TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 348.87 | Formula: C18H25ClN4O
H donors: 0 H acceptors: 3 LogP: 4.37 Rotable bonds: 7
Rule of 5 violations (Lipinski): 1
SMILES: CCCCCCO[C@H]1C[C@H]2C[C@@H]1C[C@@H]2n1cnc2c1ncnc2Cl
InChi: 1S/C18H25ClN4O/c1-2-3-4-5-6-24-15-9-12-7-13(15)8-14(12)23-11-22-16-17(19)20-10-21-18(16)23/h10-15H,2-9H2,1H3/t12-,13-,14+,15+/m1/s1
InChiKey: QAMCCSUNKJYDJW-KBXIAJHMSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	subfamily C1A non-peptidase homologue (C01 family)	0.0048	0.0013	0.0005
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0048	0.0013	0.0005
Brugia malayi	cathepsin F-like cysteine proteinase	0.0078	0.0042	0.1923
Echinococcus granulosus	cathepsin l1	0.0163	0.0122	0.6119
Onchocerca volvulus		0.0242	0.0197	1
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0078	0.0042	0.2127
Echinococcus granulosus	cathepsin l cysteine peptidase	0.0242	0.0197	1
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0013	0.0669
Loa Loa (eye worm)	cysteine proteinase cathepsin Z	0.0048	0.0013	0.0669
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0048	0.0013	0.0017
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0127	0.0088	0.2294
Brugia malayi	Cathepsin L-like precursor	0.0078	0.0042	0.1923
Brugia malayi	Papain family cysteine protease containing protein	0.0127	0.0088	0.4308
Brugia malayi	Cathepsin L-like precursor	0.0242	0.0197	1
Onchocerca volvulus		0.0242	0.0197	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0242	0.0197	0.0313
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0127	0.0088	0.0079
Echinococcus multilocularis	cysteine protease	0.0242	0.0197	1
Echinococcus multilocularis	cathepsin L	0.0048	0.0013	0.0427
Entamoeba histolytica	cysteine protease, putative	0.0127	0.0088	0.4054
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0242	0.0197	0.0313
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0013	0.0669
Onchocerca volvulus	Cathepsin L homolog	0.0242	0.0197	1
Loa Loa (eye worm)	cathepsin B	0.0092	0.0055	0.28
Echinococcus multilocularis	cathepsin L	0.0127	0.0088	0.4308
Brugia malayi	Cathepsin L-like precursor	0.0242	0.0197	1
Loa Loa (eye worm)	fibroinase	0.0242	0.0197	1
Entamoeba histolytica	cysteine proteinase, putative	0.0127	0.0088	0.4054
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0242	0.0197	0.0313
Plasmodium vivax	vivapain-2	0.0242	0.0197	0.0184
Plasmodium vivax	dipeptidyl aminopeptidase 3, putative	0.4039	0.3803	0.3794
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0242	0.0197	0.0313
Echinococcus multilocularis	cathepsin L cysteine protease	0.0242	0.0197	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0242	0.0197	1
Entamoeba histolytica	cysteine protease, putative	0.0127	0.0088	0.4054
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0242	0.0197	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0242	0.0197	1
Entamoeba histolytica	cysteine protease, putative	0.0242	0.0197	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0242	0.0197	0.0313
Trypanosoma cruzi	cysteine peptidase (N-terminal), putative	0.0127	0.0088	0.4054
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0242	0.0197	0.0313
Loa Loa (eye worm)	voltage and ligand gated potassium channel	0.004	0.0005	0.0252
Plasmodium falciparum	cysteine proteinase falcipain 3	0.0242	0.0197	0.0184
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or H-like cysteine peptidase	0.0048	0.0013	0.0017
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0013	0.0669
Leishmania major	cathepsin L-like protease	0.0242	0.0197	1
Brugia malayi	Cathepsin L-like precursor	0.0242	0.0197	1
Echinococcus granulosus	cathepsin L cysteine protease	0.0127	0.0088	0.4308
Entamoeba histolytica	cysteine proteinase, putative	0.0127	0.0088	0.4054
Trypanosoma cruzi	cysteine protease, putative	0.0127	0.0088	0.4054
Loa Loa (eye worm)	cysteine protease	0.0242	0.0197	1
Leishmania major	cathepsin L-like protease	0.0242	0.0197	1
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0127	0.0088	0.0079
Loa Loa (eye worm)	hypothetical protein	0.0078	0.0042	0.2127
Trichomonas vaginalis	conserved hypothetical protein	0.0048	0.0013	0.0017
Entamoeba histolytica	cysteine proteinase 2	0.0127	0.0088	0.4054
