Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.0064 | 0.0064 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0042 | 0.0042 |
Mycobacterium ulcerans | long-chain fatty-acid CoA ligase | 0.0024 | 0.0064 | 0.5587 |
Brugia malayi | AMP-binding enzyme family protein | 0.0007 | 0.0004 | 0.0004 |
Schistosoma mansoni | caspase-7 (C14 family) | 0.0032 | 0.009 | 0.0086 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0043 | 0.0131 | 1 |
Trichomonas vaginalis | myo inositol monophosphatase, putative | 0.0038 | 0.0112 | 0.8517 |
Echinococcus granulosus | apoptotic protease activating factor 1 | 0.0032 | 0.009 | 0.0086 |
Brugia malayi | Inositol-1 | 0.0038 | 0.0112 | 0.0112 |
Mycobacterium ulcerans | long-chain-fatty-acid--CoA ligase | 0.0024 | 0.0064 | 0.5587 |
Schistosoma mansoni | patched 1 | 0.0043 | 0.0131 | 0.0127 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0042 | 0.0042 |
Brugia malayi | oxidoreductase, short chain dehydrogenase/reductase family protein | 0.0007 | 0.0004 | 0.0004 |
Mycobacterium tuberculosis | Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase | 0.0007 | 0.0004 | 0.0357 |
Schistosoma mansoni | inositol monophosphatase | 0.0038 | 0.0112 | 0.0108 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0024 | 0.0064 | 0.5587 |
Echinococcus granulosus | muscleblind protein | 0.0153 | 0.0516 | 0.0513 |
Trypanosoma cruzi | STE/STE11 serine/threonine-protein kinase, putative | 0.0864 | 0.3011 | 1 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0024 | 0.0064 | 0.5587 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0042 | 0.0042 |
Echinococcus multilocularis | expressed conserved protein | 0.0095 | 0.0311 | 0.0308 |
Echinococcus multilocularis | muscleblind protein | 0.0153 | 0.0516 | 0.0513 |
Toxoplasma gondii | AMP-binding enzyme domain-containing protein | 0.0007 | 0.0004 | 0.0324 |
Entamoeba histolytica | myo-inositol monophosphatase, putative | 0.0038 | 0.0112 | 0.3284 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0017 | 0.0039 | 0.3972 |
Brugia malayi | Cell death protein 3 precursor | 0.0032 | 0.009 | 0.009 |
Mycobacterium ulcerans | extragenic suppressor protein SuhB | 0.0038 | 0.0112 | 1 |
Loa Loa (eye worm) | oxidoreductase | 0.0007 | 0.0004 | 0.0004 |
Brugia malayi | AMP-binding enzyme family protein | 0.0007 | 0.0004 | 0.0004 |
Mycobacterium tuberculosis | Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) | 0.0018 | 0.0042 | 0.433 |
Schistosoma mansoni | hypothetical protein | 0.0025 | 0.0066 | 0.0063 |
Schistosoma mansoni | hypothetical protein | 0.0032 | 0.009 | 0.0086 |
Loa Loa (eye worm) | hypothetical protein | 0.0007 | 0.0004 | 0.0004 |
Brugia malayi | AMP-binding enzyme family protein | 0.0007 | 0.0004 | 0.0004 |
Echinococcus granulosus | Protein patched homolog 1 | 0.0043 | 0.0131 | 0.0127 |
Brugia malayi | AMP-binding enzyme family protein | 0.0024 | 0.0064 | 0.0064 |
Trypanosoma cruzi | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0038 | 0.0112 | 0.036 |
Brugia malayi | hypothetical protein | 0.0032 | 0.009 | 0.009 |
Mycobacterium tuberculosis | Peptide synthetase MbtE (peptide synthase) | 0.0007 | 0.0004 | 0.0357 |
Plasmodium vivax | acyl-CoA synthetase, putative | 0.0018 | 0.0042 | 1 |
Trypanosoma brucei | inositol-1(or 4)-monophosphatase 1, putative | 0.0038 | 0.0112 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.0064 | 0.0064 |
Brugia malayi | AMP-binding enzyme family protein | 0.0024 | 0.0064 | 0.0064 |
Schistosoma mansoni | hypothetical protein | 0.0174 | 0.059 | 0.0586 |
Onchocerca volvulus | 0.0024 | 0.0064 | 0.7137 | |
Echinococcus multilocularis | Niemann Pick C1 protein | 0.0101 | 0.0333 | 0.0329 |
Entamoeba histolytica | acyl-coA synthetase, putative | 0.0024 | 0.0064 | 0.1835 |
Brugia malayi | Muscleblind-like protein | 0.0153 | 0.0516 | 0.0516 |
Onchocerca volvulus | 0.0007 | 0.0004 | 0.0404 | |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0024 | 0.0064 | 0.5587 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.0131 | 0.0131 |
Chlamydia trachomatis | acylglycerophosphoethanolamine acyltransferase | 0.0018 | 0.0042 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0042 | 0.0125 | 0.0122 |
