Detailed information for compound 1641551

Basic information

Technical information
  • TDR Targets ID: 1641551
  • Name: bis(bis(phenylmethyl)amino)methylideneurea
  • MW: 462.585 | Formula: C30H30N4O
  • H donors: 1 H acceptors: 1 LogP: 5.2 Rotable bonds: 11
    Rule of 5 violations (Lipinski): 1
  • SMILES: NC(=O)N=C(N(Cc1ccccc1)Cc1ccccc1)N(Cc1ccccc1)Cc1ccccc1
  • InChi: 1S/C30H30N4O/c31-29(35)32-30(33(21-25-13-5-1-6-14-25)22-26-15-7-2-8-16-26)34(23-27-17-9-3-10-18-27)24-28-19-11-4-12-20-28/h1-20H,21-24H2,(H2,31,35)
  • InChiKey: NDVUJAHUDSCWNK-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • bis(bis(phenylmethyl)amino)methyleneurea
  • bis(bis(benzyl)amino)methyleneurea
  • N-(Bis(dibenzylamino)methylene)urea hydrochloride
  • AIDS-157781
  • AIDS157781
  • NCI60_017796
  • NSC650958 (HYDROCHLORIDE SALT)

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma cruzi target of rapamycin kinase 3 0.2149 0.7937 0.7822
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.2699 1 1
Loa Loa (eye worm) hypothetical protein 0.0569 0.2009 0.2002
Loa Loa (eye worm) hypothetical protein 0.0174 0.0528 0.052
Loa Loa (eye worm) hypothetical protein 0.0511 0.179 0.1783
Mycobacterium leprae conserved hypothetical protein 0.0174 0.0528 0.5
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0336 0.1137 0.0642
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.2699 1 1
Plasmodium vivax phosphatidylinositol 3-kinase, putative 0.0174 0.0528 0.5
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0174 0.0528 0.5
Trichomonas vaginalis PIKK family atypical protein kinase 0.0905 0.327 0.327
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0511 0.179 0.1332
Echinococcus granulosus phosphatidylinositol 4 phosphate 3 kinase C2 0.0174 0.0528 0.052
Trichomonas vaginalis PIKK family atypical protein kinase 0.2008 0.7405 0.7405
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0174 0.0528 0.0528
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0174 0.0528 0.052
Trichomonas vaginalis PIKK family atypical protein kinase 0.2008 0.7405 0.7405
Echinococcus granulosus DNA dependent protein kinase catalytic subunit 0.0174 0.0528 0.052
Trichomonas vaginalis PIKK family atypical protein kinase 0.2008 0.7405 0.7405
Trichomonas vaginalis PIKK family atypical protein kinase 0.1613 0.5925 0.5925
Trichomonas vaginalis PIKK family atypical protein kinase 0.1455 0.5334 0.5334
Trichomonas vaginalis PIKK family atypical protein kinase 0.1811 0.6667 0.6667
Trichomonas vaginalis PIKK family atypical protein kinase 0.2008 0.7405 0.7405
Echinococcus granulosus serine protein kinase ATM 0.0511 0.179 0.1783
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.2149 0.7937 0.7822
Trichomonas vaginalis conserved hypothetical protein 0.0395 0.1355 0.1355
Trichomonas vaginalis PIKK family atypical protein kinase 0.2008 0.7405 0.7405
Loa Loa (eye worm) phosphatidylinositol 3 0.2699 1 1
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.2699 1 1
Echinococcus multilocularis phosphatidylinositol 4,5 bisphosphate 3 kinase 0.0174 0.0528 0.052
Loa Loa (eye worm) phosphatidylinositol kinase 0.0174 0.0528 0.052
Plasmodium falciparum phosphatidylinositol 3- and 4-kinase, putative 0.0174 0.0528 0.5
Echinococcus multilocularis DNA dependent protein kinase catalytic subunit 0.0174 0.0528 0.052
Trichomonas vaginalis PIKK family atypical protein kinase 0.0511 0.179 0.179
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.2699 1 1
Trichomonas vaginalis conserved hypothetical protein 0.0569 0.2009 0.2009
Echinococcus multilocularis PIK kinase, FAT and Armadillo domain containing protein 0.0395 0.1355 0.1348
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0174 0.0528 0.052
Trichomonas vaginalis PIKK family atypical protein kinase 0.1458 0.5342 0.5342
Trichomonas vaginalis PIKK family atypical protein kinase 0.2147 0.7928 0.7928
Trichomonas vaginalis PIKK family atypical protein kinase 0.1455 0.5334 0.5334
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.2699 1 1
Echinococcus granulosus phosphatidylinositol 4 kinase beta 0.0174 0.0528 0.052
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.0511 0.179 0.1783
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0905 0.327 0.2895
Echinococcus granulosus serine:threonine protein kinase SMG1 0.0511 0.179 0.1783
Loa Loa (eye worm) phosphatidylinositol 3 0.0905 0.327 0.3264
