Detailed information for compound 1630694

Basic information

Technical information
  • TDR Targets ID: 1630694
  • Name: 7-chloro-N-(2-dimethylaminoethyl)phenazine-1- carboxamide hydrochloride
  • MW: 365.257 | Formula: C17H18Cl2N4O
  • H donors: 1 H acceptors: 3 LogP: 3.38 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: CN(CCNC(=O)c1cccc2c1nc1ccc(cc1n2)Cl)C.Cl
  • InChi: 1S/C17H17ClN4O.ClH/c1-22(2)9-8-19-17(23)12-4-3-5-14-16(12)21-13-7-6-11(18)10-15(13)20-14;/h3-7,10H,8-9H2,1-2H3,(H,19,23);1H
  • InChiKey: PTBHXCSBYFHADS-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 7-chloro-N-(2-dimethylaminoethyl)-1-phenazinecarboxamide hydrochloride
  • NSC617979

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0085 0.0183 0.1398
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0188 0.0596 0.5505
Echinococcus granulosus cathepsin L 0.0041 0.001 0.0074
Trypanosoma cruzi cysteine peptidase, putative 0.0101 0.0248 0.2285
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0085 0.0183 1
Brugia malayi cathepsin F-like cysteine proteinase 0.0041 0.001 0.0089
Plasmodium vivax unspecified product 0.0041 0.001 0.001
Echinococcus granulosus cathepsin L cysteine protease 0.0101 0.0248 0.1889
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0188 0.0596 1
Loa Loa (eye worm) hypothetical protein 0.0129 0.0358 0.331
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0041 0.001 0.001
Trypanosoma cruzi cruzipain precursor, putative 0.0188 0.0596 0.5505
Brugia malayi Papain family cysteine protease containing protein 0.0041 0.001 0.0089
Echinococcus multilocularis cathepsin L 0.0041 0.001 0.0074
Entamoeba histolytica cysteine proteinase, putative 0.0101 0.0248 0.4054
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0101 0.0248 0.0248
Entamoeba histolytica cysteine protease, putative 0.0101 0.0248 0.4054
Plasmodium falciparum cysteine proteinase falcipain 1 0.0101 0.0248 0.0238
Brugia malayi cathepsin L-like cysteine proteinase 0.0041 0.001 0.0089
Entamoeba histolytica cysteine protease, putative 0.0101 0.0248 0.4054
Onchocerca volvulus 0.0188 0.0596 1
Echinococcus granulosus cathepsin l cysteine peptidase 0.0188 0.0596 0.4551
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0188 0.0596 0.4551
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.001 0.0016
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0085 0.0183 0.1398
Brugia malayi Cathepsin L-like precursor 0.0188 0.0596 0.5505
Onchocerca volvulus Cathepsin L homolog 0.0041 0.001 0.0162
Brugia malayi Papain family cysteine protease containing protein 0.0041 0.001 0.0089
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0041 0.001 0.0016
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0188 0.0596 0.0587
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0188 0.0596 0.096
Plasmodium falciparum cysteine proteinase falcipain 3 0.0188 0.0596 0.0587
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0188 0.0596 1
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0129 0.0358 0.331
Echinococcus granulosus cathepsin b 0.031 0.1083 0.8267
Trypanosoma cruzi cysteine peptidase, putative 0.0188 0.0596 0.5505
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0056 0.0066 0.0786
Toxoplasma gondii cathepsin CPL 0.0188 0.0596 0.0596
Leishmania major cathepsin L-like protease 0.0188 0.0596 1
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0188 0.0596 0.4551
Leishmania major cathepsin L-like protease 0.0188 0.0596 1
Leishmania major cathepsin L-like protease 0.0188 0.0596 1
Toxoplasma gondii cathepsin CPC2 0.0989 0.38 0.38
Schistosoma mansoni cathepsin F (C01 family) 0.0188 0.0596 0.0596
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0188 0.0596 0.096
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0041 0.001 0.0016
Onchocerca volvulus 0.0129 0.0358 0.6012
Plasmodium vivax serine-repeat antigen 2 (SERA) 0.0041 0.001 0.001
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0041 0.001 0.0016
Brugia malayi Papain family cysteine protease containing protein 0.0101 0.0248 0.2285
Entamoeba histolytica cysteine protease, putative 0.0101 0.0248 0.4054
Entamoeba histolytica cysteine proteinase 2 0.0101 0.0248 0.4054
Brugia malayi Cathepsin L-like precursor 0.0188 0.0596 0.5505
