Detailed information for compound 164973

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 560.42 | Formula: C23H22BrN5O5S
  • H donors: 3 H acceptors: 5 LogP: 2.4 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 2
  • SMILES: O=C(Cn1c(C)ccc(c1=O)NS(=O)(=O)Cc1ccc(cc1)Br)NCc1ccc2c(c1)onc2N
  • InChi: 1S/C23H22BrN5O5S/c1-14-2-9-19(28-35(32,33)13-15-3-6-17(24)7-4-15)23(31)29(14)12-21(30)26-11-16-5-8-18-20(10-16)34-27-22(18)25/h2-10,28H,11-13H2,1H3,(H2,25,27)(H,26,30)
  • InChiKey: PVHVKUAYRDIWEG-UHFFFAOYSA-N  

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Brugia malayi Dopamine receptor protein 2 0.013 0.0207 0.1422
Schistosoma mansoni neuropeptide receptor 0.013 0.0207 0.0207
Schistosoma mansoni bcl-2 homologous antagonist/killer (bak) 0.0193 0.0446 0.0446
Treponema pallidum amino acid ABC transporter, periplasmic binding protein 0.0081 0.0018 0.5
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.1659 0.6082 1
Echinococcus multilocularis glutamate (NMDA) receptor subunit 0.0267 0.0733 0.1206
Schistosoma mansoni neuropeptide receptor 0.013 0.0207 0.0207
Loa Loa (eye worm) hypothetical protein 0.013 0.0207 0.1422
Loa Loa (eye worm) hypothetical protein 0.013 0.0207 0.1422
Echinococcus multilocularis alpha 1A adrenergic receptor 0.013 0.0207 0.0341
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.011 0.0129 0.0212
Schistosoma mansoni alpha-1 adrenergic receptor 0.013 0.0207 0.0207
Schistosoma mansoni nAChR subunit (ShAR1-alpha-like) 0.0456 0.1459 0.1459
Schistosoma mansoni nAChR subunit 0.0142 0.0251 0.0251
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0142 0.0251 0.1723
Loa Loa (eye worm) hypothetical protein 0.0142 0.0251 0.1723
Loa Loa (eye worm) hypothetical protein 0.013 0.0207 0.1422
Schistosoma mansoni biogenic amine (dopamine) receptor 0.013 0.0207 0.0207
Echinococcus granulosus fmrfamide receptor 0.013 0.0207 0.0341
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0111 0.0133 0.0294
Loa Loa (eye worm) hypothetical protein 0.0456 0.1459 1
Loa Loa (eye worm) hypothetical protein 0.013 0.0207 0.1422
Brugia malayi Calcitonin receptor-like protein seb-1 0.028 0.0781 0.5355
Echinococcus multilocularis Tubulin beta 2C chain 0.0158 0.0313 0.0514
Loa Loa (eye worm) hypothetical protein 0.0364 0.1104 0.7569
Echinococcus granulosus allatostatin A receptor 0.013 0.0207 0.0341
Onchocerca volvulus 0.013 0.0207 0.1422
Loa Loa (eye worm) neuropeptide F receptor 0.013 0.0207 0.1422
Echinococcus granulosus Basic leucine zipper bZIP transcription factor 0.0086 0.0037 0.0061
Loa Loa (eye worm) hypothetical protein 0.013 0.0207 0.1422
Schistosoma mansoni biogenic amine (dopamine) receptor 0.013 0.0207 0.0207
Loa Loa (eye worm) G-protein coupled receptor 0.013 0.0207 0.1422
Leishmania major beta tubulin 0.0158 0.0313 0.1851
Loa Loa (eye worm) BEN-1 protein 0.0158 0.0313 0.2144
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0097 0.0079 0.0131
Schistosoma mansoni nAChR subunit 0.0142 0.0251 0.0251
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0097 0.0079 0.0131
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.013 0.0207 0.1422
Schistosoma mansoni hypothetical protein 0.011 0.0129 0.0129
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0142 0.0251 0.0413
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.011 0.0129 0.0883
Brugia malayi photoreceptor-specific nuclear receptor 0.0097 0.0079 0.0544
Trypanosoma brucei calpain-like protein, putative 0.0111 0.0133 0.0294
Echinococcus multilocularis FTZ F1 alpha 0.0097 0.0079 0.0131
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0097 0.0079 0.0544
Loa Loa (eye worm) hypothetical protein 0.011 0.0129 0.0883
Echinococcus multilocularis neuropeptide s receptor 0.013 0.0207 0.0341
Echinococcus multilocularis rhodopsin orphan GPCR 0.013 0.0207 0.0341
Echinococcus granulosus 7TM GPCR rhodopsin 0.013 0.0207 0.0341
Loa Loa (eye worm) melatonin receptor type 1A 0.013 0.0207 0.1422
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.013 0.0207 0.1422
Echinococcus granulosus rhodopsin orphan GPCR 0.013 0.0207 0.0341
Schistosoma mansoni rhodopsin-like orphan GPCR 0.013 0.0207 0.0207
Loa Loa (eye worm) hypothetical protein 0.0097 0.0079 0.0544
Brugia malayi Tachykinin-like peptides receptor 99D 0.013 0.0207 0.1422
Brugia malayi Cation transporter family protein 0.0142 0.0251 0.1723
Echinococcus granulosus neuropeptide receptor 0.013 0.0207 0.0341
Echinococcus multilocularis g protein coupled receptor 0.013 0.0207 0.0341
Loa Loa (eye worm) hypothetical protein 0.028 0.0781 0.5355
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0097 0.0079 0.0544
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0307 0.0885 0.0885
Brugia malayi hypothetical protein 0.013 0.0207 0.1422
Leishmania major beta tubulin 0.0158 0.0313 0.1851
Leishmania major beta tubulin 0.0158 0.0313 0.1851
Leishmania major beta tubulin 0.0158 0.0313 0.1851
Schistosoma mansoni tubulin subunit beta 0.0158 0.0313 0.0313
Schistosoma mansoni steroid hormone receptor ad4bp 0.0097 0.0079 0.0079
Echinococcus multilocularis GPCR, family 2 0.011 0.0129 0.0212
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0097 0.0079 0.0544
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.013 0.0207 0.0207
