Detailed information for compound 1647121

Basic information

Technical information
  • TDR Targets ID: 1647121
  • Name: [3,4-dihydroxy-5-[4-(octadecylamino)-2-oxopyr imidin-1-yl]oxolan-2-yl]methyl [3-fluoro-5-(5 -methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]m ethyl hydrogen phosphate
  • MW: 801.879 | Formula: C37H61FN5O11P
  • H donors: 5 H acceptors: 7 LogP: 5.48 Rotable bonds: 26
    Rule of 5 violations (Lipinski): 2
  • SMILES: CCCCCCCCCCCCCCCCCCNc1ccn(c(=O)n1)C1OC(C(C1O)O)COP(=O)(OCC1OC(CC1F)n1cc(C)c(=O)[nH]c1=O)O
  • InChi: 1S/C37H61FN5O11P/c1-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-20-39-30-19-21-42(36(47)40-30)35-33(45)32(44)29(54-35)25-52-55(49,50)51-24-28-27(38)22-31(53-28)43-23-26(2)34(46)41-37(43)48/h19,21,23,27-29,31-33,35,44-45H,3-18,20,22,24-25H2,1-2H3,(H,49,50)(H,39,40,47)(H,41,46,48)
  • InChiKey: BRVPZZGFLZGOIS-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • [3,4-dihydroxy-5-[4-(octadecylamino)-2-oxo-pyrimidin-1-yl]tetrahydrofuran-2-yl]methyl [3-fluoro-5-(5-methyl-2,4-dioxo-pyrimidin-1-yl)tetrahydrofuran-2-yl]methyl hydrogen phosphate
  • [3,4-dihydroxy-5-[4-(octadecylamino)-2-oxo-1-pyrimidinyl]-2-tetrahydrofuranyl]methyl [3-fluoro-5-(5-methyl-2,4-dioxo-1-pyrimidinyl)-2-tetrahydrofuranyl]methyl hydrogen phosphate
  • [3,4-dihydroxy-5-[2-keto-4-(stearylamino)pyrimidin-1-yl]tetrahydrofuran-2-yl]methyl [5-(2,4-diketo-5-methyl-pyrimidin-1-yl)-3-fluoro-tetrahydrofuran-2-yl]methyl hydrogen phosphate
  • [3,4-dihydroxy-5-[4-(octadecylamino)-2-oxo-pyrimidin-1-yl]oxolan-2-yl]methyl [3-fluoro-5-(5-methyl-2,4-dioxo-pyrimidin-1-yl)oxolan-2-yl]methyl hydrogen phosphate
  • NCI60_036445
  • NSC701598

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.1253 0.1732 0.1718
Leishmania major phosphatidylinositol 3-related kinase, putative 0.2229 0.3264 0.2953
Toxoplasma gondii FATC domain-containing protein 0.1253 0.1732 0.1855
Loa Loa (eye worm) phosphatidylinositol 3 0.0432 0.0442 0.0426
Trichomonas vaginalis PIKK family atypical protein kinase 0.2217 0.3245 0.3245
Brugia malayi phosphoinositide 3'-hydroxykinase p110-alpha subunit, putative 0.0193 0.0067 0.005
Trichomonas vaginalis PIKK family atypical protein kinase 0.5193 0.7921 0.7921
Trichomonas vaginalis PIKK family atypical protein kinase 0.3541 0.5325 0.5325
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0821 0.1054 0.064
Loa Loa (eye worm) phosphatidylinositol 3 0.0432 0.0442 0.0426
Echinococcus multilocularis 0.0432 0.0442 0.0426
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.6517 1 1
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0432 0.0442 0.0426
Trichomonas vaginalis PIKK family atypical protein kinase 0.3535 0.5316 0.5316
Giardia lamblia Phosphoinositide-3-kinase, catalytic, alpha polypeptide 0.0531 0.0598 0.0163
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0645 0.0776 0.0776
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0567 0.0655 0.0639
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.1253 0.1732 0.135
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0454 0.0476 0.0036
Echinococcus multilocularis DNA dependent protein kinase catalytic subunit 0.0719 0.0892 0.0877
Echinococcus granulosus serine:threonine protein kinase SMG1 0.1253 0.1732 0.1718
Trichomonas vaginalis PIKK family atypical protein kinase 0.4859 0.7396 0.7396
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0454 0.0476 0.0438
Mycobacterium leprae conserved hypothetical protein 0.0432 0.0442 0.5
Trichomonas vaginalis phosphatidylinositol 4-kinase, putative 0.0454 0.0476 0.0476
Trichomonas vaginalis PIKK family atypical protein kinase 0.2217 0.3245 0.3245
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.6517 1 1
Loa Loa (eye worm) hypothetical protein 0.0821 0.1054 0.1039
Onchocerca volvulus 0.0432 0.0442 0.5
Entamoeba histolytica Phosphatidylinositol 3- and 4-kinase family 0.1265 0.1751 0.1669
Leishmania major phosphatidylinositol 3-kinase, putative 0.2217 0.3245 0.2933
Schistosoma mansoni hypothetical protein 0.0964 0.1277 0.1242
Loa Loa (eye worm) phosphatidylinositol 4-kinase type 3 alpha isoform 1 0.0454 0.0476 0.046
