Detailed information for compound 1653683

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 359.464 | Formula: C23H25N3O
  • H donors: 0 H acceptors: 2 LogP: 3.72 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: N#Cc1ccc(cc1)c1ccc2c(c1)C(=O)N(CC2)CCN1CCC[C@H]1C
  • InChi: 1S/C23H25N3O/c1-17-3-2-11-25(17)13-14-26-12-10-20-8-9-21(15-22(20)23(26)27)19-6-4-18(16-24)5-7-19/h4-9,15,17H,2-3,10-14H2,1H3/t17-/m1/s1
  • InChiKey: RBKYCZCNVBZBJX-QGZVFWFLSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens histamine receptor H3 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0124 0.0709 0.0709
Echinococcus multilocularis tyrosine protein kinase Abl 0.0064 0.0189 0.0189
Trichomonas vaginalis conserved hypothetical protein 0.0905 0.7434 1
Trichomonas vaginalis CAMK family protein kinase 0.0202 0.1382 0.1381
Loa Loa (eye worm) hypothetical protein 0.0068 0.023 0.026
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0096 0.0463 0.0523
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0846 0.6921 1
Echinococcus multilocularis phosphatidylinositol 4,5 bisphosphate 3 kinase 0.1203 1 1
Trichomonas vaginalis conserved hypothetical protein 0.0905 0.7434 1
Schistosoma mansoni tyrosine kinase 0.0064 0.0189 0.0189
Loa Loa (eye worm) AGC/DMPK/ROCK protein kinase 0.0944 0.7768 0.877
Toxoplasma gondii cell-cycle-associated protein kinase GSK, putative 0.0309 0.2301 1
Schistosoma mansoni tyrosine kinase 0.0056 0.0123 0.0123
Brugia malayi cAMP-dependent protein kinase catalytic subunit, putative 0.009 0.0412 0.053
Loa Loa (eye worm) TK/FER protein kinase 0.0056 0.0123 0.0139
Echinococcus multilocularis cyclin dependent kinase 1 0.0096 0.0463 0.0463
Schistosoma mansoni serine/threonine protein kinase 0.0484 0.3807 0.3807
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0642 0.5169 0.6775
Echinococcus multilocularis phosphatidylinositol 4 phosphate 3 kinase C2 0.0474 0.3719 0.3719
Loa Loa (eye worm) phosphatidylinositol 3 0.107 0.8858 1
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0341 0.2576 0.3609
Brugia malayi Protein kinase domain containing protein 0.0944 0.7768 1
Onchocerca volvulus Tyrosine kinase homolog 0.0313 0.2335 1
Echinococcus granulosus phosphatidylinositol 4 phosphate 3 kinase C2 0.0474 0.3719 0.3719
Trichomonas vaginalis CAMK family protein kinase 0.0202 0.1382 0.1381
Echinococcus multilocularis Immunoglobulin 0.0068 0.023 0.023
Loa Loa (eye worm) TK/FER protein kinase 0.0056 0.0123 0.0139
Echinococcus granulosus tyrosine protein kinase shark 0.0496 0.3913 0.3913
Loa Loa (eye worm) hypothetical protein 0.0068 0.023 0.026
Echinococcus multilocularis cyclin dependent kinase 1 0.0096 0.0463 0.0463
Trichomonas vaginalis CAMK family protein kinase 0.0103 0.0531 0.0169
Entamoeba histolytica serine/threonine protein kinase, putative 0.0202 0.1382 0.1851
Loa Loa (eye worm) TK/FER protein kinase 0.0056 0.0123 0.0139
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.027 0.1967 0.2214
Echinococcus granulosus tyrosine kinase 0.0056 0.0123 0.0123
Loa Loa (eye worm) hypothetical protein 0.0056 0.0123 0.0139
Echinococcus multilocularis plexin a4 0.0042 0.0005 0.0005
Echinococcus granulosus phosphatidylinositol 4 kinase alpha 0.0138 0.0825 0.0825
Plasmodium vivax phosphatidylinositol 3-kinase, putative 0.0138 0.0825 0.2185
Brugia malayi cell division control protein 2 homolog 0.0096 0.0463 0.0596
Loa Loa (eye worm) hypothetical protein 0.008 0.0327 0.0369
Brugia malayi Tyrosine-protein kinase abl-1 0.0064 0.0189 0.0243