Onchocerca volvulus 0.0174 0.0528 0.5
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0174 0.0528 0.052
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0174 0.0528 0.0528
Trichomonas vaginalis PIKK family atypical protein kinase 0.2008 0.7405 0.7405
Entamoeba histolytica hypothetical protein 0.0511 0.179 0.1332
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0174 0.0528 0.052
Echinococcus multilocularis phosphatidylinositol 4 kinase alpha 0.0174 0.0528 0.052
Echinococcus multilocularis phosphatidylinositol 4 phosphate 3 kinase C2 0.0174 0.0528 0.052
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0511 0.179 0.1783
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.2699 1 1
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0905 0.327 0.2895
Plasmodium vivax hypothetical protein, conserved 0.0174 0.0528 0.5
Echinococcus granulosus phosphatidylinositol 45 bisphosphate 3 kinase 0.0174 0.0528 0.052
Trichomonas vaginalis PIKK family atypical protein kinase 0.0336 0.1137 0.1137
Trichomonas vaginalis PIKK family atypical protein kinase 0.2699 1 1
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0174 0.0528 0.0528
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0174 0.0528 0.0508
Echinococcus granulosus phosphatidylinositol 3 kinase catalytic subunit 0.0174 0.0528 0.052
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0174 0.0528 0.0508
Schistosoma mansoni hypothetical protein 0.0395 0.1355 0.1337
Trichomonas vaginalis PIKK family atypical protein kinase 0.0511 0.179 0.179
Trichomonas vaginalis PIKK family atypical protein kinase 0.0905 0.327 0.327
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.1121 0.408 0.375
Loa Loa (eye worm) phosphatidylinositol 3 0.0174 0.0528 0.052
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.2699 1 1
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0174 0.0528 0.0508
Trichomonas vaginalis PIKK family atypical protein kinase 0.0511 0.179 0.179
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.2699 1 1
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0905 0.327 0.3264
Plasmodium falciparum phosphatidylinositol 4-kinase 0.0174 0.0528 0.5
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0905 0.327 0.3264
Loa Loa (eye worm) phosphatidylinositol 3 0.0174 0.0528 0.052
Loa Loa (eye worm) hypothetical protein 0.055 0.1938 0.1931
Trichomonas vaginalis PIKK family atypical protein kinase 0.1752 0.6448 0.6448
Echinococcus multilocularis 0.0174 0.0528 0.052
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0174 0.0528 0.0528
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0174 0.0528 0.0528
Loa Loa (eye worm) hypothetical protein 0.0336 0.1137 0.1129
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0174 0.0528 0.0528
Trichomonas vaginalis PIKK family atypical protein kinase 0.0724 0.2591 0.2591
Trichomonas vaginalis PIKK family atypical protein kinase 0.1597 0.5865 0.5865
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0174 0.0528 0.0528
Schistosoma mansoni hypothetical protein 0.0174 0.0528 0.0508
Trichomonas vaginalis PIKK family atypical protein kinase 0.1458 0.5342 0.5342
Trichomonas vaginalis PIKK family atypical protein kinase 0.2147 0.7928 0.7928
Brugia malayi FAT domain containing protein 0.0395 0.1355 0.1348
Leishmania major phosphatidylinositol 3-kinase, putative 0.0905 0.327 0.2895
Schistosoma mansoni fkbp-rapamycin associated protein 0.0511 0.179 0.1772
Trichomonas vaginalis PIKK family atypical protein kinase 0.1458 0.5342 0.5342
Trichomonas vaginalis PIKK family atypical protein kinase 0.2008 0.7405 0.7405
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0174 0.0528 0.0528
Plasmodium vivax phosphatidylinositol 3- and 4-kinase, putative 0.0174 0.0528 0.5
Trichomonas vaginalis PIKK family atypical protein kinase 0.2699 1 1
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0174 0.0528 0.052
Brugia malayi phosphatidylinositol 4-kinase, catalytic, alpha polypeptide 0.0174 0.0528 0.052
Entamoeba histolytica Phosphatidylinositol 3- and 4-kinase family 0.0511 0.179 0.1332
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0511 0.179 0.1332
Echinococcus granulosus phosphatidylinositol 4 kinase alpha 0.0174 0.0528 0.052
Loa Loa (eye worm) phosphatidylinositol 3 0.0174 0.0528 0.052
Loa Loa (eye worm) hypothetical protein 0.0174 0.0528 0.052
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.1277 0.4663 0.4366