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.2719 0.4035 0.3759
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0576 0.0668 0.0668
Schistosoma mansoni phosphatidylinositol 4-kinase type-II 0.0432 0.0442 0.0403
Entamoeba histolytica phosphatidylinositol 4-kinase, putative 0.0454 0.0476 0.0382
Trichomonas vaginalis PIKK family atypical protein kinase 0.6517 1 1
Entamoeba histolytica hypothetical protein 0.0432 0.0442 0.0347
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0499 0.0547 0.011
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0645 0.0776 0.035
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0432 0.0442 0.0426
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0838 0.1079 0.1044
Entamoeba histolytica hypothetical protein 0.1253 0.1732 0.165
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0645 0.0776 0.035
Trichomonas vaginalis conserved hypothetical protein 0.1395 0.1955 0.1955
Giardia lamblia GTOR 0.6517 1 1
Trypanosoma cruzi target of rapamycin kinase 3 0.5198 0.7929 0.7833
Toxoplasma gondii target of rapamycin (TOR), putative 0.4859 0.7396 1
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0432 0.0442 0.0426
Trichomonas vaginalis PIKK family atypical protein kinase 0.3535 0.5316 0.5316
Entamoeba histolytica phosphatidylinositol 3-kinase 3, putative 0.0432 0.0442 0.0347
Trichomonas vaginalis PIKK family atypical protein kinase 0.3895 0.5882 0.5882
Trichomonas vaginalis PIKK family atypical protein kinase 0.4859 0.7396 0.7396
Trichomonas vaginalis PIKK family atypical protein kinase 0.4859 0.7396 0.7396
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0432 0.0442 0.0426
Echinococcus granulosus serine protein kinase ATM 0.1253 0.1732 0.1718
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.2273 0.3334 0.3026
Echinococcus multilocularis phosphatidylinositol 4 kinase alpha 0.0454 0.0476 0.046
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.6517 1 1
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0432 0.0442 0.0426
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0454 0.0476 0.005
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0454 0.0476 0.0438
Leishmania major phosphatidylinositol 4-kinase alpha, putative 0.0454 0.0476 0.0036
Trichomonas vaginalis PIKK family atypical protein kinase 0.4859 0.7396 0.7396
Trichomonas vaginalis PIKK family atypical protein kinase 0.1253 0.1732 0.1732
Trichomonas vaginalis PIKK family atypical protein kinase 0.4372 0.6631 0.6631
Trichomonas vaginalis PIKK family atypical protein kinase 0.4859 0.7396 0.7396
Trypanosoma brucei target of rapamycin kinase 3, putative 0.5198 0.7929 0.7833
Loa Loa (eye worm) hypothetical protein 0.0964 0.1277 0.1263
Trichomonas vaginalis PIKK family atypical protein kinase 0.1265 0.1751 0.1751
Loa Loa (eye worm) phosphatidylinositol kinase 0.0432 0.0442 0.0426
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0645 0.0776 0.0685
Loa Loa (eye worm) phosphatidylinositol 3 0.0432 0.0442 0.0426
Echinococcus granulosus PIK kinase FAT and Armadillo domain containing protein 0.0964 0.1277 0.1263
Toxoplasma gondii non-specific serine/threonine protein kinase 0.1395 0.1955 0.2177
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.6517 1 1
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.6517 1 1
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.6517 1 1
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0432 0.0442 0.0426
Trypanosoma cruzi phosphatidylinositol 3-kinase vps34-like 0.0499 0.0547 0.011
Echinococcus multilocularis phosphatidylinositol 4 phosphate 3 kinase C2 0.0567 0.0655 0.0639
Schistosoma mansoni hypothetical protein 0.0432 0.0442 0.0403
Entamoeba histolytica hypothetical protein 0.06 0.0706 0.0614
Trichomonas vaginalis PIKK family atypical protein kinase 0.0821 0.1054 0.1054
Trichomonas vaginalis PIKK family atypical protein kinase 0.3535 0.5316 0.5316
Schistosoma mansoni phosphatidylinositol 3-kinase class 0.0432 0.0442 0.0403
Trichomonas vaginalis PIKK family atypical protein kinase 0.3875 0.585 0.585
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0499 0.0547 0.0547
