TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 372.802 | Formula: C19H17ClN2O4
H donors: 0 H acceptors: 1 LogP: 4.33 Rotable bonds: 5
Rule of 5 violations (Lipinski): 1
SMILES: COc1nn(c2cccc(c2)C)c(=O)c(c1Cl)Oc1ccc(cc1)OC
InChi: 1S/C19H17ClN2O4/c1-12-5-4-6-13(11-12)22-19(23)17(16(20)18(21-22)25-3)26-15-9-7-14(24-2)8-10-15/h4-11H,1-3H3
InChiKey: OETGJXDTWBSWLY-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	neuropeptides B/W receptor 1	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	neuropeptides B/W receptor 1	328 aa	296 aa	21.3 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Onchocerca volvulus	Transient receptor potential cation channel trpm homolog	0.0026	0.0201	0.0299
Schistosoma mansoni	high voltage-activated calcium channel Cav1	0.0026	0.0201	0.0325
Schistosoma mansoni	tyrosine kinase	0.0005	0.0014	0.0023
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0005	0.0017	0.0027
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0196	0.0196
Echinococcus multilocularis	neuropeptide receptor	0.0005	0.0017	0.0027
Schistosoma mansoni	60S ribosomal protein L21	0.0026	0.0201	0.0325
Echinococcus multilocularis	transfer RNA-Gly	0.0026	0.0201	0.0325
Schistosoma mansoni	voltage-gated potassium channel	0.0026	0.0201	0.0325
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0005	0.0017	0.0027
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0048	0.0398	0.0398
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0005	0.0017	0.0027
Echinococcus granulosus	hyperpolarization activated cyclic	0.0026	0.0201	0.0325
Echinococcus granulosus	TRP transient receptor potential channel	0.0026	0.0201	0.0325
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0005	0.0014	0.0023
Echinococcus multilocularis	orexin receptor type 2	0.0005	0.0017	0.0027
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0048	0.0398	0.0398
Echinococcus multilocularis	nuclear receptor nhr 48	0.0022	0.0172	0.0279
Echinococcus granulosus	tm gpcr rhodopsin	0.0005	0.0017	0.0027
Mycobacterium tuberculosis	Nicotinic acid phosphoribosyltransferase PncB2	0.0074	0.0637	0.5
Schistosoma mansoni	nuclear hormone receptor	0.0048	0.0398	0.0646
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0005	0.0017	0.0027
Schistosoma mansoni	neuropeptide receptor	0.0005	0.0017	0.0027
Echinococcus multilocularis	fmrfamide receptor	0.0005	0.0017	0.0027
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0201	0.02
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0172	0.0172
Brugia malayi	AKH receptor	0.0005	0.0017	0.0016
Echinococcus multilocularis	vesicular acetylcholine transporter	0.0689	0.6165	1
Schistosoma mansoni	two-pore calcium channel	0.0026	0.0201	0.0325
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0005	0.0017	0.0027
Schistosoma mansoni	amine GPCR	0.0005	0.0017	0.0027
Echinococcus granulosus	potassium voltage gated channel subfamily C	0.0026	0.0201	0.0325
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0201	0.02
Loa Loa (eye worm)	hypothetical protein	0.0005	0.0017	0.0016
Schistosoma mansoni	hypothetical protein	0.0005	0.0017	0.0027
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0172	0.0172
Schistosoma mansoni	thyroid hormone receptor	0.0048	0.0398	0.0646
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0005	0.0014	0.0023
Echinococcus multilocularis	neuropeptides capa receptor	0.0005	0.0017	0.0027
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.0048	0.0398	0.0621
Toxoplasma gondii	transporter, cation channel family protein	0.0026	0.0201	0.5
Schistosoma mansoni	hyperpolarization activated cyclic nucleotide-gated potassium channel	0.0026	0.0201	0.0325
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0005	0.0017	0.0027
Echinococcus granulosus	neuropeptide receptor	0.0005	0.0017	0.0027
Echinococcus multilocularis	transient receptor potential cation channel	0.0026	0.0201	0.0325
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0048	0.0398	0.0398
Schistosoma mansoni	calcium-activated potassium channel	0.0026	0.0201	0.0325
Loa Loa (eye worm)	hypothetical protein	0.0005	0.0017	0.0016
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0005	0.0017	0.0027
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0048	0.0398	0.0398
Schistosoma mansoni	voltage-gated potassium channel	0.0026	0.0201	0.0325
Brugia malayi	Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit	0.0026	0.0201	0.02
Loa Loa (eye worm)	ion channel NompC	0.0026	0.0201	0.02
Brugia malayi	olfactory channel protein osm-9	0.0026	0.0201	0.02
Schistosoma mansoni	vesicular acetylcholine transporter	0.0689	0.6165	1
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0005	0.0014	0.0023
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0005	0.0017	0.0027
Echinococcus granulosus	orexin receptor type 2	0.0005	0.0017	0.0027
Brugia malayi	G-protein coupled receptor	0.0005	0.0017	0.0016
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0005	0.0017	0.0027
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.0004	0.0009	0.0008
Echinococcus granulosus	rhodopsin orphan GPCR	0.0005	0.0017	0.0027
Schistosoma mansoni	nicotinate phosphoribosyltransferase related pre-B cell enhancing factor	0.04	0.3567	0.5786
Echinococcus granulosus	potassium voltage gated channel subfamily D	0.0026	0.0201	0.0325
Schistosoma mansoni	amine GPCR	0.0005	0.0017	0.0027
Echinococcus multilocularis	calcium activated potassium channel	0.0026	0.0201	0.0325
Loa Loa (eye worm)	hypothetical protein	0.0005	0.0017	0.0016
Echinococcus granulosus	voltage dependent calcium channel	0.0026	0.0201	0.0325
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0048	0.0398	0.0646
Loa Loa (eye worm)	calcium channel	0.0026	0.0201	0.02
Loa Loa (eye worm)	SRC-1	0.0005	0.0014	0.0014
Brugia malayi	steroid hormone receptor	0.0048	0.0398	0.0398
Echinococcus granulosus	g protein coupled receptor	0.0005	0.0017	0.0027
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0201	0.02
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0048	0.0398	0.0646
Loa Loa (eye worm)	hypothetical protein	0.0005	0.0017	0.0016
Echinococcus granulosus	rhodopsin orphan GPCR	0.0005	0.0017	0.0027
