Detailed information for compound 1706901

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 417.232 | Formula: C18H14BrFN4O2
  • H donors: 3 H acceptors: 3 LogP: 3.55 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: Cc1cccc(c1)NC(=O)c1[nH]cnc1C(=O)Nc1cc(Br)ccc1F
  • InChi: 1S/C18H14BrFN4O2/c1-10-3-2-4-12(7-10)23-17(25)15-16(22-9-21-15)18(26)24-14-8-11(19)5-6-13(14)20/h2-9H,1H3,(H,21,22)(H,23,25)(H,24,26)
  • InChiKey: AJZDQZYCMQDUSG-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens GNAS complex locus Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma japonicum ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative Get druggable targets OG5_131088 All targets in OG5_131088
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Schistosoma mansoni GTP-binding protein alpha subunit gna GNAS complex locus 394 aa 450 aa 28.7 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Entamoeba histolytica hypothetical protein 0.0008 0.0046 0.0079
Trichomonas vaginalis pyruvate kinase, putative 0.0034 0.1181 0.8786
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0037 0.1343 0.2574
Loa Loa (eye worm) phospholipase D 0.0023 0.0726 0.1431
Brugia malayi glutathione reductase 0.0038 0.1381 0.2654
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.1299 0.7681
Giardia lamblia Pyruvate kinase 0.0034 0.1181 0.8483
Plasmodium falciparum mitochondrial cardiolipin synthase, putative 0.002 0.0568 0.2668
Loa Loa (eye worm) hypothetical protein 0.0011 0.0156 0.0307
Schistosoma mansoni ubiquitin-like protein sumo/smt3-related 0.0021 0.06 0.0881
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0036 0.1299 0.4809
Brugia malayi beta-lactamase family protein 0.0036 0.1299 0.2497
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0036 0.1299 0.1056
Plasmodium vivax hypothetical protein, conserved 0.0036 0.1299 0.9262
Echinococcus multilocularis beta LACTamase domain containing family member 0.0036 0.1299 0.249
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0097 0.3986 1
Onchocerca volvulus Pyruvate kinase homolog 0.0034 0.1181 0.232
Treponema pallidum NADH oxidase 0.0013 0.0273 0.5
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0013 0.0273 0.0524
Onchocerca volvulus 0.0036 0.1299 0.2554
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.2143 0.4113
Echinococcus multilocularis Small ubiquitin modifier 2 0.0021 0.06 0.1145
Mycobacterium tuberculosis Conserved protein 0.0036 0.1299 0.1056
Plasmodium vivax pyruvate kinase, putative 0.0034 0.1181 0.8192
Onchocerca volvulus 0.0036 0.1299 0.2554
Echinococcus granulosus phospholipase d3 0.0023 0.0726 0.1386
Mycobacterium tuberculosis Probable oxidoreductase 0.0097 0.3986 0.3818
Trypanosoma cruzi small ubiquitin protein, putative 0.0021 0.06 0.2452
Plasmodium falciparum thioredoxin reductase 0.0038 0.1381 1
Echinococcus granulosus thioredoxin glutathione reductase 0.0039 0.1404 0.2691
Onchocerca volvulus 0.0036 0.1299 0.2554
Trypanosoma brucei cardiolipin synthetase, putative 0.0043 0.1609 1
Brugia malayi latrophilin 2 splice variant baaae 0.0023 0.0702 0.1349
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.001 0.0117 0.0224
Echinococcus multilocularis pyruvate kinase 0.0017 0.0453 0.0861
Leishmania major phosphatidylglycerophosphate synthase, putative 0.0023 0.0726 0.2123
Chlamydia trachomatis pyruvate kinase 0.0034 0.1181 1
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0037 0.1343 0.5014
Loa Loa (eye worm) hypothetical protein 0.0023 0.0702 0.1384
Loa Loa (eye worm) hypothetical protein 0.0104 0.432 0.8515
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0013 0.0273 0.0515
Loa Loa (eye worm) hypothetical protein 0.0121 0.5073 1
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0037 0.1343 1
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0037 0.1343 0.2574
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.2143 0.3938
Echinococcus multilocularis GPCR, family 2 0.0011 0.0156 0.0289
Brugia malayi beta-lactamase 0.0036 0.1299 0.2497
Trichomonas vaginalis mercuric reductase, putative 0.0013 0.0273 0.1999
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.1299 0.9673
Echinococcus granulosus Small ubiquitin modifier 2 0.0021 0.06 0.1145
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0037 0.1343 1
Mycobacterium ulcerans aldehyde dehydrogenase 0.0061 0.2408 1
Echinococcus granulosus ubiquitin specific protease 41 0.0037 0.1343 0.2574
