Detailed view for EmuJ_000947300

Basic information

TDR Targets ID: 958724
Echinococcus multilocularis, Phosphatidylinositol 4 kinase type 2 beta
Source Database / ID:  GeneDB

pI: 6.2448 | Length (AA): 302 | MW (Da): 34178 | Paralog Number: 1

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00454   Phosphatidylinositol 3- and 4-kinase

Gene Ontology

Mouse over links to read term descriptions.
No GO information for this protein.

Structural information

Modbase 3D models:

There are 2 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
1 225 4wtv (B) 209 450 62.00 0 1 1.35033 -0.68
6 225 4hne (B) 229 452 65.00 0 1 1.36678 -0.81

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_129656)

Species Accession Gene Product
Brugia malayi Bm1_45895   Phosphatidylinositol 3- and 4-kinase family protein
Brugia malayi Bm1_27690   Phosphatidylinositol 3- and 4-kinase family protein
Candida albicans CaO19.9983   regulation of actin cytoskeletal organization
Candida albicans CaO19.2447   regulation of actin cytoskeletal organization
Caenorhabditis elegans CELE_C56A3.8   Protein C56A3.8, isoform A
Caenorhabditis elegans CELE_ZC8.6   Protein ZC8.6
Drosophila melanogaster Dmel_CG2929   CG2929 gene product from transcript CG2929-RC
Echinococcus granulosus EgrG_000947500   Phosphatidylinositol 4 kinase type 2 beta
Echinococcus granulosus EgrG_000947300   Phosphatidylinositol 4 kinase type 2 beta
Echinococcus multilocularis EmuJ_000947300   Phosphatidylinositol 4 kinase type 2 beta
Echinococcus multilocularis EmuJ_000947500   Phosphatidylinositol 4 kinase type 2 beta
Homo sapiens ENSG00000155252   phosphatidylinositol 4-kinase type 2 alpha
Homo sapiens ENSG00000038210   phosphatidylinositol 4-kinase type 2 beta
Loa Loa (eye worm) LOAG_05404   hypothetical protein
Loa Loa (eye worm) LOAG_09853   phosphatidylinositol 3
Loa Loa (eye worm) LOAG_11682   phosphatidylinositol kinase
Loa Loa (eye worm) LOAG_07991   phosphatidylinositol 3
Mus musculus ENSMUSG00000029186   phosphatidylinositol 4-kinase type 2 beta
Mus musculus ENSMUSG00000025178   phosphatidylinositol 4-kinase type 2 alpha
Onchocerca volvulus OVOC8638  
Onchocerca volvulus OVOC12300  
Saccharomyces cerevisiae YJL100W   1-phosphatidylinositol 4-kinase LSB6
Schistosoma mansoni Smp_018460   phosphatidylinositol 4-kinase type-II
Schmidtea mediterranea mk4.000036.00   Putative phosphatidylinositol 4-kinase type-II
Schmidtea mediterranea mk4.010123.00   Putative phosphatidylinositol 4-kinase type-II
Schmidtea mediterranea mk4.003494.00  