Echinococcus multilocularis Immunoglobulin 0.0068 0.023 0.023
Brugia malayi Protein kinase domain containing protein 0.0056 0.0123 0.0159
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0095 0.0455 0.0455
Schistosoma mansoni serine/threonine protein kinase 0.009 0.0412 0.0412
Echinococcus multilocularis phosphatidylinositol 4 kinase alpha 0.0138 0.0825 0.0825
Echinococcus multilocularis glycogen synthase kinase 3 beta 0.0309 0.2301 0.2301
Echinococcus granulosus glycogen synthase kinase 3 beta 0.0309 0.2301 0.2301
Entamoeba histolytica protein kinase domain containing protein 0.0309 0.2301 0.3203
Trichomonas vaginalis conserved hypothetical protein 0.0905 0.7434 1
Loa Loa (eye worm) hypothetical protein 0.0068 0.023 0.026
Schistosoma mansoni Neurotrimin precursor (hNT) 0.0068 0.023 0.023
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0124 0.0709 0.0709
Echinococcus multilocularis tyrosine kinase 0.0056 0.0123 0.0123
Onchocerca volvulus 0.0309 0.2301 0.9844
Echinococcus granulosus protein kinase shaggy 0.0309 0.2301 0.2301
Schistosoma mansoni tyrosine kinase 0.0462 0.3619 0.3619
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0124 0.0709 0.0709
Entamoeba histolytica phosphatidylinositol 3-kinase 1, putative 0.0814 0.6652 0.9604
Loa Loa (eye worm) hypothetical protein 0.0372 0.2843 0.321
Echinococcus granulosus tyrosine protein kinase HCK 0.0082 0.035 0.035
Trichomonas vaginalis CMGC family protein kinase 0.0309 0.2301 0.2689
Echinococcus multilocularis tyrosine protein kinase Blk 0.0116 0.0644 0.0644
Echinococcus granulosus roundabout 2 0.008 0.0327 0.0327
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0846 0.6921 0.8909
Brugia malayi Protein kinase domain containing protein 0.0056 0.0123 0.0159
Entamoeba histolytica protein kinase domain containing protein 0.0309 0.2301 0.3203
Trypanosoma cruzi cdc2-related kinase 3 0.0096 0.0463 0.0079
Trypanosoma cruzi polo-like protein kinase, putative 0.0202 0.1382 0.149
Trypanosoma brucei cdc2-related kinase 1 0.0096 0.0463 0.0272
Schistosoma mansoni nephrin 0.0073 0.0273 0.0273
Loa Loa (eye worm) CMGC/MAPK/JNK protein kinase 0.0484 0.3807 0.4298
Echinococcus granulosus cyclin dependent kinase 0.0096 0.0463 0.0463
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0202 0.1382 0.156
Brugia malayi plexin A 0.0042 0.0005 0.0007
Echinococcus granulosus c-Jun N-terminal kinases 0.0484 0.3807 0.3807
Loa Loa (eye worm) TK/FER protein kinase 0.0056 0.0123 0.0139
Schistosoma mansoni cell adhesion molecule 0.0075 0.0284 0.0284
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0064 0.0189 0.0189
Brugia malayi SH2 domain containing protein 0.0056 0.0123 0.0159
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0846 0.6921 1
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0124 0.0709 0.0709
Echinococcus granulosus tyrosine protein kinase Src42A 0.0095 0.0455 0.0455
Echinococcus granulosus tyrosine protein kinase Fyn 0.0124 0.0709 0.0709
Echinococcus multilocularis rho associated protein kinase 0.0308 0.2294 0.2294
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0124 0.0709 0.0709
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0064 0.0189 0.0189
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0124 0.0709 0.0709
Trypanosoma brucei cdc2-related kinase 3 0.0096 0.0463 0.0272
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0202 0.1382 0.1382
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0474 0.3719 0.4787
Giardia lamblia Phosphoinositide-3-kinase, class 3 0.0164 0.1052 0.1771