Echinococcus multilocularis sodium channel protein 0.0197 0.0461 0.0759
Schistosoma mansoni amine GPCR 0.013 0.0207 0.0207
Schistosoma mansoni opsin-like receptor 0.013 0.0207 0.0207
Treponema pallidum amino acid ABC transporter, periplasmic binding protein (hisJ) 0.0081 0.0018 0.5
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0097 0.0079 0.0544
Echinococcus granulosus neuropeptides capa receptor 0.013 0.0207 0.0341
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.028 0.0781 0.5355
Loa Loa (eye worm) ACC-1 protein 0.0142 0.0251 0.1723
Schistosoma mansoni amine GPCR 0.013 0.0207 0.0207
Trichomonas vaginalis glucosylceramidase, putative 0.0176 0.0384 0.1908
Echinococcus granulosus rhodopsin orphan GPCR 0.013 0.0207 0.0341
Onchocerca volvulus Protein ultraspiracle homolog 0.0097 0.0079 0.0544
Schistosoma mansoni serine-type protease inhibitor 0.2679 1 1
Schistosoma mansoni myosin xvIII 0.013 0.0207 0.0207
Loa Loa (eye worm) hypothetical protein 0.013 0.0207 0.1422
Brugia malayi Serotonin receptor 0.013 0.0207 0.1422
Echinococcus multilocularis glycine receptor subunit beta 0.0142 0.0251 0.0413
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.013 0.0207 0.0341
Echinococcus multilocularis tubulin, beta 4A class IVa 0.0158 0.0313 0.0514
Echinococcus granulosus neuropeptide Y receptor 0.013 0.0207 0.0341
Mycobacterium ulcerans hypothetical protein 0.0332 0.098 1
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0097 0.0079 0.0079
Loa Loa (eye worm) hypothetical protein 0.013 0.0207 0.1422
Leishmania major beta tubulin 0.0158 0.0313 0.1851
Loa Loa (eye worm) hypothetical protein 0.013 0.0207 0.1422
Loa Loa (eye worm) hypothetical protein 0.0142 0.0251 0.1723
Echinococcus multilocularis anti dorsalizing morphogenetic protein 1a 0.0123 0.0179 0.0294
Echinococcus multilocularis rhodopsin orphan GPCR 0.013 0.0207 0.0341
Echinococcus multilocularis neuropeptide receptor 0.013 0.0207 0.0341
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0097 0.0079 0.0544
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0142 0.0251 0.0251
Leishmania major beta tubulin 0.0158 0.0313 0.1851
Brugia malayi hypothetical protein 0.013 0.0207 0.1422
Brugia malayi Integrin alpha cytoplasmic region family protein 0.0112 0.0137 0.094
Loa Loa (eye worm) hypothetical protein 0.013 0.0207 0.1422
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0312 0.0903 0.0903
Onchocerca volvulus Bile acid receptor homolog 0.0097 0.0079 0.0544
Onchocerca volvulus 0.013 0.0207 0.1422
Echinococcus multilocularis nicotinic acetylcholine receptor beta 1 subunit 0.0142 0.0251 0.0413
Onchocerca volvulus 0.0456 0.1459 1
Loa Loa (eye worm) nicotinic acetylcholine receptor non-alpha subunit 0.0142 0.0251 0.1723
Brugia malayi Latrophilin receptor protein 2 0.011 0.0129 0.0883
Echinococcus multilocularis tubulin subunit beta 0.0158 0.0313 0.0514
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.013 0.0207 0.0341
Echinococcus granulosus g-protein coupled receptor 0.013 0.0207 0.0341
Echinococcus multilocularis tachykinin peptides receptor 99D 0.013 0.0207 0.0341
Schistosoma mansoni nAChR subunit 0.0142 0.0251 0.0251
Echinococcus multilocularis neuropeptide Y receptor 0.013 0.0207 0.0341
Echinococcus multilocularis acetylcholine receptor subunit beta 1 0.0142 0.0251 0.0413
Echinococcus granulosus voltage gated sodium channel Nav1 alpha subunit 0.0197 0.0461 0.0759
Loa Loa (eye worm) hypothetical protein 0.013 0.0207 0.1422
Leishmania major beta tubulin 0.0158 0.0313 0.1851
Echinococcus multilocularis Bcl 2 ous antagonist:killer 0.0193 0.0446 0.0734
Onchocerca volvulus Putative nachr subunit 0.0282 0.079 0.5413
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0142 0.0251 0.0413
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0097 0.0079 0.0079
Schistosoma mansoni hypothetical protein 0.017 0.0358 0.0358
Brugia malayi Cation transporter family protein 0.0456 0.1459 1
Trypanosoma cruzi C-8 sterol isomerase, putative 0.0364 0.1104 1
Trichomonas vaginalis glucosylceramidase, putative 0.0167 0.0349 0.0981
Leishmania major beta tubulin 0.0158 0.0313 0.1851
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.013 0.0207 0.1422
Loa Loa (eye worm) hypothetical protein 0.013 0.0207 0.1422
Giardia lamblia Beta tubulin 0.0158 0.0313 0.5
Echinococcus granulosus neuropeptide receptor 0.013 0.0207 0.0341
Echinococcus granulosus beta tubulin 0.0158 0.0313 0.0514
Echinococcus multilocularis nicotinic acetylcholine receptor alpha subunit 0.0282 0.079 0.1298
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0123 0.0179 0.0295
Echinococcus multilocularis allatostatin A receptor 0.013 0.0207 0.0341
Loa Loa (eye worm) hypothetical protein 0.0142 0.0251 0.1723
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.013 0.0207 0.0341
Echinococcus granulosus nicotinic acetylcholine receptor subunit alpha 8 0.0282 0.079 0.1298
Brugia malayi acetylcholine receptor alpha subunit precursor, putative 0.0142 0.0251 0.1723
Loa Loa (eye worm) hypothetical protein 0.013 0.0207 0.1422
Loa Loa (eye worm) hypothetical protein 0.0097 0.0079 0.0544
Leishmania major beta tubulin 0.0158 0.0313 0.1851
Loa Loa (eye worm) hypothetical protein 0.013 0.0207 0.1422
