TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 560.42 | Formula: C23H22BrN5O5S
H donors: 3 H acceptors: 5 LogP: 2.4 Rotable bonds: 9
Rule of 5 violations (Lipinski): 2
SMILES: O=C(Cn1c(C)ccc(c1=O)NS(=O)(=O)Cc1ccc(cc1)Br)NCc1ccc2c(c1)onc2N
InChi: 1S/C23H22BrN5O5S/c1-14-2-9-19(28-35(32,33)13-15-3-6-17(24)7-4-15)23(31)29(14)12-21(30)26-11-16-5-8-18-20(10-16)34-27-22(18)25/h2-10,28H,11-13H2,1H3,(H2,25,27)(H,26,30)
InChiKey: PVHVKUAYRDIWEG-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus multilocularis	jun protein	0.0086	0.0037	0.0061
Schistosoma mansoni	hypothetical protein	0.013	0.0207	0.0207
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.013	0.0207	0.0341
Echinococcus granulosus	neuropeptide Y receptor	0.013	0.0207	0.0341
Loa Loa (eye worm)	beta-tubulin	0.0158	0.0313	0.2144
Onchocerca volvulus		0.013	0.0207	0.1422
Trypanosoma brucei	calpain-like cysteine peptidase, putative	0.0111	0.0133	0.0294
Schistosoma mansoni	amine GPCR	0.013	0.0207	0.0207
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0332	0.098	1
Echinococcus granulosus	beta tubulin	0.0158	0.0313	0.0514
Echinococcus granulosus	EGFP:Bcl2 fusion protein	0.1488	0.5423	0.8916
Brugia malayi	sulfakinin receptor protein	0.013	0.0207	0.1422
Loa Loa (eye worm)	hypothetical protein	0.0142	0.0251	0.1723
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0097	0.0079	0.0544
Leishmania major	beta tubulin	0.0158	0.0313	0.1851
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.013	0.0207	0.1422
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.011	0.0129	0.0212
Trichomonas vaginalis	glucosylceramidase, putative	0.0255	0.0687	1
Schistosoma mansoni	nAChR subunit	0.0142	0.0251	0.0251
Giardia lamblia	Beta tubulin	0.0158	0.0313	0.5
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.013	0.0207	0.0207
Echinococcus multilocularis	neuropeptides capa receptor	0.013	0.0207	0.0341
Echinococcus granulosus	biogenic amine 5HT receptor	0.013	0.0207	0.0341
Brugia malayi	G-protein coupled receptor	0.013	0.0207	0.1422
Echinococcus granulosus	Basic leucine zipper bZIP transcription factor	0.0086	0.0037	0.0061
Echinococcus multilocularis	dro:myosuppressin receptor	0.013	0.0207	0.0341
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0097	0.0079	0.0131
Echinococcus granulosus	Tubulin beta 2C chain	0.0158	0.0313	0.0514
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.013	0.0207	0.0341
Brugia malayi	acetylcholine receptor alpha subunit precursor, putative	0.0142	0.0251	0.1723
Echinococcus multilocularis	FTZ F1 alpha	0.0097	0.0079	0.0131
Toxoplasma gondii	PAN domain-containing protein	0.0921	0.3243	1
Brugia malayi	G-protein coupled receptor	0.013	0.0207	0.1422
Schistosoma mansoni	tubulin subunit beta	0.0158	0.0313	0.0313
Echinococcus granulosus	allatostatin A receptor	0.013	0.0207	0.0341
Schistosoma mansoni	amine GPCR	0.013	0.0207	0.0207
Onchocerca volvulus	Dopamine\/Ecdysteroid receptor homolog	0.013	0.0207	0.1422
Schistosoma mansoni	hypothetical protein	0.013	0.0207	0.0207
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0097	0.0079	0.0131
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0142	0.0251	0.1723
Schistosoma mansoni	serine-type protease inhibitor	0.2679	1	1
Loa Loa (eye worm)	hypothetical protein	0.013	0.0207	0.1422
Schistosoma mansoni	hypothetical protein	0.011	0.0129	0.0129
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.013	0.0207	0.0341
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.013	0.0207	0.0341
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.013	0.0207	0.0207
Loa Loa (eye worm)	hypothetical protein	0.013	0.0207	0.1422
Trypanosoma brucei	beta tubulin	0.0158	0.0313	0.209
Loa Loa (eye worm)	hypothetical protein	0.0391	0.1207	0.8277
Brugia malayi	Calcium/calmodulin-dependent protein kinase type II alpha chain	0.0108	0.012	0.0824
Echinococcus granulosus	neuropeptides capa receptor	0.013	0.0207	0.0341
Brugia malayi	putative neuropeptide receptor NPR1	0.013	0.0207	0.1422
Echinococcus granulosus	somatostatin receptor	0.013	0.0207	0.0341
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0097	0.0079	0.0131
Echinococcus multilocularis	nicotinic acetylcholine receptor a11 subunit	0.0282	0.079	0.1298
Echinococcus granulosus	nAChR subunit	0.0142	0.0251	0.0413
Onchocerca volvulus		0.013	0.0207	0.1422
Loa Loa (eye worm)	calcium/calmodulin-dependent protein kinase subunit type II alpha	0.0108	0.012	0.0824
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.013	0.0207	0.0207
Echinococcus multilocularis	rhodopsin orphan GPCR	0.013	0.0207	0.0341
Loa Loa (eye worm)	hypothetical protein	0.013	0.0207	0.1422
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0097	0.0079	0.0131
Echinococcus granulosus	glycine receptor subunit alpha 1	0.0142	0.0251	0.0413
Entamoeba histolytica	hypothetical protein, conserved	0.0332	0.098	1
Loa Loa (eye worm)	hypothetical protein	0.0142	0.0251	0.1723
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0097	0.0079	0.0544
Echinococcus multilocularis	tubulin subunit beta	0.0158	0.0313	0.0514
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0097	0.0079	0.0544
Loa Loa (eye worm)	hypothetical protein	0.0097	0.0079	0.0544
Loa Loa (eye worm)	TYRA-2 protein	0.013	0.0207	0.1422
Echinococcus granulosus	hypothetical protein	0.013	0.0207	0.0341
