Detailed information for compound 1674629

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 393.237 | Formula: C19H13BrN4O
  • H donors: 1 H acceptors: 2 LogP: 3.44 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: N#Cc1ccc(cc1)Cn1c2ccc(cc2c2c1c(=O)[nH]nc2C)Br
  • InChi: 1S/C19H13BrN4O/c1-11-17-15-8-14(20)6-7-16(15)24(18(17)19(25)23-22-11)10-13-4-2-12(9-21)3-5-13/h2-8H,10H2,1H3,(H,23,25)
  • InChiKey: VAJPJHIORYFVGN-UHFFFAOYSA-N  


Substructure search Similarity search

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens cyclin-dependent kinase 5, regulatory subunit 1 (p35) References
Rattus norvegicus Dual specificity tyrosine-phosphorylation-regulated kinase 1A Starlite/ChEMBL References
Homo sapiens phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha Starlite/ChEMBL References
Homo sapiens phosphoinositide-3-kinase, regulatory subunit 1 (alpha) Starlite/ChEMBL References
Homo sapiens cyclin-dependent kinase 5 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Plasmodium vivax protein kinase Crk2 Get druggable targets OG5_126712 All targets in OG5_126712
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative Get druggable targets OG5_127444 All targets in OG5_127444
Echinococcus granulosus phosphatidylinositol 45 bisphosphate 3 kinase Get druggable targets OG5_127444 All targets in OG5_127444
Schistosoma japonicum Cyclin-dependent kinase 5 activator 2 precursor, putative Get druggable targets OG5_133447 All targets in OG5_133447
Leishmania infantum phosphatidylinositol 3-kinase 2, putative Get druggable targets OG5_127444 All targets in OG5_127444
Loa Loa (eye worm) CMGC/CDK/CDK5 protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma congolense serine/threonine-protein kinase, putative Get druggable targets OG5_127901 All targets in OG5_127901
Brugia malayi Protein kinase domain containing protein Get druggable targets OG5_126712 All targets in OG5_126712
Entamoeba histolytica phosphatidylinositol 3-kinase 1, putative Get druggable targets OG5_127444 All targets in OG5_127444
Schistosoma mansoni cyclin-dependent kinase 5 activator Get druggable targets OG5_133447 All targets in OG5_133447
Brugia malayi Protein kinase domain containing protein Get druggable targets OG5_127901 All targets in OG5_127901
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania braziliensis cell division protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma brucei CMGC/DYRK protein kinase, putative Get druggable targets OG5_127901 All targets in OG5_127901
Neospora caninum CMGC kinase, CDK family TgPK2, putative Get druggable targets OG5_126712 All targets in OG5_126712
Babesia bovis cell division control protein 2, putative Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma congolense serine/threonine-protein kinase, putative Get druggable targets OG5_127901 All targets in OG5_127901
Leishmania mexicana cell division protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus multilocularis dual specificity Get druggable targets OG5_127901 All targets in OG5_127901
Leishmania infantum cell division protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein Get druggable targets OG5_127444 All targets in OG5_127444
Schistosoma japonicum expressed protein Get druggable targets OG5_130060 All targets in OG5_130060
Entamoeba histolytica cell division protein kinase 2, putative Get druggable targets OG5_126712 All targets in OG5_126712
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127901 All targets in OG5_127901
Trypanosoma congolense cdc2-related kinase 3, putative Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus granulosus cyclin dependent kinase 5 Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma cruzi cdc2-related kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Giardia lamblia Phosphoinositide-3-kinase, catalytic, alpha polypeptide Get druggable targets OG5_127444 All targets in OG5_127444
Leishmania infantum serine/threonine-protein kinase, putative,protein kinase, putative Get druggable targets OG5_127901 All targets in OG5_127901
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative Get druggable targets OG5_127444 All targets in OG5_127444