Echinococcus granulosus	fmrfamide receptor	0.0005	0.0017	0.0027
Loa Loa (eye worm)	hypothetical protein	0.0005	0.0017	0.0016
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0048	0.0398	0.0398
Loa Loa (eye worm)	hypothetical protein	0.0005	0.0017	0.0016
Brugia malayi	Voltage-gated potassium channel, Shab-family (KCNB, Kv2-like) alpha-subunit. C. elegans exp-2 ortholog	0.0026	0.0201	0.02
Echinococcus granulosus	neuropeptides capa receptor	0.0005	0.0017	0.0027
Treponema pallidum	nicotinate phosphoribosyltransferase	0.0074	0.0637	0.5
Schistosoma mansoni	neuropeptide f receptor 76f	0.0005	0.0017	0.0027
Schistosoma mansoni	nuclear hormone receptor superfamily protein-related	0.0022	0.0172	0.0279
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0005	0.0017	0.0027
Schistosoma mansoni	hepatocyte nuclear factor 4-alpha (hnf-4-alpha)	0.0022	0.0172	0.0279
Echinococcus multilocularis	potassium voltage gated channel subfamily KQT	0.0026	0.0201	0.0325
Brugia malayi	hypothetical protein	0.0005	0.0017	0.0016
Brugia malayi	vesicular acetylcholine transporter unc-17	0.0689	0.6165	0.6165
Brugia malayi	Serotonin receptor	0.0005	0.0017	0.0016
Brugia malayi	cation channel family protein	0.0026	0.0201	0.02
Schistosoma mansoni	adenoreceptor	0.0005	0.0017	0.0027
Loa Loa (eye worm)	nuclear receptor nhr-7B	0.0022	0.0172	0.0172
Schistosoma mansoni	nicotinate phosphoribosyltransferase	0.0074	0.0637	0.1034
Brugia malayi	Voltage-gated potassium channel, Shaker-family (KCNA, Kv1-like) alpha-subunit	0.0026	0.0201	0.02
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0172	0.0172
Echinococcus granulosus	vesicular acetylcholine transporter	0.0689	0.6165	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0005	0.0017	0.0027
Echinococcus granulosus	voltage gated sodium channel Nav1 alpha subunit	0.0026	0.0201	0.0325
Loa Loa (eye worm)	hypothetical protein	0.0005	0.0017	0.0016
Echinococcus granulosus	voltage gated potassium channel	0.0026	0.0201	0.0325
Echinococcus multilocularis	two pore calcium channel protein 2	0.0026	0.0201	0.0325
Schistosoma mansoni	histamine h1 receptor	0.0005	0.0017	0.0027
Echinococcus multilocularis	neuropeptides capa receptor	0.0005	0.0017	0.0027
Loa Loa (eye worm)	hypothetical protein	0.0005	0.0017	0.0016
Brugia malayi	SRC-1	0.0005	0.0014	0.0014
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0048	0.0398	0.0398
Schistosoma mansoni	nuclear receptor	0.0022	0.0172	0.0279
Echinococcus granulosus	ecdysone induced protein 78C	0.0048	0.0398	0.0646
Brugia malayi	Nuclear hormone receptor E75	0.0022	0.0172	0.0172
Loa Loa (eye worm)	hypothetical protein	0.057	0.5097	0.5096
Schistosoma mansoni	opsin-like receptor	0.0005	0.0017	0.0027
Schistosoma mansoni	hypothetical protein	0.0005	0.0017	0.0027
Echinococcus multilocularis	voltage dependent calcium channel type d subunit	0.0026	0.0201	0.0325
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0022	0.0172	0.0279
Echinococcus multilocularis	tyrosine protein kinase Abl	0.0005	0.0014	0.0023
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0005	0.0017	0.0016
Echinococcus granulosus	tm gpcr rhodopsin	0.0005	0.0017	0.0027
Echinococcus granulosus	neuropeptide s receptor	0.0005	0.0017	0.0027
Echinococcus multilocularis	g protein coupled receptor	0.0005	0.0017	0.0027
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0005	0.0017	0.0016
Brugia malayi	Voltage-gated calcium channel, T-type, alpha subunit. C. elegans cca-1 ortholog	0.0026	0.0201	0.02
Schistosoma mansoni	voltage-gated potassium channel	0.0026	0.0201	0.0325
Echinococcus multilocularis	growth factor receptor bound protein 2	0.0004	0.0009	0.0014
Leishmania major	C-8 sterol isomerase-like protein	0.1116	1	1
Brugia malayi	putative neuropeptide receptor	0.0005	0.0017	0.0016
Onchocerca volvulus	Protein ultraspiracle homolog	0.0048	0.0398	0.0621
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.0022	0.0172	0.0279
Schistosoma mansoni	voltage-gated potassium channel	0.0026	0.0201	0.0325
Brugia malayi	neuropeptide F receptor	0.0005	0.0017	0.0016
Brugia malayi	Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit. C. elegans egl-36 ortholog	0.0026	0.0201	0.02
Echinococcus granulosus	g protein coupled receptor	0.0005	0.0017	0.0027
Echinococcus granulosus	potassium voltage gated channel subfamily H	0.0026	0.0201	0.0325
Loa Loa (eye worm)	voltage and ligand gated potassium channel	0.0026	0.0201	0.02
Schistosoma mansoni	transient receptor potential cation channel subfamily m member	0.0026	0.0201	0.0325
Schistosoma mansoni	voltage-gated potassium channel	0.0026	0.0201	0.0325
Schistosoma mansoni	zinc finger protein	0.0022	0.0172	0.0279
Echinococcus granulosus	hypothetical protein	0.0005	0.0017	0.0027
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0172	0.0172
Echinococcus granulosus	Nuclear hormone receptor HR96	0.0022	0.0172	0.0279
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0005	0.0014	0.0023
Loa Loa (eye worm)	hypothetical protein	0.0005	0.0017	0.0016
Schistosoma mansoni	hypothetical protein	0.0026	0.0201	0.0325
Loa Loa (eye worm)	cyclic-nucleotide gated cation channel	0.0026	0.0201	0.02
Echinococcus multilocularis	serotonin receptor	0.0005	0.0017	0.0027
Loa Loa (eye worm)	voltage-gated calcium channel	0.0026	0.0201	0.02
Schistosoma mansoni	voltage-gated potassium channel	0.0026	0.0201	0.0325
Onchocerca volvulus	Transient receptor potential cation channel trpm homolog	0.0026	0.0201	0.0299
Echinococcus granulosus	transient receptor potential gamma protein	0.0026	0.0201	0.0325
Brugia malayi	hypothetical protein	0.0005	0.0017	0.0016
Echinococcus multilocularis	potassium voltage gated channel subfamily D	0.0026	0.0201	0.0325
Schistosoma mansoni	voltage-gated ion channel	0.0026	0.0201	0.0325
Echinococcus granulosus	potassium voltage gated channel protein	0.0026	0.0201	0.0325
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0048	0.0398	0.0398
Brugia malayi	Melatonin receptor type 1A	0.0005	0.0017	0.0016
Brugia malayi	Nuclear hormone receptor-like 1	0.0025	0.0196	0.0196
Loa Loa (eye worm)	hypothetical protein	0.0005	0.0017	0.0016
Schistosoma mansoni	opsin-like receptor	0.0005	0.0017	0.0027
