TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 459.495 | Formula: C20H17N3O6S2
H donors: 3 H acceptors: 5 LogP: 3.49 Rotable bonds: 10
Rule of 5 violations (Lipinski): 1
SMILES: OC(=O)COc1ccccc1C=NNC(=O)c1ccccc1NS(=O)(=O)c1cccs1
InChi: 1S/C20H17N3O6S2/c24-18(25)13-29-17-9-4-1-6-14(17)12-21-22-20(26)15-7-2-3-8-16(15)23-31(27,28)19-10-5-11-30-19/h1-12,23H,13H2,(H,22,26)(H,24,25)
InChiKey: AIZRYXXDMOIQJU-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	GNAS complex locus	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	Get druggable targets OG5_131088	All targets in OG5_131088
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	Get druggable targets OG5_131088	All targets in OG5_131088
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	Get druggable targets OG5_131088	All targets in OG5_131088
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	Get druggable targets OG5_131088	All targets in OG5_131088
Schistosoma japonicum	ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative	Get druggable targets OG5_131088	All targets in OG5_131088
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	Get druggable targets OG5_131088	All targets in OG5_131088
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	Get druggable targets OG5_131088	All targets in OG5_131088
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	Get druggable targets OG5_131088	All targets in OG5_131088
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	Get druggable targets OG5_131088	All targets in OG5_131088
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	Get druggable targets OG5_131088	All targets in OG5_131088

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Schistosoma mansoni	GTP-binding protein alpha subunit gna	GNAS complex locus	394 aa	450 aa	28.7 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trypanosoma cruzi	hypothetical protein, conserved	0.001	0.0048	0.009
Entamoeba histolytica	acetyltransferase, GNAT family	0.0038	0.0411	0.1004
Brugia malayi	AMP-binding enzyme family protein	0.0007	0.0012	0.0031
Schistosoma mansoni	tar DNA-binding protein	0.0062	0.0713	0.1763
Echinococcus granulosus	serine:threonine protein kinase PLK1	0.0093	0.1099	0.2736
Brugia malayi	Poly	0.0322	0.3985	1
Trichomonas vaginalis	CAMK family protein kinase	0.0093	0.1099	1
Echinococcus granulosus	histone acetyltransferase KAT2B	0.0042	0.0455	0.1115
Toxoplasma gondii	poly(ADP-ribose) glycohydrolase	0.0322	0.3985	1
Loa Loa (eye worm)	hypothetical protein	0.0121	0.1448	0.3633
Loa Loa (eye worm)	abnormal chemotaxis protein 14	0.0042	0.0451	0.1131
Echinococcus multilocularis	serine:threonine protein kinase PLK1	0.0093	0.1099	0.1088
Trichomonas vaginalis	CAMK family protein kinase	0.0093	0.1099	1
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0062	0.0713	0.1789
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0016	0.0134	0.6071
Entamoeba histolytica	Niemann-Pick C1 protein, putative	0.0097	0.1149	0.2861
Echinococcus multilocularis	replication factor c subunit 1	0.001	0.0048	0.0036
Trichomonas vaginalis	bromodomain-containing protein, putative	0.0042	0.0455	0.4076
Mycobacterium tuberculosis	Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase)	0.0007	0.0012	0.0546
Leishmania major	4-coumarate:coa ligase-like protein	0.0023	0.022	0.1914
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0146	0.0366
Echinococcus granulosus	polyADP ribose glycohydrolase	0.0322	0.3985	1
Trypanosoma cruzi	poly(ADP-ribose) glycohydrolase, putative	0.0322	0.3985	1
Loa Loa (eye worm)	hypothetical protein	0.001	0.0048	0.0121
Trypanosoma cruzi	poly(ADP-ribose) glycohydrolase, putative	0.0322	0.3985	1
Echinococcus multilocularis	tar DNA binding protein	0.0062	0.0713	0.0701
Onchocerca volvulus		0.0007	0.0012	0.0085
Brugia malayi	hypothetical protein	0.001	0.0048	0.0121
