TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 490.862 | Formula: C23H18ClF3N4O3
H donors: 2 H acceptors: 3 LogP: 3.78 Rotable bonds: 8
Rule of 5 violations (Lipinski): 1
SMILES: NCc1oc(nc1C(=O)NCc1ccccc1Cl)c1ccc(c2c1ccc(n2)C(F)(F)F)OC
InChi: 1S/C23H18ClF3N4O3/c1-33-16-8-6-14(13-7-9-18(23(25,26)27)30-19(13)16)22-31-20(17(10-28)34-22)21(32)29-11-12-4-2-3-5-15(12)24/h2-9H,10-11,28H2,1H3,(H,29,32)
InChiKey: BZCNNIGZRWTXTC-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	phosphodiesterase 4B, cAMP-specific	Starlite/ChEMBL	References
Homo sapiens	phosphodiesterase 11A	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Schistosoma japonicum	IPR002073,3'5'-cyclic nucleotide phosphodiesterase,domain-containing	Get druggable targets OG5_128242	All targets in OG5_128242
Candida albicans	similar to S. cerevisiae PDE2 (YOR360C) cAMP phosphodiesterase	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Leishmania mexicana	cAMP specific phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Echinococcus multilocularis	cAMP specific 3',5' cyclic phosphodiesterase	Get druggable targets OG5_128242	All targets in OG5_128242
Trichomonas vaginalis	cAMP-specific 3,5-cyclic phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	cAMP-specific 3,5-cyclic phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	cyclic nucleotide phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trypanosoma brucei	cAMP-specific phosphodiesterase	Get druggable targets OG5_127318	All targets in OG5_127318
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	Get druggable targets OG5_128242	All targets in OG5_128242
Schistosoma japonicum	cAMP-specific 3',5'-cyclic phosphodiesterase 4D, putative	Get druggable targets OG5_128242	All targets in OG5_128242
Trichomonas vaginalis	cGMP-dependent 3,5-cyclic phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Schistosoma japonicum	expressed protein	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	cGMP-specific 3,5-cyclic phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trypanosoma cruzi	cAMP specific phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Cryptosporidium parvum	membrane associated HD superfamily cyclic nucleotide phosphodiesterase domain containing protein	Get druggable targets OG5_128242	All targets in OG5_128242
Leishmania braziliensis	cAMP specific phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trypanosoma cruzi	cAMP specific phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Schistosoma japonicum	cAMP-specific 3',5'-cyclic phosphodiesterase, isoform F, putative	Get druggable targets OG5_128242	All targets in OG5_128242
Schistosoma japonicum	cAMP-specific 3',5'-cyclic phosphodiesterase 4C, putative	Get druggable targets OG5_128242	All targets in OG5_128242
Leishmania mexicana	cAMP specific phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	conserved hypothetical protein	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	cGMP-specific 3,5-cyclic phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	cone cGMP-specific 3,5-cyclic phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	rod cGMP-specific 3,5-cyclic phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	cAMP-specific phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	conserved hypothetical protein	Get druggable targets OG5_127318	All targets in OG5_127318
Trypanosoma cruzi	cAMP specific phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Schistosoma japonicum	Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Echinococcus multilocularis	cAMP specific 3',5' cyclic phosphodiesterase	Get druggable targets OG5_128242	All targets in OG5_128242
Leishmania donovani	cAMP specific phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Echinococcus granulosus	cAMP specific 3'5' cyclic phosphodiesterase	Get druggable targets OG5_128242	All targets in OG5_128242
Trichomonas vaginalis	cone cGMP-specific 3,5-cyclic phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	cGMP-dependent 3,5-cyclic phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Schistosoma japonicum	Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	cGMP-specific 3,5-cyclic phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Giardia lamblia	CAMP-specific 3,5-cyclic phosphodiesterase 4B	Get druggable targets OG5_128242	All targets in OG5_128242
