Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | microtubule associated protein 2 | 0.0721 | 0.5621 | 0.5 |
Mycobacterium ulcerans | thioesterase TesA | 0.0502 | 0.3337 | 0.443 |
Mycobacterium tuberculosis | Phenolpthiocerol synthesis type-I polyketide synthase PpsD | 0.0602 | 0.4383 | 0.5856 |
Leishmania major | hypothetical protein, conserved | 0.0181 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks5 | 0.0583 | 0.4191 | 0.5599 |
Onchocerca volvulus | Fatty acid synthase homolog | 0.1085 | 0.9418 | 1 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSE | 0.0398 | 0.2258 | 0.2941 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSC | 0.0639 | 0.4773 | 0.6337 |
Mycobacterium tuberculosis | Polyketide synthase Pks12 | 0.0639 | 0.4773 | 0.6376 |
Mycobacterium tuberculosis | Phenolpthiocerol synthesis type-I polyketide synthase PpsC | 0.0602 | 0.4383 | 0.5856 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSB | 0.0484 | 0.3157 | 0.4155 |
Mycobacterium tuberculosis | Probable multifunctional mycocerosic acid synthase membrane-associated Mas | 0.0639 | 0.4773 | 0.6376 |
Onchocerca volvulus | 0.1048 | 0.9028 | 0.9285 | |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsD | 0.0602 | 0.4383 | 0.5834 |
Mycobacterium tuberculosis | Phenolpthiocerol synthesis type-I polyketide synthase PpsA | 0.0602 | 0.4383 | 0.5856 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsA | 0.0484 | 0.3157 | 0.4188 |
Schistosoma mansoni | microtubule-associated protein tau | 0.0721 | 0.5621 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.1011 | 0.8648 | 1 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks8 | 0.0492 | 0.324 | 0.4329 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsE | 0.0398 | 0.2258 | 0.2981 |
Mycobacterium leprae | PROBABLE THIOESTERASE TESA | 0.0502 | 0.3337 | 0.4398 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks15 | 0.0243 | 0.0647 | 0.0864 |
Echinococcus granulosus | microtubule associated protein 2 | 0.0721 | 0.5621 | 0.5 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSA | 0.0602 | 0.4383 | 0.581 |
Loa Loa (eye worm) | hypothetical protein | 0.0337 | 0.1625 | 0.0823 |
Mycobacterium tuberculosis | Probable membrane bound polyketide synthase Pks6 | 0.09 | 0.7486 | 1 |
Mycobacterium ulcerans | polyketide synthase Pks13 | 0.09 | 0.7486 | 1 |
Mycobacterium ulcerans | polyketide synthase | 0.0602 | 0.4383 | 0.5834 |
Mycobacterium leprae | Polyketide synthase Pks13 | 0.09 | 0.7486 | 1 |
Toxoplasma gondii | beta-ketoacyl synthase, N-terminal domain-containing protein | 0.039 | 0.218 | 0.2574 |
Mycobacterium ulcerans | Type I modular polyketide synthase | 0.0602 | 0.4383 | 0.5834 |
Mycobacterium ulcerans | thioesterase | 0.0502 | 0.3337 | 0.443 |
Mycobacterium tuberculosis | Probable thioesterase TesA | 0.0502 | 0.3337 | 0.4459 |
Mycobacterium tuberculosis | Polyketide synthetase MbtC (polyketide synthase) | 0.0207 | 0.0267 | 0.0356 |
Mycobacterium tuberculosis | Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) | 0.0562 | 0.3971 | 0.5305 |
Mycobacterium ulcerans | fatty acid synthase Fas | 0.0189 | 0.0081 | 0.0056 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsC | 0.0639 | 0.4773 | 0.6357 |
Brugia malayi | Beta-ketoacyl synthase, N-terminal domain containing protein | 0.0602 | 0.4383 | 0.4383 |
Mycobacterium tuberculosis | Polyketide synthase Pks13 | 0.09 | 0.7486 | 1 |
Brugia malayi | AMP-binding enzyme family protein | 0.0562 | 0.3971 | 0.3971 |
Brugia malayi | AMP-binding enzyme family protein | 0.0185 | 0.0039 | 0.0039 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0181 | 0 | 0.5 |
Mycobacterium tuberculosis | Polyketide synthetase MbtD (polyketide synthase) | 0.0185 | 0.0039 | 0.0052 |
Giardia lamblia | Methyltransferase like 2 | 0.0181 | 0 | 0.5 |
Loa Loa (eye worm) | fatty acid synthase | 0.0594 | 0.43 | 0.4318 |
Mycobacterium tuberculosis | Polyketide synthase Pks2 | 0.0583 | 0.4191 | 0.5599 |
Loa Loa (eye worm) | AMP-binding enzyme family protein | 0.0562 | 0.3971 | 0.3889 |
Mycobacterium ulcerans | polyketide synthase | 0.0639 | 0.4773 | 0.6357 |
Toxoplasma gondii | type I fatty acid synthase, putative | 0.0428 | 0.2576 | 0.3708 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSD | 0.0602 | 0.4383 | 0.581 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsB | 0.0484 | 0.3157 | 0.4188 |
Mycobacterium leprae | Probable multifunctional mycocerosic acid synthase membrane associated enzyme Mas | 0.0639 | 0.4773 | 0.6337 |
Toxoplasma gondii | type I fatty acid synthase, putative | 0.0639 | 0.4773 | 1 |
Mycobacterium tuberculosis | Probable fatty acid synthase Fas (fatty acid synthetase) | 0.0189 | 0.0081 | 0.0108 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks9 | 0.0342 | 0.1676 | 0.224 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks1 | 0.0432 | 0.2616 | 0.3495 |
Mycobacterium ulcerans | Type I modular polyketide synthase | 0.0602 | 0.4383 | 0.5834 |
Mycobacterium ulcerans | Type I modular polyketide synthase | 0.0602 | 0.4383 | 0.5834 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks7 | 0.0639 | 0.4773 | 0.6376 |
Mycobacterium ulcerans | polyketide synthase Pks9 | 0.0398 | 0.2258 | 0.2981 |
Mycobacterium leprae | Probable polyketide synthase Pks1 | 0.0639 | 0.4773 | 0.6337 |
Mycobacterium ulcerans | multifunctional mycocerosic acid synthase membrane-associated Mas | 0.0639 | 0.4773 | 0.6357 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ratio (binding) | = 0.889 | Inhibition of human neuraminidase2 using 4-MU-NANA as substrate assessed as residual activity at 100 uM preincubated for 15 mins prior addition of substrate measured after 5 mins by fluorimetry relative to control in presence of 125 uM EDTA | ChEMBL. | 22410247 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.