Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | Mastin | 0.0141 | 0.0393 | 0.0297 |
Trichomonas vaginalis | Clan SB, family S8, subtilisin-like serine peptidase | 0.0574 | 0.2941 | 0.5747 |
Echinococcus granulosus | furin | 0.1775 | 1 | 1 |
Trichomonas vaginalis | leucine-rich repeat protein, BspA family | 0.041 | 0.1975 | 0.3861 |
Trichomonas vaginalis | Clan SB, family S8, subtilisin-like serine peptidase | 0.0091 | 0.0099 | 0.0193 |
Trichomonas vaginalis | Clan SB, family S8, subtilisin-like serine peptidase | 0.0091 | 0.0099 | 0.0193 |
Schistosoma mansoni | hypothetical protein | 0.041 | 0.1975 | 0.1895 |
Echinococcus granulosus | Furin 1 | 0.0574 | 0.2941 | 0.287 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0091 | 0.0099 | 0.0193 |
Loa Loa (eye worm) | integrin beta-2 | 0.0303 | 0.1345 | 0.1259 |
Echinococcus multilocularis | epidermal growth factor receptor | 0.0316 | 0.1422 | 0.1713 |
Trichomonas vaginalis | Clan SB, family S8, subtilisin-like serine peptidase | 0.0091 | 0.0099 | 0.0193 |
Plasmodium falciparum | subtilisin-like protease 3 | 0.0091 | 0.0099 | 0.5 |
Mycobacterium leprae | Possible secreted protease | 0.0091 | 0.0099 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0358 | 0.1673 | 0.159 |
Trichomonas vaginalis | conserved hypothetical protein | 0.041 | 0.1975 | 0.3861 |
Trichomonas vaginalis | Clan SB, family S8, subtilisin-like serine peptidase | 0.0091 | 0.0099 | 0.0193 |
Trypanosoma brucei | serine peptidase, clan SB, family S8-like protein | 0.0091 | 0.0099 | 0.5 |
Trichomonas vaginalis | Clan SB, family S8, subtilisin-like serine peptidase | 0.0091 | 0.0099 | 0.0193 |
Trichomonas vaginalis | Clan SB, family S8, subtilisin-like serine peptidase | 0.0091 | 0.0099 | 0.0193 |
Onchocerca volvulus | 0.0091 | 0.0099 | 0.2438 | |
Trichomonas vaginalis | Clan SB, family S8, subtilisin-like serine peptidase | 0.0944 | 0.5116 | 1 |
Loa Loa (eye worm) | endoprotease bli-4 | 0.1775 | 1 | 1 |
Trypanosoma cruzi | subtilisin-like serine peptidase, putative | 0.0091 | 0.0099 | 0.5 |
Trichomonas vaginalis | proprotein convertase subtilisin/kexin type, putative | 0.0483 | 0.2408 | 0.4707 |
Trichomonas vaginalis | conserved hypothetical protein | 0.041 | 0.1975 | 0.3861 |
Brugia malayi | neuroendocrine convertase 1 precursor | 0.1689 | 0.9497 | 0.9492 |
Trichomonas vaginalis | conserved hypothetical protein | 0.041 | 0.1975 | 0.3861 |
Trichomonas vaginalis | Clan SB, family S8, subtilisin-like serine peptidase | 0.0164 | 0.0532 | 0.104 |
Onchocerca volvulus | 0.0142 | 0.0402 | 0.9956 | |
Echinococcus multilocularis | glycoprotein Antigen 5 | 0.0141 | 0.0393 | 0.038 |
Trypanosoma brucei | subtilisin peptidase | 0.0091 | 0.0099 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.041 | 0.1975 | 0.3861 |
Onchocerca volvulus | 0.0142 | 0.0404 | 1 | |
Mycobacterium leprae | PROBABLE MEMBRANE-ANCHORED MYCOSIN MYCP3 (SERINE PROTEASE) (SUBTILISIN-LIKE PROTEASE) (SUBTILASE-LIKE) (MYCOSIN-3) | 0.0091 | 0.0099 | 0.5 |
Mycobacterium tuberculosis | Probable alanine and proline rich membrane-anchored mycosin MycP2 (serine protease) (subtilisin-like protease) (subtilase-like) | 0.0091 | 0.0099 | 0.5 |
Trichomonas vaginalis | neuroendocrine convertase 2 precursor, putative | 0.0483 | 0.2408 | 0.4707 |
Brugia malayi | proprotein convertase 2 | 0.1405 | 0.7824 | 0.7803 |
Loa Loa (eye worm) | proprotein convertase 2 | 0.0574 | 0.2941 | 0.287 |
Plasmodium vivax | subtilisin-like protease 1 | 0.0091 | 0.0099 | 0.5 |
Brugia malayi | celfurPC protein | 0.1365 | 0.7592 | 0.7568 |
Trichomonas vaginalis | Clan SB, family S8, subtilisin-like serine peptidase | 0.0091 | 0.0099 | 0.0193 |
Trypanosoma cruzi | subtilisin peptidase | 0.0091 | 0.0099 | 0.5 |
Trichomonas vaginalis | Clan SB, family S8, subtilisin-like serine peptidase | 0.0091 | 0.0099 | 0.0193 |