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0645 0.0776 0.0761
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.5198 0.7929 0.7833
Echinococcus multilocularis phosphatidylinositol 4,5 bisphosphate 3 kinase 0.0838 0.1079 0.1065
Plasmodium falciparum phosphatidylinositol 3-kinase 0.0454 0.0476 1
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0454 0.0476 0.005
Trichomonas vaginalis PIKK family atypical protein kinase 0.3895 0.5882 0.5882
Trichomonas vaginalis conserved hypothetical protein 0.0964 0.1277 0.1277
Trichomonas vaginalis PIKK family atypical protein kinase 0.5193 0.7921 0.7921
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0432 0.0442 0.0403
Trichomonas vaginalis PIKK family atypical protein kinase 0.1253 0.1732 0.1732
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0499 0.0547 0.0547
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0645 0.0776 0.0776
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0432 0.0442 0.0442
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.1253 0.1732 0.1699
Loa Loa (eye worm) hypothetical protein 0.0432 0.0442 0.0426
Trichomonas vaginalis PIKK family atypical protein kinase 0.4859 0.7396 0.7396
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.06 0.0706 0.0614
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.6517 1 1
Trypanosoma brucei phosphatidylinositol 4-kinase alpha, putative 0.0454 0.0476 0.0036
Echinococcus granulosus DNA dependent protein kinase catalytic subunit 0.0719 0.0892 0.0877
Trichomonas vaginalis PIKK family atypical protein kinase 0.3541 0.5325 0.5325
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.1253 0.1732 0.1718
Schistosoma mansoni fkbp-rapamycin associated protein 0.1253 0.1732 0.1699
Loa Loa (eye worm) phosphatidylinositol 3 0.0432 0.0442 0.0426
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.2273 0.3334 0.3307
Echinococcus granulosus phosphatidylinositol 4 kinase beta 0.0432 0.0442 0.0426
Trichomonas vaginalis PIKK family atypical protein kinase 0.5193 0.7921 0.7921
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.1253 0.1732 0.135
Loa Loa (eye worm) phosphatidylinositol 3 0.6517 1 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.2217 0.3245 0.3245
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.2273 0.3334 0.3323
Brugia malayi FAT domain containing protein 0.0964 0.1277 0.1263
Leishmania major phosphatidylinositol 3-kinase, putative 0.0454 0.0476 0.0036
Leishmania major hypothetical protein, conserved 0.0533 0.0601 0.0167
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.2273 0.3334 0.3026
Trichomonas vaginalis PIKK family atypical protein kinase 0.0432 0.0442 0.0442
Loa Loa (eye worm) hypothetical protein 0.1395 0.1955 0.1942
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.6517 1 1
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0522 0.0584 0.0491
Onchocerca volvulus 0.0432 0.0442 0.5
Loa Loa (eye worm) hypothetical protein 0.0567 0.0655 0.0639
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0499 0.0547 0.0453
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.6517 1 1
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0499 0.0547 0.0453
Echinococcus multilocularis serine protein kinase ATM 0.1253 0.1732 0.1718
Trichomonas vaginalis PIKK family atypical protein kinase 0.2217 0.3245 0.3245
Trichomonas vaginalis PIKK family atypical protein kinase 0.3895 0.5882 0.5882
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.2273 0.3334 0.3323
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.2273 0.3334 0.3323
Trichomonas vaginalis PIKK family atypical protein kinase 0.6517 1 1
Entamoeba histolytica protein kinase rad3, putative 0.1253 0.1732 0.165
Trichomonas vaginalis PIKK family atypical protein kinase 0.2229 0.3264 0.3264
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0499 0.0547 0.0509
Giardia lamblia Phosphoinositide-3-kinase, class 3 0.0477 0.0512 0.0074
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.6517 1 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.3875 0.585 0.585
Trichomonas vaginalis PIKK family atypical protein kinase 0.175 0.2513 0.2513
