Detailed information for compound 1628426

Basic information

Technical information
  • TDR Targets ID: 1628426
  • Name: [4-(6-methylaminoimidazo[1,2-a]pyridin-2-yl)p henyl] N,N-dimethylcarbamate
  • MW: 310.35 | Formula: C17H18N4O2
  • H donors: 1 H acceptors: 2 LogP: 3.17 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: CNc1ccc2n(c1)cc(n2)c1ccc(cc1)OC(=O)N(C)C
  • InChi: 1S/C17H18N4O2/c1-18-13-6-9-16-19-15(11-21(16)10-13)12-4-7-14(8-5-12)23-17(22)20(2)3/h4-11,18H,1-3H3
  • InChiKey: QZRJZBQJBAQFKI-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • N,N-dimethylcarbamic acid [4-(6-methylamino-2-imidazo[1,2-a]pyridinyl)phenyl] ester
  • N,N-dimethylcarbamic acid [4-(6-methylaminoimidazo[1,2-a]pyridin-2-yl)phenyl] ester
  • NSC708028
  • NCI60_038298

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis conserved hypothetical protein 0.0608 0.1356 0.2235
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0235 0.0514 0.0514
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0043 0.0081 0.043
Entamoeba histolytica protein kinase domain containing protein 0.0082 0.0171 0.5
Schistosoma mansoni protein kinase 0.0082 0.0171 0.0171
Giardia lamblia hypothetical protein 0.0235 0.0514 1
Entamoeba histolytica serine/threonine protein kinase 6, putative 0.0082 0.0171 0.5
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0043 0.0081 0.043
Echinococcus granulosus aurora kinase A 0.0082 0.0171 0.0908
Trypanosoma brucei cAMP phosphodiesterase A, putative 0.0235 0.0514 0.1436
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0235 0.0514 0.3787
Toxoplasma gondii hypothetical protein 0.0608 0.1356 1
Leishmania major hypothetical protein, conserved 0.1591 0.3574 1
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0235 0.0514 0.2727
Loa Loa (eye worm) hypothetical protein 0.0235 0.0514 0.0513
Schistosoma mansoni camp-specific cyclic nucleotide phosphodiesterase 0.0235 0.0514 0.0514
Schistosoma mansoni aldehyde dehydrogenase 0.0061 0.0123 0.0123
Brugia malayi serine/threonine protein kinase 6 0.0082 0.0171 0.017
Brugia malayi Probable 3',5'-cyclic phosphodiesterase T04D3.3, putative 0.0235 0.0514 0.0513
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0235 0.0514 0.0647
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0842 0.1886 0.3233
Trypanosoma brucei GAF domain/TIP41-like family, putative 0.1591 0.3574 1
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0235 0.0514 0.0647
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0043 0.0081 0.043
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0842 0.1886 0.3233
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0235 0.0514 0.3787
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.0235 0.0514 0.0647
Echinococcus multilocularis dual 3',5' cyclic AMP and GMP phosphodiesterase 0.0842 0.1886 1
Echinococcus multilocularis aurora kinase A 0.0082 0.0171 0.0908
Entamoeba histolytica serine/threonine- protein kinase 6 , putative 0.0082 0.0171 0.5
Trypanosoma cruzi hypothetical protein, conserved 0.0235 0.0514 0.1436
Trypanosoma cruzi GAF domain/TIP41-like family, putative 0.1591 0.3574 1
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0008 0.0004 0.0019
Brugia malayi serine/threonine kinase 12 0.0082 0.0171 0.017
Plasmodium falciparum 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0235 0.0514 0.2894
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0235 0.0514 0.3787
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.0842 0.1886 0.3233
Trypanosoma brucei 3', 5'-cyclic nucleotide phosphodiesterase, putative 0.0235 0.0514 0.1436
Plasmodium falciparum cGMP-specific phosphodiesterase 0.0235 0.0514 0.2894
Loa Loa (eye worm) CAMK/CAMKL/CHK1 protein kinase 0.0152 0.0329 0.0328
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0842 0.1886 0.5275
Trichomonas vaginalis calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0235 0.0514 0.0647
Echinococcus granulosus cpg binding protein 0.0028 0.0049 0.0258
Trypanosoma brucei hypothetical protein, conserved 0.0235 0.0514 0.1436
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0842 0.1886 0.3233
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0235 0.0514 0.3787
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0235 0.0514 0.3787
Plasmodium falciparum 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0235 0.0514 0.2894
Plasmodium vivax phosphodiesterase gamma, putative 0.0235 0.0514 0.2894
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0235 0.0514 0.0514
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0235 0.0514 0.0647
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0235 0.0514 0.3787
Trypanosoma cruzi GAF domain/TIP41-like family, putative 0.1591 0.3574 1
