Detailed information for compound 1701853

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 518.647 | Formula: C30H38N4O4
  • H donors: 1 H acceptors: 4 LogP: 4.25 Rotable bonds: 11
    Rule of 5 violations (Lipinski): 2
  • SMILES: CC(C[C@H]1CN(CCCC[C@@H]2CNC(=O)C(=O)N2Cc2ccccc2)C(=O)C(=O)N1Cc1ccccc1)C
  • InChi: 1S/C30H38N4O4/c1-22(2)17-26-21-32(29(37)30(38)34(26)20-24-13-7-4-8-14-24)16-10-9-15-25-18-31-27(35)28(36)33(25)19-23-11-5-3-6-12-23/h3-8,11-14,22,25-26H,9-10,15-21H2,1-2H3,(H,31,35)/t25-,26+/m1/s1
  • InChiKey: RNBARZSXAFLNLR-FTJBHMTQSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens ataxin 2 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni ap endonuclease 0.0019 0.0244 0.0207
Loa Loa (eye worm) glutathione reductase 0.0048 0.0951 0.1495
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0037 0.069 0.0819
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0017 0.0184 0.0184
Plasmodium falciparum serine repeat antigen 3 0.0037 0.069 0.1239
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0244 0.0097
Trypanosoma brucei trypanothione reductase 0.0048 0.0951 0.1878
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0037 0.069 0.0654
Brugia malayi Cathepsin L-like precursor 0.0183 0.4264 0.6688
Trypanosoma cruzi cysteine peptidase, putative 0.0183 0.4264 1
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0124 0.2815 0.6448
Schistosoma mansoni cpg binding protein 0.0031 0.0537 0.05
Giardia lamblia Cysteine protease 0.0037 0.069 0.329
Schistosoma mansoni tar DNA-binding protein 0.0064 0.1349 0.1316
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0244 0.0244
Plasmodium falciparum serine repeat antigen 8 0.0037 0.069 0.1239
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0037 0.069 0.329
Echinococcus multilocularis ETS transcription factor Elf 2 0.0011 0.0038 0.0038
Leishmania major cathepsin L-like protease 0.0183 0.4264 1
Echinococcus granulosus cpg binding protein 0.0031 0.0537 0.0537
Entamoeba histolytica cysteine protease, putative 0.0097 0.2139 0.4713
Entamoeba histolytica cysteine proteinase, putative 0.0124 0.2815 0.6395
Brugia malayi TAR-binding protein 0.0064 0.1349 0.2074
Giardia lamblia Cathepsin B precursor 0.0079 0.1721 1
Brugia malayi Ets-domain containing protein 0.0073 0.1574 0.243
Schistosoma mansoni cpg binding protein 0.0031 0.0537 0.05
Entamoeba histolytica cysteine protease, putative 0.0097 0.2139 0.4713
Brugia malayi cathepsin L precursor 0.0037 0.069 0.1031
Schistosoma mansoni cathepsin C 0.0037 0.069 0.0654
Toxoplasma gondii LsmAD domain-containing protein 0.003 0.0522 0.0829
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0183 0.4264 0.6609
Loa Loa (eye worm) cathepsin B 0.0079 0.1721 0.2707
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0183 0.4264 0.6609
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.0059 0.1227 0.1881
Giardia lamblia Cathepsin L precursor 0.0037 0.069 0.329
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0124 0.2815 0.4262
Schistosoma mansoni subfamily C1A non-peptidase homologue (C01 family) 0.0037 0.069 0.0654
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0017 0.0184 0.0231
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0183 0.4264 0.6609
Loa Loa (eye worm) hypothetical protein 0.0037 0.069 0.1085
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0097 0.2139 0.2108
Echinococcus granulosus thioredoxin glutathione reductase 0.0048 0.0951 0.0951
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0183 0.4264 1
Brugia malayi Cathepsin L-like precursor 0.0183 0.4264 0.6688
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0183 0.4264 1