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.027 0.1967 0.2532
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0116 0.0644 0.0644
Brugia malayi serine/threonine-protein kinase plk-2 0.0202 0.1382 0.1779
Loa Loa (eye worm) TK/FER protein kinase 0.0056 0.0123 0.0139
Loa Loa (eye worm) TK/KIN16 protein kinase 0.0383 0.2936 0.3315
Echinococcus granulosus defective proboscis extension response 0.0068 0.023 0.023
Echinococcus multilocularis c Jun NH2 terminal kinase 0.0484 0.3807 0.3807
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0138 0.0825 0.0588
Echinococcus granulosus tyrosine protein kinase ABL1 0.0056 0.0123 0.0123
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0124 0.0709 0.0709
Leishmania major glycogen synthase kinase, putative;with=GeneDB:LinJ18_V3.0270 0.0309 0.2301 1
Onchocerca volvulus 0.0308 0.2294 0.9816
Schistosoma mansoni defective proboscis extension response (dpr)-related 0.0068 0.023 0.023
Loa Loa (eye worm) hypothetical protein 0.009 0.0412 0.0465
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0846 0.6921 0.9269
Trichomonas vaginalis hypothetical protein 0.0905 0.7434 1
Loa Loa (eye worm) hypothetical protein 0.0088 0.0403 0.0454
Echinococcus granulosus neuroglian 0.0073 0.0273 0.0273
Echinococcus granulosus neurotracting:lsamp:neurotrimin:obcam 0.0075 0.0284 0.0284
Trypanosoma cruzi cdc2-related kinase 3 0.0096 0.0463 0.0079
Plasmodium vivax glycogen synthase kinase 3, putative 0.0309 0.2301 1
Loa Loa (eye worm) hypothetical protein 0.0068 0.023 0.026
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0202 0.1382 0.5135
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0239 0.1698 0.1976
Loa Loa (eye worm) TK protein kinase 0.0116 0.0644 0.0727
Echinococcus granulosus tyrosine protein kinase Fyn 0.0124 0.0709 0.0709
Echinococcus multilocularis enhancer of mRNA decapping protein 4 0.0083 0.0351 0.0351
Trichomonas vaginalis CAMK family protein kinase 0.0202 0.1382 0.1381
Plasmodium falciparum glycogen synthase kinase 3 0.0309 0.2301 1
Schistosoma mansoni tyrosine kinase 0.0496 0.3913 0.3913
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.027 0.1967 0.1967
Schistosoma mansoni serine/threonine protein kinase 0.009 0.0412 0.0412
Entamoeba histolytica phosphatidylinositol-4,5-bisphosphate 3-kinase, putative 0.0138 0.0825 0.1032
Echinococcus multilocularis Zinc finger, PHD finger 0.0138 0.0825 0.0825
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.027 0.1967 0.2712
Echinococcus multilocularis tyrosine protein kinase Srms 0.0116 0.0644 0.0644
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0124 0.0709 0.0709
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.009 0.0412 0.0412
Trypanosoma cruzi cdc2-related kinase 1 0.0096 0.0463 0.0079
Echinococcus granulosus tyrosine protein kinase Srms 0.0056 0.0123 0.0123
Echinococcus granulosus Immunoglobulin 0.0068 0.023 0.023
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.027 0.1967 0.8234
Trypanosoma cruzi polo-like protein kinase, putative 0.0202 0.1382 0.149
Echinococcus granulosus c src tyrosine kinase 0.0064 0.0189 0.0189
Trichomonas vaginalis CAMK family protein kinase 0.0202 0.1382 0.1381
Entamoeba histolytica PH domain containing protein kinase, putative 0.009 0.0412 0.0425
Trichomonas vaginalis phosphatidylinositol 4-kinase, putative 0.0138 0.0825 0.0588
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0138 0.0825 0.0825
Echinococcus multilocularis tyrosine protein kinase ABL1 0.0056 0.0123 0.0123