Loa Loa (eye worm) beta-lactamase 0.0036 0.1299 0.2561
Plasmodium falciparum phosphatidylglycerophosphate synthase 0.002 0.0568 0.2668
Echinococcus granulosus pyruvate kinase 0.0017 0.0453 0.0861
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0036 0.1299 0.1056
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.06 0.4449
Trypanosoma brucei cardiolipin synthetase 0.0043 0.1609 1
Entamoeba histolytica phospholipase D, putative 0.0124 0.5203 1
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0037 0.1343 0.2353
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0087 0.3554 0.3374
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0036 0.1299 0.2561
Echinococcus multilocularis thioredoxin glutathione reductase 0.0039 0.1404 0.2691
Entamoeba histolytica phospholipase D active site domain-containing protein 0.0104 0.432 0.83
Mycobacterium ulcerans aldehyde dehydrogenase 0.0061 0.2408 1
Mycobacterium ulcerans esterase/lipase LipP 0.0036 0.1299 0.4809
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0037 0.1343 0.2353
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0037 0.1343 0.2581
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0037 0.1343 0.8008
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0061 0.2408 0.4622
Loa Loa (eye worm) glutathione reductase 0.0038 0.1381 0.2723
Trypanosoma brucei pyruvate kinase 1 0.0034 0.1181 0.6793
Brugia malayi Calcitonin receptor-like protein seb-1 0.0033 0.1173 0.2254
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0033 0.1173 0.2312
Mycobacterium leprae conserved hypothetical protein 0.0036 0.1299 0.0423
Schistosoma mansoni pyruvate kinase 0.0034 0.1181 0.2031
Trypanosoma brucei phosphatidylglycerolphosphate synthase, mitochondrial 0.002 0.0568 0.2212
Echinococcus granulosus beta LACTamase domain containing family member 0.0036 0.1299 0.249
Leishmania major small ubiquitin protein, putative 0.0021 0.06 0.1535
Loa Loa (eye worm) hypothetical protein 0.0036 0.1299 0.2561
Echinococcus multilocularis pyruvate kinase 0.0017 0.0453 0.0861
Plasmodium vivax glutathione reductase, putative 0.0038 0.1381 1
Loa Loa (eye worm) thioredoxin reductase 0.0038 0.1381 0.2723
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.1299 0.9673
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0061 0.2408 1
Echinococcus granulosus phospholipase D 0.011 0.4559 0.8761
Echinococcus multilocularis pyruvate kinase 0.0034 0.1181 0.2262
Toxoplasma gondii thioredoxin reductase 0.0038 0.1381 0.5192
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.2143 0.4113
Brugia malayi Pyruvate kinase, M2 isozyme 0.0034 0.1181 0.2269
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.1299 0.9673
Mycobacterium tuberculosis Probable esterase LipL 0.0036 0.1299 0.1056
Loa Loa (eye worm) hypothetical protein 0.0036 0.1299 0.2561
Loa Loa (eye worm) hypothetical protein 0.0033 0.1173 0.2312
Toxoplasma gondii ABC1 family protein 0.0036 0.1299 0.4809
Mycobacterium ulcerans aldehyde dehydrogenase 0.0061 0.2408 1
Plasmodium vivax phosphatidylglycerophosphate synthase, putative 0.002 0.0568 0.2668
Schistosoma mansoni phospholipase D 0.0124 0.5203 1
Trypanosoma brucei trypanothione reductase 0.0038 0.1381 0.8293
Loa Loa (eye worm) hypothetical protein 0.0034 0.1181 0.2328
Loa Loa (eye worm) hypothetical protein 0.0104 0.432 0.8515
Toxoplasma gondii phospholipase D active site domain-containing protein 0.0043 0.1609 0.6261
Loa Loa (eye worm) latrophilin receptor protein 2 0.0011 0.0156 0.0307
Schistosoma mansoni aldehyde dehydrogenase 0.0061 0.2408 0.4462
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0013 0.0273 0.0515
Chlamydia trachomatis phospholipase D superfamily protein 0.002 0.0568 0.3257
Loa Loa (eye worm) hypothetical protein 0.0037 0.1343 0.2648
Brugia malayi Phospholipase d protein 1 0.0124 0.5203 1
Echinococcus granulosus pyruvate kinase 0.0017 0.0453 0.0861
Brugia malayi hypothetical protein 0.002 0.0568 0.1092
Mycobacterium tuberculosis Probable lipase LipE 0.0036 0.1299 0.1056
Schistosoma mansoni hypothetical protein 0.0023 0.0702 0.1082
Plasmodium falciparum small ubiquitin-related modifier 0.0021 0.06 0.2957
Echinococcus granulosus pyruvate kinase 0.0017 0.0453 0.0861
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.1299 0.9673
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0013 0.0273 0.0232
Loa Loa (eye worm) hypothetical protein 0.0036 0.1299 0.2561
Leishmania major pyruvate kinase 0.0034 0.1181 0.4253
