Detailed information for compound 1647117

Basic information

Technical information
  • TDR Targets ID: 1647117
  • Name: NSC697785
  • MW: 396.872 | Formula: C15H13ClN4O3S2
  • H donors: 1 H acceptors: 4 LogP: 3.33 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: CSc1nc(Cl)c2c(n1)Sc1n(C2O)c2c(n1)cc(c(c2)OC)OC
  • InChi: 1S/C15H13ClN4O3S2/c1-22-8-4-6-7(5-9(8)23-2)20-13(21)10-11(16)18-14(24-3)19-12(10)25-15(20)17-6/h4-5,13,21H,1-3H3
  • InChiKey: CIMWSANVOPMHKO-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • AIDS152793
  • NCI60_034923
  • AIDS-152793
  • 4-Chloro-8,9-dimethoxy-2-(methylthio)-5H-pyrimido[5',4':5,6][1,3]thiazino[3,2-a]benzimidazol-5-ol

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0031 0.0432 0.0432
Entamoeba histolytica hypothetical protein 0.0092 0.1707 0.1707
Trichomonas vaginalis PIKK family atypical protein kinase 0.0163 0.3202 0.3202
Giardia lamblia Phosphoinositide-3-kinase, catalytic, alpha polypeptide 0.0031 0.0432 0.0223
Trichomonas vaginalis PIKK family atypical protein kinase 0.0262 0.5295 0.5295
Schistosoma mansoni hypothetical protein 0.0071 0.1268 0.1268
Trichomonas vaginalis PIKK family atypical protein kinase 0.0386 0.7907 0.7907
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0031 0.0432 0.0432
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0031 0.0432 0.0432
Entamoeba histolytica Phosphatidylinositol 3- and 4-kinase family 0.0092 0.1707 0.1707
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0031 0.0432 1
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0092 0.1707 0.1332
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0031 0.0432 0.0432
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0031 0.0432 0.0432
Loa Loa (eye worm) phosphatidylinositol 4-kinase type 3 alpha isoform 1 0.0031 0.0432 0.0432
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0486 1 1
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit gamma, putative 0.0031 0.0432 0.0432
Trichomonas vaginalis PIKK family atypical protein kinase 0.0262 0.5286 0.5286
Schistosoma mansoni voltage-gated potassium channel 0.0039 0.0603 0.0603
Trichomonas vaginalis PIKK family atypical protein kinase 0.0361 0.7379 0.7379
Plasmodium vivax phosphatidylinositol 3-kinase, putative 0.0031 0.0432 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0386 0.7907 0.7907
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0031 0.0432 0.0432
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.023 0.4609 0.4366
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0034 0.0483 0.0483
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0031 0.0432 0.0432
Trichomonas vaginalis AGC family protein kinase 0.0034 0.0481 0.0481
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0031 0.0432 0.0432
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0163 0.3202 0.3053
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0031 0.0432 0.0432
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0486 1 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0031 0.0432 0.0432
Loa Loa (eye worm) phosphatidylinositol kinase 0.0031 0.0432 0.0432
Echinococcus granulosus Glutaredoxin protein 5 0.0021 0.0209 0.0209
Brugia malayi phosphatidylinositol 4-kinase, catalytic, alpha polypeptide 0.0031 0.0432 0.0432
Trichomonas vaginalis PIKK family atypical protein kinase 0.0415 0.8504 0.8504
Onchocerca volvulus 0.0031 0.0432 0.5
Trichomonas vaginalis PIKK family atypical protein kinase 0.0486 1 1
Echinococcus multilocularis DNA dependent protein kinase catalytic subunit 0.0031 0.0432 0.0432
Trichomonas vaginalis PIKK family atypical protein kinase 0.0163 0.3202 0.3202
Echinococcus multilocularis serine protein kinase ATM 0.0092 0.1707 0.1707
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0486 1 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0061 0.1047 0.1047
Trichomonas vaginalis PIKK family atypical protein kinase 0.0315 0.6412 0.6412
Loa Loa (eye worm) hypothetical protein 0.0099 0.1856 0.1856
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0036 0.0533 0.0533
Schistosoma mansoni phosphatidylinositol 3-kinase class 0.0031 0.0432 0.0432
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0031 0.0432 0.0432
Trichomonas vaginalis phosphatidylinositol 4-kinase, putative 0.0031 0.0432 0.0432
Loa Loa (eye worm) AGC/AKT protein kinase 0.0034 0.0481 0.0481
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0163 0.3202 0.3053
Entamoeba histolytica hypothetical protein 0.0031 0.0432 0.0432
Entamoeba histolytica hypothetical protein 0.0031 0.0432 0.0432
Trichomonas vaginalis PIKK family atypical protein kinase 0.0287 0.5823 0.5823
Loa Loa (eye worm) hypothetical protein 0.0031 0.0432 0.0432
Trichomonas vaginalis PIKK family atypical protein kinase 0.013 0.2516 0.2516