Brugia malayi | AMP-binding enzyme family protein | 0.0024 | 0.0064 | 0.0064 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0007 | 0.0004 | 0.0357 |
Schistosoma mansoni | hypothetical protein | 0.0174 | 0.059 | 0.0586 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0017 | 0.0039 | 0.3972 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0024 | 0.0064 | 0.5587 |
Mycobacterium ulcerans | hypothetical protein | 0.0024 | 0.0064 | 0.5587 |
Wolbachia endosymbiont of Brugia malayi | fructose-1,6-bisphosphatase | 0.0038 | 0.0112 | 0.5 |
Entamoeba histolytica | acyl-CoA synthetase, putative | 0.0024 | 0.0064 | 0.1835 |
Echinococcus granulosus | Niemann Pick C1 protein | 0.0101 | 0.0333 | 0.0329 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0042 | 0.0042 |
Mycobacterium tuberculosis | Peptide synthetase MbtF (peptide synthase) | 0.0007 | 0.0004 | 0.0357 |
Loa Loa (eye worm) | abnormal chemotaxis protein 14 | 0.0043 | 0.0131 | 0.0131 |
Mycobacterium tuberculosis | Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) | 0.0007 | 0.0004 | 0.0357 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0042 | 0.0042 |
Loa Loa (eye worm) | hypothetical protein | 0.0007 | 0.0004 | 0.0004 |
Echinococcus multilocularis | geminin | 0.0174 | 0.059 | 0.0586 |
Onchocerca volvulus | 0.0007 | 0.0004 | 0.0404 | |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0017 | 0.0039 | 0.3972 |
Loa Loa (eye worm) | hypothetical protein | 0.0153 | 0.0516 | 0.0517 |
Toxoplasma gondii | Acetyl-coenzyme A synthetase 2, putative | 0.0007 | 0.0004 | 0.0324 |
Echinococcus granulosus | geminin | 0.0174 | 0.059 | 0.0586 |
Echinococcus granulosus | expressed conserved protein | 0.0095 | 0.0311 | 0.0308 |
Loa Loa (eye worm) | AMP-binding enzyme family protein | 0.0007 | 0.0004 | 0.0004 |
Mycobacterium ulcerans | fatty-acid-CoA ligase | 0.0024 | 0.0064 | 0.5587 |
Trichomonas vaginalis | myo inositol monophosphatase, putative | 0.0038 | 0.0112 | 0.8517 |
Echinococcus multilocularis | Niemann Pick C1 protein | 0.0144 | 0.0485 | 0.0481 |
Mycobacterium leprae | PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0024 | 0.0064 | 0.6416 |
Mycobacterium tuberculosis | Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0007 | 0.0004 | 0.0357 |
Onchocerca volvulus | 0.0007 | 0.0004 | 0.0404 | |
Entamoeba histolytica | acyl-CoA synthetase, putative | 0.0024 | 0.0064 | 0.1835 |
Echinococcus granulosus | inositol monophosphatase 1 | 0.0038 | 0.0112 | 0.0108 |
Loa Loa (eye worm) | hypothetical protein | 0.0101 | 0.0333 | 0.0333 |
Loa Loa (eye worm) | hypothetical protein | 0.0153 | 0.0516 | 0.0517 |
Mycobacterium tuberculosis | Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) | 0.0007 | 0.0004 | 0.0357 |
Plasmodium vivax | acetyl-CoA synthetase, putative | 0.0007 | 0.0004 | 0.0854 |
Mycobacterium ulcerans | fatty-acid-CoA ligase | 0.0018 | 0.0042 | 0.3588 |
Loa Loa (eye worm) | hypothetical protein | 0.0859 | 0.2996 | 0.3001 |
Mycobacterium tuberculosis | P-hydroxybenzoyl-AMP ligase FadD22 | 0.0007 | 0.0004 | 0.0357 |
Schistosoma mansoni | protein kinase | 0.2854 | 1 | 1 |
Trypanosoma cruzi | STE/STE11 serine/threonine-protein kinase, putative | 0.0864 | 0.3011 | 1 |
Mycobacterium leprae | possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). | 0.0034 | 0.0098 | 1 |
Schistosoma mansoni | protein kinase | 0.2854 | 1 | 1 |
Entamoeba histolytica | Niemann-Pick C1 protein, putative | 0.0101 | 0.0333 | 1 |
Mycobacterium leprae | PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0024 | 0.0064 | 0.6416 |
Echinococcus multilocularis | protein patched | 0.0043 | 0.0131 | 0.0127 |
Echinococcus granulosus | mitogen activated protein kinase kinase kinase | 0.2854 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0042 | 0.0125 | 0.0122 |
Echinococcus multilocularis | inositol monophosphatase 1 | 0.0038 | 0.0112 | 0.0108 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.0064 | 0.0064 |
Echinococcus multilocularis | protein dispatched 1 | 0.0049 | 0.0152 | 0.0148 |
Mycobacterium tuberculosis | Inositol-1-monophosphatase SuhB | 0.0034 | 0.0098 | 1 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0024 | 0.0064 | 0.6544 |
