Detailed information for compound 1637376

Basic information

Technical information
  • TDR Targets ID: 1637376
  • Name: 2-[[5-(phenylmethyl)-1H-1,2,4-triazol-3-yl]su lfanyl]acetic acid
  • MW: 249.289 | Formula: C11H11N3O2S
  • H donors: 2 H acceptors: 4 LogP: 1.87 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: OC(=O)CSc1nnc([nH]1)Cc1ccccc1
  • InChi: 1S/C11H11N3O2S/c15-10(16)7-17-11-12-9(13-14-11)6-8-4-2-1-3-5-8/h1-5H,6-7H2,(H,15,16)(H,12,13,14)
  • InChiKey: QEDGMCURIBDFME-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-[[5-(phenylmethyl)-1H-1,2,4-triazol-3-yl]thio]acetic acid
  • 2-[[5-(benzyl)-1H-1,2,4-triazol-3-yl]thio]acetic acid
  • 2-[[5-(phenylmethyl)-1H-1,2,4-triazol-3-yl]sulfanyl]ethanoic acid
  • ((5-Benzyl-4H-1,2,4-triazol-3-yl)thio)acetic acid
  • AIDS-135154
  • AIDS135154
  • NSC634499
  • NCI60_011482

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni tar DNA-binding protein 0.0074 0.0095 0.0095
Echinococcus multilocularis FTZ F1 alpha 0.0012 0.0005 0.0005
Brugia malayi ecdysteroid receptor 0.0012 0.0005 0.0012
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0034 0.0037 0.0037
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0012 0.0005 0.0005
Brugia malayi Na/Ca eXchangers family member (ncx-4) 0.0173 0.0241 0.0602
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0012 0.0005 0.0005
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0079 1
Schistosoma mansoni potassium-dependent sodium-calcium exchanger 3 4 0.0173 0.0241 0.0241
Trichomonas vaginalis alpha-L-fucosidase, putative 0.121 0.1754 1
Onchocerca volvulus 0.0016 0.0012 0.0333
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0034 0.0037 0.0037
Echinococcus multilocularis cysteine protease 0.0016 0.0012 0.0012
Onchocerca volvulus Bile acid receptor homolog 0.0012 0.0005 0.0051
Echinococcus granulosus geminin 0.0197 0.0276 0.0276
Trypanosoma cruzi PAB1-binding protein , putative 0.0029 0.0031 0.3886
Brugia malayi RNA recognition motif domain containing protein 0.0074 0.0095 0.0239
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0034 0.0037 0.0037
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0012 0.0066
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0012 0.0005 0.0005
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0079 1
Mycobacterium tuberculosis Probable ionic transporter integral membrane protein ChaA 0.0173 0.0241 0.5
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0079 1
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.001 0.0003 0.0003
Echinococcus multilocularis GPCR, family 2 0.0034 0.0037 0.0037
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0012 0.0005 0.0005
Loa Loa (eye worm) hypothetical protein 0.0012 0.0005 0.0002
Loa Loa (eye worm) hypothetical protein 0.0016 0.0012 0.0009
Trichomonas vaginalis conserved hypothetical protein 0.0173 0.0241 0.1371
Loa Loa (eye worm) latrophilin receptor protein 2 0.0034 0.0037 0.0034
Brugia malayi F/Y-rich N-terminus family protein 0.001 0.0003 0.0007
Treponema pallidum hypothetical protein 0.0173 0.0241 0.5
Schistosoma mansoni cpg binding protein 0.0035 0.0039 0.0039
Schistosoma mansoni RAR-like nuclear receptor 0.0012 0.0005 0.0005
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0012 0.0005 0.0002
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0012 0.0005 0.0005
Echinococcus multilocularis sodium:potassium:calcium exchanger 6 0.0173 0.0241 0.0241
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0012 0.0066
Brugia malayi Cathepsin L-like precursor 0.0016 0.0012 0.0029
Plasmodium falciparum ataxin-2 like protein, putative 0.0029 0.0031 0.127
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0012 0.0005 0.0012
Brugia malayi Cathepsin L-like precursor 0.0016 0.0012 0.0029
Brugia malayi K+-dependent Na+/Ca+ exchanger related-protein 0.0173 0.0241 0.0602