Echinococcus granulosus ETS transcription factor Elf 5 0.0011 0.0038 0.0038
Plasmodium vivax dipeptidyl aminopeptidase 2, putative 0.0037 0.069 0.1239
Entamoeba histolytica cysteine protease, putative 0.0037 0.069 0.1108
Echinococcus granulosus tar DNA binding protein 0.0064 0.1349 0.1349
Trypanosoma cruzi cysteine peptidase, putative 0.0183 0.4264 1
Plasmodium falciparum serine repeat antigen 9 0.0037 0.069 0.1239
Giardia lamblia Cathepsin B precursor 0.0079 0.1721 1
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0097 0.2139 0.2108
Onchocerca volvulus 0.005 0.1005 0.135
Loa Loa (eye worm) hypothetical protein 0.0059 0.1227 0.193
Loa Loa (eye worm) hypothetical protein 0.0124 0.2815 0.4428
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0037 0.069 0.0819
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0183 0.4264 0.6708
Giardia lamblia Cathepsin B precursor 0.0037 0.069 0.329
Plasmodium falciparum cysteine proteinase falcipain 3 0.0183 0.4264 1
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0244 0.0384
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0183 0.4264 0.6609
Loa Loa (eye worm) hypothetical protein 0.0037 0.069 0.1085
Echinococcus granulosus cathepsin b 0.0174 0.4023 0.4023
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.0079 0.1721 0.3766
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0183 0.4264 0.6609
Schistosoma mansoni cathepsin F (C01 family) 0.0183 0.4264 0.4242
Trypanosoma cruzi cruzipain precursor, putative 0.0183 0.4264 1
Loa Loa (eye worm) hypothetical protein 0.0037 0.069 0.1085
Echinococcus multilocularis cysteine protease 0.0183 0.4264 0.4264
Brugia malayi glutaminase DH11.1 0.0269 0.6357 1
Loa Loa (eye worm) D-ets-2 protein 0.0011 0.0038 0.006
Giardia lamblia Cathepsin B precursor 0.0037 0.069 0.329
Echinococcus granulosus ETS transcription factor Elf 2 0.0011 0.0038 0.0038
Trichomonas vaginalis conserved hypothetical protein 0.0037 0.069 0.0819
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0109 0.2453 0.8837
Echinococcus multilocularis tumor protein p63 0.0343 0.8158 0.8158
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0037 0.069 0.0654
Loa Loa (eye worm) hypothetical protein 0.0124 0.2815 0.4428
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0037 0.069 0.329
Entamoeba histolytica cysteine protease, putative 0.0097 0.2139 0.4713
Onchocerca volvulus Cathepsin L homolog 0.0183 0.4264 1
Trypanosoma brucei cysteine peptidase C (CPC) 0.0079 0.1721 0.3766
Toxoplasma gondii cathepsin B 0.0079 0.1721 0.3766
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0183 0.4264 0.6609
Entamoeba histolytica cysteine proteinase, putative 0.0183 0.4264 1
Plasmodium vivax dipeptidyl aminopeptidase 3, putative 0.0037 0.069 0.1239
Echinococcus multilocularis cathepsin L cysteine protease 0.0183 0.4264 0.4264
Echinococcus granulosus cathepsin L 0.0037 0.069 0.069
Giardia lamblia Cathepsin B precursor 0.0037 0.069 0.329
Entamoeba histolytica cysteine protease, putative 0.0097 0.2139 0.4713
Toxoplasma gondii cathepsin CPC2 0.0037 0.069 0.1239
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.0037 0.069 0.0654
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0183 0.4264 0.6609
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0097 0.2139 0.3166
Loa Loa (eye worm) hypothetical protein 0.0011 0.0038 0.006
Entamoeba histolytica cysteine proteinase, putative 0.0097 0.2139 0.4713
Onchocerca volvulus 0.0183 0.4264 1
Brugia malayi cathepsin Z-like cysteine proteinase 0.0037 0.069 0.1031
Loa Loa (eye worm) hypothetical protein 0.0037 0.069 0.1085
Echinococcus multilocularis cathepsin b 0.0174 0.4023 0.4023