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_133447 All targets in OG5_133447
Schistosoma japonicum Serine/threonine-protein kinase minibrain, putative Get druggable targets OG5_127901 All targets in OG5_127901
Leishmania mexicana phosphatidylinositol 3-kinase, putative Get druggable targets OG5_127444 All targets in OG5_127444
Trypanosoma brucei gambiense cell division protein kinase 2 homolog 1,cdc2- like protein kinase, putative Get druggable targets OG5_126712 All targets in OG5_126712
Entamoeba histolytica protein kinase, putative Get druggable targets OG5_127901 All targets in OG5_127901
Plasmodium yoelii cdc2-related kinase 2 Get druggable targets OG5_126712 All targets in OG5_126712
Entamoeba histolytica phosphatidylinositol 3-kinase, putative Get druggable targets OG5_127444 All targets in OG5_127444
Leishmania donovani cell division protein kinase 2 Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma brucei cdc2-related kinase 3 Get druggable targets OG5_126712 All targets in OG5_126712
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit gamma, putative Get druggable targets OG5_127444 All targets in OG5_127444
Trypanosoma cruzi cdc2-related kinase 3 Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus multilocularis expressed conserved protein Get druggable targets OG5_130060 All targets in OG5_130060
Schistosoma japonicum hypothetical protein Get druggable targets OG5_133447 All targets in OG5_133447
Plasmodium berghei cdc2-related kinase 2 Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus granulosus 5'partial|cyclin dependent kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127901 All targets in OG5_127901
Theileria parva cell division control protein 2 related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania major cell division related protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania major cell division protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma brucei cdc2-related kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma cruzi CMGC/DYRK protein kinase, putative Get druggable targets OG5_127901 All targets in OG5_127901
Plasmodium falciparum protein kinase 5 Get druggable targets OG5_126712 All targets in OG5_126712
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126712 All targets in OG5_126712
Loa Loa (eye worm) CMGC/DYRK/DYRK1 protein kinase Get druggable targets OG5_127901 All targets in OG5_127901
Giardia lamblia Kinase, CMGC CDK Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma congolense cdc2-related kinase 1, putative Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus multilocularis phosphatidylinositol 3 kinase regulatory subunit Get druggable targets OG5_130060 All targets in OG5_130060
Echinococcus multilocularis cyclin dependent kinase Get druggable targets OG5_126712 All targets in OG5_126712
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Plasmodium knowlesi Cell division control protein 2 homolog Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania donovani serine/threonine-protein kinase, putative Get druggable targets OG5_127901 All targets in OG5_127901
Schistosoma japonicum IPR000198,RhoGAP;IPR008936,Rho GTPase activation protein,domain-containing Get druggable targets OG5_130060 All targets in OG5_130060
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative Get druggable targets OG5_127444 All targets in OG5_127444
Brugia malayi hypothetical protein Get druggable targets OG5_133447 All targets in OG5_133447
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus granulosus cyclin dependent kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus multilocularis cyclin dependent kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus granulosus cyclin dependent kinase 5 activator 1 Get druggable targets OG5_133447 All targets in OG5_133447
Schistosoma japonicum IPR000980,SH2 motif;IPR001720,PI3 kinase, P85 regulatory subunit,domain-containing Get druggable targets OG5_130060 All targets in OG5_130060
Entamoeba histolytica hypothetical protein Get druggable targets OG5_127444 All targets in OG5_127444