Brugia malayi Probable ClpP-like protease 0.0085 0.0183 0.1691
Onchocerca volvulus 0.0188 0.0596 1
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0101 0.0248 0.0248
Loa Loa (eye worm) hypothetical protein 0.0129 0.0358 0.331
Toxoplasma gondii cathepsin B 0.0124 0.0342 0.0342
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0188 0.0596 0.096
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0188 0.0596 0.096
Brugia malayi Cathepsin L-like precursor 0.0188 0.0596 0.5505
Entamoeba histolytica cysteine protease, putative 0.0101 0.0248 0.4054
Giardia lamblia Encystation-specific protease 0.0989 0.38 0.3794
Loa Loa (eye worm) cathepsin B 0.0124 0.0342 0.3155
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0074 0.0139 0.1064
Loa Loa (eye worm) hypothetical protein 0.0041 0.001 0.0089
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0085 0.0183 0.0183
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0041 0.001 0.001
Echinococcus multilocularis cathepsin L cysteine protease 0.0188 0.0596 0.4551
Schistosoma mansoni cathepsin S (C01 family) 0.0041 0.001 0.001
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0101 0.0248 0.4151
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0188 0.0596 1
Plasmodium falciparum dipeptidyl aminopeptidase 2 0.2539 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0188 0.0596 0.096
Trypanosoma cruzi cysteine proteinase, putative 0.0101 0.0248 0.2285
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0101 0.0248 0.2285
Onchocerca volvulus 0.0054 0.0058 0.0979
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0188 0.0596 0.096
Plasmodium vivax serine-repeat antigen 4 (SERA) 0.0041 0.001 0.001
Plasmodium vivax vivapain-1 0.0101 0.0248 0.0248
Entamoeba histolytica cysteine protease, putative 0.0101 0.0248 0.4054
Brugia malayi cathepsin Z-like cysteine proteinase 0.0041 0.001 0.0089
Brugia malayi Cathepsin L-like precursor 0.0188 0.0596 0.5505
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.031 0.1083 0.1083
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0188 0.0596 0.5505
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0074 0.0139 0.1287
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0188 0.0596 0.0587
Echinococcus granulosus cysteine protease 0.0101 0.0248 0.1889
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0124 0.0342 0.0342
Echinococcus granulosus cathepsin b 0.031 0.1083 0.8267
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0074 0.0139 0.1287
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0188 0.0596 0.096
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0041 0.001 0.001
Echinococcus multilocularis cysteine protease 0.0188 0.0596 0.4551
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.001 0.0016
Echinococcus multilocularis cathepsin b 0.031 0.1083 0.8267
Onchocerca volvulus 0.0188 0.0596 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0188 0.0596 0.096
Plasmodium vivax serine-repeat antigen 3 (SERA) 0.0041 0.001 0.001
Entamoeba histolytica cysteine protease, putative 0.0101 0.0248 0.4054
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0188 0.0596 0.096
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.2539 1 1
Echinococcus granulosus peptidase Clp S14 family 0.0056 0.0066 0.0505
Brugia malayi Cathepsin L-like precursor 0.0059 0.0082 0.0753
Plasmodium vivax dipeptidyl aminopeptidase 2, putative 0.2539 1 1
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0989 0.38 0.3794
Brugia malayi cathepsin L-like precursor 0.0129 0.0358 0.331
Entamoeba histolytica cysteine proteinase, putative 0.0129 0.0358 0.5946
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0188 0.0596 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0101 0.0248 0.0399
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0069 0.012 0.0193
Trypanosoma cruzi cysteine protease, putative 0.0101 0.0248 0.2285
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0041 0.001 0.001
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0085 0.0183 0.5
Schistosoma mansoni cathepsin s 0.0059 0.0082 0.0082
Onchocerca volvulus 0.0188 0.0596 1
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0056 0.0066 0.0786