Brugia malayi	acetyltransferase, GNAT family protein	0.0143	0.1726	0.4332
Loa Loa (eye worm)	hypothetical protein	0.0007	0.0012	0.0031
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0023	0.022	0.0524
Toxoplasma gondii	exonuclease III APE	0.0019	0.0159	0.04
Plasmodium falciparum	histone acetyltransferase GCN5	0.0038	0.0411	1
Schistosoma mansoni	poly(ADP-ribose) glycohydrolase	0.0322	0.3985	1
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0451	0.1131
Loa Loa (eye worm)	hypothetical protein	0.001	0.0048	0.0121
Brugia malayi	Pax transcription activation domain interacting protein	0.001	0.0048	0.0121
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0007	0.0012	0.0031
Onchocerca volvulus		0.0007	0.0012	0.0085
Giardia lamblia	Kinase, PLK	0.0093	0.1099	1
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0016	0.0134	0.6071
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0016	0.0134	0.6071
Onchocerca volvulus	Huntingtin homolog	0.0121	0.1448	1
Trichomonas vaginalis	RNA polymerase II ctd phosphatase, putative	0.001	0.0048	0.033
Leishmania major	4-coumarate:coa ligase-like protein	0.0023	0.022	0.1914
Toxoplasma gondii	poly(ADP-ribose) polymerase catalytic domain-containing protein	0.001	0.0048	0.0121
Brugia malayi	AMP-binding enzyme family protein	0.0023	0.022	0.0553
Mycobacterium tuberculosis	Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0007	0.0012	0.0546
Trichomonas vaginalis	conserved hypothetical protein	0.001	0.0048	0.033
Mycobacterium tuberculosis	Phenyloxazoline synthase MbtB (phenyloxazoline synthetase)	0.0007	0.0012	0.0546
Schistosoma mansoni	topbp1	0.001	0.0048	0.009
Trypanosoma cruzi	polo-like protein kinase, putative	0.0093	0.1099	0.2736
Trichomonas vaginalis	CAMK family protein kinase	0.0046	0.0507	0.4549
Trichomonas vaginalis	ap endonuclease, putative	0.0019	0.0159	0.1354
Plasmodium vivax	histone acetyltransferase GCN5, putative	0.0042	0.0455	1
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0146	0.0366
Echinococcus granulosus	histone acetyltransferase KAT2B	0.0139	0.1676	0.4188
Schistosoma mansoni	gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2	0.0143	0.1726	0.4315
Plasmodium falciparum	replication factor C subunit 1, putative	0.001	0.0048	0.1171
Plasmodium vivax	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0019	0.0159	0.3502
Brugia malayi	hypothetical protein	0.001	0.0048	0.0121
Entamoeba histolytica	poly(ADP-ribose) glycohydrolase, putative	0.0322	0.3985	1
Brugia malayi	Niemann-Pick C1 protein precursor	0.0097	0.1149	0.2883
Toxoplasma gondii	Acetyl-coenzyme A synthetase 2, putative	0.0007	0.0012	0.0031
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0055	0.0623	0.1536
Loa Loa (eye worm)	hypothetical protein	0.0121	0.1448	0.3633
Trypanosoma cruzi	polo-like protein kinase, putative	0.0093	0.1099	0.2736
Trichomonas vaginalis	CAMK family protein kinase	0.0093	0.1099	1
Mycobacterium leprae	PROBABLE DNA LIGASE [NAD DEPENDENT] LIGA (POLYDEOXYRIBONUCLEOTIDE SYNTHASE [NAD+])	0.001	0.0048	0.1722
Echinococcus granulosus	Niemann Pick C1 protein	0.0139	0.1674	0.4182
Mycobacterium tuberculosis	Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0007	0.0012	0.0546
Plasmodium vivax	acyl-CoA synthetase, putative	0.0017	0.0146	0.3204
Loa Loa (eye worm)	AMP-binding enzyme family protein	0.0007	0.0012	0.0031
Brugia malayi	RNA recognition motif domain containing protein	0.0062	0.0713	0.1789
Mycobacterium tuberculosis	Peptide synthetase MbtE (peptide synthase)	0.0007	0.0012	0.0546
Brugia malayi	serine/threonine-protein kinase plk-2	0.0093	0.1099	0.2759
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0055	0.0623	0.1536
Trichomonas vaginalis	CAMK family protein kinase	0.0093	0.1099	1
Brugia malayi	hypothetical protein	0.0121	0.1448	0.3633
Brugia malayi	exodeoxyribonuclease III family protein	0.0019	0.0159	0.04