Schistosoma mansoni hypothetical protein 0.0193 0.0446 0.0446
Trichomonas vaginalis glucosylceramidase, putative 0.0167 0.0349 0.0981
Mycobacterium tuberculosis Conserved hypothetical protein 0.0332 0.098 1
Onchocerca volvulus 0.0456 0.1459 1
Loa Loa (eye worm) hypothetical protein 0.013 0.0207 0.1422
Onchocerca volvulus 0.013 0.0207 0.1422
Loa Loa (eye worm) hypothetical protein 0.0186 0.0421 0.2884
Loa Loa (eye worm) hypothetical protein 0.013 0.0207 0.1422
Loa Loa (eye worm) hypothetical protein 0.013 0.0207 0.1422
Trypanosoma brucei beta tubulin 0.0158 0.0313 0.209
Echinococcus multilocularis sex peptide receptor 0.013 0.0207 0.0341
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0142 0.0251 0.0251
Echinococcus granulosus thyrotropin releasing hormone receptor 0.013 0.0207 0.0341
Giardia lamblia Beta tubulin 0.0158 0.0313 0.5
Trichomonas vaginalis glucosylceramidase, putative 0.0167 0.0349 0.0981
Trichomonas vaginalis glucosylceramidase, putative 0.0167 0.0349 0.0981
Loa Loa (eye worm) nicotinic acetylcholine receptor alpha subunit 0.0282 0.079 0.5413
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0142 0.0251 0.1723
Schistosoma mansoni hypothetical protein 0.013 0.0207 0.0207
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.013 0.0207 0.0341
Loa Loa (eye worm) tubulin beta-1 chain 0.0158 0.0313 0.2144
Brugia malayi gamma-aminobutyric-acid receptor beta subunit precursor 0.0142 0.0251 0.1723
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0142 0.0251 0.1723
Echinococcus multilocularis neuropeptide Y receptor 0.013 0.0207 0.0341
Loa Loa (eye worm) acetylcholine receptor alpha subunit 0.0142 0.0251 0.1723
Onchocerca volvulus 0.0097 0.0079 0.0544
Echinococcus granulosus glycine receptor subunit alpha 1 0.0142 0.0251 0.0413
Echinococcus granulosus nAChR subunit 0.0142 0.0251 0.0413
Loa Loa (eye worm) hypothetical protein 0.0142 0.0251 0.1723
Onchocerca volvulus Glucosylceramidase homolog 0.0167 0.0349 0.2396
Schistosoma mansoni thyroid hormone receptor 0.0097 0.0079 0.0079
Plasmodium falciparum tubulin beta chain 0.0158 0.0313 0.5
Onchocerca volvulus 0.013 0.0207 0.1422
Schistosoma mansoni hypothetical protein 0.0103 0.0104 0.0104
Schistosoma mansoni tubulin subunit beta 0.0158 0.0313 0.0313
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.013 0.0207 0.1422
Leishmania major beta tubulin 0.0158 0.0313 0.1851
Loa Loa (eye worm) hypothetical protein 0.013 0.0207 0.1422
Onchocerca volvulus 0.013 0.0207 0.1422
Echinococcus granulosus hypothetical protein 0.013 0.0207 0.0341
Brugia malayi latrophilin 2 splice variant baaae 0.017 0.0358 0.2457
Echinococcus granulosus EGFP:Bcl2 fusion protein 0.1488 0.5423 0.8916
Brugia malayi G protein-coupled receptor 0.013 0.0207 0.1422
Trypanosoma brucei calpain, putative 0.0111 0.0133 0.0294
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0142 0.0251 0.1723
Schistosoma mansoni biogenic amine receptor 0.013 0.0207 0.0207
Brugia malayi hypothetical protein 0.013 0.0207 0.1422
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.013 0.0207 0.0207
Loa Loa (eye worm) hypothetical protein 0.0097 0.0079 0.0544
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 3 0.0113 0.014 0.023
Schistosoma mansoni nAChR subunit (ShAR1-beta-like) 0.0456 0.1459 0.1459
Brugia malayi beta-tubulin, identical 0.0158 0.0313 0.2144
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.011 0.0129 0.0212
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0097 0.0079 0.0079
Leishmania major calcium channel protein, putative,ion transporter, putative 0.0197 0.0461 0.3381
Echinococcus granulosus Tubulin beta 2C chain 0.0158 0.0313 0.0514
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0255 0.0687 0.4707
Loa Loa (eye worm) hypothetical protein 0.0097 0.0079 0.0544
Brugia malayi ORL1-like opioid receptor 0.013 0.0207 0.1422
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.011 0.0129 0.0212
Loa Loa (eye worm) ACC-1 protein 0.0142 0.0251 0.1723
Schistosoma mansoni rhodopsin-like orphan GPCR 0.013 0.0207 0.0207
Schistosoma mansoni biogenic amine (dopamine) receptor 0.013 0.0207 0.0207
Trypanosoma brucei hypothetical protein 0.0111 0.0133 0.0294
Brugia malayi Serotonin receptor 0.013 0.0207 0.1422
Loa Loa (eye worm) hypothetical protein 0.0142 0.0251 0.1723
Schistosoma mansoni hypothetical protein 0.011 0.0129 0.0129
Schistosoma mansoni integrin alpha 0.0148 0.0276 0.0276
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0111 0.0133 0.0294
Echinococcus multilocularis fmrfamide receptor 0.013 0.0207 0.0341
Brugia malayi hypothetical protein 0.013 0.0207 0.1422
Echinococcus multilocularis EGFP:Bcl2 fusion protein 0.1488 0.5423 0.8916
Schistosoma mansoni nAChR subunit 0.0142 0.0251 0.0251
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.013 0.0207 0.1422
Schistosoma mansoni nuclear hormone receptor 0.0097 0.0079 0.0079
Toxoplasma gondii PAN domain-containing protein 0.0921 0.3243 1
Leishmania major beta tubulin 0.0158 0.0313 0.1851
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0097 0.0079 0.0544
Brugia malayi putative neuropeptide receptor NPR1 0.013 0.0207 0.1422
Trypanosoma brucei beta tubulin 0.0158 0.0313 0.209
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.013 0.0207 0.0341