Brugia malayi	hypothetical protein	0.0005	0.0017	0.0016
Onchocerca volvulus	Bile acid receptor homolog	0.0048	0.0398	0.0621
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0005	0.0017	0.0027
Brugia malayi	G protein-coupled receptor F59B2.13	0.0005	0.0017	0.0016
Onchocerca volvulus		0.0022	0.0172	0.0253
Echinococcus granulosus	two pore calcium channel protein 2	0.0026	0.0201	0.0325
Echinococcus granulosus	potassium voltage gated channel protein	0.0026	0.0201	0.0325
Brugia malayi	nuclear hormone receptor	0.0022	0.0172	0.0172
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0048	0.0398	0.0398
Echinococcus multilocularis	voltage dependent calcium channel	0.0026	0.0201	0.0325
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0201	0.02
Loa Loa (eye worm)	hypothetical protein	0.0005	0.0017	0.0016
Loa Loa (eye worm)	hypothetical protein	0.0005	0.0017	0.0016
Schistosoma mansoni	cyclic-nucleotide-gated cation channel	0.0026	0.0201	0.0325
Echinococcus granulosus	tm gpcr rhodopsin	0.0005	0.0017	0.0027
Echinococcus granulosus	potassium voltage gated channel protein	0.0026	0.0201	0.0325
Schistosoma mansoni	retinoic acid receptor RXR	0.0048	0.0398	0.0646
Echinococcus granulosus	shaker cognate	0.0026	0.0201	0.0325
Echinococcus multilocularis	potassium voltage gated channel protein	0.0026	0.0201	0.0325
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0005	0.0017	0.0027
Loa Loa (eye worm)	hypothetical protein	0.0005	0.0017	0.0016
Schistosoma mansoni	voltage-gated potassium channel	0.0026	0.0201	0.0325
Brugia malayi	tailless protein	0.0022	0.0172	0.0172
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0048	0.0398	0.0398
Echinococcus multilocularis	shaker cognate	0.0026	0.0201	0.0325
Echinococcus granulosus	g-protein coupled receptor	0.0005	0.0017	0.0027
Brugia malayi	hypothetical protein	0.0026	0.0201	0.02
Plasmodium falciparum	nicotinate phosphoribosyltransferase, putative	0.0074	0.0637	0.5
Schistosoma mansoni	thyroid hormone receptor	0.0048	0.0398	0.0646
Echinococcus multilocularis	g protein coupled receptor	0.0005	0.0017	0.0027
Loa Loa (eye worm)	voltage-gated potassium channel	0.0026	0.0201	0.02
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0048	0.0398	0.0646
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0005	0.0017	0.0027
Echinococcus granulosus	ryanodine receptor 44f	0.0026	0.0201	0.0325
Schistosoma mansoni	transient receptor potential channel	0.0026	0.0201	0.0325
Brugia malayi	Nuclear hormone receptor-like 1	0.0048	0.0398	0.0398
Echinococcus multilocularis	voltage gated potassium channel	0.0026	0.0201	0.0325
Echinococcus granulosus	neuropeptide Y receptor	0.0005	0.0017	0.0027
Schistosoma mansoni	opsin-like receptor	0.0005	0.0017	0.0027
Toxoplasma gondii	hypothetical protein	0.0026	0.0201	0.5
Brugia malayi	Variant SH3 domain containing protein	0.0004	0.0009	0.0008
Loa Loa (eye worm)	hypothetical protein	0.0005	0.0017	0.0016
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0172	0.0172
Echinococcus granulosus	tyrosine protein kinase Src64B	0.0005	0.0014	0.0023
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0048	0.0398	0.0646
Toxoplasma gondii	hypothetical protein	0.0026	0.0201	0.5
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0048	0.0398	0.0646
Brugia malayi	Voltage-gated calcium channel, P/Q-type, alpha subunit. C. elegans unc-2 ortholog	0.0026	0.0201	0.02
Loa Loa (eye worm)	hypothetical protein	0.0005	0.0017	0.0016
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0048	0.0398	0.0646
Schistosoma mansoni	amine GPCR	0.0005	0.0017	0.0027
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0005	0.0017	0.0027
Echinococcus granulosus	dro:myosuppressin receptor	0.0005	0.0017	0.0027
Echinococcus multilocularis	allatostatin A receptor	0.0005	0.0017	0.0027
Brugia malayi	Cyclic-nucleotide gated cation channel	0.0026	0.0201	0.02
Echinococcus granulosus	growth factor receptor bound protein 2	0.0004	0.0009	0.0014
Schistosoma mansoni	voltage-gated potassium channel	0.0026	0.0201	0.0325
Trypanosoma brucei	C-8 sterol isomerase, putative	0.1116	1	1
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0005	0.0014	0.0023
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0005	0.0017	0.0027
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0005	0.0017	0.0027
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0201	0.02
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0005	0.0017	0.0027
Loa Loa (eye worm)	hypothetical protein	0.0005	0.0017	0.0016
Echinococcus multilocularis	short transient receptor potential channel 6	0.0026	0.0201	0.0325
Brugia malayi	nuclear hormone receptor family member nhr-6	0.0022	0.0172	0.0172
Brugia malayi	Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog	0.0026	0.0201	0.02
Schistosoma mansoni	nuclear hormone receptor	0.0022	0.0172	0.0279
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0005	0.0017	0.0027
Onchocerca volvulus	Nuclear receptor subfamily 6 group A member 1 homolog	0.0022	0.0172	0.0253
Toxoplasma gondii	transporter, cation channel family protein	0.0026	0.0201	0.5
Schistosoma mansoni	nuclear hormone receptor	0.0022	0.0172	0.0279
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0005	0.0017	0.0016
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0005	0.0017	0.0027
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0005	0.0017	0.0027
Loa Loa (eye worm)	hypothetical protein	0.0005	0.0017	0.0016
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0005	0.0017	0.0027
Brugia malayi	Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit	0.0026	0.0201	0.02
Echinococcus granulosus	hypothetical protein	0.0026	0.0201	0.0325
Echinococcus granulosus	voltage dependent calcium channel type d subunit\|voltage dependent calcium channel alpha 1	0.0026	0.0201	0.0325
Brugia malayi	Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog	0.0026	0.0201	0.02
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0201	0.02
Echinococcus multilocularis	NCK adaptor protein	0.0004	0.0009	0.0014
Brugia malayi	Dopamine receptor protein 1	0.0005	0.0017	0.0016
Echinococcus multilocularis	c src tyrosine kinase	0.0005	0.0014	0.0023