Trypanosoma brucei	calpain, putative	0.0111	0.0133	0.0294
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.0142	0.0251	0.0251
Echinococcus multilocularis	g-protein coupled receptor	0.013	0.0207	0.0341
Onchocerca volvulus		0.013	0.0207	0.1422
Loa Loa (eye worm)	hypothetical protein	0.0142	0.0251	0.1723
Brugia malayi	neuropeptide F receptor	0.013	0.0207	0.1422
Loa Loa (eye worm)	hypothetical protein	0.0142	0.0251	0.1723
Schistosoma mansoni	neuropeptide receptor	0.013	0.0207	0.0207
Loa Loa (eye worm)	hypothetical protein	0.0142	0.0251	0.1723
Echinococcus granulosus	g-protein coupled receptor	0.013	0.0207	0.0341
Brugia malayi	nuclear hormone receptor	0.0097	0.0079	0.0544
Echinococcus multilocularis	neuropeptides capa receptor	0.013	0.0207	0.0341
Loa Loa (eye worm)	hypothetical protein	0.011	0.0129	0.0883
Echinococcus granulosus	orexin receptor type 2	0.013	0.0207	0.0341
Echinococcus multilocularis	Glutamate receptor, ionotropic kainate 3	0.0113	0.014	0.023
Brugia malayi	hypothetical protein	0.013	0.0207	0.1422
Brugia malayi	acetylcholine receptor protein, alpha-like chain, putative	0.0142	0.0251	0.1723
Loa Loa (eye worm)	hypothetical protein	0.0097	0.0079	0.0544
Echinococcus granulosus	neuropeptide receptor	0.013	0.0207	0.0341
Loa Loa (eye worm)	hypothetical protein	0.013	0.0207	0.1422
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.013	0.0207	0.0207
Treponema pallidum	amino acid ABC transporter, periplasmic binding protein (hisJ)	0.0081	0.0018	0.5
Echinococcus multilocularis	Tubulin beta 2C chain	0.0158	0.0313	0.0514
Brugia malayi	Trypsin family protein	0.0307	0.0885	0.6068
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.011	0.0129	0.0883
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0097	0.0079	0.0544
Echinococcus granulosus	biogenic amine 5HT receptor	0.013	0.0207	0.0341
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.011	0.0129	0.0212
Loa Loa (eye worm)	hypothetical protein	0.0142	0.0251	0.1723
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.013	0.0207	0.0341
Loa Loa (eye worm)	hypothetical protein	0.013	0.0207	0.1422
Loa Loa (eye worm)	hypothetical protein	0.013	0.0207	0.1422
Leishmania major	beta tubulin	0.0158	0.0313	0.1851
Echinococcus granulosus	G protein coupled receptor 139	0.013	0.0207	0.0341
Echinococcus granulosus	beta tubulin	0.0158	0.0313	0.0514
Schistosoma mansoni	amine GPCR	0.013	0.0207	0.0207
Onchocerca volvulus		0.0456	0.1459	1
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.013	0.0207	0.0207
Echinococcus granulosus	Bcl 2 ous antagonist:killer	0.0193	0.0446	0.0734
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0142	0.0251	0.1723
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.013	0.0207	0.0207
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0097	0.0079	0.0131
Echinococcus granulosus	rhodopsin orphan GPCR	0.013	0.0207	0.0341
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0097	0.0079	0.0544
Echinococcus granulosus	glycine receptor subunit alpha 1	0.0142	0.0251	0.0413
Loa Loa (eye worm)	hypothetical protein	0.013	0.0207	0.1422
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0097	0.0079	0.0544
Brugia malayi	hypothetical protein	0.013	0.0207	0.1422
Loa Loa (eye worm)	hypothetical protein	0.0084	0.0028	0.0191
Loa Loa (eye worm)	hypothetical protein	0.013	0.0207	0.1422
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0097	0.0079	0.0544
Schistosoma mansoni	nAChR subunit	0.0142	0.0251	0.0251
Echinococcus multilocularis	serotonin receptor	0.013	0.0207	0.0341
Loa Loa (eye worm)	hypothetical protein	0.013	0.0207	0.1422
Echinococcus granulosus	peptide allatostatin:somatostatin	0.013	0.0207	0.0341
Schistosoma mansoni	amine GPCR	0.013	0.0207	0.0207
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.013	0.0207	0.1422
Brugia malayi	hypothetical protein	0.013	0.0207	0.1422
Loa Loa (eye worm)	BEN-1 protein	0.0158	0.0313	0.2144
Schistosoma mansoni	thyroid hormone receptor	0.0097	0.0079	0.0079
Onchocerca volvulus		0.0307	0.0885	0.6068
Trichomonas vaginalis	glucosylceramidase, putative	0.0255	0.0687	1
Trichomonas vaginalis	glucosylceramidase, putative	0.0167	0.0349	0.0981
Loa Loa (eye worm)	hypothetical protein	0.013	0.0207	0.1422
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0097	0.0079	0.0131
Echinococcus granulosus	neuronal acetylcholine receptor subunit alpha 4	0.0142	0.0251	0.0413
Loa Loa (eye worm)	nicotinic acetylcholine receptor alpha subunit	0.0282	0.079	0.5413
Loa Loa (eye worm)	hypothetical protein	0.013	0.0207	0.1422
Echinococcus multilocularis	nicotinic acetylcholine receptor beta 1 subunit	0.0142	0.0251	0.0413
Brugia malayi	Calcitonin receptor-like protein seb-1	0.028	0.0781	0.5355
Loa Loa (eye worm)	hypothetical protein	0.0082	0.002	0.014
Echinococcus multilocularis	tubulin, beta 4A class IVa	0.0158	0.0313	0.0514
Echinococcus granulosus	g protein coupled receptor	0.013	0.0207	0.0341
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0142	0.0251	0.1723
Trypanosoma cruzi	C-8 sterol isomerase, putative	0.0364	0.1104	1
Echinococcus multilocularis	integrin alpha 3	0.0114	0.0143	0.0235
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.011	0.0129	0.0212
Schistosoma mansoni	neuropeptide f receptor 76f	0.013	0.0207	0.0207
Entamoeba histolytica	tubulin family protein	0.0158	0.0313	0.3191