Essentiality

EmuJ_000947300 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
CELE_C56A3.8 Caenorhabditis elegans embryonic lethal wormbase
CELE_C56A3.8 Caenorhabditis elegans larval arrest wormbase
CELE_C56A3.8 Caenorhabditis elegans larval lethal wormbase
CELE_ZC8.6 Caenorhabditis elegans embryonic lethal wormbase
Show/Hide essentiality data references
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Homo sapiens phosphatidylinositol 4-kinase type 2 beta Compounds References
Homo sapiens phosphatidylinositol 4-kinase type 2 alpha Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.0212 0.2577 0.2577
0.0662 0.2621 0.396
0.0239 0.277 0.2764
0.0216 1 1
0.0212 0.2581 0.2581
0.0657 0.8004 0.8004
0.0896 0.3014 0.3014
0.0647 0.796 0.796
0.0453 0.2611 0.2611
0.120785 0.48885 0.508254
0.0915 1 1
0.0896 0.3014 0.3014
0.0438 0.2637 0.263
0.021 0.2578 0.2577
0.045 1 1
0.0331 0.297 0.297
0.120785 0.48885 0.508254
0.021 0.5848 0.5748
0.0435 0.3245 0.4657
0.0213 0.2817 0.2807
0.0435 0.3245 0.4688
0.0896 0.3014 0.3014
0.0955 1 1
0.0216 0.2577 0.2577
0.0969 1 1
0.0431 0.5162 0.513
0.0214 0.2557 0.2557
0.0214 0.2553 0.2552
0.0863 0.5185 0.5185
0.0449 0.5432 0.543
0.0963 1 1
0.0217 1 1
0.0286669 0.253614 0.82872
0.0216 0.943 1
0.0218 0.2581 0.2581
0.0979 0.9641 1
0.0212 0.2744 0.2744
0.0976 1 1
0.065 0.4243 0.4243
0.0908 1 1
0.025 1 1
0.0942 1 1
0.089 1 1
0.0214 0.2577 0.2577
0.0261 0.294 0.2939
0.0963 0.3484 0.3482
0.0996 0.7569 0.7569
0.066 0.8051 0.8025
0.0996 1 1
0.0996 1 1
0.0214 1 1
0.0507 1 1
0.021 0.2578 0.2577
0.0641 0.7771 0.7681
0.0292865 0.262066 0.82904
0.0914 0.7797 0.7797
0.0259 0.2538 0.2336
0.0965 1 1
0.0963 0.3484 0.3482
0.0441 0.2651 0.2651
0.0481 1 1
0.0292865 0.262066 0.82904
0.0863 1 1
0.0365 0.2805 0.1631
0.0425 0.494 0.4677
0.0214 0.2557 0.2557
0.0482 0.2893 0.2893
0.0908 0.4228 0.4228
0.019 0.3151 0.3624
0.0996 1 1
0.0215 0.3386 0.4966
0.0642 0.3973 0.3969
0.0269 1 1
0.0263 0.4712 0.4705
0.0665 0.7842 0.7738
0.044 1 1
0.025 1 1
0.0908 0.4228 0.4228
0.0507 1 1
0.044 0.2899 0.2898
0.0215 0.3386 0.4966
0.0215 0.3386 0.4966
0.0223 1 1
0.022 0.4647 1
0.0435 0.2634 0.2629
0.0972 1 1
0.025 1 1
0.0895 1 1
0.065 0.8096 0.8096
0.0215 0.3386 0.4966
0.0214 0.2553 0.2552
0.0216 0.2572 0.2572
0.0258 0.2846 0.2846
0.0239 0.3616 0.3605
0.0261 1 1
0.044 0.2899 0.2898
0.0233 0.553 0.553
0.0211 0.2553 0.2552
0.0212 0.3063 0.3063
0.0434 0.6104 1
0.0438 0.3288 0.5088
0.0425 0.5098 0.5085
0.0277772 0.428449 0.46072
0.0908 0.4228 0.4228
0.0239 0.277 0.2764
0.023 1 1
0.1012 1 1
0.0652 0.8007 0.7944
0.0426 0.3265 0.6942
0.065 0.326 0.3255
0.0449 0.5478 0.5476
0.0221 0.2577 0.2577
0.0988 1 1
0.0955 0.3983 0.3983