Echinococcus granulosus | integrin beta 2 | 0.0224 | 0.0884 | 0.0793 |
Loa Loa (eye worm) | AGC/DMPK/ROCK protein kinase | 0.0442 | 0.2167 | 0.2089 |
Trichomonas vaginalis | Clan SB, family S8, subtilisin-like serine peptidase | 0.0091 | 0.0099 | 0.0193 |
Plasmodium vivax | subtilisin-like protease 2, putative | 0.0091 | 0.0099 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0091 | 0.0099 | 0.0193 |
Brugia malayi | Protein kinase domain containing protein | 0.0442 | 0.2167 | 0.2089 |
Mycobacterium tuberculosis | Probable membrane-anchored mycosin MycP3 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-3) | 0.0091 | 0.0099 | 0.5 |
Echinococcus multilocularis | Mastin | 0.0141 | 0.0393 | 0.038 |
Echinococcus granulosus | neuroendocrine convertase 2 | 0.1405 | 0.7824 | 0.7803 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0141 | 0.0393 | 0.0297 |
Trichomonas vaginalis | hypothetical protein | 0.041 | 0.1975 | 0.3861 |
Trichomonas vaginalis | Clan SB, family S8, subtilisin-like serine peptidase | 0.0091 | 0.0099 | 0.0193 |
Schistosoma mansoni | integrin beta subunit | 0.0178 | 0.0614 | 0.052 |
Schistosoma mansoni | furin-1 (S08 family) | 0.0921 | 0.4983 | 0.4933 |
Mycobacterium tuberculosis | Probable proline rich membrane-anchored mycosin MycP5 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-5) | 0.0091 | 0.0099 | 0.5 |
Mycobacterium ulcerans | membrane-anchored serine protease (mycosin), MycP4 | 0.0091 | 0.0099 | 0.5 |
Trichomonas vaginalis | Clan SB, family S8, subtilisin-like serine peptidase | 0.0574 | 0.2941 | 0.5747 |
Trichomonas vaginalis | Clan SB, family S8, subtilisin-like serine peptidase | 0.0574 | 0.2941 | 0.5747 |
Schistosoma mansoni | subfamily S8B unassigned peptidase (S08 family) | 0.0164 | 0.0532 | 0.0438 |
Mycobacterium tuberculosis | Probable membrane-anchored mycosin MycP4 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-4) | 0.0091 | 0.0099 | 0.5 |
Mycobacterium ulcerans | proline rich membrane-anchored mycosin MycP5 | 0.0091 | 0.0099 | 0.5 |
Trichomonas vaginalis | Clan SB, family S8, subtilisin-like serine peptidase | 0.0091 | 0.0099 | 0.0193 |
Trichomonas vaginalis | conserved hypothetical protein | 0.041 | 0.1975 | 0.3861 |
Trichomonas vaginalis | Clan SB, family S8, subtilisin-like serine peptidase | 0.0091 | 0.0099 | 0.0193 |
Echinococcus multilocularis | Furin 1 | 0.0574 | 0.2941 | 0.3678 |
Mycobacterium ulcerans | membrane-anchored mycosin MycP3 | 0.0091 | 0.0099 | 0.5 |
Trichomonas vaginalis | Clan SB, family S8, subtilisin-like serine peptidase | 0.0091 | 0.0099 | 0.0193 |
Echinococcus granulosus | epidermal growth factor receptor | 0.0316 | 0.1422 | 0.1337 |
Plasmodium falciparum | subtilisin-like protease 1 | 0.0091 | 0.0099 | 0.5 |
Echinococcus multilocularis | 0.1365 | 0.7592 | 0.9699 | |
Trichomonas vaginalis | conserved hypothetical protein | 0.041 | 0.1975 | 0.3861 |
Loa Loa (eye worm) | TK/EGFR protein kinase | 0.0316 | 0.1422 | 0.1337 |
Loa Loa (eye worm) | hypothetical protein | 0.0905 | 0.4884 | 0.4833 |
Trichomonas vaginalis | Clan SB, family S8, subtilisin-like serine peptidase | 0.0091 | 0.0099 | 0.0193 |
Trichomonas vaginalis | Clan SB, family S8, subtilisin-like serine peptidase | 0.0091 | 0.0099 | 0.0193 |
Toxoplasma gondii | subtilisin SUB12 | 0.011 | 0.0211 | 0.0927 |
Trichomonas vaginalis | Clan SB, family S8, subtilisin-like serine peptidase | 0.0091 | 0.0099 | 0.0193 |
Trichomonas vaginalis | conserved hypothetical protein | 0.041 | 0.1975 | 0.3861 |
Trichomonas vaginalis | Clan SB, family S8, subtilisin-like serine peptidase | 0.0944 | 0.5116 | 1 |
Schistosoma mansoni | subfamily S8B non-peptidase homologue (S08 family) | 0.0574 | 0.2941 | 0.287 |
Trichomonas vaginalis | Clan SB, family S8, subtilisin-like serine peptidase | 0.0091 | 0.0099 | 0.0193 |
