TDR Targets

Basic information

Technical information

TDR Targets ID: 1659889
Name: 2-(3,5-dimethyl-1H-pyrazol-4-yl)-N-[(2,3,4-tr ifluorophenyl)methyl]acetamide
MW: 297.276 | Formula: C14H14F3N3O
H donors: 2 H acceptors: 2 LogP: 2.02 Rotable bonds: 5
Rule of 5 violations (Lipinski): 1
SMILES: O=C(Cc1c(C)n[nH]c1C)NCc1ccc(c(c1F)F)F
InChi: 1S/C14H14F3N3O/c1-7-10(8(2)20-19-7)5-12(21)18-6-9-3-4-11(15)14(17)13(9)16/h3-4H,5-6H2,1-2H3,(H,18,21)(H,19,20)
InChiKey: QFKNCDASCSXLHU-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

2-(3,5-dimethyl-1H-pyrazol-4-yl)-N-(2,3,4-trifluorobenzyl)acetamide
2-(3,5-dimethyl-1H-pyrazol-4-yl)-N-[(2,3,4-trifluorophenyl)methyl]ethanamide

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	purinergic receptor P2X, ligand-gated ion channel, 7	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Giardia lamblia	Prolyl-tRNA synthetase	0.0034	0.0537	1
Toxoplasma gondii	protein kinase, putative	0.0317	0.6596	1
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0154	0.0697
Brugia malayi	Major Facilitator Superfamily protein	0.0016	0.0154	0.0532
Mycobacterium ulcerans	cytochrome P450 185A4 Cyp185A4	0.0019	0.0222	0.5827
Plasmodium vivax	proline--tRNA ligase, putative	0.0039	0.0656	0.051
Schistosoma mansoni	glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs)	0.0034	0.0537	0.2288
Echinococcus granulosus	DNA apurinic or apyrimidinic site lyase	0.0018	0.021	0.0786
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0154	0.0697
Brugia malayi	Sugar transporter family protein	0.0112	0.2216	1
Onchocerca volvulus		0.0016	0.0154	0.5
Brugia malayi	Cytochrome P450 family protein	0.0019	0.0222	0.084
Mycobacterium tuberculosis	Probable conserved integral membrane transport protein	0.0016	0.0154	0.4964
Trypanosoma brucei	lysyl-tRNA synthetase, putative	0.0025	0.0353	0.5084
Leishmania major	cytochrome p450-like protein	0.0019	0.0222	0.2963
Mycobacterium ulcerans	lysyl-tRNA synthetase	0.0025	0.0353	1
Brugia malayi	Sugar transporter family protein	0.0016	0.0154	0.0532
Schistosoma mansoni	glucose transport protein	0.0112	0.2216	1
Echinococcus multilocularis	General substrate transporter	0.0096	0.1879	0.8451
Brugia malayi	exodeoxyribonuclease III family protein	0.0018	0.021	0.0786
Loa Loa (eye worm)	cytochrome P450 family protein	0.0019	0.0222	0.1
Brugia malayi	major facilitator superfamily protein	0.0016	0.0154	0.0532
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.0034	0.0552	0.2356
Leishmania major	glucose transporter, lmgt3	0.0035	0.0561	0.8462
Echinococcus multilocularis	p2X purinoceptor 4	0.0082	0.1569	0.7027
Toxoplasma gondii	cell-cycle-associated protein kinase MAPK, putative	0.0181	0.3694	0.5575
Entamoeba histolytica	hypothetical protein	0.0025	0.0353	0.4177
Plasmodium falciparum	proline--tRNA ligase	0.0039	0.0656	0.051
Schistosoma mansoni	P2X receptor subunit	0.0082	0.1569	0.7027
Trypanosoma brucei	glucose transporter, putative	0.0035	0.0561	0.8462
Trichomonas vaginalis	lysyl-tRNA synthetase, putative	0.0025	0.0353	0.0961
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0402	0.1813
Echinococcus multilocularis	p2X purinoceptor 4	0.0082	0.1569	0.7027
Trypanosoma brucei	calcium/calmodulin-dependent protein kinase, putative	0.0034	0.0552	0.8309
Giardia lamblia	Endonuclease/Exonuclease/phosphatase	0.0018	0.021	0.1447
Onchocerca volvulus		0.0016	0.0154	0.5
Plasmodium falciparum	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0018	0.021	0.0056
Leishmania major	prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative	0.0039	0.0656	1
Schistosoma mansoni	protein kinase	0.0034	0.0552	0.2356
Trichomonas vaginalis	conserved hypothetical protein	0.0035	0.0561	0.1973
Onchocerca volvulus		0.0016	0.0154	0.5
Plasmodium falciparum	mitogen-activated protein kinase 2	0.0181	0.3694	0.3595