Onchocerca volvulus		0.0007	0.0012	0.0085
Echinococcus multilocularis	Niemann Pick C1 protein	0.0139	0.1674	0.1664
Schistosoma mansoni	tar DNA-binding protein	0.0062	0.0713	0.1763
Plasmodium falciparum	acyl-CoA synthetase	0.0017	0.0146	0.3548
Trypanosoma brucei	poly(ADP-ribose) glycohydrolase, putative	0.0322	0.3985	1
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0146	0.0366
Trypanosoma brucei	BRCA1 C Terminus (BRCT) domain containing protein, putative	0.001	0.0048	0.009
Schistosoma mansoni	ap endonuclease	0.0019	0.0159	0.037
Trichomonas vaginalis	ap endonuclease, putative	0.0019	0.0159	0.1354
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0023	0.022	1
Plasmodium vivax	acetyl-CoA synthetase, putative	0.0007	0.0012	0.027
Echinococcus multilocularis	poly(ADP ribose) glycohydrolase	0.0322	0.3985	0.3978
Loa Loa (eye worm)	TAR-binding protein	0.0062	0.0713	0.1789
Brugia malayi	RNA binding protein	0.0062	0.0713	0.1789
Brugia malayi	AMP-binding enzyme family protein	0.0007	0.0012	0.0031
Schistosoma mansoni	tar DNA-binding protein	0.0062	0.0713	0.1763
Brugia malayi	AMP-binding enzyme family protein	0.0023	0.022	0.0553
Brugia malayi	TAR-binding protein	0.0062	0.0713	0.1789
Loa Loa (eye worm)	hypothetical protein	0.0007	0.0012	0.0031
Echinococcus granulosus	nibrin	0.001	0.0048	0.009
Echinococcus granulosus	DNA apurinic or apyrimidinic site lyase	0.0019	0.0159	0.037
Brugia malayi	AMP-binding enzyme family protein	0.0007	0.0012	0.0031
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0055	0.0623	0.1562
Echinococcus multilocularis	protein dispatched 1	0.0047	0.0525	0.0513
Mycobacterium tuberculosis	Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0007	0.0012	0.0546
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0007	0.0012	0.0546
Brugia malayi	AMP-binding enzyme family protein	0.0023	0.022	0.0553
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0146	0.0366
Loa Loa (eye worm)	PLK/PLK1 protein kinase	0.0093	0.1099	0.2759
Mycobacterium ulcerans	hypothetical protein	0.0023	0.022	1
Onchocerca volvulus		0.0023	0.022	0.1522
Loa Loa (eye worm)	hypothetical protein	0.001	0.0048	0.0121
Echinococcus multilocularis	Niemann Pick C1 protein	0.0097	0.1149	0.1138
Mycobacterium ulcerans	long-chain fatty-acid CoA ligase	0.0023	0.022	1
Brugia malayi	CHE-14 protein	0.0042	0.0451	0.1131
Leishmania major	4-coumarate:coa ligase-like protein	0.0023	0.022	0.1914
Mycobacterium tuberculosis	P-hydroxybenzoyl-AMP ligase FadD22	0.0007	0.0012	0.0546
Mycobacterium tuberculosis	Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase	0.0007	0.0012	0.0546
Schistosoma mansoni	hypothetical protein	0.004	0.0432	0.1056
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0055	0.0623	0.0611
Trypanosoma cruzi	hypothetical protein, conserved	0.001	0.0048	0.009
Trichomonas vaginalis	conserved hypothetical protein	0.001	0.0048	0.033
Trypanosoma brucei	polo-like protein kinase	0.0093	0.1099	0.2736
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0016	0.0134	0.6071
Mycobacterium ulcerans	NAD-dependent DNA ligase LigA	0.001	0.0048	0.1722
Schistosoma mansoni	serine/threonine protein kinase	0.0093	0.1099	0.2736
Toxoplasma gondii	histone lysine acetyltransferase GCN5-A	0.0042	0.0455	0.1143
Brugia malayi	acetyl-Coenzyme A synthetase 2	0.0007	0.0012	0.0031
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0569	0.1427
Entamoeba histolytica	acyl-coA synthetase, putative	0.0023	0.022	0.0524
Leishmania major	apurinic/apyrimidinic endonuclease-redox protein	0.0019	0.0159	0.1354
Trichomonas vaginalis	replication factor C large subunit, putative	0.001	0.0048	0.033
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0055	0.0623	0.1536
Mycobacterium tuberculosis	Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI)	0.0019	0.0159	0.7233