Echinococcus granulosus g protein coupled receptor 0.013 0.0207 0.0341
Trichomonas vaginalis glucosylceramidase, putative 0.0255 0.0687 1
Schistosoma mansoni hypothetical protein 0.013 0.0207 0.0207
Schistosoma mansoni protein kinase 0.0123 0.0179 0.0179
Echinococcus granulosus neuropeptide Y receptor 0.013 0.0207 0.0341
Echinococcus granulosus nicotinic acetylcholine receptor alpha subunit 0.0282 0.079 0.1298
Loa Loa (eye worm) hypothetical protein 0.0142 0.0251 0.1723
Mycobacterium tuberculosis Conserved protein 0.0332 0.098 1
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0097 0.0079 0.0079
Entamoeba histolytica hypothetical protein, conserved 0.0332 0.098 1
Loa Loa (eye worm) hypothetical protein 0.013 0.0207 0.1422
Leishmania major beta tubulin 0.0158 0.0313 0.1851
Brugia malayi G-protein coupled receptor 0.013 0.0207 0.1422
Schistosoma mansoni hypothetical protein 0.0193 0.0446 0.0446
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.013 0.0207 0.0341
Echinococcus multilocularis beta tubulin 0.0158 0.0313 0.0514
Echinococcus multilocularis rhodopsin orphan GPCR 0.013 0.0207 0.0341
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0123 0.0179 0.0295
Trichomonas vaginalis glucosylceramidase, putative 0.0255 0.0687 1
Echinococcus granulosus rhodopsin orphan GPCR 0.013 0.0207 0.0341
Echinococcus multilocularis ecdysone induced protein 78C 0.0097 0.0079 0.0131
Loa Loa (eye worm) hypothetical protein 0.013 0.0207 0.1422
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.011 0.0129 0.0212
Echinococcus granulosus rhodopsin orphan GPCR 0.013 0.0207 0.0341
Echinococcus multilocularis neuropeptides capa receptor 0.013 0.0207 0.0341
Echinococcus multilocularis G protein coupled receptor 139 0.013 0.0207 0.0341
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0097 0.0079 0.0131
Loa Loa (eye worm) hypothetical protein 0.0391 0.1207 0.8277
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0097 0.0079 0.0131
Schistosoma mansoni protein kinase 0.0123 0.0179 0.0179
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0111 0.0133 0.0294
Echinococcus multilocularis glycine receptor subunit beta 0.0142 0.0251 0.0413
Schistosoma mansoni neuropeptide F-like receptor 0.013 0.0207 0.0207
Echinococcus granulosus integrin alpha 3 0.0114 0.0143 0.0235
Brugia malayi Angiotensin-converting enzyme family protein 0.0158 0.0313 0.2148
Chlamydia trachomatis glutamine binding protein 0.0081 0.0018 0.5
Schistosoma mansoni hypothetical protein 0.011 0.0129 0.0129
Onchocerca volvulus 0.013 0.0207 0.1422
Onchocerca volvulus 0.013 0.0207 0.1422
Mycobacterium leprae conserved hypothetical protein 0.0332 0.098 0.5
Echinococcus granulosus Bcl 2 ous antagonist:killer 0.0193 0.0446 0.0734
Schistosoma mansoni RAR-like nuclear receptor 0.0097 0.0079 0.0079
Echinococcus granulosus neuropeptide receptor A26 0.013 0.0207 0.0341
Echinococcus granulosus tachykinin peptides receptor 99D 0.013 0.0207 0.0341
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.013 0.0207 0.0207
Onchocerca volvulus 0.0256 0.0688 0.472
Onchocerca volvulus 0.0307 0.0885 0.6068
Schistosoma mansoni coup transcription factor 0.0097 0.0079 0.0079
Onchocerca volvulus 0.013 0.0207 0.1422
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0142 0.0251 0.0413
Echinococcus granulosus glycine receptor subunit alpha 1 0.0142 0.0251 0.0413
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.013 0.0207 0.0341
Trichomonas vaginalis glucosylceramidase, putative 0.0167 0.0349 0.0981
Schistosoma mansoni amine GPCR 0.013 0.0207 0.0207
Brugia malayi neuropeptide F receptor 0.013 0.0207 0.1422
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0142 0.0251 0.1723
Brugia malayi Tubulin beta-1 chain 0.0158 0.0313 0.2144
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0097 0.0079 0.0131
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0142 0.0251 0.1723
Echinococcus granulosus biogenic amine 5HT receptor 0.013 0.0207 0.0341
Echinococcus multilocularis rhodopsin orphan GPCR 0.013 0.0207 0.0341
Schistosoma mansoni nAChR subunit 0.0142 0.0251 0.0251
Schistosoma mansoni nAChR subunit 0.0142 0.0251 0.0251
Loa Loa (eye worm) hypothetical protein 0.0082 0.002 0.014
Schistosoma mansoni protein kinase 0.0123 0.0179 0.0179
Echinococcus multilocularis rhodopsin orphan GPCR 0.013 0.0207 0.0341
Schistosoma mansoni hypothetical protein 0.0193 0.0446 0.0446
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase subunit type II alpha 0.0108 0.012 0.0824
Brugia malayi bZIP transcription factor family protein 0.0086 0.0037 0.0253
Echinococcus multilocularis jun protein 0.0086 0.0037 0.0061
Echinococcus granulosus nicotinic acetylcholine receptor beta 1 subunit 0.0142 0.0251 0.0413
Loa Loa (eye worm) follicle stimulating hormone receptor 0.013 0.0207 0.1422
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.013 0.0207 0.0341
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0097 0.0079 0.0544
Toxoplasma gondii PAN domain-containing protein 0.0921 0.3243 1
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.013 0.0207 0.0341
Schistosoma mansoni biogenic amine (5HT) receptor 0.013 0.0207 0.0207
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0097 0.0079 0.0544