Loa Loa (eye worm) TK/FER protein kinase 0.0056 0.0123 0.0139
Loa Loa (eye worm) hypothetical protein 0.008 0.0327 0.0369
Echinococcus multilocularis cyclin dependent kinase 0.0096 0.0463 0.0463
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.009 0.0412 0.0412
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0138 0.0825 0.0825
Echinococcus granulosus tyrosine protein kinase Blk 0.0116 0.0644 0.0644
Trichomonas vaginalis CMGC family protein kinase 0.0309 0.2301 0.2689
Trichomonas vaginalis CAMK family protein kinase 0.0202 0.1382 0.1381
Echinococcus granulosus cyclin dependent kinase 5 0.0096 0.0463 0.0463
Trichomonas vaginalis CAMK family protein kinase 0.0202 0.1382 0.1381
Loa Loa (eye worm) TK/FER protein kinase 0.0056 0.0123 0.0139
Leishmania major cell division related protein kinase 2,cdc2-related kinase 0.0096 0.0463 0.0272
Giardia lamblia Kinase, CMGC GSK 0.0309 0.2301 0.5225
Schistosoma mansoni serine/threonine protein kinase 0.0202 0.1382 0.1382
Loa Loa (eye worm) AGC/PKA protein kinase 0.009 0.0412 0.0465
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0124 0.0709 0.0709
Trichomonas vaginalis conserved hypothetical protein 0.0905 0.7434 1
Brugia malayi hypothetical protein 0.0068 0.023 0.0296
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit gamma, putative 0.0846 0.6921 0.9269
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0846 0.6921 0.9269
Loa Loa (eye worm) TK/FER protein kinase 0.0056 0.0123 0.0139
Echinococcus granulosus tyrosine protein kinase Fyn 0.0124 0.0709 0.0709
Schistosoma mansoni glycogen synthase kinase 3-related (gsk3) (cmgc group III) 0.0309 0.2301 0.2301
Entamoeba histolytica protein kinase, putative 0.0082 0.035 0.0333
Loa Loa (eye worm) AGC/PKA protein kinase 0.009 0.0412 0.0465
Giardia lamblia Kinase, CMGC CDK 0.0096 0.0463 0.0142
Echinococcus multilocularis cyclin dependent kinase 5 0.0096 0.0463 0.0463
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0096 0.0463 0.0523
Echinococcus multilocularis tyrosine protein kinase HCK 0.0082 0.035 0.035
Trypanosoma cruzi glycogen synthase kinase 3, putative 0.0309 0.2301 0.2902
Plasmodium falciparum protein kinase 5 0.0096 0.0463 0.0272
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0642 0.5169 0.6775
Trichomonas vaginalis CAMK family protein kinase 0.0202 0.1382 0.1381
Brugia malayi SH2 domain containing protein 0.0056 0.0123 0.0159
Brugia malayi intracellular kinase 0.0309 0.2301 0.2962
Echinococcus granulosus enhancer of mRNA decapping protein 4 0.0083 0.0351 0.0351
Echinococcus granulosus tyrosine protein kinase Lyn 0.0131 0.077 0.077
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0124 0.0709 0.0709
Echinococcus granulosus tyrosine kinase 0.0116 0.0644 0.0644
Loa Loa (eye worm) plexin A 0.0042 0.0005 0.0006
Echinococcus granulosus plexin a4 0.0042 0.0005 0.0005
Echinococcus granulosus cyclin dependent kinase 1 0.0096 0.0463 0.0463
Brugia malayi Protein kinase domain containing protein 0.0056 0.0123 0.0159
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.1203 1 1
Schistosoma mansoni kinase 0.0106 0.0553 0.0553
Brugia malayi hypothetical protein 0.0056 0.0123 0.0159
Loa Loa (eye worm) hypothetical protein 0.0075 0.0284 0.0321
Entamoeba histolytica hypothetical protein 0.0713 0.5779 0.8319
Echinococcus multilocularis basement membrane specific heparan sulfate 0.0068 0.023 0.023
Echinococcus multilocularis tyrosine protein kinase Fps85D 0.0056 0.0123 0.0123