0.0896 0.3014 0.3014
0.0662 0.7946 0.7946
0.0647 0.7947 0.784
0.0215 0.2557 0.2557
0.0996 0.7569 0.7569
0.1011 1 1
0.0896 0.3014 0.3014
0.0441 0.2633 0.2629
0.0642 0.6164 0.6164
0.0215 0.3768 0.3768
0.093 1 1
0.0379 0.3272 0.3319
0.0244 0.2647 0.2647
0.0212 0.2577 0.2577
0.0335462 1 1
0.0215 0.3768 0.3768
0.0965 0.8291 0.8291
0.022 0.2676 0.2676
0.0909 0.96 0.9592
0.0973 1 1
0.0733 0.7955 0.7953
0.0215 1 1
0.0215 0.4346 0.427
0.0986 1 1
0.0215 0.3386 0.4966
0.0935 0.7817 0.7815
0.0896 0.3014 0.3014
0.120785 0.48885 0.508254
0.0896 0.3014 0.3014
0.0286669 0.253614 0.82872
0.0269 1 1
0.089 0.9236 0.9223
0.0228 0.3161 0.3155
0.0896 0.3014 0.3014
0.0427 1 1
0.0215 0.2578 0.2577
0.0276112 0.825842 0.818783
0.0224 0.3157 0.3151
0.0908 0.4228 0.4228
0.0276112 0.825842 0.818783
0.0658 0.8001 0.793
0.0293 0.3106 0.3068
0.0223 0.2577 0.2577
0.0219 0.2572 0.2572
0.023 1 1
0.0268 1 1
0.066 0.549 0.549
0.0213 0.2578 0.2577
0.0877 0.6004 0.6001
0.0228 1 1
0.0228 1 1
0.0224 0.2564 0.2564
0.0244 0.2647 0.2647
0.0277772 0.428449 0.46072
0.0269 1 1
0.0432 0.3231 0.3552
0.021 0.259 0.2581
0.0972 1 1
0.0211 1 1
0.0942 0.8 0.8
0.0995 1 1
0.0213 0.2581 0.2581
0.0261 0.294 0.2939
0.0972 1 1
0.0662 0.3737 0.3737
0.0209 0.2568 0.2568
0.0898 0.641 1
0.0441 0.2657 0.265
0.0218 0.2581 0.2581
0.0216 1 1
0.0431 0.5079 0.5058
0.0216 0.2581 0.2581
0.0908 0.4228 0.4228
0.0218 0.2948 0.2881
0.0214 0.2593 0.2593
0.0955 0.3983 0.3983
0.024 1 1
0.0908 0.4228 0.4228
0.0425 0.5098 0.5086
0.0214 0.2581 0.2581
0.0211 0.2588 0.2581
0.0925 0.9434 0.9429
0.0431 0.3179 0.316
0.0216 0.2572 0.2572
0.098 1 1
0.0469 0.5589 0.5589
0.024 0.4411 0.4945
0.0995 1 1
0.0218 0.2557 0.2557
0.0216 0.9253 1
0.075 0.963 1
0.0637 0.7947 0.7862
0.0213 0.2581 0.2581
0.0481 1 1
0.0951 1 1
0.0906 1 1
0.0214 0.2553 0.2552
0.0379 0.3272 0.3319
0.093 0.9209 0.9209
0.0438 0.3192 0.3626
0.0214 1 1
0.0212 0.3063 0.3063
0.0896 0.3014 0.3014
0.0218 1 1
0.0215 0.2577 0.2577
0.0277772 0.428449 0.46072
0.0896 0.3014 0.3014
0.0214 0.2564 0.2564
0.0218 1 1
0.0219 0.2545 0.2542
0.0213 0.2545 0.2542
0.0379 0.3272 0.3319
0.0872 1 1
0.0239 0.277 0.2764
0.0919 0.6795 0.6757
0.0209 0.2568 0.2568
0.0958 1 1
0.0276112 0.825842 0.818783
0.0441 0.2651 0.2651
0.0647 0.7962 0.784
0.0219 0.2657 0.2657
0.0202 0.3619 0.3619
0.0896 0.3014 0.3014
0.0275944 0.825842 0.822719
0.102 1 1
0.023 1 1
0.0214 1 1
0.0261 1 1
0.0662 0.2621 0.396
0.0221 1 1

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

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Gene identifier EmuJ_000947300 (Echinococcus multilocularis), Phosphatidylinositol 4 kinase type 2 beta
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