Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Entamoeba histolytica | protein kinase, putative | 0.0066 | 0.0713 | 0.5 |
Schistosoma mansoni | acetyl-CoA C-acetyltransferase | 0.0025 | 0.0036 | 0.0036 |
Echinococcus multilocularis | aurora kinase A | 0.0066 | 0.0713 | 0.0679 |
Brugia malayi | hypothetical protein | 0.0348 | 0.548 | 0.6115 |
Echinococcus multilocularis | lipoxygenase domain containing protein | 0.0103 | 0.1344 | 0.1312 |
Loa Loa (eye worm) | AUR protein kinase | 0.0066 | 0.0713 | 0.0796 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0066 | 0.0713 | 0.0713 |
Schistosoma mansoni | hypothetical protein | 0.0103 | 0.1344 | 0.1344 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0028 | 0.0087 | 0.0515 |
Plasmodium vivax | serine/threonine protein kinase 6, putative | 0.0066 | 0.0713 | 0.5234 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0554 | 0.8948 | 1 |
Brugia malayi | hypothetical protein | 0.0103 | 0.1344 | 0.1484 |
Schistosoma mansoni | lipoxygenase | 0.0616 | 1 | 1 |
Trypanosoma cruzi | aurora B kinase, putative | 0.0066 | 0.0713 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.0066 | 0.0713 | 0.0777 |
Giardia lamblia | Kinase, TTK | 0.0554 | 0.8948 | 1 |
Brugia malayi | Bromodomain containing protein | 0.0085 | 0.1037 | 0.114 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0554 | 0.8948 | 1 |
Toxoplasma gondii | aurora kinase | 0.0066 | 0.0713 | 0.4576 |
Echinococcus granulosus | aurora kinase A | 0.0066 | 0.0713 | 0.0679 |
Plasmodium falciparum | LCCL domain-containing protein | 0.0103 | 0.1344 | 1 |
Echinococcus multilocularis | RUN | 0.0103 | 0.1344 | 0.1312 |
Brugia malayi | hypothetical protein | 0.0028 | 0.0087 | 0.0076 |
Loa Loa (eye worm) | hypothetical protein | 0.0046 | 0.0383 | 0.0428 |
Echinococcus granulosus | serine:threonine protein kinase 12 B | 0.0066 | 0.0713 | 0.0679 |
Schistosoma mansoni | bromodomain containing protein | 0.0072 | 0.0813 | 0.0813 |
Plasmodium vivax | multidomain scavenger receptor, putative | 0.0103 | 0.1344 | 1 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0041 | 0.0292 | 0.0256 |
Schistosoma mansoni | polycystin 1-related | 0.0103 | 0.1344 | 0.1344 |
Schistosoma mansoni | lipoxygenase | 0.0431 | 0.6872 | 0.6872 |
Schistosoma mansoni | microsomal glutathione s-transferase | 0.0114 | 0.1535 | 0.1535 |
Entamoeba histolytica | serine/threonine- protein kinase 6, putative | 0.0066 | 0.0713 | 0.5 |
Schistosoma mansoni | dual specificity serine/threonine tyrosine kinase | 0.0554 | 0.8948 | 0.8948 |
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 0.042 | 0.0469 |
Brugia malayi | Bromodomain containing protein | 0.0043 | 0.0337 | 0.0356 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0067 | 0.0745 | 0.0711 |
Echinococcus granulosus | lipoxygenase domain containing protein | 0.0103 | 0.1344 | 0.1312 |
Entamoeba histolytica | serine/threonine protein kinase 6, putative | 0.0066 | 0.0713 | 0.5 |
Schistosoma mansoni | loxhd1 | 0.0103 | 0.1344 | 0.1344 |
Echinococcus granulosus | lipoxygenase domain containing protein | 0.0103 | 0.1344 | 0.1312 |
Trichomonas vaginalis | AGC family protein kinase | 0.0066 | 0.0713 | 0.0777 |
Entamoeba histolytica | protein kinase domain containing protein | 0.0066 | 0.0713 | 0.5 |
Brugia malayi | serine/threonine kinase 12 | 0.0066 | 0.0713 | 0.0777 |
Trypanosoma brucei | aurora B kinase | 0.0066 | 0.0713 | 1 |
Brugia malayi | serine/threonine protein kinase 6 | 0.0066 | 0.0713 | 0.0777 |
Loa Loa (eye worm) | hypothetical protein | 0.0348 | 0.548 | 0.6124 |