Trypanosoma brucei cysteine peptidase C (CPC) 0.0124 0.0342 0.573
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0041 0.001 0.001
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0124 0.0342 0.3155
Plasmodium vivax vivapain-2 0.0188 0.0596 0.0596
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0041 0.001 0.0016
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0188 0.0596 0.096
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0188 0.0596 0.096
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0041 0.001 0.001
Entamoeba histolytica cysteine protease, putative 0.0101 0.0248 0.4054
Echinococcus granulosus cathepsin L cysteine proteinase 0.0188 0.0596 0.4551
Echinococcus granulosus cathepsin l1 0.0188 0.0596 0.4551
Echinococcus multilocularis cathepsin L 0.0101 0.0248 0.1889
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.0124 0.0342 0.573
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0041 0.001 0.001
Trypanosoma cruzi major cysteine proteinase, putative 0.0041 0.001 0.0089
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.031 0.1083 0.1083
Leishmania major cathepsin L-like protease 0.0188 0.0596 1
Loa Loa (eye worm) hypothetical protein 0.0041 0.001 0.0089
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0041 0.001 0.0016
Brugia malayi cathepsin B-like cysteine proteinase 0.031 0.1083 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0041 0.001 0.0016
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0074 0.0139 0.1064
Plasmodium vivax vivapain-3 0.0101 0.0248 0.0248
Echinococcus multilocularis tumor protein p63 0.0367 0.131 1
Onchocerca volvulus 0.0188 0.0596 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0188 0.0596 0.096
Entamoeba histolytica cysteine proteinase 1, putative 0.0101 0.0248 0.4054
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0041 0.001 0.0016
Loa Loa (eye worm) ctsf protein 0.0188 0.0596 0.5505
Onchocerca volvulus 0.0188 0.0596 1
Brugia malayi Cathepsin L-like precursor 0.0129 0.0358 0.331
Echinococcus multilocularis cathepsin L cysteine protease 0.0188 0.0596 0.4551
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0188 0.0596 0.096
Plasmodium vivax serine-repeat antigen (SERA) 0.0041 0.001 0.001
Giardia lamblia Cathepsin B precursor 0.0124 0.0342 0.0332
Echinococcus granulosus tumor protein p63 0.0367 0.131 1
Loa Loa (eye worm) hypothetical protein 0.0085 0.0183 0.1691
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0188 0.0596 0.096
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0188 0.0596 0.096
Schistosoma mansoni cathepsin B (C01 family) 0.0041 0.001 0.001
Brugia malayi Cathepsin L-like precursor 0.0188 0.0596 0.5505
Echinococcus multilocularis cathepsin b 0.031 0.1083 0.8267
Trypanosoma cruzi cysteine peptidase, putative 0.0188 0.0596 0.5505
Plasmodium vivax dipeptidyl aminopeptidase 3, putative 0.0989 0.38 0.38
Schistosoma mansoni cellular tumor antigen P53 0.0054 0.0058 0.0058
Plasmodium vivax unspecified product 0.0101 0.0248 0.0248
Plasmodium vivax serine-repeat antigen (SERA) 0.0041 0.001 0.001
Plasmodium vivax unspecified product 0.0059 0.0082 0.0082
Entamoeba histolytica cysteine proteinase, putative 0.0101 0.0248 0.4054
Loa Loa (eye worm) hypothetical protein 0.0041 0.001 0.0089
Loa Loa (eye worm) hypothetical protein 0.0054 0.0058 0.0539
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0188 0.0596 1
Plasmodium falciparum dipeptidyl aminopeptidase 1 0.2539 1 1
Toxoplasma gondii preprocathepsin c precursor, putative 0.2539 1 1
Schistosoma mansoni cathepsin F (C01 family) 0.0188 0.0596 0.0596
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0085 0.0183 1
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0085 0.0183 0.5
Leishmania major cathepsin L-like protease 0.0188 0.0596 1
Leishmania major cathepsin L-like protease 0.0188 0.0596 1
Trichomonas vaginalis Clan CA, family C1, cathepsin H-like cysteine peptidase 0.0041 0.001 0.0016
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0041 0.001 0.0016
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0041 0.001 0.0016
Plasmodium vivax vivapain-2 0.0188 0.0596 0.0596
Schistosoma mansoni voltage-gated potassium channel 0.0081 0.0167 0.0167