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease, putative	0.0019	0.0159	0.037
Plasmodium vivax	replication factor C subunit 1, putative	0.001	0.0048	0.1057
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0055	0.0623	0.0611
Treponema pallidum	exodeoxyribonuclease (exoA)	0.0019	0.0159	1
Loa Loa (eye worm)	RNA binding protein	0.0062	0.0713	0.1789
Trichomonas vaginalis	chromosome transmission fidelity factor, putative	0.001	0.0048	0.033
Mycobacterium ulcerans	acyl-CoA synthetase	0.0023	0.022	1
Echinococcus multilocularis	nibrin	0.001	0.0048	0.0036
Loa Loa (eye worm)	hypothetical protein	0.001	0.0048	0.0121
Echinococcus granulosus	Niemann Pick C1 protein	0.0097	0.1149	0.2861
Mycobacterium ulcerans	long-chain-fatty-acid--CoA ligase	0.0023	0.022	1
Trichomonas vaginalis	CAMK family protein kinase	0.0093	0.1099	1
Schistosoma mansoni	ap endonuclease	0.0019	0.0159	0.037
Toxoplasma gondii	poly(ADP-ribose) glycohydrolase	0.0143	0.1734	0.4351
Loa Loa (eye worm)	oxidoreductase	0.0007	0.0012	0.0031
Brugia malayi	DKFZp564C0469 protein	0.001	0.0048	0.0121
Echinococcus multilocularis	expressed conserved protein	0.0091	0.1075	0.1064
Echinococcus multilocularis	DNA (apurinic or apyrimidinic site) lyase	0.0019	0.0159	0.0147
Mycobacterium tuberculosis	Peptide synthetase MbtF (peptide synthase)	0.0007	0.0012	0.0546
Echinococcus multilocularis	gcn5proteinral control of amino acid synthesis	0.0143	0.1726	0.1716
Toxoplasma gondii	propionate-CoA ligase	0.0007	0.0012	0.0031
Schistosoma mansoni	hypothetical protein	0.004	0.0432	0.1056
Brugia malayi	topoisomerase	0.001	0.0048	0.0121
Brugia malayi	AMP-binding enzyme family protein	0.0007	0.0012	0.0031
Giardia lamblia	Histone acetyltransferase GCN5	0.0038	0.0411	0.3454
Loa Loa (eye worm)	Poly(ADP-ribose) glycohydrolase	0.0322	0.3985	1
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0055	0.0623	0.1536
Echinococcus granulosus	tar DNA binding protein	0.0062	0.0713	0.1763
Schistosoma mansoni	DNA ligase IV	0.001	0.0048	0.009
Trichomonas vaginalis	CAMK family protein kinase	0.0093	0.1099	1
Trichomonas vaginalis	conserved hypothetical protein	0.001	0.0048	0.033
Leishmania major	protein kinase, putative,polo-like protein kinase, putative	0.0093	0.1099	1
Chlamydia trachomatis	acylglycerophosphoethanolamine acyltransferase	0.0017	0.0146	1
Trichomonas vaginalis	cat eye syndrome critical region protein 2, cscr2, putative	0.0042	0.0455	0.4076
Onchocerca volvulus		0.0007	0.0012	0.0085
Loa Loa (eye worm)	AMP-binding enzyme family protein	0.0007	0.0012	0.0031
Mycobacterium ulcerans	exodeoxyribonuclease III protein XthA	0.0019	0.0159	0.7073
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0023	0.022	0.0524
Plasmodium falciparum	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0019	0.0159	0.3878
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0055	0.0623	0.1562
Echinococcus granulosus	replication factor c subunit 1	0.001	0.0048	0.009
Entamoeba histolytica	serine/threonine protein kinase, putative	0.0093	0.1099	0.2736
Trichomonas vaginalis	CAMK family protein kinase	0.0046	0.0507	0.4549
Mycobacterium ulcerans	acyl-CoA synthetase	0.0023	0.022	1
Onchocerca volvulus		0.001	0.0048	0.0332
Echinococcus multilocularis	sterol regulatory element binding protein	0.0042	0.0451	0.0439
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0017	0.0146	0.6421
Entamoeba histolytica	hypothetical protein	0.0322	0.3985	1
Loa Loa (eye worm)	exodeoxyribonuclease III family protein	0.0019	0.0159	0.04
Mycobacterium ulcerans	long-chain-fatty-acid-CoA ligase	0.0023	0.022	1
Mycobacterium ulcerans	acyl-CoA synthetase	0.0023	0.022	1
Mycobacterium tuberculosis	Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase)	0.0017	0.0146	0.6617
Loa Loa (eye worm)	hypothetical protein	0.0023	0.022	0.0553
Trichomonas vaginalis	RNA polymerase II ctd phosphatase, putative	0.001	0.0048	0.033