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0079 0.1721 0.1689
Echinococcus multilocularis GA binding protein alpha chain 0.0073 0.1574 0.1574
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0037 0.069 0.0819
Echinococcus multilocularis ETS transcription factor Elf 5 0.0011 0.0038 0.0038
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0097 0.2139 0.3166
Schistosoma mansoni hypothetical protein 0.0014 0.0112 0.0074
Trypanosoma cruzi PAB1-binding protein , putative 0.003 0.0522 0.0829
Entamoeba histolytica cysteine protease, putative 0.0097 0.2139 0.4713
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0124 0.2815 0.4262
Giardia lamblia Cathepsin L precursor 0.0037 0.069 0.329
Plasmodium falciparum serine repeat antigen 2 0.0037 0.069 0.1239
Brugia malayi Papain family cysteine protease containing protein 0.0097 0.2139 0.3324
Entamoeba histolytica cysteine protease, putative 0.0097 0.2139 0.4713
Loa Loa (eye worm) hypothetical protein 0.005 0.1005 0.158
Loa Loa (eye worm) hypothetical protein 0.0124 0.2815 0.4428
Leishmania major cathepsin L-like protease 0.0183 0.4264 1
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0174 0.4023 0.4
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0037 0.069 0.0654
Brugia malayi Fli-1 protein 0.0223 0.523 0.8218
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0109 0.2453 0.8837
Giardia lamblia Cathepsin L precursor 0.0037 0.069 0.329
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0097 0.2139 0.4791
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0019 0.0244 0.0147
Echinococcus multilocularis ETS transcription factor Elf 1 0.0011 0.0038 0.0038
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.0011 0.0038 0.006
Loa Loa (eye worm) hypothetical protein 0.0059 0.1227 0.193
Entamoeba histolytica cysteine protease, putative 0.0097 0.2139 0.4713
Trichomonas vaginalis conserved hypothetical protein 0.0037 0.069 0.0819
Plasmodium vivax serine-repeat antigen 5 (SERA) 0.0037 0.069 0.1239
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0019 0.0244 1
Loa Loa (eye worm) hypothetical protein 0.0037 0.069 0.1085
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0244 0.0097
Echinococcus multilocularis cpg binding protein 0.0031 0.0537 0.0537
Trichomonas vaginalis Clan CA, family C1, cathepsin L or H-like cysteine peptidase 0.0037 0.069 0.0819
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0037 0.069 0.0654
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0183 0.4264 0.6708
Echinococcus granulosus cathepsin b 0.0174 0.4023 0.4023
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0183 0.4264 0.6609
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0183 0.4264 0.6609
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0037 0.069 0.1239
Trypanosoma cruzi cysteine peptidase, putative 0.0183 0.4264 1
Brugia malayi Cathepsin L-like precursor 0.0124 0.2815 0.4394
Plasmodium vivax serine-repeat antigen 4 (SERA), putative 0.0037 0.069 0.1239
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0017 0.0184 0.5
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0183 0.4264 1
Schistosoma mansoni ets-related 0.0223 0.523 0.5212
Trypanosoma cruzi PAB1-binding protein , putative 0.003 0.0522 0.0829
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0014 0.0112 0.0112
Echinococcus granulosus cathepsin l cysteine peptidase 0.0183 0.4264 0.4264
Schistosoma mansoni tar DNA-binding protein 0.0064 0.1349 0.1316
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0037 0.069 0.0654
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0037 0.069 0.329
Echinococcus granulosus ETS transcription factor Elf 2 0.0011 0.0038 0.0038