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0012 0.0005 0.0005
Entamoeba histolytica cysteine proteinase, putative 0.0011 0.0004 0.0153
Echinococcus multilocularis cathepsin L cysteine protease 0.0016 0.0012 0.0012
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0016 0.0012 0.0012
Loa Loa (eye worm) hypothetical protein 0.0012 0.0005 0.0002
Loa Loa (eye worm) hypothetical protein 0.0012 0.0005 0.0002
Onchocerca volvulus 0.0016 0.0012 0.0333
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0079 1
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0016 0.0012 0.0012
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0012 0.0066
Trypanosoma cruzi PAB1-binding protein , putative 0.0029 0.0031 0.3886
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0012 0.0005 0.0005
Schistosoma mansoni thyroid hormone receptor 0.0012 0.0005 0.0005
Trichomonas vaginalis alpha-L-fucosidase, putative 0.121 0.1754 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0016 0.0012 0.0066
Brugia malayi photoreceptor-specific nuclear receptor 0.0012 0.0005 0.0012
Echinococcus multilocularis cpg binding protein 0.0035 0.0039 0.0039
Loa Loa (eye worm) CXXC zinc finger family protein 0.0033 0.0037 0.0034
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0013 0.0007 0.0007
Brugia malayi nuclear hormone receptor 0.0012 0.0005 0.0012
Onchocerca volvulus Cathepsin L homolog 0.0016 0.0012 0.0333
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0012 0.0005 0.0002
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0012 0.0005 0.0005
Echinococcus granulosus tar DNA binding protein 0.0074 0.0095 0.0095
Leishmania major cathepsin L-like protease 0.0062 0.0079 1
Echinococcus granulosus sodium:potassium:calcium exchanger 6 0.0173 0.0241 0.0241
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0012 0.0066
Mycobacterium leprae Probable ionic transporter integral membrane protein ChaA 0.0173 0.0241 0.5
Plasmodium vivax cation/H+ antiporter, putative 0.0173 0.0241 1
Trypanosoma brucei PAB1-binding protein , putative 0.0029 0.0031 0.3886
Schistosoma mansoni hypothetical protein 0.0034 0.0037 0.0037
Brugia malayi nuclear receptor NHR-88 0.0012 0.0005 0.0012
Loa Loa (eye worm) hypothetical protein 0.0173 0.0241 0.0238
Trypanosoma cruzi major cysteine proteinase, putative 0.0049 0.0059 0.7525
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0012 0.0005 0.0005
Schistosoma mansoni retinoic acid receptor RXR 0.0012 0.0005 0.0005
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0012 0.0066
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0012 0.0005 0.0005
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0012 0.0066
Toxoplasma gondii LsmAD domain-containing protein 0.0029 0.0031 0.0829
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0944 0.1365 0.1365
Onchocerca volvulus 0.0016 0.0012 0.0333
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0012 0.0066
Echinococcus granulosus cathepsin L cysteine proteinase 0.0016 0.0012 0.0012
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0012 0.0005 0.0002
Toxoplasma gondii histone lysine methyltransferase SET1 0.0063 0.008 0.2996
Plasmodium falciparum ataxin-2 like protein, putative 0.0029 0.0031 0.127
Echinococcus granulosus dnaJ subfamily B 0.0476 0.0683 0.0683
Loa Loa (eye worm) hypothetical protein 0.0073 0.0094 0.0091
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0079 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0012 0.0066
Schistosoma mansoni cpg binding protein 0.0033 0.0037 0.0037
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0012 0.0005 0.0002
Brugia malayi Cathepsin L-like precursor 0.0016 0.0012 0.0029
Echinococcus multilocularis dnaJ subfamily B 0.0476 0.0683 0.0683
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0012 0.0066
Schistosoma mansoni hypothetical protein 0.0034 0.0037 0.0037
Brugia malayi hypothetical protein 0.0029 0.0031 0.0076