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0005	0.0017	0.0027
Echinococcus granulosus	transient receptor potential cation channel	0.0026	0.0201	0.0325
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0005	0.0017	0.0027
Schistosoma mansoni	voltage-gated potassium channel	0.0026	0.0201	0.0325
Echinococcus granulosus	cyclic nucleotide gated cation channel	0.0026	0.0201	0.0325
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0005	0.0017	0.0027
Schistosoma mansoni	cyclic-nucleotide-gated cation channel	0.0026	0.0201	0.0325
Echinococcus granulosus	nuclear receptor subfamily 4 group A	0.0022	0.0172	0.0279
Schistosoma mansoni	tyrosine kinase	0.0005	0.0014	0.0023
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0172	0.0172
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0201	0.02
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0048	0.0398	0.0646
Schistosoma mansoni	ryanodine receptor related	0.0026	0.0201	0.0325
Loa Loa (eye worm)	hypothetical protein	0.0005	0.0017	0.0016
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.0022	0.0172	0.0279
Echinococcus granulosus	nuclear receptor nhr 48	0.0022	0.0172	0.0279
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.012	0.1049	0.1702
Echinococcus multilocularis	tyrosine protein kinase Btk29A	0.012	0.1049	0.1702
Echinococcus multilocularis	potassium large conductance calcium activated	0.0026	0.0201	0.0325
Schistosoma mansoni	neuropeptide receptor	0.0005	0.0017	0.0027
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0398	0.0398
Echinococcus granulosus	calcium activated potassium channel	0.0026	0.0201	0.0325
Brugia malayi	orphan nuclear receptor NR2E1	0.0022	0.0172	0.0172
Echinococcus multilocularis	ecdysone induced protein 78C	0.0048	0.0398	0.0646
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0048	0.0398	0.0646
Echinococcus multilocularis	potassium voltage gated channel protein	0.0026	0.0201	0.0325
Schistosoma mansoni	voltage-gated potassium channel	0.0026	0.0201	0.0325
Brugia malayi	hypothetical protein	0.0005	0.0017	0.0016
Echinococcus multilocularis	nuclear receptor subfamily 1 group D	0.0025	0.0196	0.0319
Echinococcus multilocularis	neuropeptide s receptor	0.0005	0.0017	0.0027
Brugia malayi	Voltage-gated calcium channel, alpha subunit	0.0026	0.0201	0.02
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0005	0.0017	0.0027
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0048	0.0398	0.0398
Echinococcus granulosus	potassium large conductance calcium activated	0.0026	0.0201	0.0325
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0048	0.0398	0.0398
Loa Loa (eye worm)	G-protein coupled receptor	0.0005	0.0017	0.0016
Schistosoma mansoni	biogenic amine receptor	0.0005	0.0017	0.0027
Loa Loa (eye worm)	hypothetical protein	0.0005	0.0017	0.0016
Echinococcus granulosus	tyrosine protein kinase Lyn	0.0005	0.0014	0.0023
Schistosoma mansoni	nicotinate phosphoribosyltransferase related pre-B cell enhancing factor	0.0074	0.0637	0.1034
Brugia malayi	Tyrosine-protein kinase abl-1	0.0005	0.0014	0.0014
Echinococcus multilocularis	TRP (transient receptor potential) channel	0.0026	0.0201	0.0325
Echinococcus granulosus	NCK adaptor protein	0.0004	0.0009	0.0014
Echinococcus multilocularis	neuropeptide receptor	0.0005	0.0017	0.0027
Schistosoma mansoni	amine GPCR	0.0005	0.0017	0.0027
Loa Loa (eye worm)	nuclear receptor NHR-67	0.0022	0.0172	0.0172
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0201	0.02
Echinococcus multilocularis	transient receptor potential gamma protein	0.0026	0.0201	0.0325
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0048	0.0398	0.0646
Schistosoma mansoni	voltage-gated potassium channel KCNQ	0.0026	0.0201	0.0325
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0048	0.0398	0.0646
Echinococcus granulosus	sodium leak channel non selective protein	0.0026	0.0201	0.0325
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0201	0.02
Loa Loa (eye worm)	neuropeptide F receptor	0.0005	0.0017	0.0016
Brugia malayi	larval opioid receptor	0.0005	0.0017	0.0016
Schistosoma mansoni	hypothetical protein	0.0005	0.0017	0.0027
Brugia malayi	nuclear receptor NHR-88	0.0048	0.0398	0.0398
Echinococcus multilocularis	tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase	0.0005	0.0014	0.0023
Echinococcus granulosus	voltage gated hydrogen channel 1	0.0026	0.0201	0.0325
Brugia malayi	nuclear receptor NHR-88	0.0022	0.0172	0.0172
Schistosoma mansoni	biogenic amine receptor	0.0005	0.0017	0.0027
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0201	0.02
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0048	0.0398	0.0398
Echinococcus granulosus	rhodopsin orphan GPCR	0.0005	0.0017	0.0027
Echinococcus multilocularis	tyrosine protein kinase Src64B	0.0005	0.0014	0.0023
Echinococcus multilocularis	nicotinamide phosphoribosyltransferase	0.04	0.3567	0.5786
Schistosoma mansoni	voltage-gated potassium channel	0.0026	0.0201	0.0325
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0005	0.0017	0.0027
Schistosoma mansoni	neuropeptide F-like receptor	0.0005	0.0017	0.0027
Echinococcus granulosus	somatostatin receptor	0.0005	0.0017	0.0027
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0048	0.0398	0.0398
Echinococcus multilocularis	potassium voltage gated channel protein	0.0026	0.0201	0.0325
Brugia malayi	sulfakinin receptor protein	0.0005	0.0017	0.0016
Loa Loa (eye worm)	hypothetical protein	0.0005	0.0017	0.0016
Echinococcus granulosus	voltage dependent calcium channel type d subunit\|voltage dependent calcium channel\|voltage dependent L type calcium channel subu	0.0026	0.0201	0.0325
Loa Loa (eye worm)	hypothetical protein	0.0005	0.0017	0.0016
Echinococcus multilocularis	potassium voltage gated channel protein	0.0026	0.0201	0.0325
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0026	0.0201	0.5
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0005	0.0017	0.0027
Echinococcus multilocularis	proto oncogene tyrosine protein kinase LCK	0.0005	0.0014	0.0023
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0005	0.0017	0.0027
Schistosoma mansoni	voltage-gated potassium channel	0.0026	0.0201	0.0325
Brugia malayi	hypothetical protein	0.0025	0.0196	0.0196