Plasmodium falciparum pyruvate kinase 0.0034 0.1181 0.8192
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0061 0.2408 0.4622
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.2143 0.4113
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0061 0.2408 0.2195
Onchocerca volvulus Pyruvate kinase homolog 0.0034 0.1181 0.232
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0055 0.2143 0.4225
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0121 0.5073 1
Schistosoma mansoni pyruvate kinase 0.0034 0.1181 0.2031
Loa Loa (eye worm) hypothetical protein 0.0023 0.0726 0.1431
Schistosoma mansoni pyruvate kinase 0.0017 0.0453 0.0588
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.1299 0.2266
Chlamydia trachomatis phospholipase D endonuclease family protein 0.002 0.0568 0.3257
Brugia malayi Ubiquitin-like protein SMT3 0.0021 0.06 0.1154
Echinococcus multilocularis pyruvate kinase 0.0034 0.1181 0.2262
Echinococcus multilocularis phospholipase d3 0.0023 0.0726 0.1386
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0087 0.3554 0.3374
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.1299 0.7681
Trypanosoma cruzi trypanothione reductase, putative 0.0038 0.1381 0.8293
Loa Loa (eye worm) SMO-1 protein 0.0021 0.06 0.1184
Mycobacterium tuberculosis Conserved protein 0.0036 0.1299 0.1056
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0011 0.0156 0.0289
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0087 0.3554 0.3374
Leishmania major hypothetical protein, conserved 0.0036 0.1299 0.4809
Chlamydia trachomatis phospholipase D endonuclease family protein 0.002 0.0568 0.3257
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0087 0.3554 0.8461
Loa Loa (eye worm) hypothetical protein 0.0036 0.1299 0.2561
Toxoplasma gondii pyruvate kinase PyKII 0.0017 0.0453 0.0843
Brugia malayi hypothetical protein 0.0007 0.0005 0.001
Brugia malayi Thioredoxin reductase 0.0038 0.1381 0.2654
Brugia malayi beta-lactamase family protein 0.0036 0.1299 0.2497
Echinococcus granulosus pyruvate kinase 0.0034 0.1181 0.2262
Wolbachia endosymbiont of Brugia malayi cardiolipin synthase 0.002 0.0568 1
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0011 0.0156 0.0289
Mycobacterium ulcerans pyruvate kinase 0.0034 0.1181 0.4253
Plasmodium falciparum glutathione reductase 0.0038 0.1381 1
Trypanosoma brucei pyruvate kinase 1, putative 0.0034 0.1181 0.6793
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0036 0.1299 0.1056
Trichomonas vaginalis glutathione reductase, putative 0.0013 0.0273 0.1999
Mycobacterium tuberculosis Probable hydrolase 0.0036 0.1299 0.1056
Mycobacterium ulcerans beta-lactamase 0.0036 0.1299 0.4809
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0087 0.3554 0.3374
Toxoplasma gondii aldehyde dehydrogenase 0.0061 0.2408 1
Trypanosoma brucei hypothetical protein, conserved 0.0036 0.1299 0.7681
Echinococcus granulosus phospholipase D1 0.0124 0.5203 1
Plasmodium falciparum pyruvate kinase 2 0.0017 0.0453 0.1624
Plasmodium vivax cardiolipin synthetase, putative 0.002 0.0568 0.2668
Trypanosoma cruzi cardiolipin synthetase, putative 0.0043 0.1609 1
Echinococcus multilocularis pyruvate kinase 0.0017 0.0453 0.0861
Echinococcus multilocularis phospholipase D1 0.0124 0.5203 1
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0037 0.1343 0.8008
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.1299 0.2266
Echinococcus multilocularis phospholipase D 0.011 0.4559 0.8761
Entamoeba histolytica ubiquitin like protein 0.0021 0.06 0.1145
Trypanosoma brucei small ubiquitin-related modifier 0.0021 0.06 0.2452
Mycobacterium ulcerans lipase LipD 0.0036 0.1299 0.4809
Mycobacterium ulcerans hypothetical protein 0.0036 0.1299 0.4809
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0036 0.1299 0.2497
Brugia malayi Phospholipase D. Active site motif family protein 0.0043 0.1609 0.3093
Plasmodium vivax pyruvate kinase 2, putative 0.0017 0.0453 0.1624
Leishmania major pyruvate kinase 0.0034 0.1181 0.4253
Entamoeba histolytica phospholipase D, putative 0.0124 0.5203 1
Loa Loa (eye worm) hypothetical protein 0.002 0.0568 0.112
Brugia malayi Pyruvate kinase, muscle isozyme 0.0034 0.1181 0.2269
Mycobacterium tuberculosis Probable dehydrogenase 0.0087 0.3554 0.3374
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.0034 0.1181 0.0934
Mycobacterium tuberculosis Probable lipase LipD 0.0036 0.1299 0.1056
