Detailed information for compound 1706891

Basic information

Technical information
  • TDR Targets ID: 1706891
  • Name: 2-(1H-indol-3-yl)-N-methyl-2-oxo-N-(phenylmet hyl)acetamide
  • MW: 292.332 | Formula: C18H16N2O2
  • H donors: 1 H acceptors: 2 LogP: 2.88 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: CN(C(=O)C(=O)c1c[nH]c2c1cccc2)Cc1ccccc1
  • InChi: 1S/C18H16N2O2/c1-20(12-13-7-3-2-4-8-13)18(22)17(21)15-11-19-16-10-6-5-9-14(15)16/h2-11,19H,12H2,1H3
  • InChiKey: DMYXHLDUOCLXTK-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-(benzyl)-2-(1H-indol-3-yl)-2-keto-N-methyl-acetamide
  • 2-(1H-indol-3-yl)-N-methyl-2-oxo-N-(phenylmethyl)ethanamide
  • 57547-34-9
  • ZINC01734526
  • NSC149577
  • BAS 00234544
  • N-Benzyl-2-(1H-indol-3-yl)-N-methyl-2-oxo-acetamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0878 0.4674 0.4054
Loa Loa (eye worm) hypothetical protein 0.0319 0.1071 0.1071
Echinococcus granulosus acetylcholine receptor subunit beta 1 0.0319 0.1071 0.1071
Loa Loa (eye worm) hypothetical protein 0.0166 0.0087 0.0087
Echinococcus multilocularis neuronal acetylcholine receptor subunit alpha 4 0.0319 0.1071 0.1071
Schistosoma mansoni cathepsin F (C01 family) 0.1705 1 1
Plasmodium falciparum cysteine proteinase falcipain 3 0.1705 1 1
Echinococcus multilocularis cathepsin l cysteine peptidase 0.1705 1 1
Onchocerca volvulus 0.1705 1 1
Loa Loa (eye worm) hypothetical protein 0.0319 0.1071 0.1071
Loa Loa (eye worm) papain family cysteine protease containing protein 0.1705 1 1
Entamoeba histolytica cysteine proteinase, putative 0.1705 1 1
Onchocerca volvulus Cathepsin L homolog 0.1705 1 1
Loa Loa (eye worm) hypothetical protein 0.0166 0.0087 0.0087
Entamoeba histolytica cysteine protease, putative 0.0878 0.4674 0.4627
Onchocerca volvulus 0.1705 1 1
Plasmodium vivax tryptophan-rich antigen (Pv-fam-a) 0.0653 0.3221 0.2432
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0315 0.1043 0.1043
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0319 0.1071 0.1071
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.1705 1 1
Schistosoma mansoni cathepsin s 0.0564 0.2647 0.2647
Brugia malayi cathepsin L-like precursor 0.1141 0.6369 0.6369
Loa Loa (eye worm) hypothetical protein 0.0315 0.1043 0.1043
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1705 1 1
Leishmania major cysteine peptidase A (CPA) 0.1705 1 1
Trypanosoma cruzi cysteine proteinase, putative 0.0878 0.4674 0.4054
Loa Loa (eye worm) hypothetical protein 0.0319 0.1071 0.1071
Brugia malayi Papain family cysteine protease containing protein 0.1705 1 1
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0315 0.1043 0.1043
Giardia lamblia Cathepsin L precursor 0.0315 0.1043 0.5
Loa Loa (eye worm) hypothetical protein 0.0319 0.1071 0.1071
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0878 0.4674 0.4054
Onchocerca volvulus 0.0315 0.1043 0.1043
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1705 1 1
Plasmodium vivax vivapain-3 0.0878 0.4674 0.4054
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.1705 1 1
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0319 0.1071 0.1071
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.1705 1 1
Loa Loa (eye worm) hypothetical protein 0.0319 0.1071 0.1071
Loa Loa (eye worm) hypothetical protein 0.0564 0.2647 0.2647
Loa Loa (eye worm) hypothetical protein 0.0166 0.0087 0.0087
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0166 0.0087 0.0087
Entamoeba histolytica cysteine proteinase, putative 0.1141 0.6369 0.6337