Schistosoma mansoni aldehyde dehydrogenase 0.0061 0.0123 0.0123
Entamoeba histolytica serine/threonine- protein kinase 6, putative 0.0082 0.0171 0.5
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0235 0.0514 0.3787
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0235 0.0514 0.0514
Brugia malayi Protein kinase domain containing protein 0.0152 0.0329 0.0328
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.0235 0.0514 0.2727
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.0235 0.0514 0.2727
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.0235 0.0514 0.0647
Leishmania major hypothetical protein, conserved 0.0235 0.0514 0.1436
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0842 0.1886 0.3233
Mycobacterium ulcerans aldehyde dehydrogenase 0.0061 0.0123 0.0247
Giardia lamblia Hypothetical protein 0.0235 0.0514 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0043 0.0081 0.0081
Toxoplasma gondii aldehyde dehydrogenase 0.0061 0.0123 0.09
Echinococcus granulosus dual 3'5' cyclic AMP and GMP phosphodiesterase 0.0842 0.1886 1
Echinococcus granulosus high affinity cAMP specific 3'5' cyclic 0.0235 0.0514 0.2727
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0842 0.1886 0.3233
Echinococcus multilocularis high affinity cAMP specific 3',5' cyclic 0.0235 0.0514 0.2727
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0235 0.0514 0.3787
Onchocerca volvulus 0.0027 0.0045 0.5
Brugia malayi Cytochrome P450 family protein 0.0025 0.004 0.0039
Schistosoma mansoni calcium/calmodulin-dependent 35-cyclic nucleotide phosphodiesterase 0.0235 0.0514 0.0514
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0842 0.1886 0.3233
Plasmodium falciparum cGMP-specific phosphodiesterase 0.0235 0.0514 0.2894
Trypanosoma cruzi cytochrome P450, putative 0.0025 0.004 0.011
Trypanosoma brucei 3', 5'-cyclic nucleotide phosphodiesterase, putative 0.0235 0.0514 0.1436
Entamoeba histolytica protein kinase , putative 0.0082 0.0171 0.5
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0842 0.1886 0.3233
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0025 0.004 0.008
Mycobacterium ulcerans two component sensor histidine kinase DevS 0.2199 0.4945 1
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0043 0.0081 0.008
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0235 0.0514 0.0647
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0008 0.0004 0.0019
Trichomonas vaginalis conserved hypothetical protein 0.0235 0.0514 0.0647
Toxoplasma gondii histone lysine methyltransferase SET1 0.0051 0.0099 0.0725
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0842 0.1886 0.3233
Trypanosoma brucei aurora B kinase 0.0082 0.0171 0.0476
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0043 0.0081 0.0081
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0842 0.1886 0.3233
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0235 0.0514 0.0513
Mycobacterium ulcerans aldehyde dehydrogenase 0.0061 0.0123 0.0247
Mycobacterium tuberculosis Conserved hypothetical protein 0.1591 0.3574 0.7226
Trypanosoma cruzi cAMP phosphodiesterase A, putative 0.0235 0.0514 0.1436
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0842 0.1886 0.3233
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0235 0.0514 0.3787
Giardia lamblia CAMP-specific 3,5-cyclic phosphodiesterase 4B 0.0235 0.0514 1
Loa Loa (eye worm) AUR protein kinase 0.0082 0.0171 0.017
Trypanosoma brucei cAMP-specific phosphodiesterase, putative 0.0235 0.0514 0.1436
Plasmodium falciparum GAF domain-related protein, putative 0.0608 0.1356 1
Plasmodium falciparum phosphodiesterase delta, putative 0.0235 0.0514 0.2894
Entamoeba histolytica protein kinase, putative 0.0082 0.0171 0.5
Trichomonas vaginalis conserved hypothetical protein 0.0235 0.0514 0.0647
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0235 0.0514 0.2727
Loa Loa (eye worm) CXXC zinc finger family protein 0.0027 0.0045 0.0044
Trypanosoma cruzi cyclic nucleotide phosphodiesterase 0.0235 0.0514 0.1436
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0235 0.0514 0.3787
Echinococcus granulosus high affinity cgmp specific 3' 5' cyclic 0.0235 0.0514 0.2727
Echinococcus multilocularis cAMP and cAMP inhibited cGMP 3',5' cyclic 0.0842 0.1886 1
Loa Loa (eye worm) AUR protein kinase 0.0082 0.0171 0.017
Leishmania major cAMP phosphodiesterase A, putative;with=GeneDB:LinJ18_V3.1100 0.0235 0.0514 0.1436
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.0235 0.0514 0.2727
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0061 0.0123 0.0652
Brugia malayi serine/threonine-protein kinase 6 0.0082 0.0171 0.017
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0235 0.0514 0.0514
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.0235 0.0514 0.0647