Echinococcus multilocularis Tubulin beta 2C chain 0.0158 0.0313 0.0514
Loa Loa (eye worm) hypothetical protein 0.0097 0.0079 0.0544
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0142 0.0251 0.1723
Entamoeba histolytica tubulin family protein 0.0158 0.0313 0.3191
Echinococcus granulosus tm gpcr rhodopsin 0.013 0.0207 0.0341
Loa Loa (eye worm) hypothetical protein 0.013 0.0207 0.1422
Loa Loa (eye worm) tubulin beta chain 0.0158 0.0313 0.2144
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription factor 0.0086 0.0037 0.0061
Trypanosoma brucei beta tubulin 0.0158 0.0313 0.209
Loa Loa (eye worm) hypothetical protein 0.0142 0.0251 0.1723
Trichomonas vaginalis glucosylceramidase, putative 0.0255 0.0687 1
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0255 0.0687 0.4707
Schistosoma mansoni histamine h1 receptor 0.013 0.0207 0.0207
Echinococcus granulosus sodium channel protein 0.0197 0.0461 0.0759
Loa Loa (eye worm) hypothetical protein 0.0142 0.0251 0.1723
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0097 0.0079 0.0131
Echinococcus granulosus somatostatin receptor 0.013 0.0207 0.0341
Schistosoma mansoni tubulin subunit beta 0.0158 0.0313 0.0313
Echinococcus granulosus GPCR family 2 0.011 0.0129 0.0212
Echinococcus granulosus rhodopsin orphan GPCR 0.013 0.0207 0.0341
Loa Loa (eye worm) hypothetical protein 0.013 0.0207 0.1422
Loa Loa (eye worm) hypothetical protein 0.013 0.0207 0.1422
Onchocerca volvulus 0.0142 0.0251 0.1723
Leishmania major beta tubulin 0.0158 0.0313 0.1851
Schistosoma mansoni hypothetical protein 0.013 0.0207 0.0207
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0097 0.0079 0.0544
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0108 0.012 0.0824
Leishmania major beta tubulin 0.0158 0.0313 0.1851
Brugia malayi hypothetical protein 0.013 0.0207 0.1422
Brugia malayi nuclear hormone receptor 0.0097 0.0079 0.0544
Echinococcus granulosus tm gpcr rhodopsin 0.013 0.0207 0.0341
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0097 0.0079 0.0544
Echinococcus multilocularis integrin alpha 3 0.0114 0.0143 0.0235
Brugia malayi hypothetical protein 0.013 0.0207 0.1422
Loa Loa (eye worm) hypothetical protein 0.0307 0.0885 0.6068
Echinococcus granulosus tm gpcr rhodopsin 0.1659 0.6082 1
Echinococcus multilocularis neuronal acetylcholine receptor subunit alpha 4 0.0142 0.0251 0.0413
Onchocerca volvulus 0.013 0.0207 0.1422
Chlamydia trachomatis arginine ABC transporter substrate-binding protein ArtJ 0.0081 0.0018 0.5
Loa Loa (eye worm) integrin alpha pat-2 0.0229 0.0585 0.4007
Schistosoma mansoni glutamate receptor NMDA 0.0267 0.0733 0.0733
Loa Loa (eye worm) hypothetical protein 0.013 0.0207 0.1422
Echinococcus granulosus nicotinic acetylcholine receptor a11 subunit 0.0282 0.079 0.1298
Onchocerca volvulus 0.013 0.0207 0.1422
Loa Loa (eye worm) hypothetical protein 0.013 0.0207 0.1422
Loa Loa (eye worm) hypothetical protein 0.0142 0.0251 0.1723
Schistosoma mansoni apoptosis regulator bax 0.0193 0.0446 0.0446
Schistosoma mansoni rhodopsin-like orphan GPCR 0.013 0.0207 0.0207
Echinococcus multilocularis serotonin receptor 0.013 0.0207 0.0341
Onchocerca volvulus 0.0456 0.1459 1
Brugia malayi Transforming growth factor beta like domain containing protein 0.0123 0.0179 0.1227
Echinococcus multilocularis Tubulin beta 2C chain 0.0158 0.0313 0.0514
Loa Loa (eye worm) hypothetical protein 0.0112 0.0137 0.094
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0097 0.0079 0.0544
Echinococcus multilocularis neuropeptides capa receptor 0.013 0.0207 0.0341
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.013 0.0207 0.0207
Echinococcus granulosus rhodopsin orphan GPCR 0.013 0.0207 0.0341
Echinococcus granulosus rhodopsin orphan GPCR 0.013 0.0207 0.0341
Echinococcus granulosus serotonin receptor 0.013 0.0207 0.0341
Echinococcus granulosus neuropeptide s receptor 0.013 0.0207 0.0341
Brugia malayi Dopamine receptor 0.013 0.0207 0.1422
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0142 0.0251 0.1723
Leishmania major beta tubulin 0.0158 0.0313 0.1851
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0097 0.0079 0.0544
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0097 0.0079 0.0544
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0142 0.0251 0.0413
Schistosoma mansoni neuropeptide receptor 0.013 0.0207 0.0207
Schistosoma mansoni biogenic amine (5HT) receptor 0.013 0.0207 0.0207
Loa Loa (eye worm) hypothetical protein 0.0142 0.0251 0.1723
Leishmania major beta tubulin 0.0158 0.0313 0.1851
Brugia malayi ecdysteroid receptor 0.0097 0.0079 0.0544
Echinococcus multilocularis beta tubulin 0.0158 0.0313 0.0514
Brugia malayi acetylcholine receptor, alpha-type subunit unc-38 precursor 0.0142 0.0251 0.1723
Loa Loa (eye worm) hypothetical protein 0.0142 0.0251 0.1723
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0097 0.0079 0.0544
Echinococcus granulosus glutamate NMDA receptor subunit 0.0267 0.0733 0.1206
Brugia malayi nicotinic acetylcholine receptor beta-1 chain precursor 0.0142 0.0251 0.1723
Brugia malayi steroid hormone receptor 0.0097 0.0079 0.0544
Echinococcus granulosus orexin receptor type 2 0.013 0.0207 0.0341
Echinococcus granulosus tubulin beta 1 chain 0.0158 0.0313 0.0514