Brugia malayi cathepsin F-like cysteine proteinase 0.0315 0.1043 0.1043
Giardia lamblia Cathepsin L precursor 0.0315 0.1043 0.5
Echinococcus granulosus geminin 0.0205 0.0334 0.0334
Entamoeba histolytica cysteine protease, putative 0.1705 1 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1705 1 1
Entamoeba histolytica cysteine protease, putative 0.0315 0.1043 0.0964
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1705 1 1
Onchocerca volvulus 0.1705 1 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1705 1 1
Brugia malayi acetylcholine receptor, alpha-type subunit unc-38 precursor 0.0319 0.1071 0.1071
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1705 1 1
Brugia malayi Cathepsin L-like precursor 0.1141 0.6369 0.6369
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0319 0.1071 0.1071
Loa Loa (eye worm) fibroinase 0.1705 1 1
Giardia lamblia Cathepsin B precursor 0.0315 0.1043 0.5
Loa Loa (eye worm) hypothetical protein 0.0166 0.0087 0.0087
Loa Loa (eye worm) nicotinic acetylcholine receptor alpha subunit 0.0319 0.1071 0.1071
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0319 0.1071 0.1071
Entamoeba histolytica cysteine protease, putative 0.0315 0.1043 0.0964
Loa Loa (eye worm) hypothetical protein 0.0319 0.1071 0.1071
Onchocerca volvulus Cathepsin L homolog 0.0315 0.1043 0.1043
Echinococcus granulosus cathepsin L 0.0315 0.1043 0.1043
Brugia malayi cathepsin Z-like cysteine proteinase 0.0315 0.1043 0.1043
Giardia lamblia Cathepsin L precursor 0.0315 0.1043 0.5
Onchocerca volvulus 0.1705 1 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.1705 1 1
Brugia malayi Papain family cysteine protease containing protein 0.0878 0.4674 0.4674
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0319 0.1071 0.1071
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1705 1 1
Onchocerca volvulus 0.0166 0.0087 0.0087
Echinococcus granulosus glycine receptor subunit alpha 1 0.0319 0.1071 0.1071
Loa Loa (eye worm) hypothetical protein 0.0564 0.2647 0.2647
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.1705 1 1
Loa Loa (eye worm) hypothetical protein 0.0319 0.1071 0.1071
Echinococcus multilocularis glycine receptor subunit beta 0.0319 0.1071 0.1071
Echinococcus multilocularis cathepsin L 0.0315 0.1043 0.1043
Loa Loa (eye worm) hypothetical protein 0.0319 0.1071 0.1071
Brugia malayi Papain family cysteine protease containing protein 0.0878 0.4674 0.4674
Onchocerca volvulus 0.0166 0.0087 0.0087
Echinococcus granulosus nicotinic acetylcholine receptor subunit type 0.0319 0.1071 0.1071
Trypanosoma cruzi cysteine peptidase, putative 0.0878 0.4674 0.4054
Schistosoma mansoni cathepsin F (C01 family) 0.1141 0.6369 0.6369
Loa Loa (eye worm) hypothetical protein 0.0315 0.1043 0.1043
Brugia malayi Cation transporter family protein 0.0319 0.1071 0.1071
Trypanosoma cruzi cysteine peptidase, putative 0.1705 1 1
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0319 0.1071 0.1071
Entamoeba histolytica cysteine protease, putative 0.0878 0.4674 0.4627
Entamoeba histolytica cysteine protease, putative 0.0878 0.4674 0.4627
Loa Loa (eye worm) hypothetical protein 0.0319 0.1071 0.1071
Leishmania major cathepsin L-like protease 0.1705 1 1
Brugia malayi cathepsin F-like cysteine proteinase 0.0564 0.2647 0.2647
Echinococcus granulosus cathepsin l cysteine peptidase 0.1705 1 1
Brugia malayi acetylcholine receptor alpha subunit precursor, putative 0.0319 0.1071 0.1071
Loa Loa (eye worm) hypothetical protein 0.1141 0.6369 0.6369
