Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | GABA-A receptor; anion channel | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | hypothetical protein | 0.0271 | 0.2515 | 0.2515 |
Brugia malayi | Matrixin family protein | 0.0107 | 0.0699 | 0.0699 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0093 | 0.0537 | 1 |
Giardia lamblia | Kinase, PLK | 0.0093 | 0.0537 | 0.5 |
Schistosoma mansoni | subfamily M12B unassigned peptidase (M12 family) | 0.0128 | 0.0928 | 0.2387 |
Brugia malayi | ADAMTS-like protease | 0.029 | 0.2725 | 0.2725 |
Brugia malayi | Hemopexin family protein | 0.0063 | 0.0206 | 0.0206 |
Entamoeba histolytica | serine/threonine protein kinase, putative | 0.0093 | 0.0537 | 0.5 |
Trypanosoma brucei | polo-like protein kinase | 0.0093 | 0.0537 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0945 | 1 | 1 |
Brugia malayi | Matrix metalloprotease, N-terminal domain containing protein | 0.0054 | 0.0108 | 0.0108 |
Loa Loa (eye worm) | hypothetical protein | 0.0298 | 0.2819 | 0.2819 |
Trypanosoma cruzi | polo-like protein kinase, putative | 0.0093 | 0.0537 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0054 | 0.0108 | 0.0108 |
Loa Loa (eye worm) | matrixin family protein | 0.0107 | 0.0699 | 0.0699 |
Loa Loa (eye worm) | hypothetical protein | 0.0128 | 0.0928 | 0.0928 |
Onchocerca volvulus | 0.0063 | 0.0206 | 0.0731 | |
Echinococcus granulosus | matrix metallopeptidase 7 M10 family | 0.0161 | 0.13 | 0.2277 |
Echinococcus granulosus | subfamily M12B unassigned peptidase | 0.0128 | 0.0928 | 0.1168 |
Mycobacterium tuberculosis | Probable peptidoglycan hydrolase | 0.0054 | 0.0108 | 0.5 |
Onchocerca volvulus | Matrilysin homolog | 0.0098 | 0.0601 | 0.2131 |
Mycobacterium leprae | PROBABLE HYDROLASE | 0.0054 | 0.0108 | 0.5 |
Echinococcus multilocularis | adam | 0.0271 | 0.2515 | 0.5899 |
Schistosoma mansoni | kinase | 0.0047 | 0.003 | 0.0078 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0093 | 0.0537 | 1 |
Echinococcus multilocularis | subfamily M12B unassigned peptidase | 0.0128 | 0.0928 | 0.1168 |
Loa Loa (eye worm) | hypothetical protein | 0.0143 | 0.1093 | 0.1093 |
Loa Loa (eye worm) | reprolysin | 0.0128 | 0.0928 | 0.0928 |
Loa Loa (eye worm) | hypothetical protein | 0.0128 | 0.0928 | 0.0928 |
Schistosoma mansoni | hypothetical protein | 0.0063 | 0.0206 | 0.053 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0093 | 0.0537 | 1 |
Onchocerca volvulus | Matrix metalloproteinase homolog | 0.0098 | 0.0601 | 0.2131 |
Brugia malayi | Reprolysin | 0.0128 | 0.0928 | 0.0928 |
Trypanosoma cruzi | polo-like protein kinase, putative | 0.0093 | 0.0537 | 0.5 |
Brugia malayi | angiogenesis inhibito | 0.029 | 0.2725 | 0.2725 |
Mycobacterium ulcerans | hydrolase | 0.0054 | 0.0108 | 0.5 |
Echinococcus multilocularis | matrix metallopeptidase 7 (M10 family) | 0.0161 | 0.13 | 0.2277 |
Echinococcus multilocularis | a disintegrin and metalloproteinase with | 0.0395 | 0.389 | 1 |
Loa Loa (eye worm) | PLK/PLK1 protein kinase | 0.0093 | 0.0537 | 0.0537 |
Schistosoma mansoni | ADAMTS14 peptidase (M12 family) | 0.0128 | 0.0928 | 0.2387 |
Brugia malayi | metalloprotease | 0.0128 | 0.0928 | 0.0928 |
Echinococcus granulosus | a disintegrin and metalloproteinase with | 0.0395 | 0.389 | 1 |
Schistosoma mansoni | subfamily M12B unassigned peptidase (M12 family) | 0.0128 | 0.0928 | 0.2387 |
Schistosoma mansoni | adam (A disintegrin and metalloprotease | 0.0271 | 0.2515 | 0.6465 |
Schistosoma mansoni | ADAMTS5 peptidase (M12 family) | 0.0395 | 0.389 | 1 |
Loa Loa (eye worm) | metalloprotease | 0.0128 | 0.0928 | 0.0928 |
Echinococcus granulosus | adam | 0.0271 | 0.2515 | 0.5899 |
Leishmania major | protein kinase, putative,polo-like protein kinase, putative | 0.0093 | 0.0537 | 0.5 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0093 | 0.0537 | 1 |
Onchocerca volvulus | Papilin homolog | 0.0298 | 0.2819 | 1 |
Loa Loa (eye worm) | matrixin family protein | 0.0098 | 0.0601 | 0.0601 |
Loa Loa (eye worm) | angiogenesis inhibito | 0.0147 | 0.1139 | 0.1139 |
Onchocerca volvulus | Serine\/threonine kinase homolog | 0.0093 | 0.0537 | 0.1904 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0093 | 0.0537 | 0.138 |
Loa Loa (eye worm) | hypothetical protein | 0.0271 | 0.2515 | 0.2515 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0093 | 0.0537 | 1 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0093 | 0.0537 | 1 |
Brugia malayi | serine/threonine-protein kinase plk-2 | 0.0093 | 0.0537 | 0.0537 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0093 | 0.0537 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
GABA ratio (binding) | 0 | GABA ratio of binding to rat GABA-A receptor in the presence and absence of GABA (ND=Not determined) | ChEMBL. | 1680197 |
IC50 (binding) | = 4.7 nM | Displacement of [3H]-flunitrazepam (FNZ) from GABA-A benzodiazepine receptor in rat forebrain | ChEMBL. | 1680197 |
IC50 (binding) | = 4.7 nM | Displacement of [3H]-flunitrazepam (FNZ) from GABA-A benzodiazepine receptor in rat forebrain | ChEMBL. | 1680197 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.