Detailed information for compound 1635428

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 460.033 | Formula: C27H26ClN3S
  • H donors: 1 H acceptors: 1 LogP: 5.47 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: Clc1ccc2c(c1)CCc1c(C2=C2CCN(CC2)C(=S)Nc2ccccc2C)nccc1
  • InChi: 1S/C27H26ClN3S/c1-18-5-2-3-7-24(18)30-27(32)31-15-12-19(13-16-31)25-23-11-10-22(28)17-21(23)9-8-20-6-4-14-29-26(20)25/h2-7,10-11,14,17H,8-9,12-13,15-16H2,1H3,(H,30,32)
  • InChiKey: WMDFTJFROBFCLO-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0036 0.0166 0.0166
Echinococcus granulosus serine threonine protein kinase nrc 0.0042 0.0232 0.0232
Loa Loa (eye worm) hypothetical protein 0.019 0.1913 0.1913
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0717 0.7912 0.7822
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0901 1 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.017 0.1692 0.1692
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0058 0.0415 0.0415
Trichomonas vaginalis AGC family protein kinase 0.0067 0.052 0.052
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0058 0.0415 1
Trichomonas vaginalis conserved hypothetical protein 0.0112 0.103 0.103
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0034 0.0139 0.0139
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0058 0.0415 0.0415
Trichomonas vaginalis AGC family protein kinase 0.0067 0.052 0.052
Giardia lamblia Phosphatidylinositol 4-kinase 0.0058 0.0415 0.0187
Loa Loa (eye worm) phosphatidylinositol kinase 0.0058 0.0415 0.0415
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0058 0.0415 0.0415
Loa Loa (eye worm) phosphatidylinositol 3 0.0058 0.0415 0.0415
Trichomonas vaginalis PIKK family atypical protein kinase 0.0302 0.319 0.319
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0058 0.0415 0.0187
Schistosoma mansoni fkbp-rapamycin associated protein 0.017 0.1692 0.1692
Trichomonas vaginalis PIKK family atypical protein kinase 0.067 0.7374 0.7374
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0901 1 1
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0058 0.0415 0.0415
Loa Loa (eye worm) phosphatidylinositol 3 0.0058 0.0415 0.0415
Trichomonas vaginalis PIKK family atypical protein kinase 0.0486 0.5286 0.5286
Echinococcus granulosus phosphatidylinositol 4 kinase beta 0.0058 0.0415 0.0415
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0058 0.0415 0.0415
Trichomonas vaginalis PIKK family atypical protein kinase 0.0538 0.5876 0.5876
Toxoplasma gondii target of rapamycin (TOR), putative 0.067 0.7374 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.067 0.7374 0.7374
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0058 0.0415 0.0187
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0058 0.0415 0.0187
Trypanosoma cruzi target of rapamycin kinase 3 0.0717 0.7912 0.7862
Loa Loa (eye worm) hypothetical protein 0.0132 0.1252 0.1252
Echinococcus granulosus sodium:potassium dependent atpase beta subunit 0.0042 0.0226 0.0226
Trichomonas vaginalis PIKK family atypical protein kinase 0.017 0.1692 0.1692
Schistosoma mansoni serine/threonine-protein kinase 0.0046 0.0279 0.0279
Trypanosoma cruzi phosphatidylinositol 3-kinase vps34-like 0.0058 0.0415 0.0187
Trichomonas vaginalis PIKK family atypical protein kinase 0.0604 0.6627 0.6627
Trichomonas vaginalis PIKK family atypical protein kinase 0.067 0.7374 0.7374
Trichomonas vaginalis PIKK family atypical protein kinase 0.067 0.7374 0.7374
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0058 0.0415 0.0187
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0058 0.0415 0.0415
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0058 0.0415 0.0415
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0058 0.0415 0.0415
Loa Loa (eye worm) phosphatidylinositol 3 0.0058 0.0415 0.0415
Echinococcus granulosus nervana 2 0.0042 0.0226 0.0226
Plasmodium vivax hypothetical protein, conserved 0.0058 0.0415 1
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0901 1 1
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0901 1 1
Echinococcus granulosus PIK kinase FAT and Armadillo domain containing protein 0.0132 0.1252 0.1252
Giardia lamblia Phosphoinositide-3-kinase, class 3 0.0058 0.0415 0.0187
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0901 1 1
Echinococcus multilocularis serine threonine protein kinase nrc serine threonine protein kinase gad 0.0042 0.0232 0.0232
Trichomonas vaginalis conserved hypothetical protein 0.019 0.1913 0.1913
Echinococcus granulosus serine:threonine protein kinase SMG1 0.017 0.1692 0.1692
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0058 0.0415 0.0415