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1705 1 1
Loa Loa (eye worm) cathepsin B 0.0315 0.1043 0.1043
Brugia malayi Cation transporter family protein 0.0319 0.1071 0.1071
Giardia lamblia Hypothetical protein 0.0315 0.1043 0.5
Loa Loa (eye worm) hypothetical protein 0.0319 0.1071 0.1071
Entamoeba histolytica cysteine proteinase 1, putative 0.0878 0.4674 0.4627
Plasmodium vivax vivapain-2 0.1705 1 1
Giardia lamblia Cathepsin L-like protease 0.0315 0.1043 0.5
Echinococcus granulosus nAChR subunit 0.0166 0.0087 0.0087
Loa Loa (eye worm) ctsf protein 0.1705 1 1
Echinococcus multilocularis glycine receptor subunit beta 0.0319 0.1071 0.1071
Schistosoma mansoni nAChR subunit 0.0319 0.1071 0.1071
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1705 1 1
Schistosoma mansoni nAChR subunit 0.0319 0.1071 0.1071
Onchocerca volvulus 0.0319 0.1071 0.1071
Schistosoma mansoni nicotinic acetylcholine receptor alpha 0.0166 0.0087 0.0087
Entamoeba histolytica cysteine protease, putative 0.0878 0.4674 0.4627
Schistosoma mansoni subfamily C1A non-peptidase homologue (C01 family) 0.0315 0.1043 0.1043
Loa Loa (eye worm) hypothetical protein 0.0315 0.1043 0.1043
Loa Loa (eye worm) hypothetical protein 0.0319 0.1071 0.1071
Plasmodium vivax unspecified product 0.0564 0.2647 0.1791
Echinococcus multilocularis geminin 0.0205 0.0334 0.0334
Schistosoma mansoni nAChR subunit 0.0319 0.1071 0.1071
Echinococcus granulosus glycine receptor subunit alpha 1 0.0319 0.1071 0.1071
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.1705 1 1
Echinococcus multilocularis nicotinic acetylcholine receptor alpha subunit 0.0319 0.1071 0.1071
Brugia malayi Papain family cysteine protease containing protein 0.0315 0.1043 0.1043
Loa Loa (eye worm) GABA receptor subunit 0.0166 0.0087 0.0087
Brugia malayi acetylcholine receptor protein, alpha-like chain, putative 0.0319 0.1071 0.1071
Giardia lamblia Cathepsin L precursor 0.0315 0.1043 0.5
Echinococcus granulosus glycine receptor subunit beta 0.0319 0.1071 0.1071
Brugia malayi cathepsin L-like cysteine proteinase 0.0315 0.1043 0.1043
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.0315 0.1043 0.1043
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0315 0.1043 0.1043
Echinococcus granulosus nicotinic acetylcholine receptor a11 subunit 0.0319 0.1071 0.1071
Entamoeba histolytica cysteine proteinase, putative 0.0878 0.4674 0.4627
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.1141 0.6369 0.5946
Loa Loa (eye worm) hypothetical protein 0.0166 0.0087 0.0087
Echinococcus multilocularis cysteine protease 0.1705 1 1
Giardia lamblia Cathepsin B precursor 0.0315 0.1043 0.5
Brugia malayi Cathepsin L-like precursor 0.0564 0.2647 0.2647
Schistosoma mansoni neurotransmitter gated ion channel 0.0166 0.0087 0.0087
Onchocerca volvulus 0.0319 0.1071 0.1071
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0319 0.1071 0.1071
Brugia malayi nicotinic acetylcholine receptor alpha subunit, putative 0.0319 0.1071 0.1071
Brugia malayi cathepsin L precursor 0.0315 0.1043 0.1043
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0564 0.2647 0.2647
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1705 1 1
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0315 0.1043 0.5
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0315 0.1043 0.0964
Loa Loa (eye worm) hypothetical protein 0.0319 0.1071 0.1071
Onchocerca volvulus 0.0319 0.1071 0.1071
Echinococcus granulosus cathepsin l1 0.1705 1 1