Trichomonas vaginalis	cyclic nucleotide phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Neospora caninum	cAMP-specific phosphodiesterase, putative	Get druggable targets OG5_128242	All targets in OG5_128242
Echinococcus granulosus	cAMP specific 3'5' cyclic phosphodiesterase	Get druggable targets OG5_128242	All targets in OG5_128242
Trichomonas vaginalis	conserved hypothetical protein	Get druggable targets OG5_127318	All targets in OG5_127318
Schistosoma mansoni	camp/cgmp cyclic nucleotide phosphodiesterase	Get druggable targets OG5_127318	All targets in OG5_127318
Trypanosoma brucei	cAMP-specific phosphodiesterase	Get druggable targets OG5_127318	All targets in OG5_127318
Toxoplasma gondii	hypothetical protein	Get druggable targets OG5_127318	All targets in OG5_127318
Cryptosporidium hominis	hypothetical protein	Get druggable targets OG5_128242	All targets in OG5_128242
Trypanosoma brucei gambiense	cAMP-specific phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Candida albicans	similar to S. cerevisiae PDE2 (YOR360C) cAMP phosphodiesterase	Get druggable targets OG5_127318	All targets in OG5_127318
Echinococcus granulosus	cAMP specific 3'5' cyclic phosphodiesterase	Get druggable targets OG5_128242	All targets in OG5_128242
Loa Loa (eye worm)	cyclic AMP specific phosphodiesterase PDE4D5A	Get druggable targets OG5_128242	All targets in OG5_128242
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	cAMP-specific phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Echinococcus multilocularis	dual 3',5' cyclic AMP and GMP phosphodiesterase	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	rod cGMP-specific 3,5-cyclic phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Schistosoma mansoni	camp-specific 35-cyclic phosphodiesterase	Get druggable targets OG5_128242	All targets in OG5_128242
Echinococcus multilocularis	cAMP specific 3',5' cyclic phosphodiesterase	Get druggable targets OG5_128242	All targets in OG5_128242
Trypanosoma congolense	cAMP-specific phosphodiesterase	Get druggable targets OG5_127318	All targets in OG5_127318
Trypanosoma brucei gambiense	cAMP-specific phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Brugia malayi	Probable 3',5'-cyclic phosphodiesterase R153.1, putative	Get druggable targets OG5_128242	All targets in OG5_128242
Trichomonas vaginalis	conserved hypothetical protein	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trypanosoma congolense	cAMP-specific phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trypanosoma cruzi	cAMP specific phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Schistosoma japonicum	cAMP-specific 3',5'-cyclic phosphodiesterase 4D, putative	Get druggable targets OG5_128242	All targets in OG5_128242
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	rod cGMP-specific 3,5-cyclic phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Echinococcus granulosus	dual 3'5' cyclic AMP and GMP phosphodiesterase	Get druggable targets OG5_127318	All targets in OG5_127318
Schistosoma japonicum	Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Leishmania braziliensis	cAMP specific phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_128242	All targets in OG5_128242
Trichomonas vaginalis	cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	cGMP-inhibited 3,5-cyclic phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Leishmania infantum	cAMP specific phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Leishmania infantum	cAMP specific phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	cyclic nucleotide phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	cAMP/cGMP cyclic nucleotide phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318
Trichomonas vaginalis	cAMP-specific phosphodiesterase, putative	Get druggable targets OG5_127318	All targets in OG5_127318