Brugia malayi	Dopamine receptor protein 2	0.013	0.0207	0.1422
Loa Loa (eye worm)	neuropeptide F receptor	0.013	0.0207	0.1422
Loa Loa (eye worm)	hypothetical protein	0.0142	0.0251	0.1723
Leishmania major	beta tubulin	0.0158	0.0313	0.1851
Schistosoma mansoni	integrin alpha	0.0148	0.0276	0.0276
Trypanosoma brucei	calpain-like cysteine peptidase, putative	0.0111	0.0133	0.0294
Echinococcus granulosus	tubulin subunit beta	0.0158	0.0313	0.0514
Mycobacterium leprae	conserved hypothetical protein	0.0332	0.098	0.5
Onchocerca volvulus	Putative nachr subunit	0.0282	0.079	0.5413
Schistosoma mansoni	bcl-2 homologous antagonist/killer (bak)	0.0193	0.0446	0.0446
Schistosoma mansoni	nAChR subunit (ShAR1-beta2-like)	0.0142	0.0251	0.0251
Echinococcus granulosus	sex peptide receptor	0.013	0.0207	0.0341
Leishmania major	C-8 sterol isomerase-like protein	0.0364	0.1104	1
Brugia malayi	Angiotensin-converting enzyme family protein	0.0158	0.0313	0.2148
Schistosoma mansoni	nAChR subunit	0.0142	0.0251	0.0251
Brugia malayi	Dopamine receptor	0.013	0.0207	0.1422
Loa Loa (eye worm)	hypothetical protein	0.013	0.0207	0.1422
Trypanosoma brucei	beta tubulin	0.0158	0.0313	0.209
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0097	0.0079	0.0079
Schistosoma mansoni	hypothetical protein	0.0193	0.0446	0.0446
Loa Loa (eye worm)	BEN-1 protein	0.0158	0.0313	0.2144
Loa Loa (eye worm)	hypothetical protein	0.013	0.0207	0.1422
Echinococcus granulosus	integrin alpha 3	0.0114	0.0143	0.0235
Echinococcus multilocularis	rhodopsin orphan GPCR	0.013	0.0207	0.0341
Schistosoma mansoni	hypothetical protein	0.0193	0.0446	0.0446
Onchocerca volvulus		0.013	0.0207	0.1422
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.013	0.0207	0.0207
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.013	0.0207	0.1422
Echinococcus multilocularis	somatostatin receptor	0.013	0.0207	0.0341
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.013	0.0207	0.0207
Echinococcus multilocularis	anti dorsalizing morphogenetic protein 1a	0.0123	0.0179	0.0294
Loa Loa (eye worm)	hypothetical protein	0.0193	0.0446	0.3059
Echinococcus granulosus	g protein coupled receptor	0.013	0.0207	0.0341
Loa Loa (eye worm)	hypothetical protein	0.013	0.0207	0.1422
Echinococcus multilocularis	GPCR, family 2	0.011	0.0129	0.0212
Echinococcus granulosus	glycine receptor subunit beta	0.0142	0.0251	0.0413
Leishmania major	beta tubulin	0.0158	0.0313	0.1851
Brugia malayi	Cation transporter family protein	0.0142	0.0251	0.1723
Onchocerca volvulus		0.013	0.0207	0.1422
Loa Loa (eye worm)	hypothetical protein	0.013	0.0207	0.1422
Brugia malayi	Melatonin receptor type 1A	0.013	0.0207	0.1422
Echinococcus multilocularis	neuropeptide FF receptor 2	0.013	0.0207	0.0341
Brugia malayi	Nuclear hormone receptor-like 1	0.0097	0.0079	0.0544
Echinococcus granulosus	sodium channel protein	0.0197	0.0461	0.0759
Schistosoma mansoni	amine GPCR	0.013	0.0207	0.0207
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0142	0.0251	0.1723
Trichomonas vaginalis	glucosylceramidase, putative	0.0167	0.0349	0.0981
Loa Loa (eye worm)	O-glycosyl hydrolase family 30 protein	0.0255	0.0687	0.4707
Loa Loa (eye worm)	hypothetical protein	0.0097	0.0079	0.0544
Trichomonas vaginalis	glucosylceramidase, putative	0.0176	0.0384	0.1908
Schistosoma mansoni	opsin-like receptor	0.013	0.0207	0.0207
Echinococcus multilocularis	ecdysone induced protein 78C	0.0097	0.0079	0.0131
Echinococcus multilocularis	EGFP:Bcl2 fusion protein	0.1488	0.5423	0.8916
Echinococcus multilocularis	neuropeptide Y receptor	0.013	0.0207	0.0341
Brugia malayi	Serotonin receptor	0.013	0.0207	0.1422
Loa Loa (eye worm)	excitatory GABA receptor EXP-1A	0.0142	0.0251	0.1723
Echinococcus multilocularis	allatostatin A receptor	0.013	0.0207	0.0341
Echinococcus multilocularis	sex peptide receptor	0.013	0.0207	0.0341
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.013	0.0207	0.0207
Echinococcus granulosus	rhodopsin orphan GPCR	0.013	0.0207	0.0341
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.0142	0.0251	0.0251
Loa Loa (eye worm)	hypothetical protein	0.0456	0.1459	1
Echinococcus multilocularis	neuropeptide receptor A26	0.013	0.0207	0.0341
Schistosoma mansoni	nAChR subunit	0.0142	0.0251	0.0251
Loa Loa (eye worm)	hypothetical protein	0.013	0.0207	0.1422
Onchocerca volvulus	Neuropeptide F receptor homolog	0.013	0.0207	0.1422
Plasmodium falciparum	tubulin beta chain	0.0158	0.0313	0.5
Trichomonas vaginalis	glucosylceramidase, putative	0.0167	0.0349	0.0981
Brugia malayi	Hypothetical glycine receptor like protein T20B12.9 in chromosome III	0.0142	0.0251	0.1723
Leishmania major	beta tubulin	0.0158	0.0313	0.1851
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.0142	0.0251	0.0251
Echinococcus multilocularis	glycine receptor subunit beta	0.0142	0.0251	0.0413
Echinococcus granulosus	nicotinic acetylcholine receptor subunit alpha 8	0.0282	0.079	0.1298
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0097	0.0079	0.0544
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0097	0.0079	0.0544
Trypanosoma brucei	calpain-like cysteine peptidase, putative	0.0111	0.0133	0.0294
Echinococcus multilocularis	beta tubulin	0.0158	0.0313	0.0514
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.013	0.0207	0.0341