Echinococcus granulosus glycine receptor subunit beta 0.0319 0.1071 0.1071
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0315 0.1043 0.1043
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1705 1 1
Giardia lamblia Hypothetical protein 0.0315 0.1043 0.5
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1705 1 1
Schistosoma mansoni nAChR subunit 0.0319 0.1071 0.1071
Loa Loa (eye worm) hypothetical protein 0.1147 0.6402 0.6402
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0315 0.1043 0.1043
Entamoeba histolytica cysteine protease, putative 0.0878 0.4674 0.4627
Entamoeba histolytica cysteine proteinase, putative 0.0878 0.4674 0.4627
Echinococcus granulosus neuronal acetylcholine receptor subunit alpha 4 0.0319 0.1071 0.1071
Loa Loa (eye worm) hypothetical protein 0.106 0.5842 0.5842
Leishmania major cathepsin L-like protease 0.1705 1 1
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0315 0.1043 0.1043
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0166 0.0087 0.0087
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0319 0.1071 0.1071
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0319 0.1071 0.1071
Leishmania major cathepsin L-like protease 0.1705 1 1
Entamoeba histolytica cysteine protease, putative 0.0315 0.1043 0.0964
Loa Loa (eye worm) hypothetical protein 0.0166 0.0087 0.0087
Echinococcus multilocularis cathepsin L cysteine protease 0.1705 1 1
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0319 0.1071 0.1071
Brugia malayi cathepsin B-like cysteine proteinase 0.0315 0.1043 0.1043
Giardia lamblia Cathepsin B precursor 0.0315 0.1043 0.5
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1705 1 1
Entamoeba histolytica cysteine proteinase 2 0.0878 0.4674 0.4627
Brugia malayi nicotinic acetylcholine receptor beta-1 chain precursor 0.0319 0.1071 0.1071
Loa Loa (eye worm) hypothetical protein 0.0315 0.1043 0.1043
Plasmodium vivax vivapain-2 0.1705 1 1
Brugia malayi cahepsin L-like non-peptiedase homolog 0.0315 0.1043 0.1043
Echinococcus multilocularis nicotinic acetylcholine receptor subunit alpha 8 0.0319 0.1071 0.1071
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0319 0.1071 0.1071
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0319 0.1071 0.1071
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0166 0.0087 0.0087
Leishmania major cathepsin L-like protease 0.1705 1 1
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0319 0.1071 0.1071
Leishmania major cathepsin L-like protease 0.1705 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1705 1 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.1705 1 1
Loa Loa (eye worm) hypothetical protein 0.1141 0.6369 0.6369
Loa Loa (eye worm) acetylcholine receptor alpha subunit 0.0319 0.1071 0.1071
Loa Loa (eye worm) cysteine proteinase cathepsin Z 0.0315 0.1043 0.1043
Echinococcus multilocularis cathepsin L cysteine protease 0.1705 1 1
Leishmania major cathepsin L-like protease 0.1705 1 1
Entamoeba histolytica cysteine protease, putative 0.0315 0.1043 0.0964
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0878 0.4674 0.4674
Brugia malayi Cathepsin L-like precursor 0.1705 1 1
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.0564 0.2647 0.2647
Brugia malayi Cathepsin L-like precursor 0.1705 1 1
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0315 0.1043 0.1043
Echinococcus multilocularis nicotinic acetylcholine receptor beta 1 subunit 0.0319 0.1071 0.1071
Echinococcus granulosus cathepsin L 0.0878 0.4674 0.4674