Onchocerca volvulus 0.0183 0.4264 1
Giardia lamblia Cysteine protease 0.0037 0.069 0.329
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.0496 0.078
Entamoeba histolytica cysteine protease, putative 0.0097 0.2139 0.4713
Mycobacterium tuberculosis Probable reductase 0.0109 0.2453 0.8837
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0019 0.0244 0.0147
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0019 0.0244 0.0147
Schistosoma mansoni ap endonuclease 0.0019 0.0244 0.0207
Loa Loa (eye worm) hypothetical protein 0.0183 0.4264 0.6708
Brugia malayi Papain family cysteine protease containing protein 0.0037 0.069 0.1031
Giardia lamblia Cathepsin B precursor 0.0037 0.069 0.329
Leishmania major cathepsin L-like protease 0.0183 0.4264 1
Giardia lamblia Cathepsin B precursor 0.0037 0.069 0.329
Toxoplasma gondii preprocathepsin c precursor, putative 0.0037 0.069 0.1239
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0019 0.0244 0.0234
Echinococcus multilocularis ETS domain containing protein Elk 1 0.0011 0.0038 0.0038
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0097 0.2139 0.2108
Entamoeba histolytica cysteine protease, putative 0.0037 0.069 0.1108
Echinococcus multilocularis ETS transcription factor Elf 2 0.0011 0.0038 0.0038
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0037 0.069 0.0654
Giardia lamblia Cathepsin L-like protease 0.0037 0.069 0.329
Echinococcus granulosus tumor protein p63 0.0343 0.8158 0.8158
Brugia malayi Ets-domain containing protein 0.0073 0.1574 0.243
Plasmodium falciparum dipeptidyl aminopeptidase 1 0.0037 0.069 0.1239
Schistosoma mansoni cathepsin F (C01 family) 0.0183 0.4264 0.4242
Trypanosoma cruzi major cysteine proteinase, putative 0.0037 0.069 0.1239
Brugia malayi fibroinase precursor 0.0037 0.069 0.1031
Brugia malayi cathepsin L-like cysteine proteinase 0.0037 0.069 0.1031
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0017 0.0184 0.0184
Plasmodium vivax serine-repeat antigen (SERA) 0.0037 0.069 0.1239
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0183 0.4264 0.6609
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0109 0.2453 0.8837
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0037 0.069 0.0654
Loa Loa (eye worm) hypothetical protein 0.0037 0.069 0.1085
Brugia malayi hypothetical protein 0.002 0.0259 0.0348
Echinococcus multilocularis cathepsin b 0.0174 0.4023 0.4023
Loa Loa (eye worm) hypothetical protein 0.0011 0.0038 0.006
Leishmania major cathepsin L-like protease 0.0183 0.4264 1
Loa Loa (eye worm) ets-domain-containing protein 0.0011 0.0038 0.006
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0174 0.4023 0.4
Schistosoma mansoni gabp alpha 0.0073 0.1574 0.1541
Brugia malayi hypothetical protein 0.003 0.0522 0.0766
Trichomonas vaginalis Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase 0.0037 0.069 0.0819
Loa Loa (eye worm) RNA binding protein 0.0064 0.1349 0.2122
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0012 0.0076 0.006
Giardia lamblia Cathepsin L precursor 0.0037 0.069 0.329
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0037 0.069 0.0819
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.0073 0.1574 0.2476
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0037 0.069 0.0819
Schistosoma mansoni cathepsin s 0.0059 0.1227 0.1193
Giardia lamblia Encystation-specific protease 0.0037 0.069 0.329
Echinococcus granulosus ewsr:fli fusion protein type 0.0011 0.0038 0.0038
Echinococcus granulosus cathepsin l1 0.0124 0.2815 0.2815
Treponema pallidum exodeoxyribonuclease (exoA) 0.0019 0.0244 1
Onchocerca volvulus 0.0124 0.2815 0.6155
Loa Loa (eye worm) cysteine proteinase cathepsin Z 0.0037 0.069 0.1085