Brugia malayi	neuropeptide F receptor	0.0005	0.0017	0.0016
Loa Loa (eye worm)	hypothetical protein	0.0005	0.0017	0.0016
Schistosoma mansoni	neuropeptide receptor	0.0005	0.0017	0.0027
Loa Loa (eye worm)	hypothetical protein	0.0005	0.0017	0.0016
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0005	0.0017	0.0016
Echinococcus multilocularis	voltage dependent L type calcium channel subunit	0.0026	0.0201	0.0325
Loa Loa (eye worm)	ryanodine receptor	0.0026	0.0201	0.02
Schistosoma mansoni	hyperpolarization activated cyclic nucleotide-gated potassium channel	0.0026	0.0201	0.0325
Schistosoma mansoni	adapter molecule crk	0.0004	0.0009	0.0014
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0005	0.0017	0.0027
Echinococcus multilocularis	potassium voltage gated channel subfamily D	0.0026	0.0201	0.0325
Brugia malayi	Ryanodine Receptor TM 4-6 family protein	0.0026	0.0201	0.02
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0005	0.0017	0.0027
Echinococcus granulosus	thyroid hormone receptor alpha	0.0022	0.0172	0.0279
Echinococcus granulosus	nuclear receptor subfamily 1 group D	0.0025	0.0196	0.0319
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0172	0.0172
Echinococcus granulosus	potassium channel KvQLT family member kqt 1	0.0026	0.0201	0.0325
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0005	0.0017	0.0027
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0048	0.0398	0.0646
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0201	0.02
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0026	0.0201	0.5
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0172	0.0172
Echinococcus multilocularis	cyclic nucleotide gated cation channel alpha 3	0.0026	0.0201	0.0325
Echinococcus granulosus	G protein coupled receptor 139	0.0005	0.0017	0.0027
Brugia malayi	nuclear receptor subfamily 1, group D, member 1, putative	0.0022	0.0172	0.0172
Brugia malayi	hypothetical protein	0.0025	0.0196	0.0196
Brugia malayi	G-protein coupled receptor	0.0005	0.0017	0.0016
Schistosoma mansoni	myosin xvIII	0.0005	0.0017	0.0027
Schistosoma mansoni	nck2/grb4	0.0004	0.0009	0.0014
Echinococcus multilocularis	dro:myosuppressin receptor	0.0005	0.0017	0.0027
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0201	0.02
Echinococcus multilocularis	tyrosine protein kinase Fgr	0.0005	0.0014	0.0023
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0005	0.0017	0.0027
Toxoplasma gondii	transporter, cation channel family protein	0.0026	0.0201	0.5
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0048	0.0398	0.0398
Echinococcus multilocularis	fmrfamide receptor	0.0005	0.0017	0.0027
Echinococcus multilocularis	short transient receptor potential channel 6	0.0026	0.0201	0.0325
Loa Loa (eye worm)	voltage-dependent calcium channel	0.0026	0.0201	0.02
Echinococcus multilocularis	g protein coupled receptor	0.0005	0.0017	0.0027
Brugia malayi	nuclear hormone receptor family member odr-7	0.0022	0.0172	0.0172
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0172	0.0172
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0005	0.0017	0.0027
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0005	0.0017	0.0027
Schistosoma mansoni	growth hormone secretagogue receptor	0.0005	0.0017	0.0027
Echinococcus granulosus	voltage dependent calcium channel	0.0026	0.0201	0.0325
Brugia malayi	nuclear receptor NHR-67	0.0022	0.0172	0.0172
Schistosoma mansoni	high voltage-activated calcium channel Cav2A	0.0026	0.0201	0.0325
Trichomonas vaginalis	nicotinate phosphoribosyltransferase, putative	0.0074	0.0637	1
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0048	0.0398	0.0398
Brugia malayi	ORL1-like opioid receptor	0.0005	0.0017	0.0016
Onchocerca volvulus		0.0048	0.0398	0.0621
Echinococcus granulosus	potassium voltage gated channel subfamily D	0.0026	0.0201	0.0325
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0005	0.0017	0.0027
Loa Loa (eye worm)	hypothetical protein	0.0005	0.0017	0.0016
Loa Loa (eye worm)	hypothetical protein	0.0005	0.0017	0.0016
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0201	0.02
Brugia malayi	G protein-coupled receptor	0.0005	0.0017	0.0016
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0201	0.02
Echinococcus multilocularis	voltage dependent L type calcium channel subunit	0.0026	0.0201	0.0325
Echinococcus multilocularis	potassium voltage gated channel subfamily H	0.0026	0.0201	0.0325
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0398	0.0398
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase src	0.0005	0.0014	0.0023
Brugia malayi	Pre-B cell enhancing factor precursor	0.04	0.3567	0.3567
Echinococcus granulosus	sodium channel protein	0.0026	0.0201	0.0325
Echinococcus granulosus	neuropeptide FF receptor 2	0.0005	0.0017	0.0027
Brugia malayi	Sex muscle abnormal protein 5	0.0004	0.0009	0.0008
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0398	0.0398
Echinococcus multilocularis	sodium leak channel non selective protein	0.0026	0.0201	0.0325
Loa Loa (eye worm)	hypothetical protein	0.1116	1	1
Loa Loa (eye worm)	neuropeptide F receptor	0.0005	0.0017	0.0016
Loa Loa (eye worm)	hypothetical protein	0.0005	0.0017	0.0016
Schistosoma mansoni	vesicular amine transporter	0.0026	0.0206	0.0334
Brugia malayi	hypothetical protein	0.0005	0.0017	0.0016
Echinococcus multilocularis	voltage gated potassium channel	0.0026	0.0201	0.0325
Brugia malayi	Large-conductance calcium-activated potassium channel Slo-1 (KCNMA) alpha subunit. C. elegans slo-1 ortholog	0.0026	0.0201	0.02
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0005	0.0017	0.0027
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0005	0.0017	0.0016
Echinococcus multilocularis	potassium:sodium hyperpolarization activated	0.0026	0.0201	0.0325
Echinococcus multilocularis	tyrosine protein kinase lyn tyrosine protein kinase blk	0.0005	0.0014	0.0023
Brugia malayi	RE15519p	0.0005	0.0017	0.0016
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0398	0.0398
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0005	0.0017	0.0027
Echinococcus multilocularis	potassium voltage gated channel subfamily C	0.0026	0.0201	0.0325