Toxoplasma gondii	exonuclease III APE	0.0018	0.021	0.0261
Entamoeba histolytica	protein kinase, putative	0.0034	0.0552	1
Loa Loa (eye worm)	bifunctional aminoacyl-tRNA synthetase	0.0014	0.0113	0.0508
Giardia lamblia	Lysyl-tRNA synthetase	0.0025	0.0353	0.5182
Trichomonas vaginalis	CAMK family protein kinase	0.0034	0.0552	0.1927
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0154	0.0697
Trypanosoma cruzi	cytochrome P450, putative	0.0019	0.0222	0.2963
Trichomonas vaginalis	conserved hypothetical protein	0.0112	0.2216	1
Schistosoma mansoni	glucose transporter	0.0016	0.0154	0.0532
Plasmodium vivax	mitogen-activated protein kinase 2, putative	0.0181	0.3694	0.3595
Mycobacterium leprae	Probable lysyl-tRNA synthase LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase)	0.0021	0.0272	0.4681
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0154	0.0697
Echinococcus granulosus	solute carrier family 22	0.0016	0.0154	0.0532
Onchocerca volvulus		0.0016	0.0154	0.5
Trichomonas vaginalis	ap endonuclease, putative	0.0018	0.021	0.0268
Trichomonas vaginalis	ap endonuclease, putative	0.0018	0.021	0.0268
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0112	0.2216	1
Brugia malayi	hypothetical protein	0.0016	0.0154	0.0532
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0154	0.0697
Schistosoma mansoni	protein kinase	0.0034	0.0552	0.2356
Mycobacterium tuberculosis	Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI)	0.0018	0.021	0.7337
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0035	0.0561	0.8462
Mycobacterium ulcerans	fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT	0.0016	0.0154	0.3688
Plasmodium falciparum	calcium-dependent protein kinase 5	0.0034	0.0552	0.0404
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0034	0.0552	0.2356
Echinococcus multilocularis	solute carrier family 22	0.0016	0.0154	0.0532
Echinococcus granulosus	General substrate transporter	0.0096	0.1879	0.8451
Trypanosoma brucei	glucose transporter 1E	0.0035	0.0561	0.8462
Schistosoma mansoni	sugar transporter	0.0016	0.0154	0.0532
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0112	0.2216	1
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0154	0.0697
Schistosoma mansoni	ap endonuclease	0.0018	0.021	0.0786
Plasmodium vivax	CDK-related protein kinase 6, putative	0.0476	1	1
Mycobacterium tuberculosis	Probable dicarboxylic acid transport integral membrane protein KgtP (dicarboxylate transporter)	0.0016	0.0154	0.4964
Schistosoma mansoni	P2X receptor subunit	0.0082	0.1569	0.7027
Schistosoma mansoni	sugar transporter	0.0016	0.0154	0.0532
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0353	0.1591
Brugia malayi	Calcium/calmodulin-dependent protein kinase type II alpha chain	0.0034	0.0552	0.2356
Echinococcus multilocularis	solute carrier family 2, facilitated glucose	0.0112	0.2216	1
Brugia malayi	Major Facilitator Superfamily protein	0.0016	0.0154	0.0532
Onchocerca volvulus		0.0016	0.0154	0.5
Mycobacterium ulcerans	integral membrane transport protein	0.0016	0.0154	0.3688
Onchocerca volvulus		0.0016	0.0154	0.5
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0537	0.2422
Schistosoma mansoni	sugar transporter	0.0016	0.0154	0.0532
Schistosoma mansoni	lysyl-tRNA synthetase	0.0025	0.0353	0.1442
Trypanosoma brucei	glucose transporter 2A	0.0035	0.0561	0.8462
Trichomonas vaginalis	sugar transporter, putative	0.0035	0.0561	0.1973
Trypanosoma brucei	apurinic/apyrimidinic endonuclease, putative	0.0018	0.021	0.2772
Onchocerca volvulus		0.0016	0.0154	0.5
Trichomonas vaginalis	sugar transporter, putative	0.0035	0.0561	0.1973
Trypanosoma brucei	cytochrome P450, putative	0.0019	0.0222	0.2963
Trypanosoma cruzi	glucose transporter, putative	0.0016	0.0154	0.1875
Leishmania major	glucose transporter, lmgt1	0.0035	0.0561	0.8462