Giardia lamblia Cathepsin B precursor 0.0315 0.1043 0.5
Trypanosoma cruzi cysteine peptidase, putative 0.0564 0.2647 0.1791
Plasmodium falciparum cysteine proteinase falcipain 1 0.0878 0.4674 0.4054
Entamoeba histolytica cysteine protease, putative 0.0878 0.4674 0.4627
Onchocerca volvulus 0.1705 1 1
Schistosoma mansoni cathepsin B (C01 family) 0.0315 0.1043 0.1043
Entamoeba histolytica cysteine protease, putative 0.0878 0.4674 0.4627
Giardia lamblia Cathepsin B precursor 0.0315 0.1043 0.5
Loa Loa (eye worm) hypothetical protein 0.0319 0.1071 0.1071
Loa Loa (eye worm) hypothetical protein 0.0564 0.2647 0.2647
Giardia lamblia Encystation-specific protease 0.0315 0.1043 0.5
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0319 0.1071 0.1071
Entamoeba histolytica cysteine protease, putative 0.0315 0.1043 0.0964
Giardia lamblia Cysteine protease 0.0315 0.1043 0.5
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0315 0.1043 0.1043
Trypanosoma cruzi cysteine proteinase, putative 0.0878 0.4674 0.4054
Loa Loa (eye worm) ACC-1 protein 0.0319 0.1071 0.1071
Giardia lamblia Cathepsin B precursor 0.0315 0.1043 0.5
Echinococcus multilocularis nicotinic acetylcholine receptor a11 subunit 0.0319 0.1071 0.1071
Onchocerca volvulus 0.0319 0.1071 0.1071
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.0166 0.0087 0.0087
Entamoeba histolytica cysteine protease, putative 0.0878 0.4674 0.4627
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.1705 1 1
Echinococcus multilocularis cathepsin L 0.0878 0.4674 0.4674
Trypanosoma cruzi cysteine protease, putative 0.0878 0.4674 0.4054
Brugia malayi Cathepsin L-like cysteine proteinase 0.1141 0.6369 0.6369
Loa Loa (eye worm) ligand-Gated ion Channel family member 0.0319 0.1071 0.1071
Loa Loa (eye worm) hypothetical protein 0.0319 0.1071 0.1071
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0315 0.1043 0.5
Loa Loa (eye worm) cysteine protease 0.1705 1 1
Echinococcus granulosus cathepsin L cysteine proteinase 0.1705 1 1
Giardia lamblia Cysteine protease 0.0315 0.1043 0.5
Onchocerca volvulus 0.1705 1 1
Echinococcus granulosus cathepsin b 0.0315 0.1043 0.1043
Schistosoma mansoni cathepsin F (C01 family) 0.1705 1 1
Onchocerca volvulus 0.1705 1 1
Loa Loa (eye worm) hypothetical protein 0.0315 0.1043 0.1043
Onchocerca volvulus 0.0319 0.1071 0.1071
Schistosoma mansoni nAChR subunit (ShAR1-beta2-like) 0.0319 0.1071 0.1071
Echinococcus granulosus nicotinic acetylcholine receptor beta 1 subunit 0.0319 0.1071 0.1071
Giardia lamblia Cathepsin L precursor 0.0315 0.1043 0.5
Loa Loa (eye worm) hypothetical protein 0.1141 0.6369 0.6369
Brugia malayi excitatory GABA receptor EXP-1A 0.0319 0.1071 0.1071
Schistosoma mansoni nAChR subunit (ShAR1-beta-like) 0.0319 0.1071 0.1071
Plasmodium vivax vivapain-1 0.0878 0.4674 0.4054
Giardia lamblia Cysteine protease 0.0315 0.1043 0.5
Onchocerca volvulus 0.1141 0.6369 0.6369
Plasmodium falciparum cysteine proteinase falcipain 2b 0.1705 1 1
Trypanosoma cruzi cruzipain precursor, putative 0.1705 1 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0878 0.4674 0.4054
Onchocerca volvulus 0.0319 0.1071 0.1071
Trypanosoma cruzi cysteine peptidase, putative 0.1705 1 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.1705 1 1
Brugia malayi fibroinase precursor 0.0315 0.1043 0.1043
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1705 1 1
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0315 0.1043 0.1043
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0878 0.4674 0.4054