Trypanosoma cruzi cysteine peptidase, putative 0.0062 0.0079 1
Plasmodium vivax vivapain-2 0.0016 0.0012 0.0481
Brugia malayi cathepsin L-like precursor 0.0011 0.0004 0.0009
Echinococcus multilocularis tar DNA binding protein 0.0074 0.0095 0.0095
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0012 0.0066
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0079 1
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0012 0.0005 0.0005
Entamoeba histolytica sodium/calcium exchanger protein, putative 0.0173 0.0241 1
Brugia malayi Steroid receptor seven-up type 2 0.0012 0.0005 0.0012
Echinococcus multilocularis cysteine protease 0.0016 0.0012 0.0012
Brugia malayi Calcitonin receptor-like protein seb-1 0.0107 0.0144 0.0359
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0012 0.0005 0.0051
Schistosoma mansoni hypothetical protein 0.0197 0.0276 0.0276
Loa Loa (eye worm) hypothetical protein 0.0012 0.0005 0.0002
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0079 1
Loa Loa (eye worm) hypothetical protein 0.0012 0.0005 0.0002
Schistosoma mansoni steroid hormone receptor ad4bp 0.0012 0.0005 0.0005
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0012 0.0005 0.0012
Onchocerca volvulus 0.0033 0.0037 0.1386
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0016 0.0012 0.0066
Echinococcus granulosus cathepsin l1 0.0011 0.0004 0.0004
Onchocerca volvulus 0.0016 0.0012 0.0333
Leishmania major cathepsin L-like protease 0.0062 0.0079 1
Schistosoma mansoni cathepsin F (C01 family) 0.0016 0.0012 0.0012
Brugia malayi hypothetical protein 0.0019 0.0016 0.0038
Brugia malayi Cathepsin L-like precursor 0.0016 0.0012 0.0029
Entamoeba histolytica cysteine proteinase, putative 0.0016 0.0012 0.0481
Schistosoma mansoni tar DNA-binding protein 0.0074 0.0095 0.0095
Trichomonas vaginalis conserved hypothetical protein 0.0173 0.0241 0.1371
Onchocerca volvulus 0.0016 0.0012 0.0333
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0012 0.0005 0.0005
Trypanosoma cruzi cysteine peptidase, putative 0.0062 0.0079 1
Leishmania major hypothetical protein, conserved 0.0029 0.0031 0.2831
Onchocerca volvulus Cathepsin L homolog 0.0016 0.0012 0.0333
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0012 0.0005 0.0005
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0079 1
Loa Loa (eye worm) hypothetical protein 0.2745 0.3993 0.3991
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0012 0.0066
Echinococcus granulosus ecdysone induced protein 78C 0.0012 0.0005 0.0005
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0079 1
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0012 0.0005 0.0012
Onchocerca volvulus Cathepsin F homolog 0.0016 0.0012 0.0333
Loa Loa (eye worm) TAR-binding protein 0.0074 0.0095 0.0093
Schistosoma mansoni hypothetical protein 0.0013 0.0007 0.0007
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0012 0.0005 0.0005
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0016 0.0012 0.0481
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0012 0.0066
Loa Loa (eye worm) hypothetical protein 0.0034 0.0037 0.0034
Loa Loa (eye worm) hypothetical protein 0.0011 0.0004 0.0001
Leishmania major cathepsin L-like protease 0.0062 0.0079 1
Toxoplasma gondii manganese resistance 1 protein, putative 0.0173 0.0241 1
Schistosoma mansoni cathepsin F (C01 family) 0.0011 0.0004 0.0004
Loa Loa (eye worm) hypothetical protein 0.0173 0.0241 0.0238
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0071 0.0091 0.0091
Echinococcus multilocularis cathepsin L cysteine protease 0.0016 0.0012 0.0012
Trypanosoma cruzi cruzipain precursor, putative 0.0062 0.0079 1
Trypanosoma cruzi cysteine peptidase, putative 0.0062 0.0079 1
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0012 0.0005 0.0012
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0034 0.0037 0.0093