Echinococcus multilocularis	neuropeptide receptor	0.013	0.0207	0.0341
Leishmania major	beta tubulin	0.0158	0.0313	0.1851
Echinococcus multilocularis	nicotinic acetylcholine receptor alpha subunit	0.0282	0.079	0.1298
Echinococcus granulosus	rhodopsin orphan GPCR	0.013	0.0207	0.0341
Echinococcus granulosus	neuropeptide s receptor	0.013	0.0207	0.0341
Echinococcus granulosus	fmrfamide receptor	0.013	0.0207	0.0341
Trypanosoma brucei	variant surface glycoprotein (VSG), putative	0.0111	0.0133	0.0294
Loa Loa (eye worm)	neuropeptide F receptor	0.013	0.0207	0.1422
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.013	0.0207	0.0207
Onchocerca volvulus		0.0142	0.0251	0.1723
Echinococcus multilocularis	rhodopsin orphan GPCR	0.013	0.0207	0.0341
Schistosoma mansoni	protein kinase	0.0123	0.0179	0.0179
Schistosoma mansoni	nAChR subunit (ShAR1-beta-like)	0.0456	0.1459	0.1459
Brugia malayi	neuropeptide F receptor	0.013	0.0207	0.1422
Brugia malayi	putative neuropeptide receptor	0.013	0.0207	0.1422
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.013	0.0207	0.1422
Onchocerca volvulus		0.013	0.0207	0.1422
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0312	0.0903	0.0903
Schistosoma mansoni	neuropeptide receptor	0.013	0.0207	0.0207
Trypanosoma brucei	calpain-like cysteine peptidase, putative	0.0111	0.0133	0.0294
Onchocerca volvulus		0.013	0.0207	0.1422
Onchocerca volvulus		0.013	0.0207	0.1422
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0097	0.0079	0.0544
Schistosoma mansoni	nAChR subunit	0.0142	0.0251	0.0251
Brugia malayi	nuclear receptor NHR-88	0.0097	0.0079	0.0544
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.013	0.0207	0.0341
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.028	0.0781	0.5355
Loa Loa (eye worm)	hypothetical protein	0.0097	0.0079	0.0544
Echinococcus granulosus	nicotinic acetylcholine receptor a11 subunit	0.0282	0.079	0.1298
Echinococcus multilocularis	Tubulin beta 2C chain	0.0158	0.0313	0.0514
Echinococcus multilocularis	glutamate (NMDA) receptor subunit	0.0267	0.0733	0.1206
Echinococcus granulosus	tm gpcr rhodopsin	0.013	0.0207	0.0341
Echinococcus granulosus	tachykinin peptides receptor 99D	0.013	0.0207	0.0341
Loa Loa (eye worm)	hypothetical protein	0.0186	0.0421	0.2884
Loa Loa (eye worm)	latrophilin receptor protein 2	0.011	0.0129	0.0883
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.013	0.0207	0.0341
Trypanosoma cruzi	beta tubulin, putative	0.0158	0.0313	0.1851
Echinococcus granulosus	tm gpcr rhodopsin	0.013	0.0207	0.0341
Schistosoma mansoni	neuropeptide receptor	0.013	0.0207	0.0207
Loa Loa (eye worm)	hypothetical protein	0.013	0.0207	0.1422
Loa Loa (eye worm)	hypothetical protein	0.013	0.0207	0.1422
Onchocerca volvulus		0.013	0.0207	0.1422
Schistosoma mansoni	glutamate receptor NMDA	0.0267	0.0733	0.0733
Brugia malayi	Dopamine receptor protein 1	0.013	0.0207	0.1422
Brugia malayi	hypothetical protein	0.013	0.0207	0.1422
Schistosoma mansoni	tubulin subunit beta	0.0158	0.0313	0.0313
Giardia lamblia	Beta tubulin	0.0158	0.0313	0.5
Onchocerca volvulus		0.0456	0.1459	1
Schistosoma mansoni	retinoic acid receptor RXR	0.0097	0.0079	0.0079
Echinococcus granulosus	voltage gated sodium channel Nav1 alpha subunit	0.0197	0.0461	0.0759
Loa Loa (eye worm)	angiotensin-converting enzyme family protein	0.0158	0.0313	0.2148
Schistosoma mansoni	hypothetical protein	0.013	0.0207	0.0207
Echinococcus granulosus	dro:myosuppressin receptor	0.013	0.0207	0.0341
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0097	0.0079	0.0544
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.013	0.0207	0.0341
Loa Loa (eye worm)	hypothetical protein	0.013	0.0207	0.1422
Echinococcus multilocularis	G protein coupled receptor 139	0.013	0.0207	0.0341
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0142	0.0251	0.1723
Echinococcus multilocularis	glycine receptor subunit alpha 1	0.0142	0.0251	0.0413
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.013	0.0207	0.0207
Echinococcus multilocularis	fmrfamide receptor	0.013	0.0207	0.0341
Brugia malayi	photoreceptor-specific nuclear receptor	0.0097	0.0079	0.0544
Brugia malayi	hypothetical protein	0.013	0.0207	0.1422
Echinococcus granulosus	neuropeptide receptor	0.013	0.0207	0.0341
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.013	0.0207	0.0341
Brugia malayi	acetylcholine receptor, alpha-type subunit unc-38 precursor	0.0142	0.0251	0.1723
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.013	0.0207	0.0207
Loa Loa (eye worm)	hypothetical protein	0.0116	0.0153	0.1052
Loa Loa (eye worm)	hypothetical protein	0.013	0.0207	0.1422
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.013	0.0207	0.0207
Loa Loa (eye worm)	hypothetical protein	0.013	0.0207	0.1422
Schistosoma mansoni	neuropeptide receptor	0.013	0.0207	0.0207
Onchocerca volvulus	Bile acid receptor homolog	0.0097	0.0079	0.0544
Loa Loa (eye worm)	ACC-1 protein	0.0142	0.0251	0.1723
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.013	0.0207	0.1422
Brugia malayi	RE15519p	0.013	0.0207	0.1422
Onchocerca volvulus		0.0456	0.1459	1
Echinococcus granulosus	neuropeptide Y receptor	0.013	0.0207	0.0341
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0097	0.0079	0.0544
Loa Loa (eye worm)	hypothetical protein	0.013	0.0207	0.1422