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0058 0.0415 0.0415
Trichomonas vaginalis AGC family protein kinase 0.0067 0.052 0.052
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0058 0.0415 0.0415
Plasmodium vivax hypothetical protein 0.0058 0.0415 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0486 0.5286 0.5286
Trichomonas vaginalis PIKK family atypical protein kinase 0.0901 1 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0716 0.7903 0.7903
Trichomonas vaginalis PIKK family atypical protein kinase 0.0486 0.5286 0.5286
Entamoeba histolytica hypothetical protein 0.0058 0.0415 0.0415
Echinococcus multilocularis nervana 2 0.0042 0.0226 0.0226
Entamoeba histolytica hypothetical protein 0.0058 0.0415 0.0415
Trypanosoma brucei rac serine-threonine kinase, putative 0.0067 0.052 0.011
Trichomonas vaginalis PIKK family atypical protein kinase 0.0302 0.319 0.319
Entamoeba histolytica phosphatidylinositol 4-kinase, putative 0.0058 0.0415 0.0415
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0302 0.319 0.319
Toxoplasma gondii FATC domain-containing protein 0.017 0.1692 0.1835
Giardia lamblia Phosphoinositide-3-kinase, catalytic, alpha polypeptide 0.0058 0.0415 0.0187
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0058 0.0415 0.0415
Loa Loa (eye worm) hypothetical protein 0.017 0.1692 0.1692
Trichomonas vaginalis PIKK family atypical protein kinase 0.067 0.7374 0.7374
Echinococcus multilocularis serine protein kinase ATM 0.017 0.1692 0.1692
Entamoeba histolytica PH domain containing protein kinase, putative 0.0046 0.0279 0.0279
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0058 0.0415 0.0187
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit gamma, putative 0.0058 0.0415 0.0415
Trichomonas vaginalis AGC family protein kinase 0.0067 0.052 0.052
Echinococcus granulosus serine protein kinase ATM 0.017 0.1692 0.1692
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0046 0.0279 0.0048
Brugia malayi Protein kinase domain containing protein 0.0067 0.052 0.052
Plasmodium falciparum phosphatidylinositol 4-kinase 0.0058 0.0415 1
Echinococcus multilocularis DNA dependent protein kinase catalytic subunit 0.0058 0.0415 0.0415
Echinococcus multilocularis nervana 2 0.0042 0.0226 0.0226
Echinococcus multilocularis Glutaredoxin protein 5 0.0042 0.0226 0.0226
Trichomonas vaginalis phosphatidylinositol 4-kinase, putative 0.0058 0.0415 0.0415
Entamoeba histolytica protein kinase 2, putative 0.0042 0.0232 0.0232
Brugia malayi phosphatidylinositol 4-kinase, catalytic, alpha polypeptide 0.0058 0.0415 0.0415
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0036 0.0166 0.0166
Trichomonas vaginalis PIKK family atypical protein kinase 0.0112 0.103 0.103
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0058 0.0415 0.0415
Plasmodium vivax phosphatidylinositol 3- and 4-kinase, putative 0.0058 0.0415 1
Giardia lamblia GTOR 0.0901 1 1
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0302 0.319 0.3028
Echinococcus granulosus phosphatidylinositol 4 phosphate 3 kinase C2 0.0058 0.0415 0.0415
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0058 0.0415 0.0415
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0058 0.0415 0.0415
Trichomonas vaginalis PIKK family atypical protein kinase 0.0901 1 1
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0058 0.0415 0.0415
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0058 0.0415 0.0415
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0374 0.4009 0.375
Schistosoma mansoni voltage-gated potassium channel 0.004 0.0204 0.0204
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0058 0.0415 0.0415
Brugia malayi FAT domain containing protein 0.0132 0.1252 0.1252
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.017 0.1692 0.1332
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0302 0.319 0.3028
Loa Loa (eye worm) phosphatidylinositol 4-kinase type 3 alpha isoform 1 0.0058 0.0415 0.0415
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0901 1 1
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0302 0.319 0.319
Echinococcus multilocularis 0.0058 0.0415 0.0415
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.017 0.1692 0.1495
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0901 1 1
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0112 0.103 0.0818
Trichomonas vaginalis PIKK family atypical protein kinase 0.0585 0.6405 0.6405
Entamoeba histolytica protein kinase, putative 0.0067 0.052 0.052
Loa Loa (eye worm) hypothetical protein 0.0184 0.1842 0.1842
Schistosoma mansoni serine/threonine-protein kinase 0.0046 0.0279 0.0279