Brugia malayi glutathione reductase 0.0048 0.0951 0.1444
Leishmania major cathepsin L-like protease 0.0183 0.4264 1
Giardia lamblia Cathepsin L precursor 0.0037 0.069 0.329
Echinococcus multilocularis cysteine protease 0.0183 0.4264 0.4264
Plasmodium falciparum thioredoxin reductase 0.0048 0.0951 0.1878
Brugia malayi Papain family cysteine protease containing protein 0.0037 0.069 0.1031
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0183 0.4264 1
Toxoplasma gondii cathepsin CPC1 0.0037 0.069 0.1239
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0037 0.069 0.0819
Brugia malayi Cathepsin L-like precursor 0.0183 0.4264 0.6688
Trypanosoma cruzi cysteine proteinase, putative 0.0097 0.2139 0.4791
Giardia lamblia Cathepsin L precursor 0.0037 0.069 0.329
Echinococcus multilocularis cathepsin L 0.0037 0.069 0.069
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0037 0.069 0.0819
Plasmodium vivax serine-repeat antigen (SERA) 0.0037 0.069 0.1239
Loa Loa (eye worm) hypothetical protein 0.0059 0.1227 0.193
Schistosoma mansoni tar DNA-binding protein 0.0064 0.1349 0.1316
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0183 0.4264 1
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0037 0.069 0.0819
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0183 0.4264 0.6609
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0079 0.1721 0.2489
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0183 0.4264 0.6609
Echinococcus granulosus cathepsin L cysteine proteinase 0.0183 0.4264 0.4264
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0183 0.4264 1
Onchocerca volvulus 0.0183 0.4264 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0183 0.4264 0.6609
Leishmania major cathepsin L-like protease 0.0183 0.4264 1
Echinococcus multilocularis cathepsin L cysteine protease 0.0183 0.4264 0.4264
Brugia malayi RNA recognition motif domain containing protein 0.0064 0.1349 0.2074
Trypanosoma cruzi major cysteine proteinase, putative 0.0037 0.069 0.1239
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0183 0.4264 0.6609
Trypanosoma cruzi cysteine proteinase, putative 0.0097 0.2139 0.4791
Plasmodium vivax unspecified product 0.0097 0.2139 0.4791
Entamoeba histolytica cysteine protease, putative 0.0037 0.069 0.1108
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0183 0.4264 1
Giardia lamblia Cathepsin L-like protease 0.0037 0.069 0.329
Plasmodium vivax dipeptidyl aminopeptidase 1, putative 0.0037 0.069 0.1239
Brugia malayi Cathepsin L-like precursor 0.0059 0.1227 0.1881
Trypanosoma cruzi cysteine peptidase, putative 0.0059 0.1227 0.2556
Schistosoma mansoni cathepsin F (C01 family) 0.0124 0.2815 0.2787
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0122 0.2751 1
Plasmodium falciparum serine repeat antigen 5 0.0037 0.069 0.1239
Trypanosoma cruzi cysteine protease, putative 0.0097 0.2139 0.4791
Plasmodium vivax unspecified product 0.0059 0.1227 0.2556
Echinococcus granulosus ETS transcription factor Elf 1 0.0011 0.0038 0.0038
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.0174 0.4023 0.4
Trypanosoma brucei PAB1-binding protein , putative 0.003 0.0522 0.0829
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0183 0.4264 0.6609
Schistosoma mansoni tar DNA-binding protein 0.0064 0.1349 0.1316
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0037 0.069 0.0819
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0244 0.0147
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0183 0.4264 1
Onchocerca volvulus Cathepsin L homolog 0.0183 0.4264 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0183 0.4264 0.6609
Loa Loa (eye worm) fibroinase 0.0183 0.4264 0.6708