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Brugia malayi	3'5'-cyclic nucleotide phosphodiesterase family protein	phosphodiesterase 11A	489 aa	471 aa	34.4 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0098	0.0062	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0098	0.0062	1
Echinococcus granulosus	cathepsin l1	0.0066	0.002	0.2167
Trypanosoma cruzi	cAMP specific phosphodiesterase, putative	0.0087	0.0047	0.7676
Trichomonas vaginalis	cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0087	0.0047	0.0076
Trichomonas vaginalis	conserved hypothetical protein	0.0065	0.0018	0.0029
Trichomonas vaginalis	conserved hypothetical protein	0.0065	0.0018	0.0029
Onchocerca volvulus		0.0098	0.0062	1
Entamoeba histolytica	cysteine proteinase, putative	0.0098	0.0062	1
Trypanosoma brucei	cAMP-specific phosphodiesterase	0.0087	0.0047	0.7676
Trichomonas vaginalis	conserved hypothetical protein	0.0065	0.0018	0.0029
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0098	0.0062	1
Brugia malayi	Cathepsin L-like precursor	0.0098	0.0062	1
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.0087	0.0047	0.0076
Trypanosoma cruzi	cysteine peptidase, putative	0.0098	0.0062	1
Echinococcus multilocularis	cAMP specific 3',5' cyclic phosphodiesterase	0.0098	0.0061	0.6766
Trichomonas vaginalis	cone cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0087	0.0047	0.0076
Echinococcus multilocularis	cysteine protease	0.0098	0.0062	0.6811
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0098	0.0062	0.0099
Plasmodium falciparum	dipeptidyl aminopeptidase 3	0.2972	0.3768	0.3768
Schistosoma mansoni	cathepsin F (C01 family)	0.0098	0.0062	0.0062
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0098	0.0062	0.0099
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0098	0.0062	0.0099
Onchocerca volvulus		0.0098	0.0062	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0098	0.0062	0.0099
Plasmodium vivax	dipeptidyl aminopeptidase 3, putative	0.2972	0.3768	0.3768
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.0087	0.0047	0.0076
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0098	0.0062	0.0099
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0098	0.0062	0.0099
Schistosoma mansoni	dipeptidyl-peptidase I (C01 family)	0.7802	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0098	0.0062	0.0099
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0066	0.002	0.0032
Brugia malayi	Cathepsin L-like cysteine proteinase	0.0066	0.002	0.3182
Leishmania major	cathepsin L-like protease	0.0098	0.0062	1
Trypanosoma cruzi	cysteine peptidase, putative	0.0098	0.0062	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0098	0.0062	1
Leishmania major	cysteine peptidase A (CPA)	0.0098	0.0062	1
Plasmodium falciparum	dipeptidyl aminopeptidase 2	0.7802	1	1
Trichomonas vaginalis	cAMP/cGMP cyclic nucleotide phosphodiesterase, putative	0.0087	0.0047	0.0076
Echinococcus granulosus	cathepsin l1	0.0098	0.0062	0.6811
Plasmodium vivax	vivapain-2	0.0098	0.0062	0.0062
Trypanosoma cruzi	cAMP specific phosphodiesterase, putative	0.0087	0.0047	0.7676
Trichomonas vaginalis	cyclic nucleotide phosphodiesterase, putative	0.0087	0.0047	0.0076
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.0098	0.0062	0.0062
Brugia malayi	cathepsin L-like precursor	0.0066	0.002	0.3182
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0098	0.0062	0.0099
Brugia malayi	Cathepsin L-like precursor	0.0066	0.002	0.3182
Trichomonas vaginalis	cAMP-specific phosphodiesterase, putative	0.0064	0.0017	0.0027
Leishmania major	cathepsin L-like protease	0.0098	0.0062	1
Loa Loa (eye worm)	ctsf protein	0.0098	0.0062	0.5928
Onchocerca volvulus	Cathepsin L homolog	0.0098	0.0062	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0098	0.0062	1
Echinococcus granulosus	cAMP specific 3'5' cyclic phosphodiesterase	0.0121	0.009	1
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0066	0.002	0.3182
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0098	0.0062	1
Plasmodium falciparum	cysteine proteinase falcipain 3	0.0098	0.0062	0.0062
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0098	0.0062	0.6811
Trichomonas vaginalis	rod cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0087	0.0047	0.0076