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0058 0.0415 0.0415
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0058 0.0415 0.0415
Toxoplasma gondii AGC kinase 0.0063 0.0473 0.0083
Loa Loa (eye worm) phosphatidylinositol 3 0.0302 0.319 0.319
Echinococcus granulosus serine/threonine protein kinase 0.0046 0.0279 0.0279
Entamoeba histolytica phosphatidylinositol 3-kinase 3, putative 0.0058 0.0415 0.0415
Trichomonas vaginalis PIKK family atypical protein kinase 0.0533 0.5815 0.5815
Echinococcus multilocularis phosphatidylinositol 4 kinase alpha 0.0058 0.0415 0.0415
Trichomonas vaginalis PIKK family atypical protein kinase 0.0242 0.2503 0.2503
Echinococcus multilocularis sodium:potassium dependent atpase beta subunit 0.0042 0.0226 0.0226
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0058 0.0415 0.0415
Trichomonas vaginalis PIKK family atypical protein kinase 0.017 0.1692 0.1692
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0302 0.319 0.319
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0058 0.0415 0.0415
Echinococcus multilocularis phosphatidylinositol 4 phosphate 3 kinase C2 0.0058 0.0415 0.0415
Schistosoma mansoni hypothetical protein 0.0132 0.1252 0.1252
Trichomonas vaginalis PIKK family atypical protein kinase 0.0716 0.7903 0.7903
Trichomonas vaginalis PIKK family atypical protein kinase 0.0486 0.5278 0.5278
Schistosoma mansoni hypothetical protein 0.0058 0.0415 0.0415
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.017 0.1692 0.1692
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.017 0.1692 0.1495
Echinococcus granulosus phosphatidylinositol 3 kinase catalytic subunit 0.0058 0.0415 0.0415
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0058 0.0415 0.0187
Schistosoma mansoni phosphatidylinositol 4-kinase type-II 0.0058 0.0415 0.0415
Loa Loa (eye worm) phosphatidylinositol 3 0.0901 1 1
Mycobacterium tuberculosis Conserved hypothetical protein 0.0058 0.0415 0.5
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0058 0.0415 0.0415
Trichomonas vaginalis PIKK family atypical protein kinase 0.0486 0.5278 0.5278
Trichomonas vaginalis PIKK family atypical protein kinase 0.067 0.7374 0.7374
Loa Loa (eye worm) AGC/AKT protein kinase 0.0067 0.052 0.052
Trichomonas vaginalis PIKK family atypical protein kinase 0.0716 0.7903 0.7903
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0058 0.0415 0.0415
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0058 0.0415 0.0415
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0426 0.4599 0.4366
Trichomonas vaginalis PIKK family atypical protein kinase 0.0058 0.0415 0.0415
Plasmodium falciparum phosphatidylinositol 3- and 4-kinase, putative 0.0058 0.0415 1
Entamoeba histolytica protein kinase, putative 0.0063 0.0473 0.0473
Loa Loa (eye worm) phosphatidylinositol 3 0.0058 0.0415 0.0415
Leishmania major phosphatidylinositol 3-kinase, putative 0.0302 0.319 0.2895
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0901 1 1
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0058 0.0415 0.0415
Schistosoma mansoni phosphatidylinositol 3-kinase class 0.0058 0.0415 0.0415
Echinococcus multilocularis phosphatidylinositol 4,5 bisphosphate 3 kinase 0.0058 0.0415 0.0415
Trypanosoma cruzi phosphatidylinositol kinase, putative 0.0058 0.0415 0.0187
Echinococcus granulosus calcium:calmodulin dependent protein kinase 0.0042 0.0232 0.0232
Trichomonas vaginalis PIKK family atypical protein kinase 0.0769 0.8502 0.8502
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0058 0.0415 0.0187
Loa Loa (eye worm) hypothetical protein 0.0112 0.103 0.103
Trichomonas vaginalis PIKK family atypical protein kinase 0.0538 0.5876 0.5876
Echinococcus multilocularis PIK kinase, FAT and Armadillo domain containing protein 0.0132 0.1252 0.1252
Trichomonas vaginalis PIKK family atypical protein kinase 0.0058 0.0415 0.0415
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0717 0.7912 0.7822
Trichomonas vaginalis AGC family protein kinase 0.0067 0.052 0.052
Trichomonas vaginalis PIKK family atypical protein kinase 0.0533 0.5815 0.5815
Giardia lamblia Hypothetical protein 0.0058 0.0415 0.0187
Plasmodium vivax phosphatidylinositol 3-kinase, putative 0.0058 0.0415 1
Echinococcus granulosus Glutaredoxin protein 5 0.0042 0.0226 0.0226
Entamoeba histolytica PH domain containing protein kinase, putative 0.0046 0.0279 0.0279
Onchocerca volvulus 0.0058 0.0415 0.5
Schistosoma mansoni voltage-gated potassium channel 0.004 0.0204 0.0204
Brugia malayi p70 ribosomal S6 kinase beta 0.0063 0.0473 0.0473
Trichomonas vaginalis AGC family protein kinase 0.0067 0.052 0.052