Onchocerca volvulus 0.0188 0.0596 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0188 0.0596 0.096
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0188 0.0596 0.096
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0989 0.38 0.3794
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.0059 0.0082 0.0753
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0188 0.0596 0.096
Echinococcus granulosus cathepsin l1 0.0129 0.0358 0.2736
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0188 0.0596 1
Trypanosoma cruzi cysteine peptidase, putative 0.0188 0.0596 0.5505
Trypanosoma cruzi cysteine proteinase, putative 0.0101 0.0248 0.2285
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0188 0.0596 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase 0.0041 0.001 0.0016
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0041 0.001 0.0089
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0188 0.0596 0.096
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0188 0.0596 0.096
Schistosoma mansoni voltage-gated potassium channel 0.0081 0.0167 0.0167
Plasmodium vivax dipeptidyl aminopeptidase 1, putative 0.2539 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin F-like cysteine peptidase 0.0041 0.001 0.0016
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0056 0.0066 0.3615
Entamoeba histolytica cysteine proteinase, putative 0.0188 0.0596 1
Loa Loa (eye worm) cysteine proteinase cathepsin Z 0.0041 0.001 0.0089
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0188 0.0596 0.096
Schistosoma mansoni subfamily C1A non-peptidase homologue (C01 family) 0.0041 0.001 0.001
Plasmodium vivax serine-repeat antigen 4 (SERA), putative 0.0041 0.001 0.001
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0188 0.0596 1
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0059 0.0082 0.0753
Schistosoma mansoni peptidase Clp (S14 family) 0.0085 0.0183 0.0183
Brugia malayi cathepsin F-like cysteine proteinase 0.0059 0.0082 0.0753
Onchocerca volvulus Cathepsin L homolog 0.0188 0.0596 1
Mycobacterium tuberculosis Possible penicillin-binding protein 0.025 0.0842 1
Giardia lamblia Cathepsin B precursor 0.0124 0.0342 0.0332
Loa Loa (eye worm) hypothetical protein 0.0059 0.0082 0.0753
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0188 0.0596 1
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.1591 0.6209 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0188 0.0596 0.096
Schistosoma mansoni cathepsin C 0.0041 0.001 0.001
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0041 0.001 0.001
Brugia malayi cahepsin L-like non-peptiedase homolog 0.0041 0.001 0.0089
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0085 0.0183 0.0183
Brugia malayi cathepsin L precursor 0.0041 0.001 0.0089
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0085 0.0183 0.0183
Brugia malayi Cathepsin L-like precursor 0.0188 0.0596 0.5505
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0041 0.001 0.0016
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0129 0.0358 0.0577
Loa Loa (eye worm) hypothetical protein 0.0059 0.0082 0.0753
Giardia lamblia Cathepsin B precursor 0.0124 0.0342 0.0332
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0041 0.001 0.0016
Echinococcus multilocularis peptidase Clp (S14 family) 0.0056 0.0066 0.0505
Loa Loa (eye worm) hypothetical protein 0.0041 0.001 0.0089
Entamoeba histolytica cysteine proteinase, putative 0.0101 0.0248 0.4054
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0085 0.0183 0.5
Loa Loa (eye worm) hypothetical protein 0.0041 0.001 0.0089
Trypanosoma cruzi cysteine peptidase, putative 0.0188 0.0596 0.5505
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0041 0.001 0.0016
Trichomonas vaginalis Clan CA, family C1, cathepsin L or H-like cysteine peptidase 0.0041 0.001 0.0016
Brugia malayi Cathepsin L-like cysteine proteinase 0.0129 0.0358 0.331
Loa Loa (eye worm) hypothetical protein 0.031 0.1083 1
Loa Loa (eye worm) hypothetical protein 0.0188 0.0596 0.5505
Entamoeba histolytica cysteine proteinase, putative 0.0188 0.0596 1
Trypanosoma cruzi cysteine peptidase, putative 0.0059 0.0082 0.0753
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0101 0.0248 0.0399
Loa Loa (eye worm) hypothetical protein 0.0059 0.0082 0.0753