Schistosoma mansoni hypothetical protein 0.0197 0.0276 0.0276
Loa Loa (eye worm) hypothetical protein 0.0012 0.0005 0.0002
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0012 0.0005 0.0012
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.001 0.0003 0.0003
Onchocerca volvulus Sodium\/potassium\/calcium exchanger 0.0173 0.0241 1
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0012 0.0005 0.0012
Loa Loa (eye worm) cysteine protease 0.0016 0.0012 0.0009
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0011 0.0004 0.0021
Brugia malayi Nuclear hormone receptor-like 1 0.0012 0.0005 0.0012
Brugia malayi Cathepsin L-like precursor 0.0016 0.0012 0.0029
Plasmodium falciparum cation/H+ antiporter 0.0173 0.0241 1
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0016 0.0012 0.0009
Loa Loa (eye worm) solute carrier family 8 0.6862 1 1
Echinococcus granulosus cathepsin l cysteine peptidase 0.0016 0.0012 0.0012
Schistosoma mansoni tar DNA-binding protein 0.0074 0.0095 0.0095
Schistosoma mansoni coup transcription factor 0.0012 0.0005 0.0005
Schistosoma mansoni cathepsin F (C01 family) 0.0016 0.0012 0.0012
Echinococcus granulosus GPCR family 2 0.0034 0.0037 0.0037
Schistosoma mansoni hypothetical protein 0.0476 0.0683 0.0683
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0074 0.0095 0.0093
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0012 0.0066
Plasmodium falciparum cysteine proteinase falcipain 3 0.0016 0.0012 0.0481
Echinococcus multilocularis sodium calcium exchanger 0.6862 1 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0012 0.0066
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0012 0.0005 0.0002
Brugia malayi steroid hormone receptor 0.0012 0.0005 0.0012
Echinococcus granulosus FTZ F1 alpha 0.0012 0.0005 0.0005
Schistosoma mansoni hypothetical protein 0.0173 0.0241 0.0241
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0057 0.0071 0.8997
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0079 1
Echinococcus granulosus cpg binding protein 0.0035 0.0039 0.0039
Onchocerca volvulus Protein ultraspiracle homolog 0.0012 0.0005 0.0051
Echinococcus granulosus sodium:potassium:calcium exchanger 0.0173 0.0241 0.0241
Loa Loa (eye worm) hypothetical protein 0.0173 0.0241 0.0238
Schistosoma mansoni hypothetical protein 0.0073 0.0094 0.0094
Schistosoma mansoni cpg binding protein 0.0035 0.0039 0.0039
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0012 0.0066
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0012 0.0066
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0012 0.0066
Onchocerca volvulus 0.0016 0.0012 0.0333
Loa Loa (eye worm) ctsf protein 0.0016 0.0012 0.0009
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0012 0.0066
Brugia malayi latrophilin 2 splice variant baaae 0.0073 0.0094 0.0236
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0012 0.0005 0.0012
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0012 0.0005 0.0005
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0012 0.0066
Loa Loa (eye worm) fibroinase 0.0016 0.0012 0.0009
Onchocerca volvulus 0.0012 0.0005 0.0051
Brugia malayi TAR-binding protein 0.0074 0.0095 0.0239
Loa Loa (eye worm) hypothetical protein 0.0107 0.0144 0.0141
Brugia malayi Sodium/calcium exchanger protein 0.2745 0.3993 1
Brugia malayi Latrophilin receptor protein 2 0.0034 0.0037 0.0093
Loa Loa (eye worm) hypothetical protein 0.0012 0.0005 0.0002
Schistosoma mansoni sodium/calcium exchanger 0.6862 1 1
Loa Loa (eye worm) RNA binding protein 0.0074 0.0095 0.0093
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0016 0.0012 0.0009
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0016 0.0012 0.0481
Schistosoma mansoni hypothetical protein 0.0034 0.0037 0.0037
Schistosoma mansoni potassium-dependent sodium-calcium exchanger 3 4 0.0173 0.0241 0.0241
Loa Loa (eye worm) hypothetical protein 0.0011 0.0004 0.0001