Schistosoma mansoni hypothetical protein 0.0205 0.0334 0.0334
Brugia malayi cathepsin Z-like cysteine proteinase 0.0315 0.1043 0.1043
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0319 0.1071 0.1071
Loa Loa (eye worm) hypothetical protein 0.0315 0.1043 0.1043
Brugia malayi Papain family cysteine protease containing protein 0.0315 0.1043 0.1043
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0315 0.1043 0.1043
Loa Loa (eye worm) hypothetical protein 0.0166 0.0087 0.0087
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1705 1 1
Entamoeba histolytica cysteine proteinase, putative 0.1705 1 1
Echinococcus multilocularis acetylcholine receptor subunit beta 1 0.0319 0.1071 0.1071
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1705 1 1
Brugia malayi Cathepsin L-like precursor 0.1705 1 1
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0315 0.1043 0.0964
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.0315 0.1043 0.1043
Loa Loa (eye worm) hypothetical protein 0.0319 0.1071 0.1071
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.1705 1 1
Entamoeba histolytica hypothetical protein 0.0315 0.1043 0.0964
Brugia malayi gamma-aminobutyric-acid receptor beta subunit precursor 0.1299 0.7386 0.7386
Leishmania major cathepsin L-like protease 0.1705 1 1
Echinococcus multilocularis cathepsin b 0.0315 0.1043 0.1043
Giardia lamblia Cathepsin B precursor 0.0315 0.1043 0.5
Brugia malayi Cation transporter family protein 0.0319 0.1071 0.1071
Loa Loa (eye worm) hypothetical protein 0.0315 0.1043 0.1043
Trypanosoma cruzi cysteine peptidase, putative 0.1705 1 1
Loa Loa (eye worm) ACC-1 protein 0.0319 0.1071 0.1071
Loa Loa (eye worm) hypothetical protein 0.0166 0.0087 0.0087
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0166 0.0087 0.0087
Onchocerca volvulus Putative nachr subunit 0.0319 0.1071 0.1071
Entamoeba histolytica cysteine protease, putative 0.0315 0.1043 0.0964
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0315 0.1043 0.1043
Echinococcus multilocularis cathepsin l cysteine peptidase 0.1705 1 1
Schistosoma mansoni cathepsin S (C01 family) 0.0315 0.1043 0.1043
Plasmodium vivax unspecified product 0.0878 0.4674 0.4054
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1705 1 1
Giardia lamblia Cathepsin B precursor 0.0315 0.1043 0.5
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0319 0.1071 0.1071
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0315 0.1043 0.1043
Toxoplasma gondii cathepsin CPL 0.1705 1 1
Entamoeba histolytica cysteine protease, putative 0.0878 0.4674 0.4627
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1141 0.6369 0.5946
Schistosoma mansoni nAChR subunit 0.0319 0.1071 0.1071
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0319 0.1071 0.1071
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.1705 1 1
Entamoeba histolytica cysteine protease, putative 0.0878 0.4674 0.4627
Giardia lamblia Cysteine protease 0.0315 0.1043 0.5
Entamoeba histolytica cysteine proteinase, putative 0.0878 0.4674 0.4627
Trypanosoma cruzi cysteine peptidase, putative 0.1705 1 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1705 1 1
Loa Loa (eye worm) excitatory GABA receptor EXP-1A 0.0319 0.1071 0.1071
Entamoeba histolytica cysteine protease, putative 0.0878 0.4674 0.4627
Brugia malayi Cathepsin L-like precursor 0.1705 1 1
Onchocerca volvulus Cathepsin F homolog 0.1705 1 1
Plasmodium falciparum cysteine proteinase falcipain 2a 0.1705 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1141 0.6369 0.5946
