Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | butyrylcholinesterase | Starlite/ChEMBL | References |
Homo sapiens | acetylcholinesterase (Yt blood group) | Starlite/ChEMBL | References |
Bos taurus | Acetylcholinesterase | Starlite/ChEMBL | References |
Equus caballus | Cholinesterase | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Onchocerca volvulus | Putative nuclear protein | Acetylcholinesterase | 613 aa | 572 aa | 41.6 % |
Brugia malayi | Carboxylesterase family protein | butyrylcholinesterase | 602 aa | 546 aa | 30.2 % |
Brugia malayi | Carboxylesterase family protein | Cholinesterase | 574 aa | 538 aa | 31.4 % |
Loa Loa (eye worm) | hypothetical protein | Acetylcholinesterase | 613 aa | 561 aa | 24.6 % |
Drosophila melanogaster | CG10175 gene product from transcript CG10175-RE | Acetylcholinesterase | 613 aa | 527 aa | 32.3 % |
Brugia malayi | Carboxylesterase family protein | acetylcholinesterase (Yt blood group) | 614 aa | 510 aa | 26.5 % |
Echinococcus granulosus | BC026374 protein S09 family | Acetylcholinesterase | 613 aa | 627 aa | 34.0 % |
Onchocerca volvulus | Carnitine O-palmitoyltransferase 2, mitochondrial homolog | Acetylcholinesterase | 613 aa | 511 aa | 39.9 % |
Echinococcus multilocularis | neuroligin | Acetylcholinesterase | 613 aa | 534 aa | 23.2 % |
Loa Loa (eye worm) | hypothetical protein | Acetylcholinesterase | 613 aa | 573 aa | 26.5 % |
Brugia malayi | Carboxylesterase family protein | Acetylcholinesterase | 613 aa | 569 aa | 31.3 % |
Onchocerca volvulus | Acetylcholinesterase | 613 aa | 613 aa | 26.8 % | |
Brugia malayi | Carboxylesterase family protein | Acetylcholinesterase | 613 aa | 491 aa | 26.7 % |
Onchocerca volvulus | Molybdopterin synthase catalytic subunit homolog | Acetylcholinesterase | 613 aa | 564 aa | 30.3 % |
Onchocerca volvulus | Acetylcholinesterase | 613 aa | 565 aa | 26.0 % | |
Onchocerca volvulus | Acetylcholinesterase | 613 aa | 552 aa | 31.3 % | |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | Acetylcholinesterase | 613 aa | 601 aa | 23.6 % |
Echinococcus granulosus | neuroligin | Cholinesterase | 574 aa | 492 aa | 24.4 % |
Schistosoma japonicum | ko:K01050 cholinesterase [EC3.1.1.8], putative | Cholinesterase | 574 aa | 577 aa | 36.9 % |
Echinococcus multilocularis | BC026374 protein (S09 family) | Acetylcholinesterase | 613 aa | 627 aa | 33.8 % |
Schistosoma mansoni | gliotactin | Cholinesterase | 574 aa | 587 aa | 27.9 % |
Onchocerca volvulus | Galectin homolog | Cholinesterase | 574 aa | 531 aa | 39.7 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | TGF-beta receptor type-1 | 0.034 | 0.5746 | 0.5746 |
Schistosoma mansoni | microsomal glutathione s-transferase | 0.0478 | 1 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.0327 | 0.5364 | 0.5364 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0327 | 0.5364 | 0.5364 |
Echinococcus granulosus | TGF beta receptor type 1 | 0.034 | 0.5746 | 0.5746 |
Echinococcus granulosus | acetylcholinesterase | 0.0327 | 0.5364 | 0.5364 |
Echinococcus multilocularis | acetylcholinesterase | 0.0327 | 0.5364 | 0.5364 |
Loa Loa (eye worm) | TKL/STKR/TYPE1 protein kinase | 0.0339 | 0.5731 | 1 |
Brugia malayi | bone morphogenetic protein type 1 receptor | 0.0339 | 0.5731 | 1 |
Echinococcus multilocularis | microsomal glutathione S transferase 3 | 0.0478 | 1 | 1 |
Schistosoma mansoni | membrane associated proteins in eicosanoid and glutathione metabolism family member | 0.0478 | 1 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.0327 | 0.5364 | 0.5364 |
Echinococcus multilocularis | TGF beta receptor type 1 | 0.034 | 0.5746 | 0.5746 |
Toxoplasma gondii | MAPEG family protein | 0.0478 | 1 | 0.5 |
Echinococcus granulosus | carboxylesterase 5A | 0.0327 | 0.5364 | 0.5364 |
Schistosoma mansoni | protein kinase | 0.034 | 0.5746 | 0.0823 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.2 nM | Inhibition of human erythrocytes AChE by Ellman's method | ChEMBL. | 22243648 |
IC50 (binding) | = 0.85 nM | Inhibition of horse serum BChE by Ellman's method | ChEMBL. | 22243648 |
IC50 (binding) | = 6.5 nM | Inhibition of bovine erythrocytes AChE by Ellman's method | ChEMBL. | 22243648 |
IC50 (binding) | = 50 nM | Inhibition of human serum BChE by Ellman's method | ChEMBL. | 22243648 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.