Echinococcus multilocularis	neuropeptide Y receptor	0.013	0.0207	0.0341
Echinococcus granulosus	glutamate NMDA receptor subunit	0.0267	0.0733	0.1206
Schistosoma mansoni	tubulin subunit beta	0.0158	0.0313	0.0313
Loa Loa (eye worm)	hypothetical protein	0.0142	0.0251	0.1723
Entamoeba histolytica	tubulin family protein	0.0158	0.0313	0.3191
Loa Loa (eye worm)	hypothetical protein	0.013	0.0207	0.1422
Trichomonas vaginalis	glucosylceramidase, putative	0.0176	0.0384	0.1908
Loa Loa (eye worm)	hypothetical protein	0.0142	0.0251	0.1723
Onchocerca volvulus		0.0097	0.0079	0.0544
Loa Loa (eye worm)	hypothetical protein	0.028	0.0781	0.5355
Loa Loa (eye worm)	hypothetical protein	0.0142	0.0251	0.1723
Onchocerca volvulus	Glucosylceramidase homolog	0.0167	0.0349	0.2396
Onchocerca volvulus		0.013	0.0207	0.1422
Brugia malayi	Integrin alpha cytoplasmic region family protein	0.0112	0.0137	0.094
Brugia malayi	G protein-coupled receptor	0.013	0.0207	0.1422
Loa Loa (eye worm)	melatonin receptor type 1A	0.013	0.0207	0.1422
Echinococcus multilocularis	nmda type glutamate receptor	0.0113	0.014	0.023
Loa Loa (eye worm)	integrin alpha pat-2	0.0229	0.0585	0.4007
Echinococcus multilocularis	nicotinic acetylcholine receptor subunit alpha 8	0.0282	0.079	0.1298
Echinococcus granulosus	glycine receptor subunit beta	0.0142	0.0251	0.0413
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0097	0.0079	0.0079
Echinococcus multilocularis	neuropeptide receptor	0.013	0.0207	0.0341
Loa Loa (eye worm)	hypothetical protein	0.013	0.0207	0.1422
Brugia malayi	O-Glycosyl hydrolase family 30 protein	0.0255	0.0687	0.4707
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.013	0.0207	0.0341
Echinococcus granulosus	rhodopsin orphan GPCR	0.013	0.0207	0.0341
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.013	0.0207	0.0207
Brugia malayi	Steroid receptor seven-up type 2	0.0097	0.0079	0.0544
Loa Loa (eye worm)	hypothetical protein	0.013	0.0207	0.1422
Echinococcus granulosus	tm gpcr rhodopsin	0.1659	0.6082	1
Brugia malayi	hypothetical protein	0.013	0.0207	0.1422
Onchocerca volvulus		0.013	0.0207	0.1422
Leishmania major	beta tubulin	0.0158	0.0313	0.1851
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.013	0.0207	0.0207
Brugia malayi	hypothetical protein	0.013	0.0207	0.1422
Schistosoma mansoni	tubulin subunit beta	0.0158	0.0313	0.0313
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0097	0.0079	0.0079
Echinococcus multilocularis	g protein coupled receptor	0.013	0.0207	0.0341
Trichomonas vaginalis	glucosylceramidase, putative	0.0255	0.0687	1
Echinococcus granulosus	GPCR family 2	0.011	0.0129	0.0212
Echinococcus multilocularis	glycine receptor subunit alpha 1	0.0142	0.0251	0.0413
Mycobacterium tuberculosis	Conserved protein	0.0332	0.098	1
Schistosoma mansoni	thyroid hormone receptor	0.0097	0.0079	0.0079
Schistosoma mansoni	coup transcription factor	0.0097	0.0079	0.0079
Loa Loa (eye worm)	bone morphogenic protein 6	0.0123	0.0179	0.1227
Brugia malayi	Transforming growth factor beta like domain containing protein	0.0123	0.0179	0.1227
Echinococcus multilocularis	sodium channel protein	0.0197	0.0461	0.0759
Trichomonas vaginalis	glucosylceramidase, putative	0.0255	0.0687	1
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0097	0.0079	0.0131
Trichomonas vaginalis	glucosylceramidase, putative	0.0255	0.0687	1
Leishmania major	beta tubulin	0.0158	0.0313	0.1851
Echinococcus granulosus	Tubulin beta 2C chain	0.0158	0.0313	0.0514
Brugia malayi	Latrophilin receptor protein 2	0.011	0.0129	0.0883
Trichomonas vaginalis	glucosylceramidase, putative	0.0167	0.0349	0.0981
Trichomonas vaginalis	glucosylceramidase, putative	0.0167	0.0349	0.0981
Brugia malayi	excitatory GABA receptor EXP-1A	0.0142	0.0251	0.1723
Brugia malayi	beta-tubulin, identical	0.0158	0.0313	0.2144
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0097	0.0079	0.0544
Echinococcus multilocularis	Cys loop ligand gated ion channel subunit	0.0142	0.0251	0.0413
Onchocerca volvulus		0.013	0.0207	0.1422
Loa Loa (eye worm)	hypothetical protein	0.0142	0.0251	0.1723
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.0097	0.0079	0.0544
Onchocerca volvulus		0.013	0.0207	0.1422
Trypanosoma brucei	calpain-like protein, putative	0.0111	0.0133	0.0294
Trypanosoma brucei	C-8 sterol isomerase, putative	0.0364	0.1104	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.013	0.0207	0.0341
Brugia malayi	Tubulin beta-1 chain	0.0158	0.0313	0.2144
Echinococcus multilocularis	Bcl 2 ous antagonist:killer	0.0193	0.0446	0.0734
Loa Loa (eye worm)	hypothetical protein	0.0142	0.0251	0.1723
Trypanosoma brucei	hypothetical protein	0.0111	0.0133	0.0294
Echinococcus multilocularis	Tubulin beta 2C chain	0.0158	0.0313	0.0514
Leishmania major	beta tubulin	0.0158	0.0313	0.1851
Schistosoma mansoni	hypothetical protein	0.011	0.0129	0.0129
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0097	0.0079	0.0079
Loa Loa (eye worm)	hypothetical protein	0.013	0.0207	0.1422
Onchocerca volvulus		0.013	0.0207	0.1422
Brugia malayi	Apoptosis regulator proteins, Bcl-2 family protein	0.0193	0.0446	0.3059
Loa Loa (eye worm)	hypothetical protein	0.0456	0.1459	1
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0097	0.0079	0.0131
Brugia malayi	ORL1-like opioid receptor	0.013	0.0207	0.1422
