerca volvulus | Pyruvate kinase homolog | 0.0035 | 0.0285 | 0.1391 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0136 | 0.1649 | 0.2759 |
Loa Loa (eye worm) | hypothetical protein | 0.0072 | 0.0789 | 0.1321 |
Leishmania major | hypothetical protein, conserved | 0.0072 | 0.0789 | 1 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0032 | 0.0246 | 0.0413 |
Mycobacterium ulcerans | esterase/lipase LipP | 0.0072 | 0.0789 | 1 |
Onchocerca volvulus | Pyruvate kinase homolog | 0.0035 | 0.0285 | 0.1391 |
Loa Loa (eye worm) | hypothetical protein | 0.0072 | 0.0789 | 0.1321 |
Plasmodium vivax | pyruvate kinase, putative | 0.0035 | 0.0285 | 0.3104 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0072 | 0.0789 | 1 |
Echinococcus granulosus | survival motor neuron protein 1 | 0.0459 | 0.5975 | 1 |
Trichomonas vaginalis | esterase, putative | 0.0072 | 0.0789 | 0.9462 |
Trichomonas vaginalis | alpha-L-fucosidase, putative | 0.0075 | 0.0818 | 1 |
Trichomonas vaginalis | alpha-L-fucosidase, putative | 0.0075 | 0.0818 | 1 |
Echinococcus granulosus | lamin dm0 | 0.0025 | 0.0157 | 0.0236 |
Mycobacterium ulcerans | beta-lactamase | 0.0072 | 0.0789 | 1 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0025 | 0.0157 | 0.0263 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0072 | 0.0789 | 0.9462 |
Loa Loa (eye worm) | pyruvate kinase | 0.0035 | 0.0285 | 0.0477 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0047 | 0.0445 | 0.0744 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0136 | 0.1649 | 0.2739 |
Onchocerca volvulus | 0.0094 | 0.1074 | 1 | |
Loa Loa (eye worm) | pyruvate kinase | 0.0035 | 0.0285 | 0.0477 |
Onchocerca volvulus | 0.0072 | 0.0789 | 0.689 | |
Toxoplasma gondii | pyruvate kinase PyK1 | 0.0035 | 0.0285 | 0.3104 |
Onchocerca volvulus | 0.0072 | 0.0789 | 0.689 | |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0015 | 0.0017 | 0.0028 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0072 | 0.0789 | 0.9462 |
Schistosoma mansoni | pyruvate kinase | 0.0018 | 0.0058 | 0.0075 |
Schistosoma mansoni | intermediate filament proteins | 0.0025 | 0.0157 | 0.0257 |
Onchocerca volvulus | 0.0072 | 0.0789 | 0.689 | |
Echinococcus multilocularis | lamin dm0 | 0.0025 | 0.0157 | 0.0141 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0072 | 0.0789 | 0.1413 |
Echinococcus granulosus | pyruvate kinase | 0.0018 | 0.0058 | 0.0069 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.0144 | 0.0241 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0072 | 0.0789 | 1 |
Echinococcus granulosus | intermediate filament protein | 0.0025 | 0.0157 | 0.0236 |
Echinococcus multilocularis | pyruvate kinase | 0.0035 | 0.0285 | 0.0269 |
Echinococcus multilocularis | pyruvate kinase | 0.0027 | 0.0187 | 0.017 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0.0151 | 0.0253 |
Echinococcus multilocularis | sodium calcium exchanger | 0.0422 | 0.5483 | 0.5475 |
Mycobacterium tuberculosis | Possible conserved lipoprotein LpqK | 0.0072 | 0.0789 | 0.0879 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0072 | 0.0789 | 0.9462 |
Brugia malayi | hypothetical protein | 0.0459 | 0.5975 | 1 |
Loa Loa (eye worm) | pyruvate kinase | 0.0035 | 0.0285 | 0.0477 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0462 | 0.6018 | 1 |
Brugia malayi | beta-lactamase family protein | 0.0072 | 0.0789 | 0.1321 |
Echinococcus granulosus | pyruvate kinase | 0.0035 | 0.0285 | 0.045 |
Schistosoma mansoni | hypothetical protein | 0.0094 | 0.1074 | 0.1935 |
Echinococcus multilocularis | lamin | 0.0025 | 0.0157 | 0.0141 |
Loa Loa (eye worm) | intermediate filament protein | 0.0025 | 0.0157 | 0.0263 |
Brugia malayi | Pyruvate kinase, muscle isozyme | 0.0035 | 0.0285 | 0.0477 |
Echinococcus multilocularis | musashi | 0.0025 | 0.0157 | 0.0141 |
Mycobacterium leprae | Probable lipase LipE | 0.0072 | 0.0789 | 1 |
Echinococcus granulosus | pyruvate kinase | 0.0035 | 0.0285 | 0.045 |
Echinococcus multilocularis | pyruvate kinase | 0.0018 | 0.0058 | 0.0041 |
Schistosoma mansoni | sodium/calcium exchanger | 0.0422 | 0.5483 | 1 |
Echinococcus multilocularis | pyruvate kinase | 0.0018 | 0.0058 | 0.0041 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0072 | 0.0789 | 1 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0015 | 0.0017 | 0.0028 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0136 | 0.1649 | 0.2986 |
Brugia malayi | Iron-sulfur cluster assembly accessory protein | 0.0094 | 0.1074 | 0.1798 |
Echinococcus granulosus | pyruvate kinase | 0.0018 | 0.0058 | 0.0069 |
Toxoplasma gondii | ABC1 family protein | 0.0072 | 0.0789 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0136 | 0.1649 | 0.1635 |
Brugia malayi | intermediate filament protein | 0.0025 | 0.0157 | 0.0263 |
Loa Loa (eye worm) | hypothetical protein | 0.0072 | 0.0789 | 0.1321 |
Brugia malayi | beta-lactamase family protein | 0.0072 | 0.0789 | 0.1321 |
Loa Loa (eye worm) | solute carrier family 8 | 0.0422 | 0.5483 | 0.9177 |
Schistosoma mansoni | survival motor neuron protein | 0.0094 | 0.1074 | 0.1935 |
Plasmodium falciparum | pyruvate kinase | 0.0035 | 0.0285 | 1 |
Loa Loa (eye worm) | pyruvate kinase-PB | 0.0024 | 0.0144 | 0.0241 |
Brugia malayi | Sodium/calcium exchanger protein | 0.0169 | 0.2084 | 0.3489 |
Echinococcus granulosus | lamin | 0.0025 | 0.0157 | 0.0236 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0072 | 0.0789 | 0.9462 |
Brugia malayi | beta-lactamase | 0.0072 | 0.0789 | 0.1321 |
Echinococcus multilocularis | beta LACTamase domain containing family member | 0.0072 | 0.0789 | 0.0774 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
GI50 (functional) | -4.615 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.57 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.503 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.217 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.