Leishmania major serine/threonine-protein kinase, putative,protein kinase, putative Get druggable targets OG5_127901 All targets in OG5_127901
Schistosoma mansoni hypothetical protein Get druggable targets OG5_130060 All targets in OG5_130060
Leishmania braziliensis cell division related protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Schistosoma japonicum ko:K02649 phosphoinositide-3-kinase, regulatory subunit, putative Get druggable targets OG5_130060 All targets in OG5_130060
Cryptosporidium parvum Cdc2-like CDK2/CDC28 like protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma brucei gambiense serine/threonine-protein kinase, putative,protein kinase, putative Get druggable targets OG5_127901 All targets in OG5_127901
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K Get druggable targets OG5_127444 All targets in OG5_127444
Entamoeba histolytica phosphatidylinositol 3-kinase, putative Get druggable targets OG5_127444 All targets in OG5_127444
Echinococcus multilocularis phosphatidylinositol 4,5 bisphosphate 3 kinase Get druggable targets OG5_127444 All targets in OG5_127444
Leishmania braziliensis serine/threonine-protein kinase, putative,protein kinase, putative Get druggable targets OG5_127901 All targets in OG5_127901
Brugia malayi SH2 domain containing protein Get druggable targets OG5_130060 All targets in OG5_130060
Entamoeba histolytica cell division protein kinase 2, putative Get druggable targets OG5_126712 All targets in OG5_126712
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_130060 All targets in OG5_130060
Leishmania mexicana cell division related protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus granulosus expressed conserved protein Get druggable targets OG5_130060 All targets in OG5_130060
Toxoplasma gondii cell-cycle-associated protein kinase CDK, putative Get druggable targets OG5_126712 All targets in OG5_126712
Entamoeba histolytica hypothetical protein Get druggable targets OG5_127901 All targets in OG5_127901
Trichomonas vaginalis phosphatidylinositol kinase, putative Get druggable targets OG5_127444 All targets in OG5_127444
Entamoeba histolytica protein kinase domain containing protein Get druggable targets OG5_127901 All targets in OG5_127901
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_133447 All targets in OG5_133447
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_127901 All targets in OG5_127901
Echinococcus multilocularis cyclin dependent kinase 5 activator 1 Get druggable targets OG5_133447 All targets in OG5_133447
Candida albicans Protein kinase that can substitute for S. cerevisiae CDC28 (YBR160W) main cell cycle cyclin-dependent kinase Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma cruzi CMGC/DYRK protein kinase, putative Get druggable targets OG5_127901 All targets in OG5_127901
Leishmania donovani phosphatidylinositol 3-kinase 2, putative Get druggable targets OG5_127444 All targets in OG5_127444
Entamoeba histolytica protein kinase, putative Get druggable targets OG5_127901 All targets in OG5_127901
Schistosoma japonicum expressed protein Get druggable targets OG5_127901 All targets in OG5_127901
Echinococcus granulosus phosphatidylinositol 3 kinase regulatory subunit Get druggable targets OG5_130060 All targets in OG5_130060
Echinococcus multilocularis cyclin dependent kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Schistosoma japonicum IPR000980,SH2 motif;IPR000198,RhoGAP;IPR008936,Rho GTPase activation protein,domain-containing Get druggable targets OG5_130060 All targets in OG5_130060
Loa Loa (eye worm) phosphatidylinositol 3 Get druggable targets OG5_127444 All targets in OG5_127444
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127444 All targets in OG5_127444
Schistosoma japonicum ko:K00922 phosphatidylinositol-4,5-bisphosphate 3-kinase [EC2.7.1.153], putative Get druggable targets OG5_127444 All targets in OG5_127444
Trypanosoma cruzi cdc2-related kinase 3 Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania mexicana serine/threonine-protein kinase, putative,protein kinase, putative Get druggable targets OG5_127901 All targets in OG5_127901