Brugia malayi	larval opioid receptor	0.013	0.0207	0.1422
Brugia malayi	Cation transporter family protein	0.0142	0.0251	0.1723
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0142	0.0251	0.1723
Loa Loa (eye worm)	hypothetical protein	0.0307	0.0885	0.6068
Echinococcus granulosus	nicotinic acetylcholine receptor alpha subunit	0.0282	0.079	0.1298
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0097	0.0079	0.0131
Loa Loa (eye worm)	acetylcholine receptor alpha subunit	0.0142	0.0251	0.1723
Schistosoma mansoni	nAChR subunit	0.0142	0.0251	0.0251
Onchocerca volvulus		0.013	0.0207	0.1422
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0307	0.0885	0.0885
Loa Loa (eye worm)	hypothetical protein	0.0142	0.0251	0.1723
Mycobacterium ulcerans	hypothetical protein	0.0332	0.098	1
Echinococcus granulosus	neuropeptides capa receptor	0.013	0.0207	0.0341
Brugia malayi	steroid hormone receptor	0.0097	0.0079	0.0544
Echinococcus granulosus	7TM GPCR rhodopsin	0.013	0.0207	0.0341
Brugia malayi	hypothetical protein	0.013	0.0207	0.1422
Leishmania major	beta tubulin	0.0158	0.0313	0.1851
Loa Loa (eye worm)	tubulin beta-2A chain	0.0158	0.0313	0.2144
Echinococcus granulosus	anti dorsalizing morphogenetic protein 1a	0.0123	0.0179	0.0294
Echinococcus multilocularis	glycine receptor subunit beta	0.0142	0.0251	0.0413
Loa Loa (eye worm)	hypothetical protein	0.013	0.0207	0.1422
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0142	0.0251	0.1723
Brugia malayi	hypothetical protein	0.013	0.0207	0.1422
Onchocerca volvulus		0.013	0.0207	0.1422
Loa Loa (eye worm)	hypothetical protein	0.013	0.0207	0.1422
Schistosoma mansoni	hypothetical protein	0.0193	0.0446	0.0446
Loa Loa (eye worm)	hypothetical protein	0.0112	0.0137	0.094
Loa Loa (eye worm)	hypothetical protein	0.0097	0.0079	0.0544
Brugia malayi	gamma-aminobutyric-acid receptor beta subunit precursor	0.0142	0.0251	0.1723
Schistosoma mansoni	neuropeptide F-like receptor	0.013	0.0207	0.0207
Schistosoma mansoni	myosin xvIII	0.013	0.0207	0.0207
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0097	0.0079	0.0079
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.013	0.0207	0.0341
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0097	0.0079	0.0544
Schistosoma mansoni	histamine h1 receptor	0.013	0.0207	0.0207
Leishmania major	beta tubulin	0.0158	0.0313	0.1851
Schistosoma mansoni	biogenic amine receptor	0.013	0.0207	0.0207
Trypanosoma brucei	beta tubulin	0.0158	0.0313	0.209
Brugia malayi	follicle stimulating hormone receptor	0.013	0.0207	0.1422
Echinococcus granulosus	7tm_1 domain containing protein	0.013	0.0207	0.0341
Loa Loa (eye worm)	hypothetical protein	0.013	0.0207	0.1422
Loa Loa (eye worm)	hypothetical protein	0.013	0.0207	0.1422
Brugia malayi	ecdysteroid receptor	0.0097	0.0079	0.0544
Echinococcus granulosus	FTZ F1 alpha	0.0097	0.0079	0.0131
Schistosoma mansoni	nAChR subunit	0.0142	0.0251	0.0251
Schistosoma mansoni	hypothetical protein	0.0103	0.0104	0.0104
Brugia malayi	AKH receptor	0.013	0.0207	0.1422
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.013	0.0207	0.1422
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0097	0.0079	0.0544
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0097	0.0079	0.0131
Echinococcus multilocularis	rhodopsin orphan GPCR	0.013	0.0207	0.0341
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0097	0.0079	0.0131
Leishmania major	beta tubulin	0.0158	0.0313	0.1851
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0142	0.0251	0.1723
Loa Loa (eye worm)	tubulin beta-1 chain	0.0158	0.0313	0.2144
Schistosoma mansoni	hypothetical protein	0.017	0.0358	0.0358
Echinococcus multilocularis	tubulin beta 1 chain	0.0158	0.0313	0.0514
Loa Loa (eye worm)	G-protein coupled receptor	0.013	0.0207	0.1422
Echinococcus multilocularis	g protein coupled receptor	0.013	0.0207	0.0341
Trichomonas vaginalis	glucosylceramidase, putative	0.0167	0.0349	0.0981
Echinococcus multilocularis	fmrfamide receptor	0.013	0.0207	0.0341
Mycobacterium ulcerans	hypothetical protein	0.0332	0.098	1
Loa Loa (eye worm)	ligand-Gated ion Channel family member	0.0142	0.0251	0.1723
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0097	0.0079	0.0544
Echinococcus granulosus	neuropeptide FF receptor 2	0.013	0.0207	0.0341
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.013	0.0207	0.1422
Echinococcus granulosus	neuropeptide receptor A26	0.013	0.0207	0.0341
Loa Loa (eye worm)	nicotinic acetylcholine receptor non-alpha subunit	0.0142	0.0251	0.1723
Giardia lamblia	Beta tubulin	0.0158	0.0313	0.5
Echinococcus granulosus	nicotinic acetylcholine receptor subunit type	0.0142	0.0251	0.0413
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.013	0.0207	0.0207
Echinococcus granulosus	tubulin beta 1 chain	0.0158	0.0313	0.0514
Trichomonas vaginalis	glucosylceramidase, putative	0.0255	0.0687	1
Toxoplasma gondii	PAN domain-containing protein	0.0921	0.3243	1
Loa Loa (eye worm)	hypothetical protein	0.0097	0.0079	0.0544
Schistosoma mansoni	alpha-1 adrenergic receptor	0.013	0.0207	0.0207
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0097	0.0079	0.0544
Echinococcus granulosus	g protein coupled receptor	0.013	0.0207	0.0341
Loa Loa (eye worm)	G-protein coupled receptor	0.013	0.0207	0.1422
Echinococcus granulosus	jun protein	0.0086	0.0037	0.0061