Loa Loa (eye worm) | hypothetical protein | 0.285 | 0.9985 | 1 |
Echinococcus granulosus | sterol regulatory element binding protein | 0.0043 | 0.0131 | 0.0127 |
Schistosoma mansoni | inositol monophosphatase | 0.0038 | 0.0112 | 0.0108 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0024 | 0.0064 | 0.5587 |
Mycobacterium tuberculosis | Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) | 0.0024 | 0.0064 | 0.6544 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.009 | 0.009 |
Schistosoma mansoni | hypothetical protein | 0.0042 | 0.0125 | 0.0122 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0017 | 0.0039 | 0.3972 |
Loa Loa (eye worm) | hypothetical protein | 0.0053 | 0.0165 | 0.0165 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0024 | 0.0064 | 0.5587 |
Onchocerca volvulus | 0.0007 | 0.0004 | 0.0404 | |
Brugia malayi | CHE-14 protein | 0.0043 | 0.0131 | 0.0131 |
Plasmodium falciparum | acyl-CoA synthetase | 0.0018 | 0.0042 | 1 |
Mycobacterium tuberculosis | Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0007 | 0.0004 | 0.0357 |
Loa Loa (eye worm) | AMP-binding enzyme family protein | 0.0007 | 0.0004 | 0.0004 |
Mycobacterium ulcerans | long-chain-fatty-acid-CoA ligase | 0.0024 | 0.0064 | 0.5587 |
Echinococcus multilocularis | apoptotic protease activating factor 1 | 0.0032 | 0.009 | 0.0086 |
Plasmodium falciparum | acetyl-CoA synthetase, putative | 0.0007 | 0.0004 | 0.0854 |
Toxoplasma gondii | inositol(myo)-1(or 4)-monophosphatase 2, putative | 0.0038 | 0.0112 | 1 |
Echinococcus multilocularis | caspase 2 | 0.0032 | 0.009 | 0.0086 |
Trypanosoma cruzi | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0038 | 0.0112 | 0.036 |
Mycobacterium tuberculosis | Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0007 | 0.0004 | 0.0357 |
Onchocerca volvulus | Cell death protein 3 homolog | 0.0032 | 0.009 | 1 |
Brugia malayi | acetyl-Coenzyme A synthetase 2 | 0.0007 | 0.0004 | 0.0004 |
Mycobacterium tuberculosis | Probable peptide synthetase Nrp (peptide synthase) | 0.0007 | 0.0004 | 0.0357 |
Toxoplasma gondii | propionate-CoA ligase | 0.0007 | 0.0004 | 0.0324 |
Loa Loa (eye worm) | STE/STE11/ASK protein kinase | 0.0864 | 0.3011 | 0.3015 |
Echinococcus granulosus | caspase 2 | 0.0032 | 0.009 | 0.0086 |
Echinococcus multilocularis | sterol regulatory element binding protein | 0.0043 | 0.0131 | 0.0127 |
Schistosoma mansoni | niemann-pick C1 (NPC1) | 0.0102 | 0.0338 | 0.0335 |
Echinococcus granulosus | Niemann Pick C1 protein | 0.0144 | 0.0485 | 0.0481 |
Brugia malayi | AMP-binding enzyme family protein | 0.0007 | 0.0004 | 0.0004 |
Schistosoma mansoni | hypothetical protein | 0.0042 | 0.0125 | 0.0122 |
Loa Loa (eye worm) | inositol-1 | 0.0038 | 0.0112 | 0.0112 |
Echinococcus multilocularis | mitogen activated protein kinase kinase kinase | 0.2854 | 1 | 1 |
Brugia malayi | Niemann-Pick C1 protein precursor | 0.0101 | 0.0333 | 0.0333 |
Trichomonas vaginalis | inositol monophosphatase, putative | 0.0038 | 0.0112 | 0.8517 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.009 | 0.009 |
Echinococcus multilocularis | muscleblind protein 1 | 0.0153 | 0.0516 | 0.0513 |
Leishmania major | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0038 | 0.0112 | 1 |
Onchocerca volvulus | 0.0032 | 0.009 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
GI50 (functional) | -5.834 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.888 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MDA-N Breast cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.847 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-5 Melanoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.767 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.753 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the DU-145 Prostate cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.733 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.719 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.675 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.589 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.