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0048	0.0398	0.0398
Schistosoma mansoni	voltage-gated cation channel	0.0026	0.0201	0.0325
Loa Loa (eye worm)	hypothetical protein	0.0005	0.0017	0.0016
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0005	0.0017	0.0027
Echinococcus granulosus	biogenic amine 5HT receptor	0.0005	0.0017	0.0027
Loa Loa (eye worm)	hypothetical protein	0.0005	0.0017	0.0016
Schistosoma mansoni	voltage-gated potassium channel	0.0026	0.0201	0.0325
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0005	0.0014	0.0023
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0005	0.0017	0.0027
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0048	0.0398	0.0646
Schistosoma mansoni	nuclear receptor nhr-48	0.0022	0.0172	0.0279
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0196	0.0196
Echinococcus granulosus	transient receptor potential cation channel	0.0026	0.0201	0.0325
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0005	0.0017	0.0027
Loa Loa (eye worm)	vesicular acetylcholine transporter unc-17	0.0689	0.6165	0.6165
Loa Loa (eye worm)	DR-78	0.0022	0.0172	0.0172
Schistosoma mansoni	neuropeptide receptor	0.0005	0.0017	0.0027
Echinococcus multilocularis	transient receptor potential cation channel	0.0026	0.0201	0.0325
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0398	0.0398
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0048	0.0398	0.0646
Echinococcus granulosus	neuropeptides capa receptor	0.0005	0.0017	0.0027
Schistosoma mansoni	transient receptor potential cation channel subfamily m member	0.0026	0.0201	0.0325
Loa Loa (eye worm)	hypothetical protein	0.0005	0.0017	0.0016
Entamoeba histolytica	nicotinate phosphoribosyltransferase, putative	0.0074	0.0637	1
Loa Loa (eye worm)	hypothetical protein	0.0005	0.0017	0.0016
Brugia malayi	voltage-dependent calcium channel	0.0026	0.0201	0.02
Brugia malayi	hypothetical protein	0.0005	0.0017	0.0016
Echinococcus multilocularis	potassium voltage gated channel subfamily H	0.0026	0.0201	0.0325
Schistosoma mansoni	tyrosine kinase	0.0005	0.0014	0.0023
Trypanosoma brucei	nicotinate phosphoribosyltransferase, putative	0.0074	0.0637	0.0446
Echinococcus multilocularis	FTZ F1 alpha	0.0048	0.0398	0.0646
Echinococcus granulosus	cyclic nucleotide gated cation channel alpha 3	0.0026	0.0201	0.0325
Echinococcus multilocularis	transient receptor potential cation channel	0.0026	0.0201	0.0325
Echinococcus granulosus	7TM GPCR rhodopsin	0.0005	0.0017	0.0027
Brugia malayi	Transient-receptor-potential like protein	0.0026	0.0201	0.02
Echinococcus granulosus	c src tyrosine kinase	0.0005	0.0014	0.0023
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0005	0.0017	0.0016
Loa Loa (eye worm)	hypothetical protein	0.0005	0.0017	0.0016
Echinococcus multilocularis	two pore calcium channel protein 1	0.0026	0.0201	0.0325
Schistosoma mansoni	voltage-gated potassium channel	0.0026	0.0201	0.0325
Schistosoma mansoni	neuropeptide F-like receptor	0.0005	0.0017	0.0027
Echinococcus multilocularis	voltage dependent calcium channel	0.0026	0.0201	0.0325
Echinococcus multilocularis	voltage gated hydrogen channel 1	0.0026	0.0201	0.0325
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0048	0.0398	0.0646
Echinococcus multilocularis	ryanodine receptor 44f	0.0026	0.0201	0.0325
Echinococcus granulosus	biogenic amine 5HT receptor	0.0005	0.0017	0.0027
Echinococcus multilocularis	cyclic nucleotide gated cation channel	0.0026	0.0201	0.0325
Schistosoma mansoni	growth factor receptor-bound protein	0.0004	0.0009	0.0014
Brugia malayi	Steroid receptor seven-up type 2	0.0048	0.0398	0.0398
Echinococcus multilocularis	conserved hypothetical protein	0.0026	0.0201	0.0325
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0005	0.0017	0.0016
Echinococcus multilocularis	g-protein coupled receptor	0.0005	0.0017	0.0027
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0172	0.0172
Loa Loa (eye worm)	hypothetical protein	0.0005	0.0017	0.0016
Loa Loa (eye worm)	melatonin receptor type 1A	0.0005	0.0017	0.0016
Loa Loa (eye worm)	hypothetical protein	0.0005	0.0017	0.0016
Brugia malayi	cation channel family protein	0.0026	0.0201	0.02
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0048	0.0398	0.0398
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0201	0.02
Echinococcus multilocularis	transient receptor potential cation channel	0.0026	0.0201	0.0325
Echinococcus multilocularis	hyperpolarization activated cyclic	0.0026	0.0201	0.0325
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0005	0.0017	0.0027
Echinococcus granulosus	potassium voltage gated channel protein	0.0026	0.0201	0.0325
Schistosoma mansoni	hypothetical protein	0.0005	0.0017	0.0027
Echinococcus granulosus	3'partial\|tyrosine protein kinase Fgr	0.0005	0.0014	0.0023
Loa Loa (eye worm)	G-protein coupled receptor	0.0005	0.0017	0.0016
Echinococcus multilocularis	neuropeptide Y receptor	0.0005	0.0017	0.0027
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0201	0.02
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0005	0.0017	0.0027
Brugia malayi	Variant SH3 domain containing protein	0.0004	0.0009	0.0008
Brugia malayi	hypothetical protein	0.0022	0.0172	0.0172
Schistosoma mansoni	transient receptor potential cation channel subfamily m member	0.0026	0.0201	0.0325
Echinococcus granulosus	7tm_1 domain containing protein	0.0005	0.0017	0.0027
Loa Loa (eye worm)	sex muscle abnormal protein 5	0.0004	0.0009	0.0008
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0005	0.0017	0.0016
Brugia malayi	Voltage-gated calcium channel, L-type, alpha subunit. C. elegans egl-19 ortholog	0.0026	0.0201	0.02
Brugia malayi	follicle stimulating hormone receptor	0.0005	0.0017	0.0016
Loa Loa (eye worm)	hypothetical protein	0.0005	0.0017	0.0016
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0048	0.0398	0.0646
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0025	0.0196	0.0319
Loa Loa (eye worm)	hypothetical protein	0.0005	0.0017	0.0016
Brugia malayi	Serotonin receptor	0.0005	0.0017	0.0016
Loa Loa (eye worm)	hypothetical protein	0.0004	0.0009	0.0008
Loa Loa (eye worm)	hypothetical protein	0.0005	0.0017	0.0016