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0183 0.4264 0.6609
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0244 0.0147
Schistosoma mansoni hypothetical protein 0.0418 1 1
Entamoeba histolytica cysteine protease, putative 0.0037 0.069 0.1108
Brugia malayi cathepsin Z-like cysteine proteinase 0.0037 0.069 0.1031
Echinococcus multilocularis dnaJ subfamily B 0.0418 1 1
Onchocerca volvulus 0.0183 0.4264 1
Leishmania major cysteine peptidase A (CPA) 0.0183 0.4264 1
Trypanosoma cruzi cruzipain precursor, putative 0.0059 0.1227 0.2556
Brugia malayi Papain family cysteine protease containing protein 0.0097 0.2139 0.3324
Plasmodium vivax vivapain-3 0.0097 0.2139 0.4791
Echinococcus multilocularis ewsr:fli fusion protein type 0.0011 0.0038 0.0038
Plasmodium vivax glutathione reductase, putative 0.0048 0.0951 0.1878
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.0244 0.0147
Echinococcus granulosus cathepsin L 0.0097 0.2139 0.2139
Entamoeba histolytica cysteine protease, putative 0.0097 0.2139 0.4713
Onchocerca volvulus Cathepsin L homolog 0.0037 0.069 0.0515
Trichomonas vaginalis Clan CA, family C1, cathepsin F-like cysteine peptidase 0.0037 0.069 0.0819
Plasmodium falciparum serine repeat antigen 1 0.0037 0.069 0.1239
Toxoplasma gondii exonuclease III APE 0.0019 0.0244 0.0147
Echinococcus multilocularis protein C ets 2 0.0011 0.0038 0.0038
Brugia malayi cathepsin L-like precursor 0.0124 0.2815 0.4394
Entamoeba histolytica cysteine proteinase, putative 0.0097 0.2139 0.4713
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0037 0.069 0.0819
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0109 0.2453 0.8837
Schistosoma mansoni cathepsin B (C01 family) 0.0037 0.069 0.0654
Brugia malayi Cathepsin L-like precursor 0.0183 0.4264 0.6688
Echinococcus granulosus GA binding protein alpha chain 0.0073 0.1574 0.1574
Entamoeba histolytica cysteine protease, putative 0.0097 0.2139 0.4713
Entamoeba histolytica cysteine proteinase, putative 0.0097 0.2139 0.4713
Loa Loa (eye worm) DNA-binding protein D-ETS-3 0.0011 0.0038 0.006
Brugia malayi Cathepsin L-like cysteine proteinase 0.0124 0.2815 0.4394
Schistosoma mansoni cathepsin S (C01 family) 0.0037 0.069 0.0654
Schistosoma mansoni tar DNA-binding protein 0.0064 0.1349 0.1316
Trypanosoma cruzi cysteine peptidase, putative 0.0183 0.4264 1
Giardia lamblia Hypothetical protein 0.0037 0.069 0.329
Brugia malayi cathepsin F-like cysteine proteinase 0.0059 0.1227 0.1881
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0019 0.0244 0.0097
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0183 0.4264 0.6609
Echinococcus granulosus protein C ets 2 0.0011 0.0038 0.0038
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0183 0.4264 1
Plasmodium falciparum serine repeat antigen 4 0.0037 0.069 0.1239
Brugia malayi Papain family cysteine protease containing protein 0.0183 0.4264 0.6688
Onchocerca volvulus 0.0183 0.4264 1
Loa Loa (eye worm) hypothetical protein 0.0063 0.1313 0.2066
Loa Loa (eye worm) fli-1 protein 0.0223 0.523 0.8228
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0183 0.4264 1
Entamoeba histolytica cysteine proteinase 2 0.0097 0.2139 0.4713
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0037 0.069 0.1239
Entamoeba histolytica cysteine protease, putative 0.0183 0.4264 1
Echinococcus granulosus cysteine protease 0.0097 0.2139 0.2139
Loa Loa (eye worm) TAR-binding protein 0.0064 0.1349 0.2122
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0183 0.4264 0.4264
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0037 0.069 0.1085
Plasmodium vivax ataxin-2 like protein, putative 0.003 0.0522 0.0829
