Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | cholinergic receptor, nicotinic, alpha 7 (neuronal) | Starlite/ChEMBL | References |
Homo sapiens | cholinergic receptor, nicotinic, beta 2 (neuronal) | References | |
Homo sapiens | cholinergic receptor, nicotinic, alpha 4 (neuronal) | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | Cation transporter family protein | cholinergic receptor, nicotinic, beta 2 (neuronal) | 502 aa | 482 aa | 32.4 % |
Brugia malayi | acetylcholine receptor alpha subunit precursor, putative | cholinergic receptor, nicotinic, alpha 7 (neuronal) | 502 aa | 513 aa | 33.9 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | sodium bile acid cotransporter | 1.2973 | 1 | 1 |
Echinococcus multilocularis | sodium bile acid cotransporter | 1.2973 | 1 | 1 |
Trypanosoma brucei | 3-methylcrotonoyl-CoA carboxylase beta subunit, putative | 0.0492 | 0.0142 | 0.0541 |
Mycobacterium ulcerans | acetyl-/propionyl-CoA carboxylase subunit beta | 0.0492 | 0.0142 | 0.1676 |
Schistosoma mansoni | sodium-bile acid cotransporter related | 1.2973 | 1 | 1 |
Echinococcus multilocularis | acetyl coenzyme A carboxylase 1 | 0.3633 | 0.2622 | 0.2516 |
Echinococcus multilocularis | sodium bile acid cotransporter | 1.2973 | 1 | 1 |
Giardia lamblia | Acetyl-CoA carboxylase/pyruvate carboxylase fusion protein, putative | 0.062 | 0.0242 | 0.5 |
Echinococcus granulosus | acetyl coenzyme A carboxylase 1 | 0.3633 | 0.2622 | 0.2516 |
Mycobacterium ulcerans | acetyl-/propionyl-coenzyme a carboxylase alpha chain, AccA2 | 0.1384 | 0.0846 | 1 |
Echinococcus granulosus | sodium bile acid cotransporter | 1.2973 | 1 | 1 |
Mycobacterium tuberculosis | Probable acetyl-/propionyl-coenzyme A carboxylase alpha chain (alpha subunit) AccA2: biotin carboxylase + biotin carboxyl carrie | 0.1384 | 0.0846 | 1 |
Trypanosoma brucei | unspecified product | 0.091 | 0.0471 | 0.1798 |
Trypanosoma cruzi | acetyl-CoA carboxylase, putative | 0.0492 | 0.0142 | 0.0927 |
Toxoplasma gondii | pyruvate carboxylase | 0.1384 | 0.0846 | 0.3226 |
Wolbachia endosymbiont of Brugia malayi | Acetyl-CoA carboxylase, carboxyltransferase component | 0.0492 | 0.0142 | 0.1676 |
Mycobacterium ulcerans | acetyl-/propionyl-coenzyme a carboxylase alpha chain AccA1 | 0.1384 | 0.0846 | 1 |
Trypanosoma brucei | 3-methylcrotonyl-CoA carboxylase alpha subunit, putative | 0.1384 | 0.0846 | 0.3226 |
Leishmania major | methylcrotonoyl-coa carboxylase biotinylated subunitprotein-like protein | 0.1384 | 0.0846 | 0.3226 |
Onchocerca volvulus | 1.2973 | 1 | 1 | |
Chlamydia trachomatis | biotin carboxylase | 0.1257 | 0.0745 | 1 |
Loa Loa (eye worm) | carboxyl transferase domain-containing protein | 0.3506 | 0.2522 | 0.2285 |
Schistosoma mansoni | pyruvate carboxylase | 0.1384 | 0.0846 | 0.0846 |
Schistosoma mansoni | peroxidasin | 0.0701 | 0.0307 | 0.0307 |
Mycobacterium ulcerans | pyruvate carboxylase | 0.1384 | 0.0846 | 1 |
Schistosoma mansoni | sodium-bile acid cotransporter | 0.7713 | 0.5845 | 0.5845 |
Leishmania major | acetyl-CoA carboxylase, putative | 0.3633 | 0.2622 | 1 |
Schistosoma mansoni | acetyl-CoA carboxylase | 0.3633 | 0.2622 | 0.2622 |
Entamoeba histolytica | acetyl-coA carboxylase, putative | 0.062 | 0.0242 | 0.5 |
Echinococcus granulosus | sodium bile acid cotransporter | 1.2973 | 1 | 1 |
Mycobacterium tuberculosis | Probable pyruvate carboxylase Pca (pyruvic carboxylase) | 0.1384 | 0.0846 | 1 |
Trypanosoma cruzi | 3-methylcrotonoyl-CoA carboxylase beta subunit, putative | 0.0492 | 0.0142 | 0.0927 |
Trypanosoma cruzi | 3-methylcrotonyl-CoA carboxylase, putative | 0.1384 | 0.0846 | 0.5531 |
Echinococcus multilocularis | peroxidasin | 0.0701 | 0.0307 | 0.0168 |
Leishmania major | 3-methylcrotonoyl-CoA carboxylase beta subunit, putative | 0.0492 | 0.0142 | 0.0541 |
Echinococcus multilocularis | sodium bile acid cotransporter | 1.2973 | 1 | 1 |
