Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | 0.267 | 1 | 1 | |
Echinococcus multilocularis | Fatty acid desaturase, type 1 | 0.0225 | 0.0516 | 1 |
Loa Loa (eye worm) | fatty acid desaturase | 0.0225 | 0.0516 | 0.0565 |
Mycobacterium ulcerans | linoleoyl-CoA desaturase, DesA3 | 0.0225 | 0.0516 | 0.5 |
Trypanosoma brucei | fatty acid desaturase, putative | 0.267 | 1 | 1 |
Mycobacterium tuberculosis | Probable transmembrane alkane 1-monooxygenase AlkB (alkane 1-hydroxylase) (lauric acid omega-hydroxylase) (omega-hydroxylase) (f | 0.0225 | 0.0516 | 0.5 |
Brugia malayi | Fatty acid desaturase family protein | 0.0225 | 0.0516 | 0.0565 |
Mycobacterium tuberculosis | Probable conserved membrane protein | 0.0225 | 0.0516 | 0.5 |
Trypanosoma cruzi | fatty acid desaturase, putative | 0.267 | 1 | 1 |
Mycobacterium ulcerans | transmembrane alkane 1-monooxygenase AlkB | 0.0225 | 0.0516 | 0.5 |
Trypanosoma cruzi | fatty acid desaturase, putative | 0.2445 | 0.9127 | 0.9079 |
Echinococcus multilocularis | Peptidase M, neutral zinc metallopeptidases, zinc binding site | 0.0225 | 0.0516 | 1 |
Brugia malayi | acyl-CoA desaturase | 0.2445 | 0.9127 | 1 |
Mycobacterium ulcerans | hypothetical protein | 0.0225 | 0.0516 | 0.5 |
Mycobacterium ulcerans | electron transfer protein FdxB | 0.0225 | 0.0516 | 0.5 |
Mycobacterium ulcerans | linoleoyl-CoA desaturase, DesA3 | 0.0225 | 0.0516 | 0.5 |
Echinococcus granulosus | Fatty acid desaturase type 1 | 0.0225 | 0.0516 | 1 |
Onchocerca volvulus | 0.267 | 1 | 1 | |
Plasmodium vivax | stearoyl-CoA desaturase (acyl-CoA desaturase, faty acid desaturase), putative | 0.2445 | 0.9127 | 0.5 |
Leishmania major | fatty-acid desaturase, putative | 0.267 | 1 | 1 |
Loa Loa (eye worm) | acyl-CoA desaturase | 0.2445 | 0.9127 | 1 |
Loa Loa (eye worm) | fatty acid desaturase | 0.0225 | 0.0516 | 0.0565 |
Brugia malayi | Delta5 fatty acid desaturase | 0.0225 | 0.0516 | 0.0565 |
Loa Loa (eye worm) | FAT-3 protein | 0.0225 | 0.0516 | 0.0565 |
Mycobacterium ulcerans | linoleoyl-CoA desaturase, DesA3_2 | 0.0225 | 0.0516 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0225 | 0.0516 | 0.0565 |
Plasmodium falciparum | stearoyl-CoA desaturase | 0.2445 | 0.9127 | 0.5 |
Brugia malayi | Fatty acid desaturase family protein | 0.0225 | 0.0516 | 0.0565 |
Toxoplasma gondii | sphingolipid delta 4 desaturase/c-4 hydroxylase protein des2 family protein | 0.0225 | 0.0516 | 0.5 |
Mycobacterium ulcerans | hypothetical protein | 0.0225 | 0.0516 | 0.5 |
Schistosoma mansoni | fatty acid desaturase | 0.0225 | 0.0516 | 1 |
Trypanosoma cruzi | fatty acid desaturase, putative | 0.2445 | 0.9127 | 0.9079 |
Echinococcus multilocularis | Peptidase M, neutral zinc metallopeptidases, zinc binding site | 0.0225 | 0.0516 | 1 |
Mycobacterium tuberculosis | Possible electron transfer protein FdxB | 0.0225 | 0.0516 | 0.5 |
Echinococcus granulosus | Sphingolipid delta4 desaturase DES1 | 0.0225 | 0.0516 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Kinact (binding) | = 784 /mM/min | Inhibition of human recombinant AChE after 6 mins by Ellman assay | ChEMBL. | 22738634 |
Kinact (binding) | = 7600 /mM/min | Inhibition of Anopheles gambiae AChE expressed in Escherichia coli after 6 mins by Ellman assay | ChEMBL. | 22738634 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.