Echinococcus multilocularis cyclin dependent kinase 5 Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus granulosus cyclin dependent kinase Get druggable targets OG5_126712 All targets in OG5_126712
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative Get druggable targets OG5_127444 All targets in OG5_127444
Leishmania donovani cdc2-related kinase 3, putative Get druggable targets OG5_126712 All targets in OG5_126712
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Giardia lamblia Kinase, CMGC CDK Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma cruzi cdc2-related kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative Get druggable targets OG5_127444 All targets in OG5_127444
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_133447 All targets in OG5_133447
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma brucei gambiense cell division related protein kinase 2, putative,CDC2-related protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania infantum cell division related protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Schistosoma japonicum ko:K02090 cyclin-dependent kinase 5, putative Get druggable targets OG5_126712 All targets in OG5_126712
Schistosoma japonicum ko:K02087 cyclin-dependent kinase 1, putative Get druggable targets OG5_126712 All targets in OG5_126712
Brugia malayi cell division control protein 2 homolog Get druggable targets OG5_126712 All targets in OG5_126712
Cryptosporidium hominis cdc2-like protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus granulosus dual specificity Get druggable targets OG5_127901 All targets in OG5_127901
Candida albicans Protein kinase that can substitute for S. cerevisiae CDC28 (YBR160W) main cell cycle cyclin-dependent kinase Get druggable targets OG5_126712 All targets in OG5_126712
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Trypanosoma brucei mitogen-activated protein kinase 5 cyclin-dependent kinase 5 260 aa 307 aa 28.3 %
Entamoeba histolytica phosphatidylinositol 3-kinase, putative phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha 1068 aa 927 aa 29.0 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit gamma, putative 0.0118 0.2122 1
Echinococcus granulosus expressed conserved protein 0.0099 0.1589 0.1788
Loa Loa (eye worm) CMGC/CDK/CDK5 protein kinase 0.0053 0.0353 0.0298
Trichomonas vaginalis CMGC family protein kinase 0.0053 0.0353 0.1664
Trypanosoma brucei cdc2-related kinase 1 0.0053 0.0353 0.1905
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0053 0.0353 0.0298
Echinococcus granulosus cyclin dependent kinase 5 activator 1 0.0309 0.7265 1
Entamoeba histolytica hypothetical protein 0.0094 0.1471 0.6931
Plasmodium vivax protein kinase Crk2 0.0053 0.0353 0.5
Giardia lamblia Phosphoinositide-3-kinase, catalytic, alpha polypeptide 0.0057 0.0472 1
Echinococcus multilocularis phosphatidylinositol 4,5 bisphosphate 3 kinase 0.0222 0.493 0.6622
Brugia malayi Protein kinase domain containing protein 0.0108 0.1854 0.1854
Entamoeba histolytica phosphatidylinositol 3-kinase 1, putative 0.0115 0.2027 0.9555
Entamoeba histolytica protein kinase, putative 0.0108 0.1854 0.8738
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0108 0.1854 0.8738
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0222 0.493 0.6786
Brugia malayi cell division control protein 2 homolog 0.0053 0.0353 0.0353
Loa Loa (eye worm) hypothetical protein 0.0411 1 1
Trypanosoma cruzi cdc2-related kinase 3 0.0053 0.0353 0.1664
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0118 0.2122 1
Loa Loa (eye worm) hypothetical protein 0.0309 0.7265 0.7249
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0053 0.0353 0.0298
Echinococcus granulosus phosphatidylinositol 4 phosphate 3 kinase C2 0.0077 0.0998 0.0934
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0094 0.1471 0.6931
Entamoeba histolytica cell division protein kinase 2, putative 0.0053 0.0353 0.1664
Entamoeba histolytica protein kinase, putative 0.0108 0.1854 0.8738
Entamoeba histolytica protein kinase domain containing protein 0.0108 0.1854 0.8738