Entamoeba histolytica hypothetical protein 0.0058 0.0415 0.0415
Trichomonas vaginalis PIKK family atypical protein kinase 0.0486 0.5286 0.5286
Trichomonas vaginalis PIKK family atypical protein kinase 0.0486 0.5278 0.5278
Entamoeba histolytica protein kinase, putative 0.0067 0.052 0.052
Plasmodium falciparum phosphatidylinositol 3-kinase 0.0058 0.0415 1
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.017 0.1692 0.1692
Trichomonas vaginalis PIKK family atypical protein kinase 0.0901 1 1
Loa Loa (eye worm) AGC/RSK/P70 protein kinase 0.0063 0.0473 0.0473
Trichomonas vaginalis PIKK family atypical protein kinase 0.067 0.7374 0.7374
Echinococcus granulosus nervana 2 0.0042 0.0226 0.0226
Entamoeba histolytica phosphatidylinositol-4,5-bisphosphate 3-kinase, putative 0.0058 0.0415 0.0415
Loa Loa (eye worm) phosphatidylinositol 3 0.0058 0.0415 0.0415
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0058 0.0415 0.0187
Echinococcus granulosus DNA dependent protein kinase catalytic subunit 0.0058 0.0415 0.0415
Entamoeba histolytica Phosphatidylinositol 3- and 4-kinase family 0.017 0.1692 0.1692
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0058 0.0415 0.0415
Echinococcus granulosus phosphatidylinositol 45 bisphosphate 3 kinase 0.0058 0.0415 0.0415
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0034 0.0139 0.0139
Trichomonas vaginalis PIKK family atypical protein kinase 0.0716 0.7903 0.7903
Trichomonas vaginalis AGC family protein kinase 0.0067 0.052 0.052
Mycobacterium leprae conserved hypothetical protein 0.0058 0.0415 0.5
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.017 0.1692 0.1692
Trichomonas vaginalis PIKK family atypical protein kinase 0.0302 0.319 0.319
Loa Loa (eye worm) hypothetical protein 0.0058 0.0415 0.0415
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0058 0.0415 1
Loa Loa (eye worm) hypothetical protein 0.0031 0.0111 0.0111
Loa Loa (eye worm) hypothetical protein 0.0058 0.0415 0.0415
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0302 0.319 0.2895
Trichomonas vaginalis conserved hypothetical protein 0.0132 0.1252 0.1252
Entamoeba histolytica protein kinase rad3, putative 0.017 0.1692 0.1692
Trichomonas vaginalis PIKK family atypical protein kinase 0.0716 0.7903 0.7903
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0036 0.0166 0.0166
Echinococcus granulosus phosphatidylinositol 4 kinase alpha 0.0058 0.0415 0.0415
Trichomonas vaginalis PIKK family atypical protein kinase 0.0302 0.319 0.319
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0901 1 1
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.017 0.1692 0.1692
Entamoeba histolytica hypothetical protein 0.0058 0.0415 0.0415
Trichomonas vaginalis PIKK family atypical protein kinase 0.0302 0.319 0.319
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0302 0.319 0.319
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0302 0.319 0.2895
Trichomonas vaginalis PIKK family atypical protein kinase 0.0538 0.5876 0.5876
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0302 0.319 0.2895
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0036 0.0166 0.0166
Trypanosoma cruzi Protein kinase B 0.0046 0.0279 0.0048
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0901 1 1
Onchocerca volvulus 0.0058 0.0415 0.5
Entamoeba histolytica hypothetical protein 0.017 0.1692 0.1692
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0058 0.0415 0.0415
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0058 0.0415 0.0415
Echinococcus multilocularis Zinc finger, PHD finger 0.0058 0.0415 0.0415
Echinococcus multilocularis rac serine:threonine kinase 0.0046 0.0279 0.0279
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0058 0.0415 0.0415
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0058 0.0415 0.0415
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0901 1 1
Toxoplasma gondii non-specific serine/threonine protein kinase 0.019 0.1913 0.2153
Trichomonas vaginalis AGC family protein kinase 0.0026 0.0047 0.0047

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) = 5.4 uM Antiproliferative activity against human MCF7 cells assessed as growth inhibition after 144 hrs by crystal violet staining method ChEMBL. 22450132
Inhibition (functional) = 13.04 % Antiinflammatory activity in overnight fasted Kunming mouse assessed as inhibition of xylene-induced ear swelling at 4 mg/kg, ip administered before challenge for 5 days measured 1 hr post xylene challenge ChEMBL. 22450132

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23 22450132

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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