Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | Fatty acid desaturase type 1 | 0.0226 | 0.1975 | 0.5 |
Trypanosoma brucei | delta-6 fatty acid desaturase, putative | 0.0226 | 0.1975 | 0.1975 |
Echinococcus multilocularis | Peptidase M, neutral zinc metallopeptidases, zinc binding site | 0.0226 | 0.1975 | 0.5 |
Trypanosoma cruzi | fatty acid desaturase, putative | 0.0226 | 0.1975 | 0.1975 |
Loa Loa (eye worm) | fatty acid desaturase | 0.0226 | 0.1975 | 0.2506 |
Trypanosoma cruzi | fatty acid desaturase, putative | 0.0856 | 0.788 | 0.788 |
Echinococcus granulosus | Sphingolipid delta4 desaturase DES1 | 0.0226 | 0.1975 | 0.5 |
Mycobacterium tuberculosis | Probable transmembrane alkane 1-monooxygenase AlkB (alkane 1-hydroxylase) (lauric acid omega-hydroxylase) (omega-hydroxylase) (f | 0.0226 | 0.1975 | 0.5 |
Trypanosoma cruzi | fatty acid desaturase, putative | 0.0856 | 0.788 | 0.788 |
Trypanosoma cruzi | fatty acid desaturase, putative | 0.1082 | 1 | 1 |
Trypanosoma brucei | fatty acid desaturase, putative | 0.1082 | 1 | 1 |
Plasmodium vivax | stearoyl-CoA desaturase (acyl-CoA desaturase, faty acid desaturase), putative | 0.0856 | 0.788 | 0.5 |
Onchocerca volvulus | 0.1082 | 1 | 1 | |
Leishmania major | delta-6 fatty acid desaturase | 0.0226 | 0.1975 | 0.1975 |
Mycobacterium ulcerans | hypothetical protein | 0.0226 | 0.1975 | 1 |
Trypanosoma cruzi | fatty acid desaturase, putative | 0.0226 | 0.1975 | 0.1975 |
Leishmania major | fatty acid desaturase, putative,sphingolipid delta 4 desaturase, putative | 0.0226 | 0.1975 | 0.1975 |
Trypanosoma brucei | sphingolipid delta 4 desaturase, putative | 0.0226 | 0.1975 | 0.1975 |
Mycobacterium ulcerans | linoleoyl-CoA desaturase, DesA3_2 | 0.0226 | 0.1975 | 1 |
Loa Loa (eye worm) | fatty acid desaturase | 0.0226 | 0.1975 | 0.2506 |
Leishmania major | delta-5 fatty acid desaturase | 0.0226 | 0.1975 | 0.1975 |
Mycobacterium ulcerans | linoleoyl-CoA desaturase, DesA3 | 0.0226 | 0.1975 | 1 |
Mycobacterium tuberculosis | Probable conserved membrane protein | 0.0226 | 0.1975 | 0.5 |
Leishmania major | delta-12 fatty acid desaturase | 0.0226 | 0.1975 | 0.1975 |
Leishmania major | fatty-acid desaturase, putative | 0.1082 | 1 | 1 |
Brugia malayi | Fatty acid desaturase family protein | 0.0226 | 0.1975 | 0.2506 |
Mycobacterium ulcerans | hypothetical protein | 0.0226 | 0.1975 | 1 |
Plasmodium falciparum | stearoyl-CoA desaturase | 0.0856 | 0.788 | 0.5 |
Brugia malayi | Fatty acid desaturase family protein | 0.0226 | 0.1975 | 0.2506 |
Leishmania major | fatty acid desaturase, putative,sphingolipid delta 4 desaturase, putative | 0.0226 | 0.1975 | 0.1975 |
Mycobacterium tuberculosis | Possible electron transfer protein FdxB | 0.0226 | 0.1975 | 0.5 |
Leishmania major | fatty acid desaturase, putative,sphingolipid delta 4 desaturase, putative | 0.0226 | 0.1975 | 0.1975 |
Brugia malayi | Delta5 fatty acid desaturase | 0.0226 | 0.1975 | 0.2506 |
Onchocerca volvulus | 0.1082 | 1 | 1 | |
Schistosoma mansoni | fatty acid desaturase | 0.0226 | 0.1975 | 0.5 |
Loa Loa (eye worm) | FAT-3 protein | 0.0226 | 0.1975 | 0.2506 |
Loa Loa (eye worm) | acyl-CoA desaturase | 0.0856 | 0.788 | 1 |
Leishmania major | fatty acid desaturase, putative,sphingolipid delta 4 desaturase, putative | 0.0226 | 0.1975 | 0.1975 |
Echinococcus multilocularis | Peptidase M, neutral zinc metallopeptidases, zinc binding site | 0.0226 | 0.1975 | 0.5 |
Trypanosoma cruzi | sphingolipid delta 4 desaturase, putative | 0.0226 | 0.1975 | 0.1975 |
Loa Loa (eye worm) | hypothetical protein | 0.0226 | 0.1975 | 0.2506 |
Leishmania major | fatty acid desaturase, putative | 0.0226 | 0.1975 | 0.1975 |
Trypanosoma cruzi | cytochrome b5-dependent oleate desaturase | 0.0226 | 0.1975 | 0.1975 |
Trypanosoma brucei | cytochrome b5-dependent oleate desaturase | 0.0226 | 0.1975 | 0.1975 |
Leishmania major | fatty acid desaturase, putative | 0.0226 | 0.1975 | 0.1975 |
Leishmania major | delta-4 fatty acid desaturase | 0.0226 | 0.1975 | 0.1975 |
Mycobacterium ulcerans | linoleoyl-CoA desaturase, DesA3 | 0.0226 | 0.1975 | 1 |
Echinococcus multilocularis | Fatty acid desaturase, type 1 | 0.0226 | 0.1975 | 0.5 |
Mycobacterium ulcerans | transmembrane alkane 1-monooxygenase AlkB | 0.0226 | 0.1975 | 1 |
Trypanosoma cruzi | delta-4 fatty acid desaturase, putative | 0.0226 | 0.1975 | 0.1975 |
Toxoplasma gondii | sphingolipid delta 4 desaturase/c-4 hydroxylase protein des2 family protein | 0.0226 | 0.1975 | 0.5 |
Trypanosoma brucei | delta-4 fatty acid desaturase | 0.0226 | 0.1975 | 0.1975 |
Trypanosoma cruzi | delta-4 fatty acid desaturase, putative | 0.0226 | 0.1975 | 0.1975 |
Mycobacterium ulcerans | electron transfer protein FdxB | 0.0226 | 0.1975 | 1 |
Brugia malayi | acyl-CoA desaturase | 0.0856 | 0.788 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
GI50 (functional) | -6.692 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -6.371 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -5.704 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -5.691 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -5.659 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -5.647 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MALME-3M Melanoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -5.641 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -5.52 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-5 Melanoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -5.352 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.