Echinococcus granulosus serine/threonine protein kinase 0.0023 0.0258 0.0258
Brugia malayi p70 ribosomal S6 kinase beta 0.0032 0.0437 0.0437
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0163 0.3202 0.2895
Trypanosoma cruzi phosphatidylinositol 3-kinase vps34-like 0.0031 0.0432 0.0223
Echinococcus granulosus nervana 2 0.0021 0.0209 0.0209
Loa Loa (eye worm) phosphatidylinositol 3 0.0031 0.0432 0.0432
Loa Loa (eye worm) phosphatidylinositol 3 0.0163 0.3202 0.3202
Brugia malayi FAT domain containing protein 0.0071 0.1268 0.1268
Trichomonas vaginalis PIKK family atypical protein kinase 0.0092 0.1707 0.1707
Trichomonas vaginalis PIKK family atypical protein kinase 0.0386 0.7907 0.7907
Plasmodium vivax hypothetical protein, conserved 0.0031 0.0432 1
Echinococcus granulosus serine threonine protein kinase nrc 0.0021 0.0214 0.0214
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0163 0.3202 0.3202
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0486 1 1
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0092 0.1707 0.1707
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0163 0.3202 0.2895
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0031 0.0432 0.0223
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0163 0.3202 0.2895
Trichomonas vaginalis PIKK family atypical protein kinase 0.029 0.5884 0.5884
Trichomonas vaginalis PIKK family atypical protein kinase 0.0163 0.3202 0.3202
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0163 0.3202 0.3202
Echinococcus granulosus phosphatidylinositol 4 kinase beta 0.0031 0.0432 0.0432
Echinococcus multilocularis nervana 2 0.0021 0.0209 0.0209
Trichomonas vaginalis PIKK family atypical protein kinase 0.0486 1 1
Echinococcus multilocularis phosphatidylinositol 4 kinase alpha 0.0031 0.0432 0.0432
Trichomonas vaginalis PIKK family atypical protein kinase 0.0092 0.1707 0.1707
Echinococcus multilocularis Zinc finger, PHD finger 0.0031 0.0432 0.0432
Schistosoma mansoni phosphatidylinositol 4-kinase type-II 0.0031 0.0432 0.0432
Entamoeba histolytica protein kinase, putative 0.0032 0.0437 0.0437
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0031 0.0432 0.0432
Trichomonas vaginalis AGC family protein kinase 0.0034 0.0481 0.0481
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0031 0.0432 0.0432
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0486 1 1
Trichomonas vaginalis AGC family protein kinase 0.0013 0.0044 0.0044
Loa Loa (eye worm) hypothetical protein 0.0102 0.1928 0.1928
Trichomonas vaginalis PIKK family atypical protein kinase 0.0031 0.0432 0.0432
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0061 0.1047 0.0851
Trichomonas vaginalis PIKK family atypical protein kinase 0.029 0.5884 0.5884
Trichomonas vaginalis conserved hypothetical protein 0.0071 0.1268 0.1268
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0031 0.0432 0.0432
Trypanosoma cruzi target of rapamycin kinase 3 0.0387 0.7916 0.787
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0034 0.0483 0.0483
Trichomonas vaginalis PIKK family atypical protein kinase 0.0287 0.5823 0.5823
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0031 0.0432 0.0432
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0031 0.0432 0.0432
Entamoeba histolytica protein kinase 2, putative 0.0021 0.0214 0.0214
Entamoeba histolytica phosphatidylinositol-4,5-bisphosphate 3-kinase, putative 0.0031 0.0432 0.0432
Loa Loa (eye worm) phosphatidylinositol 3 0.0031 0.0432 0.0432
Echinococcus granulosus nervana 2 0.0021 0.0209 0.0209
Trichomonas vaginalis AGC family protein kinase 0.0034 0.0481 0.0481
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0036 0.0533 0.0533
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0031 0.0432 0.0432
Trichomonas vaginalis PIKK family atypical protein kinase 0.0262 0.5295 0.5295
Trichomonas vaginalis PIKK family atypical protein kinase 0.0262 0.5295 0.5295
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0036 0.0533 0.0533
Entamoeba histolytica hypothetical protein 0.0031 0.0432 0.0432
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.0092 0.1707 0.1707
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0486 1 1
Entamoeba histolytica PH domain containing protein kinase, putative 0.0023 0.0258 0.0258
Toxoplasma gondii target of rapamycin (TOR), putative 0.0361 0.7379 1
Giardia lamblia Hypothetical protein 0.0031 0.0432 0.0223
Trichomonas vaginalis AGC family protein kinase 0.0034 0.0481 0.0481
Loa Loa (eye worm) phosphatidylinositol 3 0.0031 0.0432 0.0432
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0031 0.0432 0.0223
Trypanosoma cruzi phosphatidylinositol kinase, putative 0.0031 0.0432 0.0223
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0092 0.1707 0.1525
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0031 0.0432 0.0223