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0012 0.0005 0.0012
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0012 0.0005 0.0012
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0079 1
Schistosoma mansoni thyroid hormone receptor 0.0012 0.0005 0.0005
Loa Loa (eye worm) hypothetical protein 0.0029 0.0031 0.0028
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0107 0.0144 0.0359
Brugia malayi Papain family cysteine protease containing protein 0.0016 0.0012 0.0029
Brugia malayi Cathepsin L-like cysteine proteinase 0.0011 0.0004 0.0009
Echinococcus multilocularis sodium:potassium:calcium exchanger 0.0173 0.0241 0.0241
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0012 0.0005 0.0005
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0012 0.0005 0.0005
Echinococcus multilocularis thyroid hormone receptor alpha 0.0012 0.0005 0.0005
Brugia malayi RNA binding protein 0.0074 0.0095 0.0239
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0012 0.0066
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0012 0.0066
Plasmodium vivax ataxin-2 like protein, putative 0.0029 0.0031 0.127
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0012 0.0005 0.0012
Schistosoma mansoni tar DNA-binding protein 0.0074 0.0095 0.0095
Brugia malayi Cathepsin L-like precursor 0.0011 0.0004 0.0009
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0012 0.0005 0.0012
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0012 0.0005 0.0005
Schistosoma mansoni tar DNA-binding protein 0.0074 0.0095 0.0095
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0013 0.0007 0.0007
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0012 0.0005 0.0012
Trichomonas vaginalis conserved hypothetical protein 0.0173 0.0241 0.1371
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0012 0.0005 0.0002
Echinococcus multilocularis geminin 0.0197 0.0276 0.0276
Schistosoma mansoni na/ca exchanger 0.0173 0.0241 0.0241
Schistosoma mansoni nuclear hormone receptor 0.0012 0.0005 0.0005
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0034 0.0037 0.0037
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0011 0.0004 0.0021
Loa Loa (eye worm) hypothetical protein 0.0012 0.0005 0.0002
Brugia malayi Cathepsin L-like precursor 0.0016 0.0012 0.0029
Entamoeba histolytica cysteine protease, putative 0.0016 0.0012 0.0481
Entamoeba histolytica cysteine proteinase, putative 0.0016 0.0012 0.0481
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0107 0.0144 0.0141
Trypanosoma cruzi cysteine peptidase, putative 0.0016 0.0012 0.1472
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0012 0.0005 0.0005
Loa Loa (eye worm) hypothetical protein 0.0011 0.0004 0.0001
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0012 0.0066
Loa Loa (eye worm) steroid hormone receptor 0.0012 0.0005 0.0002
Brugia malayi CXXC zinc finger family protein 0.0033 0.0037 0.0091
Schistosoma mansoni hypothetical protein 0.0034 0.0037 0.0037
Onchocerca volvulus 0.0016 0.0012 0.0333
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0012 0.0066
Brugia malayi Cathepsin L-like precursor 0.0011 0.0004 0.0009
Echinococcus granulosus cathepsin l1 0.0016 0.0012 0.0012
Plasmodium vivax vivapain-2 0.0016 0.0012 0.0481
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0012 0.0005 0.0002
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0012 0.0005 0.0012
Loa Loa (eye worm) Na/Ca eXchangers family member 0.0173 0.0241 0.0238
Echinococcus multilocularis ecdysone induced protein 78C 0.0012 0.0005 0.0005

Activities

Activity type Activity value Assay description Source Reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-5 Melanoma cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MALME-3M Melanoma cell line. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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