Echinococcus multilocularis orexin receptor type 2 0.013 0.0207 0.0341
Loa Loa (eye worm) hypothetical protein 0.013 0.0207 0.1422
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0111 0.0133 0.0294
Loa Loa (eye worm) hypothetical protein 0.013 0.0207 0.1422
Schistosoma mansoni tubulin subunit beta 0.0158 0.0313 0.0313
Loa Loa (eye worm) BEN-1 protein 0.0158 0.0313 0.2144
Onchocerca volvulus 0.013 0.0207 0.1422
Echinococcus granulosus tubulin beta 4A class IVa 0.0158 0.0313 0.0514
Loa Loa (eye worm) hypothetical protein 0.0142 0.0251 0.1723
Loa Loa (eye worm) hypothetical protein 0.013 0.0207 0.1422
Echinococcus granulosus neuropeptide FF receptor 2 0.013 0.0207 0.0341
Loa Loa (eye worm) hypothetical protein 0.013 0.0207 0.1422
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0111 0.0133 0.0294
Loa Loa (eye worm) steroid hormone receptor 0.0097 0.0079 0.0544
Loa Loa (eye worm) hypothetical protein 0.0116 0.0153 0.1052
Echinococcus granulosus Tubulin beta 2C chain 0.0158 0.0313 0.0514
Echinococcus multilocularis somatostatin receptor 0.013 0.0207 0.0341
Onchocerca volvulus 0.013 0.0207 0.1422
Brugia malayi G-protein coupled receptor 0.013 0.0207 0.1422
Loa Loa (eye worm) hypothetical protein 0.013 0.0207 0.1422
Trichomonas vaginalis glucosylceramidase, putative 0.0167 0.0349 0.0981
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0097 0.0079 0.0131
Brugia malayi nicotinic acetylcholine receptor alpha subunit, putative 0.0282 0.079 0.5413
Echinococcus granulosus dro:myosuppressin receptor 0.013 0.0207 0.0341
Echinococcus granulosus peptide allatostatin:somatostatin 0.013 0.0207 0.0341
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0142 0.0251 0.1723
Brugia malayi GnHR receptor homolog 0.013 0.0207 0.1422
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0097 0.0079 0.0544
Schistosoma mansoni neuropeptide f receptor 76f 0.013 0.0207 0.0207
Loa Loa (eye worm) LGC-31 protein 0.0142 0.0251 0.1723
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0097 0.0079 0.0544
Loa Loa (eye worm) latrophilin receptor protein 2 0.011 0.0129 0.0883
Echinococcus granulosus neuronal acetylcholine receptor subunit alpha 4 0.0142 0.0251 0.0413
Echinococcus granulosus g protein coupled receptor 0.013 0.0207 0.0341
Schistosoma mansoni rhodopsin-like orphan GPCR 0.013 0.0207 0.0207
Leishmania major C-8 sterol isomerase-like protein 0.0364 0.1104 1
Brugia malayi hypothetical protein 0.013 0.0207 0.1422
Loa Loa (eye worm) hypothetical protein 0.0142 0.0251 0.1723
Leishmania major beta tubulin 0.0158 0.0313 0.1851
Onchocerca volvulus 0.0142 0.0251 0.1723
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.013 0.0207 0.0341
Echinococcus granulosus ecdysone induced protein 78C 0.0097 0.0079 0.0131
Echinococcus multilocularis rhodopsin orphan GPCR 0.013 0.0207 0.0341
Loa Loa (eye worm) hypothetical protein 0.013 0.0207 0.1422
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.013 0.0207 0.0341
Loa Loa (eye worm) hypothetical protein 0.0193 0.0446 0.3059
Brugia malayi Dopamine receptor protein 1 0.013 0.0207 0.1422
Echinococcus granulosus beta tubulin 0.0158 0.0313 0.0514
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.013 0.0207 0.0207
Schistosoma mansoni rhodopsin-like orphan GPCR 0.013 0.0207 0.0207
Loa Loa (eye worm) hypothetical protein 0.0097 0.0079 0.0544
Loa Loa (eye worm) bone morphogenic protein 6 0.0123 0.0179 0.1227
Brugia malayi G protein-coupled receptor F59B2.13 0.013 0.0207 0.1422
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0142 0.0251 0.0413
Echinococcus granulosus acetylcholine receptor subunit beta 1 0.0142 0.0251 0.0413
Trypanosoma cruzi beta tubulin, putative 0.0158 0.0313 0.1851
Schistosoma mansoni adenoreceptor 0.013 0.0207 0.0207
Schistosoma mansoni amine GPCR 0.013 0.0207 0.0207
Schistosoma mansoni neuropeptide F-like receptor 0.013 0.0207 0.0207
Trypanosoma brucei C-8 sterol isomerase, putative 0.0364 0.1104 1
Echinococcus granulosus nmda type glutamate receptor 0.0113 0.014 0.023
Brugia malayi putative neuropeptide receptor 0.013 0.0207 0.1422
Echinococcus multilocularis G-protein coupled receptor, putative 0.013 0.0207 0.0341
Schistosoma mansoni retinoic acid receptor RXR 0.0097 0.0079 0.0079
Loa Loa (eye worm) ligand-Gated ion Channel family member 0.0142 0.0251 0.1723
Echinococcus granulosus glycine receptor subunit alpha 1 0.0142 0.0251 0.0413
Brugia malayi excitatory GABA receptor EXP-1A 0.0142 0.0251 0.1723
Trypanosoma brucei beta tubulin 0.0158 0.0313 0.209
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0097 0.0079 0.0131
Echinococcus multilocularis nicotinic acetylcholine receptor a11 subunit 0.0282 0.079 0.1298
Echinococcus granulosus tubulin subunit beta 0.0158 0.0313 0.0514
Schistosoma mansoni tubulin subunit beta 0.0158 0.0313 0.0313
Echinococcus multilocularis nicotinic acetylcholine receptor subunit alpha 8 0.0282 0.079 0.1298
Trichomonas vaginalis glucosylceramidase, putative 0.0255 0.0687 1
Schistosoma mansoni peptide (allatostatin)-like receptor 0.013 0.0207 0.0207
Loa Loa (eye worm) tubulin beta-4 chain 0.0158 0.0313 0.2144
Brugia malayi Melatonin receptor type 1A 0.013 0.0207 0.1422
Loa Loa (eye worm) hypothetical protein 0.013 0.0207 0.1422
Trichomonas vaginalis glucosylceramidase, putative 0.0176 0.0384 0.1908