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1705 1 1
Echinococcus multilocularis nAChR subunit 0.0166 0.0087 0.0087
Trypanosoma cruzi cruzipain precursor, putative 0.0564 0.2647 0.1791
Entamoeba histolytica cysteine protease, putative 0.0878 0.4674 0.4627
Loa Loa (eye worm) hypothetical protein 0.0319 0.1071 0.1071
Schistosoma mansoni nAChR subunit (ShAR1-alpha-like) 0.0319 0.1071 0.1071
Schistosoma mansoni hypothetical protein 0.0205 0.0334 0.0334
Leishmania major cathepsin L-like protease 0.1705 1 1
Giardia lamblia Cathepsin B-like cysteine proteinase 3 precursor 0.0315 0.1043 0.5
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0319 0.1071 0.1071
Echinococcus granulosus nicotinic acetylcholine receptor subunit alpha 8 0.0319 0.1071 0.1071
Giardia lamblia Cathepsin L precursor 0.0315 0.1043 0.5
Entamoeba histolytica cysteine protease, putative 0.0878 0.4674 0.4627
Loa Loa (eye worm) hypothetical protein 0.0319 0.1071 0.1071
Giardia lamblia Cathepsin L-like protease 0.0315 0.1043 0.5
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0878 0.4674 0.4674
Brugia malayi Papain family cysteine protease containing protein 0.0315 0.1043 0.1043
Echinococcus multilocularis nAChR subunit 0.0319 0.1071 0.1071
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1705 1 1
Onchocerca volvulus Cathepsin L homolog 0.1705 1 1
Loa Loa (eye worm) hypothetical protein 0.1705 1 1
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0878 0.4674 0.4674
Echinococcus granulosus cathepsin b 0.0315 0.1043 0.1043
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1705 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1705 1 1
Brugia malayi Cathepsin L-like precursor 0.1141 0.6369 0.6369
Echinococcus multilocularis cathepsin b 0.0315 0.1043 0.1043
Schistosoma mansoni cathepsin C 0.0315 0.1043 0.1043
Loa Loa (eye worm) hypothetical protein 0.1299 0.7386 0.7386
Echinococcus granulosus nicotinic acetylcholine receptor alpha subunit 0.0319 0.1071 0.1071
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1705 1 1
Brugia malayi Cathepsin L-like precursor 0.1705 1 1
Echinococcus granulosus cysteine protease 0.0878 0.4674 0.4674
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.1705 1 1
Schistosoma mansoni nAChR subunit 0.0319 0.1071 0.1071
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0315 0.1043 0.5
Echinococcus multilocularis cysteine protease 0.1705 1 1
Echinococcus granulosus cathepsin l1 0.1141 0.6369 0.6369
Loa Loa (eye worm) LGC-31 protein 0.0319 0.1071 0.1071
Echinococcus granulosus nAChR subunit 0.0319 0.1071 0.1071
Loa Loa (eye worm) nicotinic acetylcholine receptor non-alpha subunit 0.0319 0.1071 0.1071
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0315 0.1043 0.1043
Echinococcus granulosus glycine receptor subunit alpha 1 0.0319 0.1071 0.1071
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1705 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0878 0.4674 0.4054
Entamoeba histolytica cysteine proteinase, putative 0.0878 0.4674 0.4627
Echinococcus granulosus cathepsin L cysteine protease 0.0878 0.4674 0.4674
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0319 0.1071 0.1071
Schistosoma mansoni nAChR subunit 0.0319 0.1071 0.1071

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 28.1838 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 56.2341 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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