Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0038 | 0.1889 | 0.4427 |
Loa Loa (eye worm) | bromodomain containing protein | 0.0018 | 0.0061 | 0.0061 |
Schistosoma mansoni | hypothetical protein | 0.0022 | 0.0358 | 0.0774 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.237 | 0.237 |
Schistosoma mansoni | hypothetical protein | 0.0034 | 0.1569 | 0.3391 |
Echinococcus granulosus | fetal alzheimer antigen falz | 0.0024 | 0.0549 | 0.1287 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0062 | 0.4268 | 1 |
Echinococcus multilocularis | zinc finger protein | 0.002 | 0.0253 | 0.0592 |
Loa Loa (eye worm) | hypothetical protein | 0.005 | 0.3085 | 0.3085 |
Schistosoma mansoni | zinc finger protein | 0.002 | 0.0253 | 0.0546 |
Brugia malayi | Bromodomain containing protein | 0.004 | 0.2126 | 0.1454 |
Loa Loa (eye worm) | hypothetical protein | 0.0074 | 0.5371 | 0.5371 |
Brugia malayi | Bromodomain containing protein | 0.0078 | 0.5799 | 0.5441 |
Schistosoma mansoni | acetyl-CoA C-acetyltransferase | 0.0024 | 0.0549 | 0.1188 |
Echinococcus granulosus | zinc finger protein | 0.002 | 0.0253 | 0.0592 |
Loa Loa (eye worm) | PHD-finger family protein | 0.0022 | 0.0358 | 0.0358 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0122 | 1 | 1 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0034 | 0.1569 | 0.0849 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.005 | 0.3085 | 0.2495 |
Loa Loa (eye worm) | hypothetical protein | 0.0045 | 0.2561 | 0.2561 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0122 | 1 | 1 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0062 | 0.4268 | 1 |
Schistosoma mansoni | bromodomain containing protein | 0.0066 | 0.4626 | 1 |
Echinococcus multilocularis | fetal alzheimer antigen, falz | 0.0024 | 0.0549 | 0.1287 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0038 | 0.1889 | 0.4427 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.2133 | 0.2133 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.005 | 0.3085 | 0.3085 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.1569 | 0.1569 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.005 | 0.3085 | 0.2495 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
GI50 (functional) | -4.332 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.227 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.201 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.119 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.106 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MALME-3M Melanoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.