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0174 0.0528 0.052
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0174 0.0528 0.0528
Trichomonas vaginalis PIKK family atypical protein kinase 0.2147 0.7928 0.7928
Trichomonas vaginalis PIKK family atypical protein kinase 0.2305 0.8519 0.8519
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit gamma, putative 0.0174 0.0528 0.0528
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0174 0.0528 0.0508
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0174 0.0528 0.052
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.2699 1 1
Plasmodium falciparum phosphatidylinositol 3-kinase 0.0174 0.0528 0.5
Trichomonas vaginalis PIKK family atypical protein kinase 0.0905 0.327 0.327
Trypanosoma brucei target of rapamycin kinase 3, putative 0.2149 0.7937 0.7822
Loa Loa (eye worm) phosphatidylinositol 4-kinase type 3 alpha isoform 1 0.0174 0.0528 0.052
Trichomonas vaginalis PIKK family atypical protein kinase 0.1613 0.5925 0.5925
Loa Loa (eye worm) hypothetical protein 0.0395 0.1355 0.1348
Schistosoma mansoni phosphatidylinositol 3-kinase class 0.0174 0.0528 0.0508
Trichomonas vaginalis PIKK family atypical protein kinase 0.0174 0.0528 0.0528
Trichomonas vaginalis conserved hypothetical protein 0.0336 0.1137 0.1137
Trichomonas vaginalis PIKK family atypical protein kinase 0.1455 0.5334 0.5334
Onchocerca volvulus 0.0174 0.0528 0.5
Loa Loa (eye worm) phosphatidylinositol 3 0.0174 0.0528 0.052
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0174 0.0528 0.0508
Trichomonas vaginalis PIKK family atypical protein kinase 0.1597 0.5865 0.5865
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0174 0.0528 0.052
Giardia lamblia GTOR 0.2699 1 1
Toxoplasma gondii target of rapamycin (TOR), putative 0.2008 0.7405 1
Loa Loa (eye worm) phosphatidylinositol 3 0.0174 0.0528 0.052
Toxoplasma gondii FATC domain-containing protein 0.0511 0.179 0.1835
Trichomonas vaginalis PIKK family atypical protein kinase 0.1458 0.5342 0.5342
Echinococcus multilocularis Zinc finger, PHD finger 0.0174 0.0528 0.052
Mycobacterium tuberculosis Conserved hypothetical protein 0.0174 0.0528 0.5
Entamoeba histolytica protein kinase rad3, putative 0.0511 0.179 0.1332
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0174 0.0528 0.5
Trichomonas vaginalis PIKK family atypical protein kinase 0.2147 0.7928 0.7928
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0511 0.179 0.1332
Echinococcus granulosus PIK kinase FAT and Armadillo domain containing protein 0.0395 0.1355 0.1348
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0905 0.327 0.2895
Trichomonas vaginalis PIKK family atypical protein kinase 0.0174 0.0528 0.0528
Trichomonas vaginalis PIKK family atypical protein kinase 0.0905 0.327 0.327
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0174 0.0528 0.052
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0905 0.327 0.3264
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0511 0.179 0.1772
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0905 0.327 0.3256
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.2699 1 1
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0511 0.179 0.1783
Trichomonas vaginalis PIKK family atypical protein kinase 0.2147 0.7928 0.7928
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0174 0.0528 0.0528
Echinococcus multilocularis serine protein kinase ATM 0.0511 0.179 0.1783
Plasmodium vivax hypothetical protein 0.0174 0.0528 0.5
Schistosoma mansoni phosphatidylinositol 4-kinase type-II 0.0174 0.0528 0.0508
Trichomonas vaginalis PIKK family atypical protein kinase 0.2699 1 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0905 0.327 0.327
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0905 0.327 0.2895
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0905 0.327 0.2895
Trichomonas vaginalis PIKK family atypical protein kinase 0.1613 0.5925 0.5925
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.2699 1 1
Toxoplasma gondii non-specific serine/threonine protein kinase 0.0569 0.2009 0.2153
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0174 0.0528 0.0528
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0174 0.0528 0.052
Trichomonas vaginalis phosphatidylinositol 4-kinase, putative 0.0174 0.0528 0.0528

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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