Schistosoma mansoni	subfamily C1A unassigned peptidase (C01 family)	0.0048	0.0013	0.0005
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0242	0.0197	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0092	0.0055	0.0085
Brugia malayi	cathepsin F-like cysteine proteinase	0.0048	0.0013	0.0427
Brugia malayi	cathepsin B-like cysteine proteinase	0.0191	0.0149	0.7496
Giardia lamblia	Cathepsin B precursor	0.0092	0.0055	0.0042
Plasmodium vivax	unspecified product	0.0127	0.0088	0.0075
Plasmodium vivax	vivapain-2	0.0242	0.0197	0.0184
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0013	0.0669
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.6576	0.6211	1
Echinococcus granulosus	cathepsin l1	0.0242	0.0197	1
Entamoeba histolytica	cysteine protease, putative	0.0127	0.0088	0.4054
Giardia lamblia	Cathepsin B precursor	0.0092	0.0055	0.0042
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0048	0.0013	0.0017
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0242	0.0197	1
Trypanosoma cruzi	cysteine proteinase, putative	0.0127	0.0088	0.4054
Entamoeba histolytica	cysteine proteinase, putative	0.0242	0.0197	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0242	0.0197	0.0313
Leishmania major	cathepsin L-like protease	0.0242	0.0197	1
Onchocerca volvulus		0.0163	0.0122	0.5946
Brugia malayi	cathepsin L precursor	0.0048	0.0013	0.0427
Onchocerca volvulus		0.0242	0.0197	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0242	0.0197	0.0313
Onchocerca volvulus	Cathepsin F homolog	0.0242	0.0197	1
Echinococcus multilocularis	cathepsin b	0.0191	0.0149	0.7496
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0242	0.0197	1
Loa Loa (eye worm)	hypothetical protein	0.0191	0.0149	0.7559
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0048	0.0013	0.0669
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0048	0.0013	0.0017
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0048	0.0013	0.0017
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0048	0.0013	0.0017
Entamoeba histolytica	cysteine protease, putative	0.0127	0.0088	0.4054
Brugia malayi	cahepsin L-like non-peptiedase homolog	0.0048	0.0013	0.0427
Plasmodium vivax	vivapain-1	0.0127	0.0088	0.0075
Onchocerca volvulus		0.0242	0.0197	1
Brugia malayi	Papain family cysteine protease containing protein	0.0242	0.0197	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0242	0.0197	0.0313
Echinococcus granulosus	cathepsin b	0.0191	0.0149	0.7496
Trypanosoma cruzi	cysteine peptidase, putative	0.0242	0.0197	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0242	0.0197	0.0313
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0163	0.0122	0.5946
Schistosoma mansoni	cathepsin C	0.0048	0.0013	0.0005
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0127	0.0088	0.2294
Leishmania major	cathepsin L-like protease	0.0242	0.0197	1
Trypanosoma cruzi	cysteine proteinase, putative	0.0127	0.0088	0.4054
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0191	0.0149	0.014
Trichomonas vaginalis	Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase	0.0048	0.0013	0.0017
Entamoeba histolytica	cysteine protease, putative	0.0127	0.0088	0.4054
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0048	0.0013	0.0017
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0242	0.0197	0.0313
Entamoeba histolytica	cysteine protease, putative	0.0127	0.0088	0.4054
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0048	0.0013	0.0005
Toxoplasma gondii	preprocathepsin c precursor, putative	1.0567	1	1
Brugia malayi	cathepsin L-like precursor	0.0163	0.0122	0.6119
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0242	0.0197	1
Trypanosoma cruzi	cruzipain precursor, putative	0.0078	0.0042	0.1563
Loa Loa (eye worm)	hypothetical protein	0.0078	0.0042	0.2127
Plasmodium falciparum	dipeptidyl aminopeptidase 3	0.4039	0.3803	0.3794
Brugia malayi	Cathepsin L-like precursor	0.0163	0.0122	0.6119
Trypanosoma cruzi	cysteine peptidase, putative	0.0127	0.0088	0.4054
Entamoeba histolytica	cysteine proteinase, putative	0.0163	0.0122	0.5946
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0242	0.0197	0.0313
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0048	0.0013	0.0017