Plasmodium falciparum dipeptidyl aminopeptidase 2 0.0037 0.069 0.1239
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0122 0.2751 1
Loa Loa (eye worm) hypothetical protein 0.0174 0.4023 0.6328
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0244 0.0326
Plasmodium falciparum glutathione reductase 0.0048 0.0951 0.1878
Brugia malayi cathepsin F-like cysteine proteinase 0.0037 0.069 0.1031
Echinococcus multilocularis cathepsin L 0.0097 0.2139 0.2139
Plasmodium falciparum ataxin-2 like protein, putative 0.003 0.0522 0.0829
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0174 0.4023 0.4
Entamoeba histolytica cysteine protease, putative 0.0037 0.069 0.1108
Loa Loa (eye worm) thioredoxin reductase 0.0048 0.0951 0.1495
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0183 0.4264 1
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0059 0.1227 0.193
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0064 0.1349 0.2122
Brugia malayi CXXC zinc finger family protein 0.0029 0.0496 0.0724
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0183 0.4264 0.6609
Brugia malayi Cathepsin L-like precursor 0.0124 0.2815 0.4394
Brugia malayi Cathepsin L-like precursor 0.0183 0.4264 0.6688
Plasmodium falciparum cysteine proteinase falcipain 1 0.0097 0.2139 0.4791
Plasmodium vivax serine-repeat antigen 4 (SERA) 0.0037 0.069 0.1239
Entamoeba histolytica cysteine proteinase, putative 0.0097 0.2139 0.4713
Brugia malayi Papain family cysteine protease containing protein 0.0037 0.069 0.1031
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0174 0.4023 0.9409
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0183 0.4264 0.4264
Brugia malayi RNA binding protein 0.0064 0.1349 0.2074
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0037 0.069 0.0819
Plasmodium falciparum dipeptidyl aminopeptidase 3 0.0037 0.069 0.1239
Plasmodium vivax thioredoxin reductase, putative 0.0048 0.0951 0.1878
Leishmania major cathepsin L-like protease 0.0183 0.4264 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0097 0.2139 0.4791
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0183 0.4264 0.6609
Echinococcus granulosus cathepsin l1 0.0183 0.4264 0.4264
Echinococcus granulosus ETS domain containing protein Elk 1 0.0011 0.0038 0.0038
Onchocerca volvulus 0.0183 0.4264 1
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0014 0.0112 0.0112
Plasmodium vivax serine-repeat antigen 2 (SERA) 0.0037 0.069 0.1239
Trichomonas vaginalis glutaminase, putative 0.0269 0.6357 1
Plasmodium falciparum serine repeat antigen 6 0.0037 0.069 0.1239
Toxoplasma gondii cathepsin CPL 0.0183 0.4264 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0183 0.4264 0.6609
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0097 0.2139 0.4791
Echinococcus multilocularis thioredoxin glutathione reductase 0.0048 0.0951 0.0951
Loa Loa (eye worm) glutaminase 2 0.0269 0.6357 1
Entamoeba histolytica cysteine protease, putative 0.0097 0.2139 0.4713
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0183 0.4264 0.6609
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0122 0.2751 1
Loa Loa (eye worm) cysteine protease 0.0183 0.4264 0.6708
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0037 0.069 0.0819
Entamoeba histolytica cysteine protease, putative 0.0097 0.2139 0.4713
Schistosoma mansoni cpg binding protein 0.0029 0.0496 0.0459
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0183 0.4264 0.6609
Brugia malayi cathepsin B-like cysteine proteinase 0.0174 0.4023 0.6306
Brugia malayi cahepsin L-like non-peptiedase homolog 0.0037 0.069 0.1031
Plasmodium vivax unspecified product 0.0037 0.069 0.1239