Schistosoma mansoni	biogenic amine receptor	0.013	0.0207	0.0207
Leishmania major	beta tubulin	0.0158	0.0313	0.1851
Loa Loa (eye worm)	hypothetical protein	0.013	0.0207	0.1422
Echinococcus multilocularis	g protein coupled receptor	0.013	0.0207	0.0341
Schistosoma mansoni	hypothetical protein	0.011	0.0129	0.0129
Echinococcus multilocularis	rhodopsin orphan GPCR	0.013	0.0207	0.0341
Schistosoma mansoni	adenoreceptor	0.013	0.0207	0.0207
Loa Loa (eye worm)	hypothetical protein	0.0282	0.079	0.5413
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0097	0.0079	0.0131
Schistosoma mansoni	hypothetical protein	0.011	0.0129	0.0129
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.013	0.0207	0.0341
Brugia malayi	Serotonin receptor	0.013	0.0207	0.1422
Loa Loa (eye worm)	apoptosis regulator protein	0.0193	0.0446	0.3059
Loa Loa (eye worm)	hypothetical protein	0.013	0.0207	0.1422
Echinococcus multilocularis	acetylcholine receptor subunit beta 1	0.0142	0.0251	0.0413
Echinococcus multilocularis	Tubulin beta 2C chain	0.0158	0.0313	0.0514
Treponema pallidum	amino acid ABC transporter, periplasmic binding protein	0.0081	0.0018	0.5
Schistosoma mansoni	protein kinase	0.0123	0.0179	0.0179
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.013	0.0207	0.1422
Schistosoma mansoni	hypothetical protein	0.013	0.0207	0.0207
Schistosoma mansoni	biogenic amine (5HT) receptor	0.013	0.0207	0.0207
Chlamydia trachomatis	glutamine binding protein	0.0081	0.0018	0.5
Schistosoma mansoni	tubulin subunit beta	0.0158	0.0313	0.0313
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.013	0.0207	0.0207
Schistosoma mansoni	growth hormone secretagogue receptor	0.013	0.0207	0.0207
Loa Loa (eye worm)	hypothetical protein	0.013	0.0207	0.1422
Echinococcus granulosus	ecdysone induced protein 78C	0.0097	0.0079	0.0131
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.013	0.0207	0.0207
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0097	0.0079	0.0131
Loa Loa (eye worm)	hypothetical protein	0.017	0.0358	0.2457
Echinococcus multilocularis	orexin receptor type 2	0.013	0.0207	0.0341
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0097	0.0079	0.0544
Onchocerca volvulus		0.0256	0.0688	0.472
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0097	0.0079	0.0079
Echinococcus multilocularis	G-protein coupled receptor, putative	0.013	0.0207	0.0341
Loa Loa (eye worm)	ACC-1 protein	0.0142	0.0251	0.1723
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.0123	0.0179	0.0295
Loa Loa (eye worm)	hypothetical protein	0.013	0.0207	0.1422
Brugia malayi	hypothetical protein	0.013	0.0207	0.1422
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.013	0.0207	0.0207
Leishmania major	beta tubulin	0.0158	0.0313	0.1851
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.011	0.0129	0.0212
Echinococcus multilocularis	rhodopsin orphan GPCR	0.013	0.0207	0.0341
Brugia malayi	nicotinic acetylcholine receptor beta-1 chain precursor	0.0142	0.0251	0.1723
Loa Loa (eye worm)	hypothetical protein	0.013	0.0207	0.1422
Echinococcus granulosus	rhodopsin orphan GPCR	0.013	0.0207	0.0341
Schistosoma mansoni	tubulin subunit beta	0.0158	0.0313	0.0313
Leishmania major	beta tubulin	0.0158	0.0313	0.1851
Brugia malayi	Tachykinin-like peptides receptor 99D	0.013	0.0207	0.1422
Loa Loa (eye worm)	hypothetical protein	0.0307	0.0885	0.6068
Brugia malayi	nicotinic acetylcholine receptor alpha subunit, putative	0.0282	0.079	0.5413
Loa Loa (eye worm)	tubulin beta chain	0.0158	0.0313	0.2144
Echinococcus multilocularis	glycine receptor subunit alpha 1	0.0142	0.0251	0.0413
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.028	0.0781	0.5355
Trypanosoma brucei	calpain-like cysteine peptidase, putative	0.0111	0.0133	0.0294
Leishmania major	beta tubulin	0.0158	0.0313	0.1851
Loa Loa (eye worm)	hypothetical protein	0.013	0.0207	0.1422
Schistosoma mansoni	opsin-like receptor	0.013	0.0207	0.0207
Echinococcus granulosus	Tubulin beta 2C chain	0.0158	0.0313	0.0514
Leishmania major	beta tubulin	0.0158	0.0313	0.1851
Schistosoma mansoni	protein kinase	0.0123	0.0179	0.0179
Loa Loa (eye worm)	hypothetical protein	0.0097	0.0079	0.0544
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.013	0.0207	0.0341
Brugia malayi	Cation transporter family protein	0.0456	0.1459	1
Brugia malayi	bZIP transcription factor family protein	0.0086	0.0037	0.0253
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.013	0.0207	0.0341
Trypanosoma brucei	beta tubulin	0.0158	0.0313	0.209
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.013	0.0207	0.0341
Brugia malayi	Integrin alpha pat-2 precursor	0.0148	0.0276	0.1892
Loa Loa (eye worm)	tubulin beta-4 chain	0.0158	0.0313	0.2144
Loa Loa (eye worm)	LGC-31 protein	0.0142	0.0251	0.1723
Echinococcus multilocularis	rhodopsin orphan GPCR	0.013	0.0207	0.0341
Echinococcus multilocularis	neuronal acetylcholine receptor subunit alpha 4	0.0142	0.0251	0.0413
Schistosoma mansoni	biogenic amine receptor	0.013	0.0207	0.0207
Trichomonas vaginalis	glucosylceramidase, putative	0.0167	0.0349	0.0981
Echinococcus granulosus	rhodopsin orphan GPCR	0.013	0.0207	0.0341
Schistosoma mansoni	opsin-like receptor	0.013	0.0207	0.0207
Echinococcus multilocularis	neuropeptide s receptor	0.013	0.0207	0.0341
Schistosoma mansoni	RAR-like nuclear receptor	0.0097	0.0079	0.0079