Toxoplasma gondii	lysine-tRNA ligase	0.0025	0.0353	0.0479
Loa Loa (eye worm)	major facilitator superfamily transporter	0.0016	0.0154	0.0697
Onchocerca volvulus		0.0016	0.0154	0.5
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease	0.0018	0.021	0.2772
Trichomonas vaginalis	prolyl-tRNA synthetase, putative	0.0034	0.0537	0.1855
Brugia malayi	Bifunctional aminoacyl-tRNA synthetase	0.0034	0.0537	0.2288
Plasmodium falciparum	calcium-dependent protein kinase 1	0.0034	0.0552	0.0404
Entamoeba histolytica	prolyl-tRNA synthetase, putative	0.0034	0.0537	0.9565
Mycobacterium leprae	Probable prolyl tRNA synthetase ProS	0.0034	0.0537	1
Leishmania major	hypothetical protein, conserved	0.0016	0.0154	0.1875
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0154	0.0697
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0034	0.0552	0.2356
Leishmania major	lysyl-tRNA synthetase, putative	0.0025	0.0353	0.5084
Schistosoma mansoni	P2X receptor subunit	0.0082	0.1569	0.7027
Brugia malayi	Sugar transporter family protein	0.0016	0.0154	0.0532
Schistosoma mansoni	glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs)	0.0034	0.0537	0.2288
Plasmodium vivax	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0018	0.021	0.0056
Brugia malayi	hypothetical protein	0.0016	0.0154	0.0532
Plasmodium falciparum	calcium-dependent protein kinase 3	0.0034	0.0552	0.0404
Onchocerca volvulus		0.0016	0.0154	0.5
Schistosoma mansoni	P2X receptor subunit	0.0082	0.1569	0.7027
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0154	0.0697
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.0034	0.0552	0.2356
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0112	0.2216	1
Leishmania major	glucose transporter, lmgt2	0.0035	0.0561	0.8462
Echinococcus granulosus	calcium dependent protein kinase	0.0032	0.0506	0.2148
Loa Loa (eye worm)	exodeoxyribonuclease III family protein	0.0018	0.021	0.0946
Echinococcus granulosus	synaptic vesicle 2 protein	0.0016	0.0154	0.0532
Loa Loa (eye worm)	sugar transporter	0.0016	0.0154	0.0697
Loa Loa (eye worm)	CYP4Cod1	0.0019	0.0222	0.1
Schistosoma mansoni	sugar transporter	0.0016	0.0154	0.0532
Schistosoma mansoni	protein kinase	0.0034	0.0552	0.2356
Brugia malayi	lysyl-tRNA synthetase	0.0025	0.0353	0.1442
Trypanosoma cruzi	hexose transporter, putative	0.0035	0.0561	0.8462
Trypanosoma brucei	myo-inositol/proton symporter (MIT)	0.0016	0.0154	0.1875
Echinococcus granulosus	solute carrier family 22	0.0016	0.0154	0.0532
Mycobacterium tuberculosis	Lysyl-tRNA synthetase 2 LysX	0.0021	0.0272	1
Toxoplasma gondii	facilitative glucose transporter GT1	0.0112	0.2216	0.3321
Mycobacterium ulcerans	exodeoxyribonuclease III protein XthA	0.0018	0.021	0.5451
Toxoplasma gondii	sugar transporter ST3	0.0016	0.0154	0.0177
Leishmania major	protein kinase, putative	0.0034	0.0552	0.8309
Trypanosoma cruzi	hexose transporter, putative	0.0035	0.0561	0.8462
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0112	0.2216	1
Loa Loa (eye worm)	CAMK/CAMK2 protein kinase	0.0034	0.0552	0.2489
Trypanosoma brucei	glucose transporter, putative	0.0035	0.0561	0.8462
Toxoplasma gondii	sugar transporter ST1	0.0016	0.0154	0.0177
Echinococcus granulosus	solute carrier family 22	0.0016	0.0154	0.0532
Echinococcus multilocularis	lysyl tRNA synthetase	0.0025	0.0353	0.1442
Echinococcus multilocularis	p2X purinoceptor 4	0.0082	0.1569	0.7027
Brugia malayi	major facilitator superfamily protein	0.0016	0.0154	0.0532
Trypanosoma cruzi	prolyl-tRNA synthetase, putative	0.0039	0.0656	1
Onchocerca volvulus		0.0016	0.0154	0.5
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0035	0.0561	0.8462
Trypanosoma brucei	bifunctional aminoacyl-tRNA synthetase, putative	0.0039	0.0656	1
Schistosoma mansoni	glucose transport protein	0.0112	0.2216	1
Schistosoma mansoni	hypothetical protein	0.0112	0.2216	1