Trypanosoma cruzi trypanothione reductase, putative 0.0048 0.0951 0.1878
Loa Loa (eye worm) hypothetical protein 0.003 0.0522 0.0822
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0037 0.069 0.1108
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0079 0.1721 0.3766
Plasmodium vivax vivapain-1 0.0097 0.2139 0.4791
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0048 0.0951 0.2985
Mycobacterium ulcerans glutaminase 0.0269 0.6357 1
Trypanosoma cruzi cysteine peptidase, putative 0.0097 0.2139 0.4791
Toxoplasma gondii histone lysine methyltransferase SET1 0.0056 0.1138 0.2337
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0183 0.4264 0.6609
Toxoplasma gondii thioredoxin reductase 0.0048 0.0951 0.1878
Giardia lamblia Cysteine protease 0.0037 0.069 0.329
Entamoeba histolytica hypothetical protein 0.0037 0.069 0.1108
Plasmodium falciparum serine repeat antigen 7 0.0037 0.069 0.1239
Onchocerca volvulus 0.0037 0.069 0.0515
Echinococcus granulosus cathepsin L cysteine protease 0.0097 0.2139 0.2139
Mycobacterium tuberculosis Probable oxidoreductase 0.0122 0.2751 1
Schistosoma mansoni glutaminase 0.0269 0.6357 0.6343
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0183 0.4264 1
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0017 0.0184 0.0146
Giardia lamblia Hypothetical protein 0.0037 0.069 0.329
Entamoeba histolytica cysteine proteinase 1, putative 0.0097 0.2139 0.4713
Leishmania major hypothetical protein, conserved 0.003 0.0522 0.0829
Entamoeba histolytica cysteine proteinase, putative 0.0183 0.4264 1
Leishmania major trypanothione reductase 0.0048 0.0951 0.1878
Leishmania major cathepsin L-like protease 0.0183 0.4264 1
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0244 0.0244
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0183 0.4264 1
Schistosoma mansoni cellular tumor antigen P53 0.005 0.1005 0.097
Echinococcus multilocularis ets variant gene 4 0.0011 0.0038 0.0038
Giardia lamblia Cathepsin B precursor 0.0079 0.1721 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0183 0.4264 0.6609
Echinococcus multilocularis tar DNA binding protein 0.0064 0.1349 0.1349
Plasmodium vivax vivapain-2 0.0183 0.4264 1
Giardia lamblia Cysteine protease 0.0037 0.069 0.329
Mycobacterium tuberculosis Probable dehydrogenase 0.0109 0.2453 0.8837
Brugia malayi Thioredoxin reductase 0.0048 0.0951 0.1444
Plasmodium falciparum ataxin-2 like protein, putative 0.003 0.0522 0.0829
Trichomonas vaginalis Clan CA, family C1, cathepsin H-like cysteine peptidase 0.0037 0.069 0.0819
Onchocerca volvulus 0.0183 0.4264 1
Onchocerca volvulus Cathepsin F homolog 0.0183 0.4264 1
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0019 0.0244 0.0391
Giardia lamblia Cathepsin B-like cysteine proteinase 3 precursor 0.0037 0.069 0.329
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0037 0.069 0.1085
Plasmodium vivax serine-repeat antigen 3 (SERA) 0.0037 0.069 0.1239
Loa Loa (eye worm) glutaminase 0.0269 0.6357 1
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0037 0.069 0.1108
Plasmodium vivax vivapain-2 0.0183 0.4264 1
Brugia malayi Cathepsin L-like precursor 0.0183 0.4264 0.6688
Entamoeba histolytica cysteine protease, putative 0.0037 0.069 0.1108
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0037 0.069 0.0819
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0062 0.13 0.1267
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0012 0.0076 0.006
Entamoeba histolytica cysteine protease, putative 0.0097 0.2139 0.4713
Loa Loa (eye worm) ctsf protein 0.0183 0.4264 0.6708

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 10 uM PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.