Echinococcus multilocularis	cAMP specific 3',5' cyclic phosphodiesterase	0.0121	0.009	1
Trichomonas vaginalis	cAMP-specific phosphodiesterase, putative	0.0087	0.0047	0.0076
Brugia malayi	Cathepsin L-like precursor	0.0098	0.0062	1
Brugia malayi	Cathepsin L-like precursor	0.0098	0.0062	1
Toxoplasma gondii	preprocathepsin c precursor, putative	0.7802	1	1
Leishmania major	cathepsin L-like protease	0.0098	0.0062	1
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0098	0.0062	0.6811
Giardia lamblia	Encystation-specific protease	0.2972	0.3768	0.3712
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0087	0.0047	0.0076
Brugia malayi	Probable 3',5'-cyclic phosphodiesterase R153.1, putative	0.0098	0.0061	0.9934
Onchocerca volvulus	Cathepsin L homolog	0.0098	0.0062	1
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.0087	0.0047	0.0076
Brugia malayi	Cathepsin L-like precursor	0.0098	0.0062	1
Loa Loa (eye worm)	cysteine protease	0.0098	0.0062	0.5928
Leishmania major	cathepsin L-like protease	0.0098	0.0062	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0098	0.0062	0.0099
Onchocerca volvulus		0.0098	0.0062	1
Giardia lamblia	Dipeptidyl-peptidase I precursor	0.2972	0.3768	0.3712
Echinococcus multilocularis	dual 3',5' cyclic AMP and GMP phosphodiesterase	0.0087	0.0047	0.5228
Leishmania major	cathepsin L-like protease	0.0098	0.0062	1
Plasmodium vivax	dipeptidyl aminopeptidase 2, putative	0.7802	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0098	0.0062	0.0099
Trichomonas vaginalis	cGMP-dependent 3,5-cyclic phosphodiesterase, putative	0.0087	0.0047	0.0076
Onchocerca volvulus		0.0098	0.0062	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0098	0.0062	1
Entamoeba histolytica	cysteine proteinase, putative	0.0098	0.0062	1
Onchocerca volvulus	Cathepsin F homolog	0.0098	0.0062	1
Schistosoma mansoni	cathepsin F (C01 family)	0.0098	0.0062	0.0062
Trypanosoma cruzi	cysteine peptidase, putative	0.0098	0.0062	1
Loa Loa (eye worm)	cyclic AMP specific phosphodiesterase PDE4D5A	0.0098	0.0061	0.5871
Trichomonas vaginalis	cone cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0087	0.0047	0.0076
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.0087	0.0047	0.0076
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0098	0.0062	0.0099
Trichomonas vaginalis	cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0087	0.0047	0.0076
Trypanosoma cruzi	cysteine peptidase, putative	0.0098	0.0062	1
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0121	0.009	0.0072
Echinococcus granulosus	cathepsin L cysteine proteinase	0.0098	0.0062	0.6811
Trichomonas vaginalis	cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0087	0.0047	0.0076
Entamoeba histolytica	cysteine protease, putative	0.0098	0.0062	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0066	0.002	0.0032
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0098	0.0062	0.0099
Trypanosoma brucei	cAMP-specific phosphodiesterase	0.0087	0.0047	0.7676
Echinococcus multilocularis	cysteine protease	0.0098	0.0062	0.6811
Toxoplasma gondii	cathepsin CPL	0.0098	0.0062	0.0044
Giardia lamblia	Dipeptidyl-peptidase I precursor	0.2972	0.3768	0.3712
Echinococcus granulosus	cAMP specific 3'5' cyclic phosphodiesterase	0.0121	0.009	1
Leishmania major	cathepsin L-like protease	0.0098	0.0062	1
Onchocerca volvulus		0.0098	0.0062	1
Trichomonas vaginalis	cAMP-specific phosphodiesterase, putative	0.0087	0.0047	0.0076
Brugia malayi	Cathepsin L-like precursor	0.0098	0.0062	1
Onchocerca volvulus		0.0098	0.0062	1
Brugia malayi	Papain family cysteine protease containing protein	0.0098	0.0062	1
Trichomonas vaginalis	cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative	0.0064	0.0017	0.0027
Schistosoma mansoni	camp/cgmp cyclic nucleotide phosphodiesterase	0.0087	0.0047	0.0047
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0098	0.0062	0.0099
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0098	0.0062	0.5928
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0098	0.0062	0.0099
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.0098	0.0062	0.5928
Loa Loa (eye worm)	hypothetical protein	0.0098	0.0062	0.5928
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0098	0.0062	0.0099