Trypanosoma brucei	glucose transporter, putative	0.0035	0.0561	0.8462
Trichomonas vaginalis	glucose transporter, putative	0.0035	0.0561	0.1973
Plasmodium vivax	hexose transporter	0.0112	0.2216	0.2094
Plasmodium falciparum	protein kinase 7	0.0317	0.6596	0.6542
Trichomonas vaginalis	glucose transporter, putative	0.0035	0.0561	0.1973
Echinococcus multilocularis	solute carrier family 22	0.0016	0.0154	0.0532
Onchocerca volvulus		0.0016	0.0154	0.5
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0552	0.2489
Entamoeba histolytica	protein kinase, putative	0.0034	0.0552	1
Brugia malayi	bifunctional aminoacyl-tRNA synthetase	0.0034	0.0537	0.2288
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0035	0.0561	0.8462
Echinococcus granulosus	p2X purinoceptor 4	0.0082	0.1569	0.7027
Loa Loa (eye worm)	calcium/calmodulin-dependent protein kinase ID	0.0034	0.0552	0.2489
Plasmodium falciparum	calcium-dependent protein kinase 2	0.0034	0.0552	0.0404
Echinococcus granulosus	glutamyl tRNA synthetase cytoplasmic	0.0034	0.0537	0.2288
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0154	0.0697
Trypanosoma cruzi	sugar transporter, putative	0.0016	0.0154	0.1875
Mycobacterium tuberculosis	Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase)	0.0021	0.0272	1
Brugia malayi	Major Facilitator Superfamily protein	0.0016	0.0154	0.0532
Echinococcus granulosus	p2X purinoceptor 4	0.0082	0.1569	0.7027
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type 1	0.0034	0.0552	0.2356
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0034	0.0552	0.2356
Leishmania major	glucose transporter/membrane transporter D2, putative	0.0035	0.0561	0.8462
Schistosoma mansoni	glucose transport protein	0.0112	0.2216	1
Trichomonas vaginalis	sugar transporter, putative	0.0035	0.0561	0.1973
Echinococcus multilocularis	DNA (apurinic or apyrimidinic site) lyase	0.0018	0.021	0.0786
Plasmodium vivax	calcium-dependent protein kinase 3, putative	0.0034	0.0552	0.0404
Loa Loa (eye worm)	sugar transporter	0.0112	0.2216	1
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0112	0.2216	1
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0154	0.0697
Leishmania major	myo-inositol/proton symporter (MIT)	0.0016	0.0154	0.1875
Echinococcus granulosus	lysyl tRNA synthetase	0.0025	0.0353	0.1442
Toxoplasma gondii	calcium-dependent protein kinase CDPK3	0.0034	0.0552	0.0783
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0154	0.0697
Treponema pallidum	exodeoxyribonuclease (exoA)	0.0018	0.021	1
Loa Loa (eye worm)	cytochrome P450	0.001	0.0039	0.0174
Toxoplasma gondii	calcium-dependent protein kinase CDPK2A	0.0034	0.0552	0.0783
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0112	0.2216	1
Trypanosoma cruzi	hexose transporter	0.0035	0.0561	0.8462
Onchocerca volvulus	Putative transporter	0.0016	0.0154	0.5
Loa Loa (eye worm)	major facilitator superfamily transporter	0.0016	0.0154	0.0697
Trypanosoma brucei	glucose transporter, putative	0.0035	0.0561	0.8462
Trypanosoma cruzi	hexose transporter, putative	0.0016	0.0154	0.1875
Mycobacterium ulcerans	sugar-transport integral membrane protein SugI	0.0016	0.0154	0.3688
Trypanosoma brucei	glucose transporter, putative	0.0035	0.0561	0.8462
Mycobacterium ulcerans	prolyl-tRNA synthetase	0.0012	0.0071	0.1041
Mycobacterium ulcerans	sugar transporter	0.0016	0.0154	0.3688
Toxoplasma gondii	transporter, major facilitator family protein	0.0016	0.0154	0.0177
Trypanosoma cruzi	lysyl-tRNA synthetase, putative	0.0025	0.0353	0.5084
Brugia malayi	Cytochrome P450 family protein	0.0019	0.0222	0.084
Chlamydia trachomatis	lysine--tRNA ligase	0.0025	0.0353	1
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0537	0.2422
Echinococcus granulosus	Sugar transporter ERD6 protein	0.0016	0.0154	0.0532
Schistosoma mansoni	ap endonuclease	0.0018	0.021	0.0786