Echinococcus granulosus phosphatidylinositol 4 kinase alpha 0.0454 0.0476 0.046
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0576 0.0668 0.0668
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.2217 0.3245 0.2933
Echinococcus granulosus phosphatidylinositol 45 bisphosphate 3 kinase 0.0838 0.1079 0.1065
Entamoeba histolytica hypothetical protein 0.0432 0.0442 0.0347
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0454 0.0476 0.0476
Trichomonas vaginalis PIKK family atypical protein kinase 0.4229 0.6407 0.6407
Loa Loa (eye worm) phosphatidylinositol 3 0.0793 0.1009 0.0994
Loa Loa (eye worm) hypothetical protein 0.1319 0.1835 0.1821
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0454 0.0476 0.0476
Mycobacterium tuberculosis Conserved hypothetical protein 0.0432 0.0442 0.5
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0499 0.0547 0.0531
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.6517 1 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.4859 0.7396 0.7396
Trichomonas vaginalis conserved hypothetical protein 0.0821 0.1054 0.1054
Trichomonas vaginalis PIKK family atypical protein kinase 0.3541 0.5325 0.5325
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0432 0.0442 0.0442
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.1253 0.1732 0.135
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.1253 0.1732 0.1718
Trichomonas vaginalis PIKK family atypical protein kinase 0.0432 0.0442 0.0442
Entamoeba histolytica phosphatidylinositol-4,5-bisphosphate 3-kinase, putative 0.0454 0.0476 0.0382
Trichomonas vaginalis PIKK family atypical protein kinase 0.5193 0.7921 0.7921
Echinococcus multilocularis PIK kinase, FAT and Armadillo domain containing protein 0.0964 0.1277 0.1263
Trichomonas vaginalis PIKK family atypical protein kinase 0.3541 0.5325 0.5325
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0499 0.0547 0.0547
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.1253 0.1732 0.1718
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.2229 0.3264 0.2953
Echinococcus granulosus phosphatidylinositol 3 kinase catalytic subunit 0.0454 0.0476 0.046
Plasmodium vivax phosphatidylinositol 3-kinase, putative 0.0454 0.0476 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.5553 0.8486 0.8486
Loa Loa (eye worm) phosphatidylinositol 3 0.2229 0.3264 0.3253
Brugia malayi phosphatidylinositol 4-kinase, catalytic, alpha polypeptide 0.0454 0.0476 0.046
Echinococcus multilocularis Zinc finger, PHD finger 0.0454 0.0476 0.046
Trichomonas vaginalis PIKK family atypical protein kinase 0.6517 1 1
Entamoeba histolytica hypothetical protein 0.0432 0.0442 0.0347
Echinococcus granulosus phosphatidylinositol 4 phosphate 3 kinase C2 0.0567 0.0655 0.0639
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit gamma, putative 0.0645 0.0776 0.0776
Trichomonas vaginalis PIKK family atypical protein kinase 0.5193 0.7921 0.7921
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0432 0.0442 0.0426
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0454 0.0476 0.0036
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.3074 0.4592 0.4342

Activities

Activity type Activity value Assay description Source Reference
GI50 (functional) -5.263 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -5.104 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -5.089 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MDA-N Breast cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -5.063 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -5.024 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -5.005 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-5 Melanoma cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.943 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the DU-145 Prostate cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.885 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.88 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.824 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MALME-3M Melanoma cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.735 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.