Echinococcus granulosus sodium:potassium dependent atpase beta subunit 0.0021 0.0209 0.0209
Entamoeba histolytica hypothetical protein 0.0031 0.0432 0.0432
Trichomonas vaginalis PIKK family atypical protein kinase 0.0386 0.7907 0.7907
Trichomonas vaginalis AGC family protein kinase 0.0034 0.0481 0.0481
Trichomonas vaginalis PIKK family atypical protein kinase 0.0092 0.1707 0.1707
Loa Loa (eye worm) hypothetical protein 0.0031 0.0432 0.0432
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0031 0.0432 0.0432
Loa Loa (eye worm) hypothetical protein 0.0071 0.1268 0.1268
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0387 0.7916 0.7822
Entamoeba histolytica PH domain containing protein kinase, putative 0.0023 0.0258 0.0258
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0031 0.0432 0.0432
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0092 0.1707 0.1525
Giardia lamblia Phosphatidylinositol 4-kinase 0.0031 0.0432 0.0223
Trichomonas vaginalis PIKK family atypical protein kinase 0.0326 0.6633 0.6633
Trichomonas vaginalis PIKK family atypical protein kinase 0.0361 0.7379 0.7379
Trichomonas vaginalis PIKK family atypical protein kinase 0.0361 0.7379 0.7379
Giardia lamblia Phosphoinositide-3-kinase, class 3 0.0031 0.0432 0.0223
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0031 0.0432 0.0432
Trichomonas vaginalis AGC family protein kinase 0.0034 0.0481 0.0481
Schistosoma mansoni serine/threonine-protein kinase 0.0023 0.0258 0.0258
Plasmodium falciparum phosphatidylinositol 3- and 4-kinase, putative 0.0031 0.0432 1
Onchocerca volvulus 0.0031 0.0432 0.5
Plasmodium falciparum phosphatidylinositol 4-kinase 0.0031 0.0432 1
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0486 1 1
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0486 1 1
Echinococcus multilocularis PIK kinase, FAT and Armadillo domain containing protein 0.0071 0.1268 0.1268
Echinococcus granulosus phosphatidylinositol 4 phosphate 3 kinase C2 0.0031 0.0432 0.0432
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0486 1 1
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0023 0.0258 0.0045
Trichomonas vaginalis conserved hypothetical protein 0.0102 0.1928 0.1928
Echinococcus granulosus serine protein kinase ATM 0.0092 0.1707 0.1707
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0031 0.0432 0.0223
Brugia malayi Protein kinase domain containing protein 0.0034 0.0481 0.0481
Echinococcus granulosus phosphatidylinositol 4 kinase alpha 0.0031 0.0432 0.0432
Echinococcus multilocularis nervana 2 0.0021 0.0209 0.0209
Trypanosoma cruzi Protein kinase B 0.0023 0.0258 0.0045
Toxoplasma gondii non-specific serine/threonine protein kinase 0.0102 0.1928 0.2153
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0387 0.7916 0.7822
Trichomonas vaginalis PIKK family atypical protein kinase 0.0486 1 1
Entamoeba histolytica protein kinase, putative 0.0034 0.0481 0.0481
Entamoeba histolytica phosphatidylinositol 4-kinase, putative 0.0031 0.0432 0.0432
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0092 0.1707 0.1707
Trichomonas vaginalis conserved hypothetical protein 0.0061 0.1047 0.1047
Plasmodium falciparum phosphatidylinositol 3-kinase 0.0031 0.0432 1
Echinococcus multilocularis serine threonine protein kinase nrc serine threonine protein kinase gad 0.0021 0.0214 0.0214
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0031 0.0432 0.0432
Entamoeba histolytica protein kinase, putative 0.0034 0.0481 0.0481
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0031 0.0432 0.0432
Loa Loa (eye worm) phosphatidylinositol 3 0.0031 0.0432 0.0432
Loa Loa (eye worm) hypothetical protein 0.0031 0.0432 0.0432
Mycobacterium tuberculosis Conserved hypothetical protein 0.0031 0.0432 0.5
Leishmania major phosphatidylinositol 3-kinase, putative 0.0163 0.3202 0.2895
Plasmodium vivax phosphatidylinositol 3- and 4-kinase, putative 0.0031 0.0432 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0361 0.7379 0.7379
Echinococcus granulosus serine:threonine protein kinase SMG1 0.0092 0.1707 0.1707
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0031 0.0432 0.0432
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0486 1 1
Plasmodium vivax hypothetical protein 0.0031 0.0432 1
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0031 0.0432 0.0223
Trichomonas vaginalis PIKK family atypical protein kinase 0.0262 0.5286 0.5286
Schistosoma mansoni hypothetical protein 0.0031 0.0432 0.0432
Trichomonas vaginalis PIKK family atypical protein kinase 0.0361 0.7379 0.7379
Trichomonas vaginalis PIKK family atypical protein kinase 0.029 0.5884 0.5884
Trichomonas vaginalis PIKK family atypical protein kinase 0.0361 0.7379 0.7379
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0031 0.0432 0.0223