Trichomonas vaginalis CMGC family protein kinase 0.0053 0.0353 0.1664
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0081 0.1123 0.5294
Brugia malayi phosphoinositide 3'-hydroxykinase p110-alpha subunit, putative 0.0104 0.1742 0.1742
Leishmania major serine/threonine-protein kinase, putative,protein kinase, putative 0.0108 0.1854 1
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0118 0.2122 1
Echinococcus granulosus dual specificity 0.0108 0.1854 0.2171
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0077 0.0998 0.0998
Echinococcus multilocularis phosphatidylinositol 3 kinase regulatory subunit 0.0105 0.1752 0.2024
Loa Loa (eye worm) hypothetical protein 0.0107 0.1824 0.1777
Schistosoma mansoni serine/threonine protein kinase 0.0053 0.0353 0.0486
Trypanosoma cruzi cdc2-related kinase 1 0.0053 0.0353 0.1664
Brugia malayi Protein kinase domain containing protein 0.0053 0.0353 0.0353
Trypanosoma cruzi cdc2-related kinase 3 0.0053 0.0353 0.1664
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0118 0.2122 1
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0052 0.0347 0.1637
Loa Loa (eye worm) hypothetical protein 0.0107 0.1824 0.1777
Echinococcus multilocularis expressed conserved protein 0.0099 0.1589 0.1788
Loa Loa (eye worm) hypothetical protein 0.0148 0.2922 0.2881
Schistosoma mansoni serine/threonine protein kinase 0.0108 0.1854 0.2552
Echinococcus granulosus phosphatidylinositol 45 bisphosphate 3 kinase 0.0222 0.493 0.6622
Toxoplasma gondii cell-cycle-associated protein kinase CDK, putative 0.0053 0.0353 0.5
Entamoeba histolytica hypothetical protein 0.0108 0.1854 0.8738
Loa Loa (eye worm) CMGC/DYRK/DYRK1 protein kinase 0.0108 0.1854 0.1807
Brugia malayi hypothetical protein 0.0148 0.2922 0.2922
Entamoeba histolytica cell division protein kinase 2, putative 0.0053 0.0353 0.1664
Trypanosoma cruzi cdc2-related kinase 1 0.0053 0.0353 0.1664
Echinococcus granulosus phosphatidylinositol 3 kinase regulatory subunit 0.0105 0.1752 0.2024
Echinococcus multilocularis cyclin dependent kinase 5 activator 1 0.0309 0.7265 1
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0081 0.1123 0.5294
Schistosoma mansoni hypothetical protein 0.0099 0.1589 0.2187
Loa Loa (eye worm) hypothetical protein 0.0077 0.0998 0.0947
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0118 0.2122 1
Loa Loa (eye worm) phosphatidylinositol 3 0.0198 0.4279 0.4246
Loa Loa (eye worm) hypothetical protein 0.0148 0.2922 0.2881
Schistosoma mansoni cyclin-dependent kinase 5 activator 0.0309 0.7265 1
Loa Loa (eye worm) hypothetical protein 0.0052 0.0323 0.0268
Plasmodium falciparum protein kinase 5 0.0053 0.0353 0.5
Trypanosoma brucei CMGC/DYRK protein kinase, putative 0.0108 0.1854 1
Echinococcus multilocularis phosphatidylinositol 4 phosphate 3 kinase C2 0.0077 0.0998 0.0934
Trypanosoma brucei cdc2-related kinase 3 0.0053 0.0353 0.1905
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0118 0.2122 0.2122
Echinococcus multilocularis dual specificity 0.0108 0.1854 0.2171
Schistosoma mansoni serine/threonine protein kinase 0.0053 0.0353 0.0486
Trichomonas vaginalis CMGC family protein kinase 0.0053 0.0353 0.1664
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0118 0.2122 1
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0108 0.1854 0.8738

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 1.9 uM Inhibition of PI3K p110alpha/p85alpha by fluorescence based immunoassay ChEMBL. 23063566
IC50 (functional) = 2 uM Antiproliferative activity against human HuH7 cells incubated for 48 hrs by Hoechst 3342 dye staining based assay ChEMBL. 23063566
IC50 (binding) > 10 uM Inhibition of rat recombinant GST-tagged DYRK1A expressed in Escherichia coli using myelin basic protein substrate ChEMBL. 23063566
IC50 (binding) > 10 uM Inhibition of human recombinant CDK5/P25 using myelin basic protein substrate ChEMBL. 23063566
IC50 (binding) > 10 uM Inhibition of PI3K p110gamma by fluorescence based immunoassay ChEMBL. 23063566

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23 23063566

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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