Trichomonas vaginalis glucosylceramidase, putative 0.0255 0.0687 1
Echinococcus granulosus neuropeptides capa receptor 0.013 0.0207 0.0341
Loa Loa (eye worm) hypothetical protein 0.013 0.0207 0.1422
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0097 0.0079 0.0544
Echinococcus multilocularis rhodopsin orphan GPCR 0.013 0.0207 0.0341
Onchocerca volvulus 0.0142 0.0251 0.1723
Echinococcus multilocularis fmrfamide receptor 0.013 0.0207 0.0341
Echinococcus multilocularis serotonin receptor 0.013 0.0207 0.0341
Echinococcus multilocularis dro:myosuppressin receptor 0.013 0.0207 0.0341
Echinococcus granulosus biogenic amine 5HT receptor 0.013 0.0207 0.0341
Trichomonas vaginalis glucosylceramidase, putative 0.0167 0.0349 0.0981
Echinococcus granulosus 7tm_1 domain containing protein 0.013 0.0207 0.0341
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.013 0.0207 0.0207
Loa Loa (eye worm) hypothetical protein 0.013 0.0207 0.1422
Echinococcus granulosus FTZ F1 alpha 0.0097 0.0079 0.0131
Schistosoma mansoni rhodopsin-like orphan GPCR 0.013 0.0207 0.0207
Echinococcus multilocularis nmda type glutamate receptor 0.0113 0.014 0.023
Brugia malayi AKH receptor 0.013 0.0207 0.1422
Schistosoma mansoni biogenic amine receptor 0.013 0.0207 0.0207
Echinococcus granulosus G protein coupled receptor 139 0.013 0.0207 0.0341
Echinococcus multilocularis g protein coupled receptor 0.013 0.0207 0.0341
Loa Loa (eye worm) hypothetical protein 0.013 0.0207 0.1422
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0097 0.0079 0.0079
Brugia malayi Serotonin/octopamine receptor family protein 7 0.013 0.0207 0.1422
Echinococcus granulosus nicotinic acetylcholine receptor subunit type 0.0142 0.0251 0.0413
Brugia malayi RE15519p 0.013 0.0207 0.1422
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.013 0.0207 0.0341
Echinococcus multilocularis neuropeptide receptor A26 0.013 0.0207 0.0341
Loa Loa (eye worm) hypothetical protein 0.0142 0.0251 0.1723
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0142 0.0251 0.1723
Echinococcus granulosus alpha 1A adrenergic receptor 0.013 0.0207 0.0341
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.013 0.0207 0.0207
Onchocerca volvulus 0.013 0.0207 0.1422
Onchocerca volvulus 0.013 0.0207 0.1422
Schistosoma mansoni neuropeptide receptor 0.013 0.0207 0.0207
Loa Loa (eye worm) beta-tubulin 0.0158 0.0313 0.2144
Onchocerca volvulus Neuropeptide F receptor homolog 0.013 0.0207 0.1422
Loa Loa (eye worm) excitatory GABA receptor EXP-1A 0.0142 0.0251 0.1723
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0097 0.0079 0.0544
Echinococcus multilocularis g-protein coupled receptor 0.013 0.0207 0.0341
Loa Loa (eye worm) hypothetical protein 0.0097 0.0079 0.0544
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0097 0.0079 0.0131
Loa Loa (eye worm) hypothetical protein 0.0142 0.0251 0.1723
Loa Loa (eye worm) hypothetical protein 0.0142 0.0251 0.1723
Echinococcus granulosus glycine receptor subunit beta 0.0142 0.0251 0.0413
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.013 0.0207 0.0341
Brugia malayi Trypsin family protein 0.0307 0.0885 0.6068
Schistosoma mansoni hypothetical protein 0.013 0.0207 0.0207
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0097 0.0079 0.0079
Loa Loa (eye worm) TYRA-2 protein 0.013 0.0207 0.1422
Echinococcus multilocularis neuropeptide FF receptor 2 0.013 0.0207 0.0341
Schistosoma mansoni opsin-like receptor 0.013 0.0207 0.0207
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0142 0.0251 0.1723
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.013 0.0207 0.1422
Loa Loa (eye worm) angiotensin-converting enzyme family protein 0.0158 0.0313 0.2148
Schistosoma mansoni rhodopsin-like orphan GPCR 0.013 0.0207 0.0207
Loa Loa (eye worm) hypothetical protein 0.013 0.0207 0.1422
Loa Loa (eye worm) hypothetical protein 0.013 0.0207 0.1422
Schistosoma mansoni opsin-like receptor 0.013 0.0207 0.0207
Schistosoma mansoni rhodopsin-like orphan GPCR 0.013 0.0207 0.0207
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.013 0.0207 0.0207
Loa Loa (eye worm) hypothetical protein 0.0307 0.0885 0.6068
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.013 0.0207 0.0341
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0097 0.0079 0.0544
Giardia lamblia Beta tubulin 0.0158 0.0313 0.5
Brugia malayi hypothetical protein 0.013 0.0207 0.1422
Brugia malayi Steroid receptor seven-up type 2 0.0097 0.0079 0.0544
Echinococcus granulosus glycine receptor subunit beta 0.0142 0.0251 0.0413
Loa Loa (eye worm) hypothetical protein 0.0084 0.0028 0.0191
Loa Loa (eye worm) hypothetical protein 0.013 0.0207 0.1422
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.013 0.0207 0.0207
Leishmania major beta tubulin 0.0158 0.0313 0.1851
Schistosoma mansoni amine GPCR 0.013 0.0207 0.0207
Brugia malayi acetylcholine receptor protein, alpha-like chain, putative 0.0142 0.0251 0.1723
Echinococcus multilocularis Tubulin beta 2C chain 0.0158 0.0313 0.0514
Brugia malayi sulfakinin receptor protein 0.013 0.0207 0.1422
Trypanosoma brucei variant surface glycoprotein (VSG), putative 0.0111 0.0133 0.0294
Echinococcus granulosus sex peptide receptor 0.013 0.0207 0.0341