Trypanosoma brucei | acetyl-CoA carboxylase | 0.3633 | 0.2622 | 1 |
Mycobacterium ulcerans | acetyl/propionyl CoA carboxylase subunit beta | 0.0492 | 0.0142 | 0.1676 |
Mycobacterium ulcerans | propionyl-CoA carboxylase beta chain 5 AccD5 | 0.0492 | 0.0142 | 0.1676 |
Trypanosoma cruzi | 3-methylcrotonoyl-CoA carboxylase beta subunit, putative | 0.0492 | 0.0142 | 0.0927 |
Leishmania major | carboxylase, putative | 0.1384 | 0.0846 | 0.3226 |
Mycobacterium ulcerans | acetyl-coenzyme a carboxylase carboxyl transferase (subunit beta) AccD3 | 0.0492 | 0.0142 | 0.1676 |
Mycobacterium ulcerans | propionyl-CoA carboxylase beta chain 4 AccD4_2 | 0.0492 | 0.0142 | 0.1676 |
Schistosoma mansoni | peroxidasin | 0.0701 | 0.0307 | 0.0307 |
Trypanosoma cruzi | acetyl-CoA carboxylase | 0.2249 | 0.1529 | 1 |
Schistosoma mansoni | sodium-bile acid cotransporter related | 0.5261 | 0.3908 | 0.3908 |
Brugia malayi | Carboxyl transferase domain containing protein | 0.3506 | 0.2522 | 0.2285 |
Echinococcus granulosus | peroxidasin | 0.0701 | 0.0307 | 0.0168 |
Toxoplasma gondii | acyl-CoA carboxyltransferase beta chain, putative | 0.0492 | 0.0142 | 0.0541 |
Loa Loa (eye worm) | hypothetical protein | 1.2973 | 1 | 1 |
Trypanosoma cruzi | 3-methylcrotonyl-CoA carboxylase, putative | 0.1384 | 0.0846 | 0.5531 |
Leishmania major | propionyl-coa carboxylase beta chain, putative | 0.0492 | 0.0142 | 0.0541 |
Schistosoma mansoni | methylcrotonyl-CoA carboxylase | 0.1384 | 0.0846 | 0.0846 |
Schistosoma mansoni | methylcrotonyl-CoA carboxylase | 0.1384 | 0.0846 | 0.0846 |
Plasmodium falciparum | biotin carboxylase subunit of acetyl CoA carboxylase, putative | 0.2629 | 0.1829 | 1 |
Mycobacterium ulcerans | bifunctional protein acetyl-/propionyl-coenzyme a carboxylase (alpha chain) AccA3 | 0.1384 | 0.0846 | 1 |
Plasmodium vivax | biotin carboxylase subunit of acetyl CoA carboxylase, putative | 0.2629 | 0.1829 | 1 |
Echinococcus granulosus | propionyl coenzyme A carboxylase alpha chain | 0.1384 | 0.0846 | 0.0714 |
Mycobacterium leprae | Probable bifunctional protein acetyl-/propionyl-coenzyme A carboxylase, alpha chain AccA3 (BccP) | 0.1384 | 0.0846 | 1 |
Mycobacterium ulcerans | propionyl-CoA carboxylase beta chain 4 AccD4 | 0.0492 | 0.0142 | 0.1676 |
Trypanosoma brucei | 3-methylcrotonyl-CoA carboxylase alpha subunit, putative | 0.1384 | 0.0846 | 0.3226 |
Echinococcus multilocularis | propionyl coenzyme A carboxylase alpha chain | 0.1384 | 0.0846 | 0.0714 |
Toxoplasma gondii | acetyl-coA carboxylase ACC2 | 0.3633 | 0.2622 | 1 |
Toxoplasma gondii | acetyl-CoA carboxylase ACC1 | 0.3633 | 0.2622 | 1 |
Schistosoma mansoni | propionyl-CoA carboxylase beta chain mitochondrial precursor | 0.0492 | 0.0142 | 0.0142 |
Wolbachia endosymbiont of Brugia malayi | Acetyl/propionyl-CoA carboxylase, alpha subunit | 0.1384 | 0.0846 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 450 nM | Binding affinity at heteropentameric Nicotinic acetylcholine receptor alpha4-beta2 subtype using [3H]-bungarotoxin as radioligand | ChEMBL. | 10447950 |
Ki (binding) | = 450 nM | Binding affinity at heteropentameric Nicotinic acetylcholine receptor alpha4-beta2 subtype using [3H]-bungarotoxin as radioligand | ChEMBL. | 10447950 |
Ki (binding) | = 9700 nM | Binding affinity at homopentameric Nicotinic acetylcholine receptor alpha7 subtype using [3H]-S-(-)-nicotine as radioligand | ChEMBL. | 10447950 |
Ki (binding) | = 9700 nM | Binding affinity at homopentameric Nicotinic acetylcholine receptor alpha7 subtype using [3H]-S-(-)-nicotine as radioligand | ChEMBL. | 10447950 |
Potency (functional) | 37.6858 uM | PUBCHEM_BIOASSAY: Inhibitors of Regulator of G Protein Signaling (RGS) 4: qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504856] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.