Loa Loa (eye worm)	hypothetical protein	0.0364	0.1104	0.7569
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0142	0.0251	0.1723
Schistosoma mansoni	neuropeptide F-like receptor	0.013	0.0207	0.0207
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0123	0.0179	0.0295
Loa Loa (eye worm)	hypothetical protein	0.0142	0.0251	0.1723
Onchocerca volvulus	Protein ultraspiracle homolog	0.0097	0.0079	0.0544
Leishmania major	beta tubulin	0.0158	0.0313	0.1851
Loa Loa (eye worm)	hypothetical protein	0.013	0.0207	0.1422
Echinococcus granulosus	Tubulin beta 2C chain	0.0158	0.0313	0.0514
Schistosoma mansoni	nAChR subunit (ShAR1-alpha-like)	0.0456	0.1459	0.1459
Loa Loa (eye worm)	hypothetical protein	0.0142	0.0251	0.1723
Trypanosoma brucei	cysteine peptidase, Clan CA, family C2, putative	0.0111	0.0133	0.0294
Loa Loa (eye worm)	hypothetical protein	0.013	0.0207	0.1422
Echinococcus granulosus	alpha 1A adrenergic receptor	0.013	0.0207	0.0341
Loa Loa (eye worm)	hypothetical protein	0.013	0.0207	0.1422
Brugia malayi	GnHR receptor homolog	0.013	0.0207	0.1422
Echinococcus granulosus	acetylcholine receptor subunit beta 1	0.0142	0.0251	0.0413
Brugia malayi	ERG2 and Sigma1 receptor like protein	0.0364	0.1104	0.7569
Echinococcus multilocularis	nAChR subunit	0.0142	0.0251	0.0413
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0097	0.0079	0.0544
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0097	0.0079	0.0131
Echinococcus granulosus	Tubulin beta 2C chain	0.0158	0.0313	0.0514
Echinococcus granulosus	nmda type glutamate receptor	0.0113	0.014	0.023
Leishmania major	calcium channel protein, putative,ion transporter, putative	0.0197	0.0461	0.3381
Echinococcus granulosus	nicotinic acetylcholine receptor beta 1 subunit	0.0142	0.0251	0.0413
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription factor	0.0086	0.0037	0.0061
Chlamydia trachomatis	arginine ABC transporter substrate-binding protein ArtJ	0.0081	0.0018	0.5
Loa Loa (eye worm)	hypothetical protein	0.013	0.0207	0.1422
Plasmodium vivax	tubulin beta chain, putative	0.0158	0.0313	0.5
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.1659	0.6082	1
Onchocerca volvulus		0.013	0.0207	0.1422
Schistosoma mansoni	nuclear hormone receptor	0.0097	0.0079	0.0079
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.013	0.0207	0.0207
Loa Loa (eye worm)	hypothetical protein	0.013	0.0207	0.1422
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.013	0.0207	0.0341
Loa Loa (eye worm)	hypothetical protein	0.013	0.0207	0.1422
Schistosoma mansoni	biogenic amine (5HT) receptor	0.013	0.0207	0.0207
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.013	0.0207	0.1422
Echinococcus granulosus	Cys loop ligand gated ion channel subunit	0.0142	0.0251	0.0413
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.013	0.0207	0.0341
Onchocerca volvulus		0.0142	0.0251	0.1723
Echinococcus granulosus	serotonin receptor	0.013	0.0207	0.0341
Loa Loa (eye worm)	hypothetical protein	0.013	0.0207	0.1422
Loa Loa (eye worm)	hypothetical protein	0.013	0.0207	0.1422
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.013	0.0207	0.0341
Onchocerca volvulus		0.0142	0.0251	0.1723
Echinococcus granulosus	tubulin beta 4A class IVa	0.0158	0.0313	0.0514
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.013	0.0207	0.0207
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.013	0.0207	0.0207
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0097	0.0079	0.0544
Loa Loa (eye worm)	steroid hormone receptor	0.0097	0.0079	0.0544
Echinococcus multilocularis	serotonin receptor	0.013	0.0207	0.0341
Echinococcus granulosus	rhodopsin orphan GPCR	0.013	0.0207	0.0341
Loa Loa (eye worm)	hypothetical protein	0.013	0.0207	0.1422
Echinococcus multilocularis	Tubulin beta 2C chain	0.0158	0.0313	0.0514
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0097	0.0079	0.0079
Loa Loa (eye worm)	hypothetical protein	0.0142	0.0251	0.1723
Loa Loa (eye worm)	glutamate-gated chloride channel alpha3A subunit	0.0142	0.0251	0.1723
Brugia malayi	latrophilin 2 splice variant baaae	0.017	0.0358	0.2457
Brugia malayi	G protein-coupled receptor F59B2.13	0.013	0.0207	0.1422
Schistosoma mansoni	apoptosis regulator bax	0.0193	0.0446	0.0446
Echinococcus granulosus	glycine receptor subunit alpha 1	0.0142	0.0251	0.0413
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.013	0.0207	0.1422
Echinococcus multilocularis	beta tubulin	0.0158	0.0313	0.0514
Loa Loa (eye worm)	hypothetical protein	0.0097	0.0079	0.0544

Activities

Activity type	Activity value	Assay description	Source	Reference
AUC (ADMET)	= 328 ug min ml-1	AUC in dog after oral dose (1 mg/kg)	ChEMBL.	12270176
Cmax (ADMET)	= 1.52 ug ml-1	Cmax in dog plasma after oral dose (1 mg/kg)	ChEMBL.	12270176
Ki (binding)	= 22.2 ug nM-1	In vitro inhibitory activity against human Thrombin (FIIa) cleavage of the chromogenic substrate	ChEMBL.	12270176
Ki (binding)	= 22.2 ug nM-1	In vitro inhibitory activity against human Thrombin (FIIa) cleavage of the chromogenic substrate	ChEMBL.	12270176
pKa	= 8.6	Ionisation constant (pKa)	ChEMBL.	12270176
T1/2 (ADMET)	= 109 min	t1/2 in dog after oral dose (1 mg/kg)	ChEMBL.	12270176

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL101974

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 164973