Schistosoma mansoni serine/threonine protein kinase 0.0308 0.2294 0.2294
Giardia lamblia Kinase, CMGC GSK 0.0309 0.2301 0.5225
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0713 0.5779 0.8319
Brugia malayi phosphoinositide 3'-hydroxykinase p110-alpha subunit, putative 0.0358 0.272 0.3501
Entamoeba histolytica PH domain containing protein kinase, putative 0.009 0.0412 0.0425
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.027 0.1967 0.2214
Loa Loa (eye worm) phosphatidylinositol 4-kinase type 3 alpha isoform 1 0.0138 0.0825 0.0931
Loa Loa (eye worm) hypothetical protein 0.0068 0.023 0.026
Plasmodium falciparum phosphatidylinositol 3-kinase 0.0138 0.0825 0.2185
Loa Loa (eye worm) phosphatidylinositol 3 0.0239 0.1698 0.1917
Brugia malayi Protein kinase domain containing protein 0.0056 0.0123 0.0159
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0138 0.0825 0.2185
Schistosoma mansoni vesicular amine transporter 0.0068 0.023 0.023
Echinococcus granulosus rho-associated protein kinase 1 0.0308 0.2294 0.2294
Brugia malayi Fibronectin type III domain containing protein 0.0068 0.023 0.0296
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.027 0.1967 0.2712
Trichomonas vaginalis CAMK family protein kinase 0.0103 0.0531 0.0169
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0138 0.0825 0.2185
Schistosoma mansoni tyrosine kinase 0.0124 0.0709 0.0709
Echinococcus multilocularis neuroglian 0.0073 0.0273 0.0273
Schistosoma mansoni serine/threonine protein kinase 0.009 0.0412 0.0412
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0138 0.0825 0.0634
Entamoeba histolytica protein kinase, putative 0.0309 0.2301 0.3203
Leishmania major phosphatidylinositol 3-kinase, putative 0.0138 0.0825 0.2185
Echinococcus multilocularis tyrosine protein kinase shark 0.0496 0.3913 0.3913
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.009 0.0412 0.0412
Trypanosoma cruzi cdc2-related kinase 1 0.0096 0.0463 0.0079
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0309 0.2301 0.2597
Brugia malayi Protein kinase domain containing protein 0.0096 0.0463 0.0596
Echinococcus multilocularis c src tyrosine kinase 0.0064 0.0189 0.0189
Onchocerca volvulus 0.0301 0.2234 0.9541
Echinococcus granulosus tyrosine protein kinase Src64B 0.0124 0.0709 0.0709
Echinococcus multilocularis roundabout 2 0.008 0.0327 0.0327
Brugia malayi phosphatidylinositol 4-kinase, catalytic, alpha polypeptide 0.0138 0.0825 0.1062
Schistosoma mansoni tyrosine kinase 0.0064 0.0189 0.0189
Trypanosoma cruzi phosphatidylinositol 3-kinase vps34-like 0.027 0.1967 0.2389
Echinococcus granulosus tyrosine protein kinase Fps85D 0.0056 0.0123 0.0123
Echinococcus granulosus 5'partial|cyclin dependent kinase 1 0.0096 0.0463 0.0463
Trichomonas vaginalis CMGC family protein kinase 0.0096 0.0463 0.0073
Loa Loa (eye worm) CMGC/CDK/CDK5 protein kinase 0.0096 0.0463 0.0523
Entamoeba histolytica cell division protein kinase 2, putative 0.0096 0.0463 0.05
Onchocerca volvulus 0.0286 0.2104 0.8954
Echinococcus granulosus tyrosine protein kinase Src42A 0.0124 0.0709 0.0709
Echinococcus granulosus twitchin 0.008 0.0333 0.0333
Loa Loa (eye worm) TK protein kinase 0.0082 0.035 0.0395
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.027 0.1967 0.2214
Brugia malayi protein-tyrosine kinase 0.0116 0.0644 0.0829
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0309 0.2301 0.2597
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.009 0.0412 0.0412
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.009 0.0412 0.0412