Toxoplasma gondii cathepsin CPC1 0.2539 1 1
Entamoeba histolytica cysteine protease, putative 0.0188 0.0596 1
Loa Loa (eye worm) hypothetical protein 0.0129 0.0358 0.331
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0085 0.0183 1
Entamoeba histolytica cysteine proteinase, putative 0.0101 0.0248 0.4054
Schistosoma mansoni cathepsin F (C01 family) 0.0129 0.0358 0.0358
Leishmania major cathepsin L-like protease 0.0188 0.0596 1
Brugia malayi Cathepsin L-like precursor 0.0129 0.0358 0.331
Loa Loa (eye worm) cysteine protease 0.0188 0.0596 0.5505
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.031 0.1083 0.1083
Brugia malayi Papain family cysteine protease containing protein 0.0188 0.0596 0.5505
Entamoeba histolytica cysteine protease, putative 0.0101 0.0248 0.4054
Entamoeba histolytica cysteine protease, putative 0.0101 0.0248 0.4054
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0129 0.0358 0.0577
Plasmodium vivax serine-repeat antigen 5 (SERA) 0.0041 0.001 0.001
Entamoeba histolytica cysteine protease, putative 0.0101 0.0248 0.4054
Trypanosoma cruzi cruzipain precursor, putative 0.0059 0.0082 0.0753
Trypanosoma cruzi major cysteine proteinase, putative 0.0041 0.001 0.0089
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0188 0.0596 0.096
Brugia malayi cathepsin Z-like cysteine proteinase 0.0041 0.001 0.0089
Onchocerca volvulus Cathepsin L homolog 0.0188 0.0596 1
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0101 0.0248 0.0248
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0085 0.0183 0.5
Echinococcus multilocularis cysteine protease 0.0188 0.0596 0.4551
Entamoeba histolytica cysteine protease, putative 0.0101 0.0248 0.4054
Plasmodium falciparum dipeptidyl aminopeptidase 3 0.0989 0.38 0.3794
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.031 0.1083 0.1083
Onchocerca volvulus Cathepsin F homolog 0.0188 0.0596 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0188 0.0596 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0188 0.0596 1
Entamoeba histolytica cysteine protease, putative 0.0101 0.0248 0.4054
Onchocerca volvulus 0.0041 0.001 0.0162
Loa Loa (eye worm) hypothetical protein 0.0064 0.01 0.0926
Brugia malayi fibroinase precursor 0.0041 0.001 0.0089
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0041 0.001 0.001
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0085 0.0183 0.0174
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0069 0.012 0.0193
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0188 0.0596 0.096
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0101 0.0248 0.4151
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.031 0.1083 1
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0124 0.0342 0.055
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0188 0.0596 0.096
Leishmania major cathepsin L-like protease 0.0188 0.0596 1
Loa Loa (eye worm) hypothetical protein 0.0041 0.001 0.0089
Leishmania major cysteine peptidase A (CPA) 0.0188 0.0596 1
Entamoeba histolytica cysteine protease, putative 0.0101 0.0248 0.4054
Loa Loa (eye worm) fibroinase 0.0188 0.0596 0.5505
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0041 0.001 0.0089
Brugia malayi Papain family cysteine protease containing protein 0.0041 0.001 0.0089
Brugia malayi Papain family cysteine protease containing protein 0.0101 0.0248 0.2285
Echinococcus granulosus cathepsin L 0.0101 0.0248 0.1889

Activities

Activity type Activity value Assay description Source Reference
GI50 (functional) -5.993 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -5.732 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MALME-3M Melanoma cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -5.698 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -5.683 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -5.506 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -5.496 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-5 Melanoma cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -5.479 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -5.371 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -5.239 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.