Schistosoma mansoni	transient receptor potential channel 4	0.0026	0.0201	0.0325
Echinococcus granulosus	two pore calcium channel protein 1	0.0026	0.0201	0.0325
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0196	0.0196
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0201	0.02
Brugia malayi	hypothetical protein	0.0005	0.0017	0.0016
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0005	0.0017	0.0016
Onchocerca volvulus		0.0022	0.0172	0.0253
Echinococcus granulosus	hyperpolarization activated cyclic	0.0026	0.0201	0.0325
Echinococcus multilocularis	sex peptide receptor	0.0005	0.0017	0.0027
Loa Loa (eye worm)	pre-B cell enhancing factor	0.04	0.3567	0.3567
Echinococcus multilocularis	retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha	0.0022	0.0172	0.0279
Echinococcus granulosus	g protein coupled receptor	0.0005	0.0017	0.0027
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0048	0.0398	0.0398
Schistosoma mansoni	transient receptor potential channel	0.0026	0.0201	0.0325
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0005	0.0017	0.0027
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0201	0.02
Brugia malayi	nuclear hormone receptor	0.0048	0.0398	0.0398
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0196	0.0196
Loa Loa (eye worm)	TYRA-2 protein	0.0005	0.0017	0.0016
Echinococcus multilocularis	voltage dependent calcium channel type d subunit	0.0026	0.0201	0.0325
Schistosoma mansoni	tyrosine kinase	0.0118	0.103	0.1671
Echinococcus granulosus	potassium voltage gated channel subfamily D	0.0026	0.0201	0.0325
Echinococcus granulosus	allatostatin A receptor	0.0005	0.0017	0.0027
Onchocerca volvulus		0.0026	0.0201	0.0299
Loa Loa (eye worm)	hypothetical protein	0.0005	0.0017	0.0016
Brugia malayi	hypothetical protein	0.0005	0.0017	0.0016
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0048	0.0398	0.0646
Echinococcus granulosus	rhodopsin orphan GPCR	0.0005	0.0017	0.0027
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0005	0.0017	0.0016
Echinococcus multilocularis	neuropeptide receptor A26	0.0005	0.0017	0.0027
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0005	0.0017	0.0027
Echinococcus granulosus	potassium voltage gated channel subfamily A	0.0026	0.0201	0.0325
Echinococcus granulosus	neuropeptide receptor A26	0.0005	0.0017	0.0027
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0048	0.0398	0.0646
Loa Loa (eye worm)	hypothetical protein	0.0005	0.0017	0.0016
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0398	0.0398
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0005	0.0017	0.0027
Loa Loa (eye worm)	hypothetical protein	0.0005	0.0017	0.0016
Schistosoma mansoni	voltage-gated potassium channel	0.0026	0.0201	0.0325
Echinococcus granulosus	potassium voltage gated channel protein	0.0026	0.0201	0.0325
Echinococcus multilocularis	sodium channel protein	0.0026	0.0201	0.0325
Loa Loa (eye worm)	cyclic-nucleotide gated cation channel	0.0026	0.0201	0.02
Brugia malayi	Voltage-gated potassium channel, Shab-family (KCNB, Kv2-like) alpha-subunit	0.0026	0.0201	0.02
Schistosoma mansoni	transient receptor potential cation channel subfamily m member	0.0026	0.0201	0.0325
Schistosoma mansoni	cyclic-nucleotide-gated cation channel	0.0026	0.0201	0.0325
Schistosoma mansoni	cyclic-nucleotide-gated cation channel	0.0026	0.0201	0.0325
Echinococcus granulosus	rhodopsin orphan GPCR	0.0005	0.0017	0.0027
Brugia malayi	conserved hypotetical protein	0.0022	0.0172	0.0172
Brugia malayi	ecdysone receptor	0.0022	0.0172	0.0172
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0201	0.02
Schistosoma mansoni	growth factor receptor-bound protein	0.0004	0.0009	0.0014
Brugia malayi	hypothetical protein	0.0005	0.0017	0.0016
Brugia malayi	photoreceptor-specific nuclear receptor	0.0048	0.0398	0.0398
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0172	0.0172
Schistosoma mansoni	biogenic amine receptor	0.0005	0.0017	0.0027
Schistosoma mansoni	voltage-gated potassium channel	0.0026	0.0201	0.0325
Brugia malayi	hypothetical protein	0.0022	0.0172	0.0172
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0048	0.0398	0.0398
Loa Loa (eye worm)	hypothetical protein	0.0005	0.0017	0.0016
Brugia malayi	hypothetical protein	0.0005	0.0017	0.0016
Schistosoma mansoni	voltage-dependent calcium channel	0.0026	0.0201	0.0325
Schistosoma mansoni	transient receptor potential cation channel subfamily m member	0.0026	0.0201	0.0325
Schistosoma mansoni	voltage-gated potassium channel	0.0026	0.0201	0.0325
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0398	0.0398
Trypanosoma cruzi	C-8 sterol isomerase, putative	0.1116	1	1
Loa Loa (eye worm)	hypothetical protein	0.0005	0.0017	0.0016
Brugia malayi	Voltage-gated potassium channel, KCNQ (Kv7-like) alpha-subunit. C. elegans kqt-1 ortholog	0.0026	0.0201	0.02
Echinococcus multilocularis	potassium voltage gated channel subfamily D	0.0026	0.0201	0.0325
Schistosoma mansoni	vav2	0.0003	0	0.0001
Schistosoma mansoni	hyperpolarization activated cyclic nucleotide-gated potassium channel	0.0026	0.0201	0.0325
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0196	0.0196
Echinococcus multilocularis	transient receptor potential cation channel	0.0026	0.0201	0.0325
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0048	0.0398	0.0646
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0172	0.0172
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0048	0.0398	0.0646
Mycobacterium tuberculosis	Nicotinic acid phosphoribosyltransferase PncB1	0.0074	0.0637	0.5
Echinococcus granulosus	neuropeptide Y receptor	0.0005	0.0017	0.0027
Echinococcus multilocularis	potassium voltage gated channel subfamily A	0.0026	0.0201	0.0325
Trypanosoma cruzi	nicotinate phosphoribosyltransferase, putative	0.0074	0.0637	0.0446
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0005	0.0014	0.0023
Loa Loa (eye worm)	hypothetical protein	0.0005	0.0017	0.0016
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0005	0.0017	0.0027
Echinococcus granulosus	rhodopsin orphan GPCR	0.0005	0.0017	0.0027
Echinococcus granulosus	FTZ F1 alpha	0.0048	0.0398	0.0646
Schistosoma mansoni	amine GPCR	0.0005	0.0017	0.0027