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0842 0.1886 0.3233
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.0235 0.0514 0.2727
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0842 0.1886 0.3233
Leishmania major protein kinase, putative 0.0082 0.0171 0.0476
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0235 0.0514 0.3787
Loa Loa (eye worm) cytochrome P450 family protein 0.0025 0.004 0.0039
Trypanosoma brucei cytochrome P450, putative 0.0025 0.004 0.011
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0235 0.0514 0.3787
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0842 0.1886 0.3233
Plasmodium vivax 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0235 0.0514 0.2894
Echinococcus multilocularis high affinity cgmp specific 3' 5' cyclic 0.0235 0.0514 0.2727
Trypanosoma cruzi hypothetical protein, conserved 0.0235 0.0514 0.1436
Loa Loa (eye worm) cytochrome P450 family protein 0.0025 0.004 0.0039
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0057 0.0113 0.0113
Trypanosoma cruzi hypothetical protein, conserved 0.0235 0.0514 0.1436
Plasmodium vivax 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0235 0.0514 0.2894
Echinococcus multilocularis 0.0007 0.0001 0.0005
Echinococcus granulosus cytochrome P450 2K1 0.0007 0.0001 0.0005
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0235 0.0514 0.0514
Leishmania major cytochrome p450-like protein 0.0025 0.004 0.011
Trichomonas vaginalis conserved hypothetical protein 0.0608 0.1356 0.2235
Trichomonas vaginalis conserved hypothetical protein 0.0608 0.1356 0.2235
Schistosoma mansoni cpg binding protein 0.0028 0.0049 0.0049
Trichomonas vaginalis conserved hypothetical protein 0.0608 0.1356 0.2235
Mycobacterium ulcerans putative regulatory protein 0.0608 0.1356 0.2741
Plasmodium vivax hypothetical protein, conserved 0.0608 0.1356 1
Trypanosoma cruzi cAMP phosphodiesterase A, putative 0.0235 0.0514 0.1436
Plasmodium vivax cyclic nucleotide phosphodiesterase, putative 0.0235 0.0514 0.2894
Echinococcus granulosus serine:threonine protein kinase 12 B 0.0082 0.0171 0.0908
Trypanosoma cruzi hypothetical protein, conserved 0.0235 0.0514 0.1436
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.2433 0.5475 1
Schistosoma mansoni hypothetical protein 0.0007 0.0001 0.0001
Brugia malayi Probable 3',5'-cyclic phosphodiesterase R153.1, putative 0.0235 0.0514 0.0513
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0235 0.0514 0.3787
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0842 0.1886 0.3233
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0842 0.1886 0.5275
Plasmodium falciparum phosphodiesterase gamma, putative 0.0235 0.0514 0.2894
Schistosoma mansoni cpg binding protein 0.0028 0.0049 0.0049
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0842 0.1886 0.3233
Loa Loa (eye worm) hypothetical protein 0.0608 0.1356 0.1356
Loa Loa (eye worm) CYP4Cod1 0.0025 0.004 0.0039
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0842 0.1886 0.5275
Loa Loa (eye worm) hypothetical protein 0.4439 1 1
Trypanosoma cruzi hypothetical protein, conserved 0.0235 0.0514 0.1436
Toxoplasma gondii GAF domain-containing protein 0.0608 0.1356 1
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0235 0.0514 0.0514
Brugia malayi Cytochrome P450 family protein 0.0025 0.004 0.0039
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0842 0.1886 0.3233
Toxoplasma gondii aurora kinase 0.0082 0.0171 0.1256
Schistosoma mansoni camp/cgmp cyclic nucleotide phosphodiesterase 0.0842 0.1886 0.1886
Mycobacterium leprae conserved hypothetical protein 0.0608 0.1356 1
Echinococcus granulosus cAMP and cAMP inhibited cGMP 3'5' cyclic 0.0842 0.1886 1
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0842 0.1886 0.3233
Toxoplasma gondii hypothetical protein 0.0608 0.1356 1
Loa Loa (eye worm) hypothetical protein 0.0017 0.0024 0.0023
Schistosoma mansoni TPX2 protein 0.0106 0.0224 0.0224
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0842 0.1886 0.3233
Schistosoma mansoni cytochrome P450 0.0007 0.0001 0.0001
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0842 0.1886 0.3233
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.1825 0.4103 0.7414
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0043 0.0081 0.043
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0235 0.0514 0.3787
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0235 0.0514 0.3787
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0235 0.0514 0.2727
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0842 0.1886 0.5275
Brugia malayi Probable 3',5'-cyclic phosphodiesterase C32E12.2, putative 0.0842 0.1886 0.1885
Trypanosoma cruzi cAMP-specific phosphodiesterase, putative 0.0235 0.0514 0.1436