Loa Loa (eye worm) hypothetical protein 0.0068 0.023 0.026
Trypanosoma brucei polo-like protein kinase 0.0202 0.1382 0.5135
Loa Loa (eye worm) TK/FER protein kinase 0.0056 0.0123 0.0139
Onchocerca volvulus Serine\/threonine kinase homolog 0.0202 0.1382 0.569
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0124 0.0709 0.0709
Leishmania major cell division protein kinase 2,cdc2-related kinase 0.0096 0.0463 0.0272
Schistosoma mansoni serine/threonine protein kinase 0.0096 0.0463 0.0463
Trichomonas vaginalis conserved hypothetical protein 0.0905 0.7434 1
Brugia malayi SRC-1 0.0124 0.0709 0.0913
Schistosoma mansoni serine/threonine protein kinase 0.0096 0.0463 0.0463
Brugia malayi Immunoglobulin I-set domain containing protein 0.0383 0.2936 0.378
Trypanosoma brucei phosphatidylinositol 4-kinase alpha, putative 0.0138 0.0825 0.2185
Loa Loa (eye worm) TK/FER protein kinase 0.0056 0.0123 0.0139
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0138 0.0825 0.0634
Loa Loa (eye worm) hypothetical protein 0.0474 0.3719 0.4198
Echinococcus granulosus phosphatidylinositol 3 kinase catalytic subunit 0.0138 0.0825 0.0825
Trichomonas vaginalis CMGC family protein kinase 0.0096 0.0463 0.0073
Loa Loa (eye worm) SRC-1 0.0124 0.0709 0.0801
Leishmania major phosphatidylinositol 4-kinase alpha, putative 0.0138 0.0825 0.2185
Trichomonas vaginalis CMGC family protein kinase 0.0096 0.0463 0.0073
Loa Loa (eye worm) TK/ABL protein kinase 0.0056 0.0123 0.0139
Trichomonas vaginalis conserved hypothetical protein 0.0905 0.7434 1
Schistosoma mansoni tyrosine kinase 0.0124 0.0709 0.0709
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0116 0.0644 0.0644
Brugia malayi Immunoglobulin I-set domain containing protein 0.0068 0.023 0.0296
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.0064 0.0189 0.0189
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.009 0.0412 0.0412
Giardia lamblia Kinase, CMGC CDK 0.0096 0.0463 0.0142
Plasmodium vivax protein kinase Crk2 0.0096 0.0463 0.0272
Trypanosoma brucei protein kinase, putative 0.0309 0.2301 1
Entamoeba histolytica phosphatidylinositol 4-kinase, putative 0.0138 0.0825 0.1032
Entamoeba histolytica cell division protein kinase 2, putative 0.0096 0.0463 0.05
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.009 0.0412 0.0412
Toxoplasma gondii cell-cycle-associated protein kinase CDK, putative 0.0096 0.0463 0.0272
Trichomonas vaginalis conserved hypothetical protein 0.0905 0.7434 1
Echinococcus multilocularis protein kinase shaggy 0.0309 0.2301 0.2301
Brugia malayi Protein kinase domain containing protein 0.0056 0.0123 0.0159
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0138 0.0825 0.0588
Brugia malayi Stress-activated protein kinase jnk-1 0.0484 0.3807 0.4901
Giardia lamblia Phosphoinositide-3-kinase, catalytic, alpha polypeptide 0.0509 0.4027 1
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0846 0.6921 1
Giardia lamblia Kinase, PLK 0.0202 0.1382 0.2683
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0202 0.1382 0.1382

Activities

Activity type Activity value Assay description Source Reference
Inhibition (binding) = 98 % Inhibition of human ERG at 10 uM by IonWorks assay ChEMBL. 22313242
Ki (binding) = 2.4 nM Displacement of [3H]-(R)-alpha-methylhistamine from human H3 receptor expressed in HEK293T cells after 120 mins by scintillation counting ChEMBL. 22313242

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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