Echinococcus multilocularis g protein coupled receptor 0.013 0.0207 0.0341
Echinococcus multilocularis nAChR subunit 0.0142 0.0251 0.0413
Loa Loa (eye worm) hypothetical protein 0.013 0.0207 0.1422
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0097 0.0079 0.0131
Loa Loa (eye worm) hypothetical protein 0.0456 0.1459 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0097 0.0079 0.0544
Echinococcus multilocularis rhodopsin orphan GPCR 0.013 0.0207 0.0341
Echinococcus multilocularis Tubulin beta 2C chain 0.0158 0.0313 0.0514
Loa Loa (eye worm) hypothetical protein 0.013 0.0207 0.1422
Brugia malayi gonadotropin-releasing hormone receptor 2 0.013 0.0207 0.1422
Schistosoma mansoni biogenic amine receptor 0.013 0.0207 0.0207
Brugia malayi Nuclear hormone receptor-like 1 0.0097 0.0079 0.0544
Echinococcus granulosus Tubulin beta 2C chain 0.0158 0.0313 0.0514
Onchocerca volvulus 0.013 0.0207 0.1422
Brugia malayi hypothetical protein 0.013 0.0207 0.1422
Brugia malayi nuclear receptor NHR-88 0.0097 0.0079 0.0544
Entamoeba histolytica tubulin family protein 0.0158 0.0313 0.3191
Echinococcus multilocularis thyroid hormone receptor alpha 0.0097 0.0079 0.0131
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.013 0.0207 0.0341
Schistosoma mansoni nAChR subunit 0.0142 0.0251 0.0251
Schistosoma mansoni tubulin subunit beta 0.0158 0.0313 0.0313
Echinococcus granulosus jun protein 0.0086 0.0037 0.0061
Schistosoma mansoni nAChR subunit (ShAR1-beta2-like) 0.0142 0.0251 0.0251
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0111 0.0133 0.0294
Schistosoma mansoni thyroid hormone receptor 0.0097 0.0079 0.0079
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0097 0.0079 0.0131
Brugia malayi ERG2 and Sigma1 receptor like protein 0.0364 0.1104 0.7569
Loa Loa (eye worm) hypothetical protein 0.013 0.0207 0.1422
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0097 0.0079 0.0544
Loa Loa (eye worm) hypothetical protein 0.0097 0.0079 0.0544
Loa Loa (eye worm) hypothetical protein 0.013 0.0207 0.1422
Echinococcus multilocularis biogenic amine (5HT) receptor 0.013 0.0207 0.0341
Loa Loa (eye worm) hypothetical protein 0.0282 0.079 0.5413
Echinococcus granulosus g protein coupled receptor 0.013 0.0207 0.0341
Loa Loa (eye worm) G-protein coupled receptor 0.013 0.0207 0.1422
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.013 0.0207 0.1422
Echinococcus multilocularis neuropeptide receptor 0.013 0.0207 0.0341
Echinococcus granulosus Tubulin beta 2C chain 0.0158 0.0313 0.0514
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0142 0.0251 0.0251
Brugia malayi Integrin alpha pat-2 precursor 0.0148 0.0276 0.1892
Echinococcus granulosus anti dorsalizing morphogenetic protein 1a 0.0123 0.0179 0.0294
Loa Loa (eye worm) hypothetical protein 0.013 0.0207 0.1422
Loa Loa (eye worm) hypothetical protein 0.017 0.0358 0.2457
Brugia malayi follicle stimulating hormone receptor 0.013 0.0207 0.1422
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0097 0.0079 0.0131
Echinococcus multilocularis tubulin beta 1 chain 0.0158 0.0313 0.0514
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.013 0.0207 0.1422
Loa Loa (eye worm) apoptosis regulator protein 0.0193 0.0446 0.3059
Mycobacterium ulcerans hypothetical protein 0.0332 0.098 1
Loa Loa (eye worm) hypothetical protein 0.013 0.0207 0.1422
Onchocerca volvulus 0.013 0.0207 0.1422
Schistosoma mansoni rhodopsin-like orphan GPCR 0.013 0.0207 0.0207
Brugia malayi neuropeptide F receptor 0.013 0.0207 0.1422
Trichomonas vaginalis glucosylceramidase, putative 0.0255 0.0687 1
Loa Loa (eye worm) hypothetical protein 0.013 0.0207 0.1422
Plasmodium vivax tubulin beta chain, putative 0.0158 0.0313 0.5
Schistosoma mansoni hypothetical protein 0.011 0.0129 0.0129
Loa Loa (eye worm) tubulin beta-2A chain 0.0158 0.0313 0.2144
Brugia malayi hypothetical protein 0.013 0.0207 0.1422
Loa Loa (eye worm) pigment dispersing factor receptor c 0.028 0.0781 0.5355
Loa Loa (eye worm) neuropeptide F receptor 0.013 0.0207 0.1422
Brugia malayi larval opioid receptor 0.013 0.0207 0.1422
Echinococcus granulosus Tubulin beta 2C chain 0.0158 0.0313 0.0514
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0097 0.0079 0.0131
Onchocerca volvulus 0.013 0.0207 0.1422
Loa Loa (eye worm) hypothetical protein 0.013 0.0207 0.1422
Brugia malayi Cation transporter family protein 0.0142 0.0251 0.1723
Schistosoma mansoni growth hormone secretagogue receptor 0.013 0.0207 0.0207
Brugia malayi Apoptosis regulator proteins, Bcl-2 family protein 0.0193 0.0446 0.3059

Activities

Activity type Activity value Assay description Source Reference
AUC (ADMET) = 328 ug min ml-1 AUC in dog after oral dose (1 mg/kg) ChEMBL. 12270176
Cmax (ADMET) = 1.52 ug ml-1 Cmax in dog plasma after oral dose (1 mg/kg) ChEMBL. 12270176
Ki (binding) = 22.2 ug nM-1 In vitro inhibitory activity against human Thrombin (FIIa) cleavage of the chromogenic substrate ChEMBL. 12270176
Ki (binding) = 22.2 ug nM-1 In vitro inhibitory activity against human Thrombin (FIIa) cleavage of the chromogenic substrate ChEMBL. 12270176
pKa = 8.6 Ionisation constant (pKa) ChEMBL. 12270176
T1/2 (ADMET) = 109 min t1/2 in dog after oral dose (1 mg/kg) ChEMBL. 12270176

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.