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.2143 0.3938
Trichomonas vaginalis pyruvate kinase, putative 0.0034 0.1181 0.8786
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.1299 0.9673
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0011 0.0156 0.0289
Giardia lamblia Pyruvate kinase 0.0017 0.0453 0.1681
Onchocerca volvulus Pyruvate kinase homolog 0.0034 0.1181 0.232
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.2143 0.3938
Schistosoma mansoni CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase 0.002 0.0568 0.0818
Plasmodium vivax small ubiquitin-related modifier, putative 0.0021 0.06 0.2957
Brugia malayi Protein K4 0.002 0.0568 0.1092
Trypanosoma cruzi small ubiquitin protein, putative 0.0021 0.06 0.2452
Entamoeba histolytica pyruvate kinase, putative 0.0023 0.0728 0.1391
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0037 0.1343 0.2574
Mycobacterium leprae Probable lipase LipE 0.0036 0.1299 0.0423
Toxoplasma gondii small ubiquitin family modifier, putative 0.0021 0.06 0.1535
Echinococcus multilocularis pyruvate kinase 0.0027 0.0866 0.1655
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0037 0.1343 0.2574
Loa Loa (eye worm) hypothetical protein 0.0036 0.1299 0.2561
Trypanosoma cruzi pyruvate kinase 2, putative 0.0034 0.1181 0.6793
Trypanosoma cruzi cardiolipin synthetase, putative 0.0043 0.1609 1
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0097 0.3986 0.3818
Brugia malayi N-terminal motif family protein 0.0121 0.5073 0.975
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0038 0.1381 0.114
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0037 0.1343 0.2574
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0055 0.2143 0.4119
Leishmania major cardiolipin synthetase, putative 0.002 0.0568 0.1385
Loa Loa (eye worm) hypothetical protein 0.0036 0.1299 0.2561
Onchocerca volvulus Putative phospholipase D 0.0023 0.0726 0.1422
Schistosoma mansoni aldehyde dehydrogenase 0.0061 0.2408 0.4462
Loa Loa (eye worm) pyruvate kinase 0.0034 0.1181 0.2328
Plasmodium vivax thioredoxin reductase, putative 0.0038 0.1381 1
Trypanosoma cruzi pyruvate kinase 2, putative 0.0034 0.1181 0.6793
Loa Loa (eye worm) pyruvate kinase-PB 0.0023 0.0728 0.1435
Mycobacterium tuberculosis Probable reductase 0.0087 0.3554 0.3374
Loa Loa (eye worm) pyruvate kinase 0.0034 0.1181 0.2328
Loa Loa (eye worm) hypothetical protein 0.0007 0.0005 0.001
Giardia lamblia Sentrin 0.0021 0.06 0.3062
Chlamydia trachomatis phospholipase D endonuclease family protein 0.002 0.0568 0.3257
Chlamydia trachomatis phospholipase D superfamily protein 0.002 0.0568 0.3257
Brugia malayi Latrophilin receptor protein 2 0.0011 0.0156 0.0299
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.001 0.0117 0.0224
Leishmania major trypanothione reductase 0.0038 0.1381 0.5192
Trichomonas vaginalis esterase, putative 0.0036 0.1299 0.9673
Echinococcus granulosus pyruvate kinase 0.0034 0.1181 0.2262
Loa Loa (eye worm) hypothetical protein 0.0081 0.3279 0.6463
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0011 0.0156 0.0289
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0037 0.1343 0.8008
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0037 0.1343 1
Brugia malayi Pyruvate kinase, alpha/beta domain containing protein 0.001 0.0137 0.0264
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.2143 0.4113
Loa Loa (eye worm) hypothetical protein 0.0081 0.3279 0.6463
Loa Loa (eye worm) pyruvate kinase 0.0034 0.1181 0.2328
Trichomonas vaginalis conserved hypothetical protein 0.0037 0.1343 1
Toxoplasma gondii pyruvate kinase PyK1 0.0034 0.1181 0.4253
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0097 0.3986 0.3818
Echinococcus granulosus GPCR family 2 0.0011 0.0156 0.0289
Chlamydia trachomatis phospholipase D endonuclease family protein 0.002 0.0568 0.3257
Mycobacterium tuberculosis Conserved protein 0.0036 0.1299 0.1056
Brugia malayi Phospholipase D. Active site motif family protein 0.0023 0.0726 0.1395
Echinococcus multilocularis ubiquitin specific protease 41 0.0037 0.1343 0.2574
Loa Loa (eye worm) hypothetical protein 0.0023 0.0728 0.1435
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0033 0.1173 0.2254
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0011 0.0156 0.0299

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 5.6234 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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