Loa Loa (eye worm) calcium/calmodulin-stimulated cyclic nucleotide phosphodiesterase 0.0235 0.0514 0.0513
Entamoeba histolytica protein kinase, putative 0.0082 0.0171 0.5
Schistosoma mansoni cpg binding protein 0.0027 0.0045 0.0045
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0235 0.0514 0.0513
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0235 0.0514 0.3787
Loa Loa (eye worm) AUR protein kinase 0.0082 0.0171 0.017
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0061 0.0123 0.0342
Echinococcus multilocularis cpg binding protein 0.0028 0.0049 0.0258
Loa Loa (eye worm) histone methyltransferase 0.0008 0.0004 0.0003
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0061 0.0123 0.0652
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0061 0.0123 0.0247
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0235 0.0514 0.2727
Mycobacterium ulcerans aldehyde dehydrogenase 0.0061 0.0123 0.0247
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0842 0.1886 0.3233
Leishmania major hypothetical protein, conserved 0.0235 0.0514 0.1436
Leishmania major cAMP-specific phosphodiesterase, putative 0.0235 0.0514 0.1436
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0842 0.1886 0.3233
Brugia malayi CXXC zinc finger family protein 0.0027 0.0045 0.0044
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0842 0.1886 0.3233
Trypanosoma cruzi cytochrome P450, putative 0.0025 0.004 0.011
Schistosoma mansoni serine/threonine protein kinase 0.0152 0.0329 0.0329
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.1825 0.4103 0.7414
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0235 0.0514 0.0647
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0235 0.0514 0.3787
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0235 0.0514 0.3787
Trypanosoma cruzi hypothetical protein, conserved 0.0235 0.0514 0.1436
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0235 0.0514 0.0514
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0043 0.0081 0.008
Toxoplasma gondii hypothetical protein 0.0608 0.1356 1
Trypanosoma cruzi aurora B kinase, putative 0.0082 0.0171 0.0476
Trichomonas vaginalis conserved hypothetical protein 0.2433 0.5475 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0043 0.0081 0.0081
Schistosoma mansoni cgmp-dependent 35-cyclic phosphodiesterase 0.4439 1 1
Mycobacterium tuberculosis Two component sensor histidine kinase DevS 0.2199 0.4945 1
Trichomonas vaginalis cAMP/cGMP cyclic nucleotide phosphodiesterase, putative 0.0842 0.1886 0.3233
Loa Loa (eye worm) PDE1B protein 0.0235 0.0514 0.0513
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0842 0.1886 0.3233
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0842 0.1886 0.3233
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.2433 0.5475 1
Loa Loa (eye worm) hypothetical protein 0.0235 0.0514 0.0513
Echinococcus multilocularis serine:threonine protein kinase 12 B 0.0082 0.0171 0.0908
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0842 0.1886 0.3233
Mycobacterium tuberculosis Two component sensor histidine kinase DosT 0.0608 0.1356 0.2741
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0235 0.0514 0.1436
Mycobacterium ulcerans putative regulatory protein 0.0608 0.1356 0.2741
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0235 0.0514 0.0647
Brugia malayi F/Y-rich N-terminus family protein 0.0008 0.0003 0.0002
Schistosoma mansoni serine/threonine protein kinase 0.0082 0.0171 0.0171
Loa Loa (eye worm) hypothetical protein 0.0235 0.0514 0.0513
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0842 0.1886 0.5275
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0842 0.1886 0.3233
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.2433 0.5475 1

Activities

Activity type Activity value Assay description Source Reference
GI50 (functional) -4.85 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.717 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MDA-N Breast cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.717 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.676 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.674 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.647 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.646 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.637 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-5 Melanoma cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.614 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the DU-145 Prostate cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.265 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MALME-3M Melanoma cell line. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.