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0005	0.0014	0.0023
Loa Loa (eye worm)	hypothetical protein	0.0005	0.0017	0.0016
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0398	0.0398
Echinococcus granulosus	voltage dependent L type calcium channel subunit\|voltage dependent calcium channel	0.0026	0.0201	0.0325
Loa Loa (eye worm)	hypothetical protein	0.0005	0.0017	0.0016
Echinococcus multilocularis	G protein coupled receptor 139	0.0005	0.0017	0.0027
Loa Loa (eye worm)	nuclear hormone receptor	0.0022	0.0172	0.0172
Schistosoma mansoni	transient receptor potential channel	0.0026	0.0201	0.0325
Echinococcus multilocularis	transient receptor potential cation channel	0.0026	0.0201	0.0325
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0201	0.02
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0005	0.0017	0.0027
Echinococcus multilocularis	somatostatin receptor	0.0005	0.0017	0.0027
Schistosoma mansoni	nuclear receptor	0.0022	0.0172	0.0279
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0048	0.0398	0.0398
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0005	0.0017	0.0016
Brugia malayi	ion channel NompC	0.0026	0.0201	0.02
Brugia malayi	Dopamine receptor	0.0005	0.0017	0.0016
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0201	0.02
Loa Loa (eye worm)	nuclear hormone receptor-like 1	0.0025	0.0196	0.0196
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0005	0.0017	0.0027
Loa Loa (eye worm)	voltage-gated potassium channel	0.0026	0.0201	0.02
Brugia malayi	nuclear receptor RXR	0.0022	0.0172	0.0172
Echinococcus granulosus	potassium:sodium hyperpolarization activated	0.0026	0.0201	0.0325
Schistosoma mansoni	voltage-gated potassium channel	0.0026	0.0201	0.0325
Brugia malayi	Dopamine receptor protein 2	0.0005	0.0017	0.0016
Schistosoma mansoni	tyrosine kinase	0.0005	0.0014	0.0023
Echinococcus granulosus	short transient receptor potential channel 6	0.0026	0.0201	0.0325
Echinococcus granulosus	rhodopsin orphan GPCR	0.0005	0.0017	0.0027
Echinococcus granulosus	short transient receptor potential channel 6	0.0026	0.0201	0.0325
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0005	0.0017	0.0027
Brugia malayi	putative neuropeptide receptor NPR1	0.0005	0.0017	0.0016
Echinococcus granulosus	serotonin receptor	0.0005	0.0017	0.0027
Echinococcus granulosus	transient receptor potential cation channel	0.0026	0.0201	0.0325
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0048	0.0398	0.0646
Schistosoma mansoni	inositol 145-trisphosphate receptor	0.0026	0.0201	0.0325
Echinococcus multilocularis	neuropeptide Y receptor	0.0005	0.0017	0.0027
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0005	0.0017	0.0027
Echinococcus multilocularis	hyperpolarization activated cyclic	0.0026	0.0201	0.0325
Echinococcus granulosus	sex peptide receptor	0.0005	0.0017	0.0027
Onchocerca volvulus	Vesicular acetylcholine transporter homolog	0.0689	0.6165	1
Echinococcus multilocularis	nuclear receptor subfamily 4 group A	0.0022	0.0172	0.0279
Echinococcus granulosus	neuropeptide receptor	0.0005	0.0017	0.0027
Echinococcus granulosus	Nuclear hormone receptor HR96	0.0022	0.0172	0.0279
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0201	0.02
Brugia malayi	Nuclear hormone receptor E75	0.0022	0.0172	0.0172
Brugia malayi	Nuclear hormone receptor-like 1	0.0025	0.0196	0.0196
Echinococcus granulosus	Potassium voltage gated channel protein Shaw	0.0026	0.0201	0.0325
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0172	0.0172
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0005	0.0017	0.0027
Schistosoma mansoni	RAR-like nuclear receptor	0.0048	0.0398	0.0646
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0048	0.0398	0.0646
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0005	0.0017	0.0027
Brugia malayi	GnHR receptor homolog	0.0005	0.0017	0.0016
Schistosoma mansoni	calcium channel voltage-dependent p/q type alpha 1a-related	0.0026	0.0201	0.0325
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase abl1	0.0004	0.0009	0.0014
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0005	0.0017	0.0027
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0005	0.0017	0.0027
Brugia malayi	ecdysteroid receptor	0.0048	0.0398	0.0398
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0005	0.0017	0.0027
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0022	0.0172	0.0279
Loa Loa (eye worm)	hypothetical protein	0.0005	0.0017	0.0016
Echinococcus granulosus	proto oncogene tyrosine protein kinase LCK	0.0005	0.0014	0.0023
Schistosoma mansoni	ecdysone-induced protein 78c (dr-78)	0.0025	0.0196	0.0319
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0005	0.0017	0.0027
Echinococcus granulosus	transient receptor potential cation channel	0.0026	0.0201	0.0325
Echinococcus granulosus	transient receptor potential cation channel	0.0026	0.0201	0.0325
Echinococcus granulosus	cyclic nucleotide gated cation channel	0.0026	0.0201	0.0325
Echinococcus granulosus	potassium voltage gated channel subfamily H	0.0026	0.0201	0.0325
Echinococcus granulosus	nicotinamide phosphoribosyltransferase	0.04	0.3567	0.5786
Brugia malayi	nuclear receptor RXR	0.0025	0.0196	0.0196
Leishmania major	nicotinate phosphoribosyltransferase, putative	0.0074	0.0637	0.0446
Echinococcus granulosus	voltage gated potassium channel	0.0026	0.0201	0.0325
Echinococcus multilocularis	serotonin receptor	0.0005	0.0017	0.0027
Loa Loa (eye worm)	steroid hormone receptor	0.0048	0.0398	0.0398
Onchocerca volvulus	Nuclear receptor subfamily 6 group A member 1 homolog	0.0022	0.0172	0.0253
Schistosoma mansoni	coup transcription factor	0.0048	0.0398	0.0646
Echinococcus granulosus	transient receptor potential cation channel	0.0026	0.0201	0.0325
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0005	0.0017	0.0027

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (functional)	= 2.1 uM	Antagonist activity at human NPBWR1 expressed in HEK293T cells co-expressing Galphaqi3 assessed as calcium release after 15 mins by FLIPR assay assay	ChEMBL.	23079522

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL2207116

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 1686895