Loa Loa (eye worm) | hypothetical protein | 0.1775 | 1 | 1 |
Trichomonas vaginalis | Clan SB, family S8, subtilisin-like serine peptidase | 0.0574 | 0.2941 | 0.5747 |
Trichomonas vaginalis | Clan SB, family S8, subtilisin-like serine peptidase | 0.0574 | 0.2941 | 0.5747 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0091 | 0.0099 | 0.0193 |
Brugia malayi | Furin-like cysteine rich region family protein | 0.0316 | 0.1422 | 0.1337 |
Echinococcus multilocularis | rho associated protein kinase | 0.0142 | 0.0404 | 0.0395 |
Brugia malayi | Integrin beta pat-3 precursor | 0.0303 | 0.1345 | 0.1259 |
Trypanosoma cruzi | serine peptidase, clan SB, family S8-like protein | 0.0091 | 0.0099 | 0.5 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0142 | 0.0404 | 0.0308 |
Trichomonas vaginalis | conserved hypothetical protein | 0.041 | 0.1975 | 0.3861 |
Trichomonas vaginalis | Clan SB, family S8, subtilisin-like serine peptidase | 0.0091 | 0.0099 | 0.0193 |
Trichomonas vaginalis | conserved hypothetical protein | 0.041 | 0.1975 | 0.3861 |
Trichomonas vaginalis | Clan SB, family S8, subtilisin-like serine peptidase | 0.0091 | 0.0099 | 0.0193 |
Giardia lamblia | Furin precursor putative serine protease | 0.0483 | 0.2408 | 1 |
Echinococcus multilocularis | proprotein convertase subtilisin:kexin type 5 | 0.0944 | 0.5116 | 0.6495 |
Trichomonas vaginalis | conserved hypothetical protein | 0.041 | 0.1975 | 0.3861 |
Echinococcus granulosus | glycoprotein Antigen 5 | 0.0141 | 0.0393 | 0.0297 |
Echinococcus granulosus | enteropeptidase | 0.0141 | 0.0393 | 0.0297 |
Echinococcus granulosus | proprotein convertase subtilisin:kexin type 5 | 0.0944 | 0.5116 | 0.5067 |
Schistosoma mansoni | tyrosine kinase | 0.0316 | 0.1422 | 0.1337 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0091 | 0.0099 | 0.0193 |
Trichomonas vaginalis | Clan SB, family S8, subtilisin-like serine peptidase | 0.0091 | 0.0099 | 0.0193 |
Echinococcus multilocularis | integrin beta 2 | 0.0224 | 0.0884 | 0.1017 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0091 | 0.0099 | 0.0193 |
Echinococcus multilocularis | enteropeptidase | 0.0141 | 0.0393 | 0.038 |
Mycobacterium leprae | PROBABLE PROLINE RICH MEMBRANE-ANCHORED MYCOSIN MYCP5 (SERINE PROTEASE) (SUBTILISIN-LIKE PROTEASE) (SUBTILASE-LIKE) (MYCOSIN-5) | 0.0091 | 0.0099 | 0.5 |
Plasmodium vivax | subtilisin-like serine protease, putative | 0.0091 | 0.0099 | 0.5 |
Echinococcus granulosus | rho-associated protein kinase 1 | 0.0142 | 0.0404 | 0.0308 |
Trichomonas vaginalis | Clan SB, family S8, subtilisin-like serine peptidase | 0.0091 | 0.0099 | 0.0193 |
Toxoplasma gondii | PAN domain-containing protein | 0.0296 | 0.1309 | 1 |
Trichomonas vaginalis | Clan SB, family S8, subtilisin-like serine peptidase | 0.0091 | 0.0099 | 0.0193 |
Echinococcus multilocularis | neuroendocrine convertase 2 | 0.1405 | 0.7824 | 1 |
Trichomonas vaginalis | Clan SB, family S8, subtilisin-like serine peptidase | 0.0091 | 0.0099 | 0.0193 |
Schistosoma mansoni | subfamily S8B unassigned peptidase (S08 family) | 0.1775 | 1 | 1 |
Trichomonas vaginalis | Clan SB, family S8, subtilisin-like serine peptidase | 0.0574 | 0.2941 | 0.5747 |
Toxoplasma gondii | PAN domain-containing protein | 0.0296 | 0.1309 | 1 |
Leishmania major | subtilisin-like serine peptidase | 0.0091 | 0.0099 | 0.5 |
Plasmodium falciparum | subtilisin-like protease 2 | 0.0091 | 0.0099 | 0.5 |
Trypanosoma cruzi | subtilisin-like serine peptidase, putative | 0.0091 | 0.0099 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.041 | 0.1975 | 0.3861 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (ADMET) | > 30 uM | Cytotoxicity against mouse RAW264.7 cells by MTT assay | ChEMBL. | 22677029 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.