Schistosoma mansoni	chromosome transmission fidelity factor	0.001	0.0048	0.009
Echinococcus granulosus	Protein patched homolog 1	0.0042	0.0451	0.1104
Echinococcus granulosus	expressed conserved protein	0.0091	0.1075	0.2674
Mycobacterium tuberculosis	Probable peptide synthetase Nrp (peptide synthase)	0.0007	0.0012	0.0546
Schistosoma mansoni	kinase	0.0047	0.0522	0.1284
Schistosoma mansoni	niemann-pick C1 (NPC1)	0.0098	0.1168	0.2909
Entamoeba histolytica	exodeoxyribonuclease III, putative	0.0019	0.0159	0.037
Toxoplasma gondii	ATPase, AAA family protein	0.001	0.0048	0.0121
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0146	0.0366
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0023	0.022	1
Onchocerca volvulus	Serine\/threonine kinase homolog	0.0093	0.1099	0.7593
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease	0.0019	0.0159	0.037
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0023	0.022	1
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0023	0.022	1
Schistosoma mansoni	patched 1	0.0042	0.0451	0.1104
Brugia malayi	ATP dependent DNA ligase C terminal region family protein	0.001	0.0048	0.0121
Toxoplasma gondii	histone lysine acetyltransferase GCN5-B	0.0042	0.0455	0.1143
Trichomonas vaginalis	CAMK family protein kinase	0.0093	0.1099	1
Entamoeba histolytica	hypothetical protein	0.001	0.0048	0.009
Toxoplasma gondii	AMP-binding enzyme domain-containing protein	0.0007	0.0012	0.0031
Entamoeba histolytica	poly(ADP-ribose) glycohydrolase, putative	0.0143	0.1734	0.4334
Trypanosoma brucei	apurinic/apyrimidinic endonuclease, putative	0.0019	0.0159	0.037
Loa Loa (eye worm)	hypothetical protein	0.001	0.0048	0.0121
Schistosoma mansoni	hypothetical protein	0.004	0.0432	0.1056
Entamoeba histolytica	hypothetical protein	0.0143	0.1734	0.4334
Onchocerca volvulus	Huntingtin homolog	0.0121	0.1448	1
Schistosoma mansoni	hypothetical protein	0.004	0.0432	0.1056
Mycobacterium tuberculosis	Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase)	0.0023	0.022	1
Loa Loa (eye worm)	hypothetical protein	0.0023	0.022	0.0553
Loa Loa (eye worm)	hypothetical protein	0.0097	0.1149	0.2883
Plasmodium falciparum	acetyl-CoA synthetase, putative	0.0007	0.0012	0.0299
Schistosoma mansoni	tar DNA-binding protein	0.0062	0.0713	0.1763
Schistosoma mansoni	topbp1	0.001	0.0048	0.009
Echinococcus granulosus	sterol regulatory element binding protein	0.0042	0.0451	0.1104
Trichomonas vaginalis	conserved hypothetical protein	0.001	0.0048	0.033
Trichomonas vaginalis	conserved hypothetical protein	0.0042	0.0451	0.4033
Echinococcus multilocularis	protein patched	0.0042	0.0451	0.0439
Loa Loa (eye worm)	acetyltransferase	0.0143	0.1726	0.4332
Trypanosoma cruzi	FHA domain containing protein, putative	0.001	0.0048	0.009
Loa Loa (eye worm)	hypothetical protein	0.0023	0.022	0.0553
Giardia lamblia	Endonuclease/Exonuclease/phosphatase	0.0019	0.0159	0.1059
Trypanosoma cruzi	BRCA1 C Terminus (BRCT) domain containing protein, putative	0.001	0.0048	0.009
Trichomonas vaginalis	conserved hypothetical protein	0.001	0.0048	0.033
Entamoeba histolytica	Activator 1 140 kDa subunit, putative	0.001	0.0048	0.009
Loa Loa (eye worm)	hypothetical protein	0.001	0.0048	0.0121
Trichomonas vaginalis	chromosome transmission fidelity factor, putative	0.001	0.0048	0.033
Wolbachia endosymbiont of Brugia malayi	exonuclease III	0.0019	0.0159	1
Schistosoma mansoni	tar DNA-binding protein	0.0062	0.0713	0.1763
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0055	0.0623	0.1536

Activities

Activity type	Activity value	Assay description	Source	Reference
Potency (functional)	14.1254 uM	PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory)	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

ChEMBL: CHEMBL2134446

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1712054