Wolbachia endosymbiont of Brugia malayi	exonuclease III	0.0018	0.021	1
Onchocerca volvulus		0.0016	0.0154	0.5
Echinococcus multilocularis	glutamyl tRNA synthetase cytoplasmic	0.0034	0.0537	0.2288
Trypanosoma brucei	glucose transporter, putative	0.0035	0.0561	0.8462
Echinococcus multilocularis	Sugar transporter ERD6 protein	0.0016	0.0154	0.0532
Trypanosoma brucei	glucose transporter, putative	0.0035	0.0561	0.8462
Plasmodium falciparum	hexose transporter	0.0112	0.2216	0.2094
Leishmania major	prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative	0.0039	0.0656	1
Brugia malayi	hypothetical protein	0.0016	0.0154	0.0532
Toxoplasma gondii	prolyl-tRNA synthetase (ProRS)	0.0039	0.0656	0.0942
Echinococcus multilocularis	calcium dependent protein kinase	0.0032	0.0506	0.2148
Onchocerca volvulus		0.0016	0.0154	0.5
Echinococcus multilocularis	solute carrier family 22	0.0016	0.0154	0.0532
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0154	0.0697
Onchocerca volvulus		0.0016	0.0154	0.5
Trypanosoma cruzi	hexose transporter, putative	0.0035	0.0561	0.8462
Trichomonas vaginalis	conserved hypothetical protein	0.0035	0.0561	0.1973
Schistosoma mansoni	serine/threonine protein kinase	0.0034	0.0552	0.2356
Plasmodium falciparum	lysine--tRNA ligase	0.0025	0.0353	0.0201
Mycobacterium leprae	Possible lysyl-tRNA synthetase 2 LysX	0.0025	0.0353	0.6302
Echinococcus granulosus	p2X purinoceptor 4	0.0082	0.1569	0.7027
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0154	0.0697
Leishmania major	apurinic/apyrimidinic endonuclease-redox protein	0.0018	0.021	0.2772
Trypanosoma cruzi	prolyl-tRNA synthetase, putative	0.0039	0.0656	1
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0154	0.0697
Loa Loa (eye worm)	cytochrome P450 family protein	0.0019	0.0222	0.1
Loa Loa (eye worm)	cytochrome P450 family protein	0.001	0.0039	0.0174
Trypanosoma brucei	glucose transporter, putative	0.0035	0.0561	0.8462
Brugia malayi	Cam kinase protein 1	0.0034	0.0552	0.2356
Onchocerca volvulus		0.0016	0.0154	0.5
Schistosoma mansoni	nuclear transcription factor X-box binding 1 (nfx1)	0.0016	0.0154	0.0532
Trypanosoma cruzi	hexose transporter, putative	0.0019	0.0224	0.2999
Trypanosoma cruzi	cytochrome P450, putative	0.0019	0.0222	0.2963
Echinococcus granulosus	solute carrier family 22	0.0016	0.0154	0.0532
Onchocerca volvulus		0.0016	0.0154	0.5
Echinococcus multilocularis	synaptic vesicle 2 protein	0.0016	0.0154	0.0532
Plasmodium vivax	calcium-dependent protein kinase 1, putative	0.0034	0.0552	0.0404
Plasmodium falciparum	calcium-dependent protein kinase 4	0.0034	0.0552	0.0404
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0034	0.0552	0.2356
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0112	0.2216	1
Trypanosoma brucei	sugar transporter, putative	0.0016	0.0154	0.1875
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease, putative	0.0018	0.021	0.2772
Plasmodium vivax	calcium-dependent protein kinase 4, putative	0.0034	0.0552	0.0404
Trichomonas vaginalis	lysyl-tRNA synthetase, putative	0.0022	0.0287	0.0641
Toxoplasma gondii	calcium-dependent protein kinase CDPK2B	0.0034	0.0552	0.0783
Echinococcus multilocularis	solute carrier family 22	0.0016	0.0154	0.0532
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.0034	0.0552	0.2356
Plasmodium vivax	lysine--tRNA ligase, putative	0.0025	0.0353	0.0201
Schistosoma mansoni	lysyl-tRNA synthetase	0.0025	0.0353	0.1442
Plasmodium vivax	calcium-dependent protein kinase, putative	0.0034	0.0552	0.0404
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0154	0.0697
Toxoplasma gondii	sugar transporter ST2	0.0016	0.0154	0.0177
Mycobacterium ulcerans	lysyl-tRNA synthetase	0.0025	0.0353	1

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL2094197

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1659889