Leishmania major	cathepsin L-like protease	0.0098	0.0062	1
Trichomonas vaginalis	cAMP-specific 3,5-cyclic phosphodiesterase, putative	0.0087	0.0047	0.0076
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0098	0.0062	0.0099
Trypanosoma cruzi	cAMP specific phosphodiesterase, putative	0.0087	0.0047	0.7676
Echinococcus multilocularis	cAMP specific 3',5' cyclic phosphodiesterase	0.0121	0.009	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0098	0.0062	0.0099
Trypanosoma cruzi	cAMP specific phosphodiesterase, putative	0.0064	0.0017	0.2754
Trichomonas vaginalis	cyclic nucleotide phosphodiesterase, putative	0.0087	0.0047	0.0076
Brugia malayi	Cathepsin L-like precursor	0.0066	0.002	0.3182
Brugia malayi	Cathepsin L-like precursor	0.0098	0.0062	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0098	0.0062	1
Schistosoma mansoni	camp-specific 35-cyclic phosphodiesterase	0.0121	0.009	0.009
Entamoeba histolytica	cysteine proteinase, putative	0.0066	0.002	0.3182
Trypanosoma cruzi	cruzipain precursor, putative	0.0098	0.0062	1
Echinococcus multilocularis	cathepsin L cysteine protease	0.0098	0.0062	0.6811
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.4848	0.619	1
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0087	0.0047	0.0076
Trichomonas vaginalis	rod cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0087	0.0047	0.0076
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0098	0.0062	0.0099
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0098	0.0062	0.0099
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0098	0.0062	0.0099
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.0087	0.0047	0.0076
Loa Loa (eye worm)	hypothetical protein	0.0121	0.009	1
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.0098	0.0062	0.0062
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0098	0.0062	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0098	0.0062	0.0099
Plasmodium vivax	vivapain-2	0.0098	0.0062	0.0062
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0098	0.0062	0.0099
Trichomonas vaginalis	cyclic nucleotide phosphodiesterase, putative	0.0087	0.0047	0.0076
Echinococcus granulosus	cathepsin l cysteine peptidase	0.0098	0.0062	0.6811
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0098	0.0062	0.0099
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0098	0.0062	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0098	0.0062	0.0099
Trichomonas vaginalis	cGMP-inhibited 3,5-cyclic phosphodiesterase, putative	0.0087	0.0047	0.0076
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0098	0.0062	0.0099
Echinococcus granulosus	cAMP specific 3'5' cyclic phosphodiesterase	0.0098	0.0061	0.6766
Trichomonas vaginalis	conserved hypothetical protein	0.0087	0.0047	0.0076
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0098	0.0062	1
Trichomonas vaginalis	rod cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0087	0.0047	0.0076
Loa Loa (eye worm)	fibroinase	0.0098	0.0062	0.5928
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0087	0.0047	0.0076
Schistosoma mansoni	cathepsin F (C01 family)	0.0066	0.002	0.002
Toxoplasma gondii	cathepsin CPC1	0.7802	1	1
Onchocerca volvulus		0.0098	0.0062	1
Trichomonas vaginalis	cGMP-dependent 3,5-cyclic phosphodiesterase, putative	0.0087	0.0047	0.0076
Toxoplasma gondii	cathepsin CPC2	0.2972	0.3768	0.3757
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0087	0.0047	0.0076
Echinococcus granulosus	dual 3'5' cyclic AMP and GMP phosphodiesterase	0.0087	0.0047	0.5228
Leishmania major	cathepsin L-like protease	0.0098	0.0062	1
Trichomonas vaginalis	cAMP-specific 3,5-cyclic phosphodiesterase, putative	0.0087	0.0047	0.0076
Plasmodium vivax	dipeptidyl aminopeptidase 1, putative	0.7802	1	1
Echinococcus multilocularis	cathepsin L cysteine protease	0.0098	0.0062	0.6811
Plasmodium falciparum	dipeptidyl aminopeptidase 1	0.7802	1	1

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 1.2 nM	Inhibition of PDE4B	ChEMBL.	22401864
IC50 (binding)	= 2300 nM	Inhibition of PDE11	ChEMBL.	22401864

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL2012215

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 1634044