Echinococcus granulosus calcium:calmodulin dependent protein kinase 0.0021 0.0214 0.0214
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0031 0.0432 0.0432
Echinococcus multilocularis sodium:potassium dependent atpase beta subunit 0.0021 0.0209 0.0209
Loa Loa (eye worm) hypothetical protein 0.0061 0.1047 0.1047
Echinococcus multilocularis 0.0031 0.0432 0.0432
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0031 0.0432 0.0432
Loa Loa (eye worm) phosphatidylinositol 3 0.0486 1 1
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0163 0.3202 0.3202
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0031 0.0432 1
Mycobacterium leprae conserved hypothetical protein 0.0031 0.0432 0.5
Echinococcus multilocularis phosphatidylinositol 4 phosphate 3 kinase C2 0.0031 0.0432 0.0432
Giardia lamblia GTOR 0.0486 1 1
Trypanosoma brucei rac serine-threonine kinase, putative 0.0034 0.0481 0.0051
Echinococcus granulosus phosphatidylinositol 3 kinase catalytic subunit 0.0031 0.0432 0.0432
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0202 0.402 0.375
Echinococcus multilocularis Glutaredoxin protein 5 0.0021 0.0209 0.0209
Echinococcus granulosus PIK kinase FAT and Armadillo domain containing protein 0.0071 0.1268 0.1268
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0031 0.0432 0.0432
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0092 0.1707 0.1707
Trichomonas vaginalis PIKK family atypical protein kinase 0.0163 0.3202 0.3202
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0031 0.0432 0.0432
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0031 0.0432 0.0223
Trichomonas vaginalis PIKK family atypical protein kinase 0.0262 0.5286 0.5286
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0486 1 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0386 0.7907 0.7907
Trichomonas vaginalis PIKK family atypical protein kinase 0.0262 0.5295 0.5295
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0031 0.0432 0.0432
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0031 0.0432 0.0432
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0031 0.0432 0.0432
Schistosoma mansoni voltage-gated potassium channel 0.0039 0.0603 0.0603
Trichomonas vaginalis PIKK family atypical protein kinase 0.0163 0.3202 0.3202
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0031 0.0432 0.0223
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0163 0.3202 0.3202
Loa Loa (eye worm) hypothetical protein 0.0092 0.1707 0.1707
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0031 0.0432 0.0432
Toxoplasma gondii FATC domain-containing protein 0.0092 0.1707 0.1835
Entamoeba histolytica phosphatidylinositol 3-kinase 3, putative 0.0031 0.0432 0.0432
Trichomonas vaginalis PIKK family atypical protein kinase 0.0361 0.7379 0.7379
Schistosoma mansoni fkbp-rapamycin associated protein 0.0092 0.1707 0.1707
Echinococcus granulosus DNA dependent protein kinase catalytic subunit 0.0031 0.0432 0.0432
Echinococcus multilocularis phosphatidylinositol 4,5 bisphosphate 3 kinase 0.0031 0.0432 0.0432
Loa Loa (eye worm) phosphatidylinositol 3 0.0031 0.0432 0.0432
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0036 0.0533 0.0533
Entamoeba histolytica protein kinase rad3, putative 0.0092 0.1707 0.1707
Trichomonas vaginalis AGC family protein kinase 0.0034 0.0481 0.0481
Echinococcus granulosus phosphatidylinositol 45 bisphosphate 3 kinase 0.0031 0.0432 0.0432
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0031 0.0432 0.0432
Loa Loa (eye worm) AGC/RSK/P70 protein kinase 0.0032 0.0437 0.0437
Echinococcus multilocularis rac serine:threonine kinase 0.0023 0.0258 0.0258
Schistosoma mansoni serine/threonine-protein kinase 0.0023 0.0258 0.0258
Toxoplasma gondii AGC kinase 0.0032 0.0437 0.0007

Activities

Activity type Activity value Assay description Source Reference
GI50 (functional) -5.922 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MALME-3M Melanoma cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -5.717 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-5 Melanoma cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -5.622 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the DU-145 Prostate cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -5.619 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -5.524 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -5.482 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -5.474 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MDA-N Breast cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -5.413 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -5.376 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.915 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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