Toxoplasma gondii	cathepsin CPC1	1.0567	1	1
Plasmodium vivax	dipeptidyl aminopeptidase 1, putative	1.0567	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0048	0.0013	0.0017
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0048	0.0013	0.0005
Brugia malayi	Papain family cysteine protease containing protein	0.0048	0.0013	0.0427
Echinococcus granulosus	cathepsin L	0.0048	0.0013	0.0427
Loa Loa (eye worm)	hypothetical protein	0.0242	0.0197	1
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.0242	0.0197	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0163	0.0122	0.0193
Entamoeba histolytica	cysteine proteinase 1, putative	0.0127	0.0088	0.4054
Leishmania major	cathepsin L-like protease	0.0242	0.0197	1
Entamoeba histolytica	cysteine proteinase, putative	0.0127	0.0088	0.4054
Echinococcus granulosus	cysteine protease	0.0127	0.0088	0.4308
Entamoeba histolytica	cysteine proteinase, putative	0.0127	0.0088	0.4054
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0242	0.0197	0.0313
Entamoeba histolytica	cysteine protease, putative	0.0127	0.0088	0.4054
Schistosoma mansoni	cathepsin F (C01 family)	0.0163	0.0122	0.0114
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0127	0.0088	0.0137
Echinococcus multilocularis	cysteine protease	0.0242	0.0197	1
Echinococcus multilocularis	cathepsin b	0.0191	0.0149	0.7496
Echinococcus multilocularis	cathepsin L cysteine protease	0.0242	0.0197	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0242	0.0197	0.0313
Giardia lamblia	Encystation-specific protease	0.4039	0.3803	0.3794
Echinococcus granulosus	cathepsin L cysteine proteinase	0.0242	0.0197	1
Brugia malayi	Papain family cysteine protease containing protein	0.0127	0.0088	0.4308
Schistosoma mansoni	cathepsin F (C01 family)	0.0242	0.0197	0.0189
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0048	0.0013	0.0017
Leishmania major	cathepsin L-like protease	0.0242	0.0197	1
Onchocerca volvulus		0.0242	0.0197	1
Leishmania major	cathepsin L-like protease	0.0242	0.0197	1
Schistosoma mansoni	subfamily C1A unassigned peptidase (C01 family)	0.0048	0.0013	0.0005
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0048	0.0013	0.0017
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0242	0.0197	0.0313
Trichomonas vaginalis	Clan CA, family C1, cathepsin F-like cysteine peptidase	0.0048	0.0013	0.0017
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0242	0.0197	0.0313
Entamoeba histolytica	cysteine protease, putative	0.0127	0.0088	0.4054
Leishmania major	cathepsin L-like protease	0.0242	0.0197	1
Giardia lamblia	Dipeptidyl-peptidase I precursor	0.4039	0.3803	0.3794
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0242	0.0197	0.0313
Plasmodium falciparum	dipeptidyl aminopeptidase 2	1.0567	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0048	0.0013	0.0017
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0242	0.0197	0.0313
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0013	0.0669
Brugia malayi	Cathepsin L-like precursor	0.0242	0.0197	1
Entamoeba histolytica	cysteine protease, putative	0.0127	0.0088	0.4054
Echinococcus granulosus	cathepsin L	0.0127	0.0088	0.4308
Brugia malayi	fibroinase precursor	0.0048	0.0013	0.0427
Brugia malayi	cathepsin Z-like cysteine proteinase	0.0048	0.0013	0.0427
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0242	0.0197	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0242	0.0197	1
Trichomonas vaginalis	conserved hypothetical protein	0.0048	0.0013	0.0017
Plasmodium falciparum	dipeptidyl aminopeptidase 1	1.0567	1	1
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0191	0.0149	0.7385
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0048	0.0013	0.0005
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0092	0.0055	0.2284
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0191	0.0149	0.014
Loa Loa (eye worm)	hypothetical protein	0.0163	0.0122	0.6217
Trypanosoma cruzi	cruzipain precursor, putative	0.0242	0.0197	1
Plasmodium vivax	vivapain-3	0.0127	0.0088	0.0075
Loa Loa (eye worm)	hypothetical protein	0.0163	0.0122	0.6217
Trypanosoma cruzi	cysteine peptidase, putative	0.0242	0.0197	1
Schistosoma mansoni	cathepsin S (C01 family)	0.0048	0.0013	0.0005