Trichomonas vaginalis | AGC family protein kinase | 0.0066 | 0.0713 | 0.0777 |
Brugia malayi | Doublecortin family protein | 0.0103 | 0.1344 | 0.1484 |
Brugia malayi | PHD-finger family protein | 0.0028 | 0.0082 | 0.007 |
Trichomonas vaginalis | AGC family protein kinase | 0.0066 | 0.0713 | 0.0777 |
Brugia malayi | serine/threonine-protein kinase 6 | 0.0066 | 0.0713 | 0.0777 |
Onchocerca volvulus | 0.0103 | 0.1344 | 0.1484 | |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.0338 | 0.0378 |
Loa Loa (eye worm) | hypothetical protein | 0.0103 | 0.1344 | 0.1502 |
Onchocerca volvulus | 0.0103 | 0.1344 | 0.1484 | |
Loa Loa (eye worm) | TTK protein kinase | 0.0554 | 0.8948 | 1 |
Schistosoma mansoni | protein kinase | 0.0066 | 0.0713 | 0.0713 |
Brugia malayi | hypothetical protein | 0.0103 | 0.1344 | 0.1484 |
Schistosoma mansoni | rab6-interacting | 0.0103 | 0.1344 | 0.1344 |
Schistosoma mansoni | membrane associated proteins in eicosanoid and glutathione metabolism family member | 0.0499 | 0.8021 | 0.8021 |
Entamoeba histolytica | serine/threonine- protein kinase 6 , putative | 0.0066 | 0.0713 | 0.5 |
Echinococcus multilocularis | serine:threonine protein kinase 12 B | 0.0066 | 0.0713 | 0.0679 |
Loa Loa (eye worm) | hypothetical protein | 0.0103 | 0.1344 | 0.1502 |
Echinococcus multilocularis | arachidonate 5 lipoxygenase | 0.0616 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.008 | 0.0955 | 0.1068 |
Schistosoma mansoni | rab6-interacting | 0.0103 | 0.1344 | 0.1344 |
Echinococcus multilocularis | lipoxygenase domain containing protein | 0.0103 | 0.1344 | 0.1312 |
Onchocerca volvulus | Dual specificity protein kinase TTK homolog | 0.0554 | 0.8948 | 1 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0028 | 0.0087 | 0.0515 |
Echinococcus multilocularis | microsomal glutathione S transferase 3 | 0.0114 | 0.1535 | 0.1504 |
Brugia malayi | Protein kinase domain containing protein | 0.0554 | 0.8948 | 1 |
Echinococcus multilocularis | dual specificity serine:threonine tyrosine | 0.0554 | 0.8948 | 0.8944 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.0028 | 0.0087 | 0.045 |
Echinococcus granulosus | dual specificity serine:threonine tyrosine | 0.0554 | 0.8948 | 0.8944 |
Plasmodium falciparum | serine/threonine protein kinase, putative | 0.0066 | 0.0713 | 0.5234 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.0019 | 0.0021 |
Loa Loa (eye worm) | AUR protein kinase | 0.0066 | 0.0713 | 0.0796 |
Loa Loa (eye worm) | doublecortin family protein | 0.0103 | 0.1344 | 0.1502 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0067 | 0.0745 | 0.0711 |
Leishmania major | protein kinase, putative | 0.0066 | 0.0713 | 1 |
Echinococcus granulosus | microsomal glutathione S transferase 3 | 0.0114 | 0.1535 | 0.1504 |
Echinococcus granulosus | Polycystic kidney disease protein | 0.0103 | 0.1344 | 0.1312 |
Entamoeba histolytica | protein kinase , putative | 0.0066 | 0.0713 | 0.5 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0028 | 0.0087 | 0.0515 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0041 | 0.0292 | 0.0256 |
Entamoeba histolytica | protein kinase, putative | 0.0066 | 0.0713 | 0.5 |
Echinococcus granulosus | RUN | 0.0103 | 0.1344 | 0.1312 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.0087 | 0.0097 |
Toxoplasma gondii | MAPEG family protein | 0.0114 | 0.1535 | 1 |
Echinococcus multilocularis | Polycystic kidney disease protein | 0.0103 | 0.1344 | 0.1312 |
Loa Loa (eye worm) | AUR protein kinase | 0.0066 | 0.0713 | 0.0796 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.