Entamoeba histolytica	cysteine protease, putative	0.0127	0.0088	0.4054
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0013	0.0669
Brugia malayi	cathepsin L-like cysteine proteinase, identical	0.0078	0.0042	0.1923
Entamoeba histolytica	cysteine protease, putative	0.0127	0.0088	0.4054
Entamoeba histolytica	cysteine protease, putative	0.0127	0.0088	0.4054
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0242	0.0197	1
Leishmania major	cysteine peptidase A (CPA)	0.0242	0.0197	1
Trypanosoma cruzi	cysteine peptidase, putative	0.0078	0.0042	0.1563
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.0242	0.0197	0.0184
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0242	0.0197	0.0313
Loa Loa (eye worm)	hypothetical protein	0.0078	0.0042	0.2127
Entamoeba histolytica	cysteine protease, putative	0.0127	0.0088	0.4054
Echinococcus granulosus	cathepsin b	0.0191	0.0149	0.7496
Schistosoma mansoni	SmCB2 peptidase (C01 family)	0.0191	0.0149	0.014
Toxoplasma gondii	cathepsin CPL	0.0242	0.0197	0.0142
Schistosoma mansoni	cathepsin s	0.0078	0.0042	0.0033
Schistosoma mansoni	cathepsin B (C01 family)	0.0048	0.0013	0.0005
Brugia malayi	cathepsin Z-like cysteine proteinase	0.0048	0.0013	0.0427
Trypanosoma cruzi	cysteine peptidase, putative	0.0242	0.0197	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0242	0.0197	0.0313
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0242	0.0197	0.0313
Plasmodium falciparum	cysteine proteinase falcipain 1	0.0127	0.0088	0.0075
Loa Loa (eye worm)	ctsf protein	0.0242	0.0197	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin H-like cysteine peptidase	0.0048	0.0013	0.0017
Loa Loa (eye worm)	hypothetical protein	0.0163	0.0122	0.6217
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0048	0.0013	0.0017
Schistosoma mansoni	dipeptidyl-peptidase I (C01 family)	1.0567	1	1
Onchocerca volvulus		0.0242	0.0197	1
Entamoeba histolytica	cysteine proteinase, putative	0.0242	0.0197	1
Onchocerca volvulus	Cathepsin L homolog	0.0242	0.0197	1
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0048	0.0013	0.0669
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0127	0.0088	0.0079
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0127	0.0088	0.0137
Giardia lamblia	Cathepsin B precursor	0.0092	0.0055	0.0042
Brugia malayi	Papain family cysteine protease containing protein	0.0048	0.0013	0.0427
Brugia malayi	Cathepsin L-like precursor	0.0242	0.0197	1
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0092	0.0055	0.0047
Toxoplasma gondii	cathepsin CPC2	0.4039	0.3803	0.3768
Brugia malayi	cathepsin L-like cysteine proteinase	0.0048	0.0013	0.0427
Brugia malayi	Cathepsin L-like cysteine proteinase	0.0163	0.0122	0.6119
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0242	0.0197	0.0313
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0242	0.0197	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0242	0.0197	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0242	0.0197	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0242	0.0197	0.0313
Giardia lamblia	Dipeptidyl-peptidase I precursor	0.4039	0.3803	0.3794
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0242	0.0197	0.0313
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0163	0.0122	0.0193
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0242	0.0197	0.0313
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0242	0.0197	1
Plasmodium vivax	dipeptidyl aminopeptidase 2, putative	1.0567	1	1
Brugia malayi	Cathepsin L-like precursor	0.0163	0.0122	0.6119
Brugia malayi	Cathepsin L-like precursor	0.0242	0.0197	1
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.0242	0.0197	0.0184
Schistosoma mansoni	cathepsin F (C01 family)	0.0242	0.0197	0.0189
Onchocerca volvulus		0.0242	0.0197	1
Trypanosoma cruzi	cysteine peptidase, putative	0.0242	0.0197	1
Brugia malayi	Papain family cysteine protease containing protein	0.0048	0.0013	0.0427
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0048	0.0013	0.0005
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0191	0.0149	0.014
Plasmodium vivax	unspecified product	0.0078	0.0042	0.0029

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL2012054

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1634041