Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium falciparum | ornithine aminotransferase | 0.0023 | 0.0798 | 0.4929 |
Toxoplasma gondii | histone lysine acetyltransferase GCN5-A | 0.0045 | 0.1787 | 0.3482 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0014 | 0.0381 | 0.0476 |
Trichomonas vaginalis | bromodomain-containing protein, putative | 0.0045 | 0.1787 | 0.2479 |
Echinococcus granulosus | cpg binding protein | 0.0064 | 0.2662 | 0.412 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.0128 | 0.5585 | 0.8392 |
Loa Loa (eye worm) | CXXC zinc finger family protein | 0.0061 | 0.2506 | 0.2506 |
Trypanosoma brucei | ISWI complex protein | 0.0006 | 0.0047 | 0.0371 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0045 | 0.1781 | 0.1781 |
Loa Loa (eye worm) | RNA binding protein | 0.0066 | 0.2773 | 0.2773 |
Trypanosoma cruzi | Present in the outer mitochondrial membrane proteome 4 | 0.0033 | 0.1276 | 1 |
Schistosoma mansoni | cpg binding protein | 0.0064 | 0.2662 | 0.4 |
Plasmodium falciparum | FAD-linked sulfhydryl oxidase ERV1, putative | 0.0033 | 0.1276 | 0.7885 |
Plasmodium falciparum | histone acetyltransferase GCN5 | 0.0041 | 0.1618 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0066 | 0.2773 | 0.4167 |
Onchocerca volvulus | 0.0061 | 0.2506 | 1 | |
Echinococcus multilocularis | Aminotransferase class III | 0.0023 | 0.0798 | 0.1198 |
Schistosoma mansoni | bromodomain containing protein | 0.0007 | 0.0084 | 0.0127 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0045 | 0.1781 | 0.2677 |
Wolbachia endosymbiont of Brugia malayi | acetylornithine transaminase protein | 0.0023 | 0.0798 | 0.5 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0014 | 0.0381 | 0.0476 |
Brugia malayi | RNA binding protein | 0.0066 | 0.2773 | 0.2773 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0007 | 0.0084 | 0.0131 |
Toxoplasma gondii | ornithine aminotransferase, mitochondrial precursor, putative | 0.0023 | 0.0798 | 0.1554 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.0015 | 0.0441 | 0.0663 |
Schistosoma mansoni | tar DNA-binding protein | 0.0066 | 0.2773 | 0.4167 |
Echinococcus multilocularis | FAD linked sulfhydryl oxidase ALR | 0.0033 | 0.1276 | 0.1917 |
Trichomonas vaginalis | chromodomain-helicase-DNA-binding protein, putative | 0.0014 | 0.0381 | 0.0476 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0007 | 0.0093 | 0.0065 |
Loa Loa (eye worm) | hepatopoietin HPO2 | 0.0033 | 0.1276 | 0.1276 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0045 | 0.1781 | 0.2757 |
Echinococcus multilocularis | tar DNA binding protein | 0.0066 | 0.2773 | 0.4167 |
Trypanosoma cruzi | ISWI complex protein | 0.0006 | 0.0047 | 0.0371 |
Chlamydia trachomatis | glutamate-1-semialdehyde-2,1-aminomutase | 0.0023 | 0.0798 | 0.5 |
Loa Loa (eye worm) | histone methyltransferase | 0.0019 | 0.0609 | 0.0609 |
Echinococcus granulosus | tar DNA binding protein | 0.0066 | 0.2773 | 0.4291 |
Echinococcus granulosus | histone acetyltransferase KAT2B | 0.0148 | 0.6462 | 1 |
Echinococcus granulosus | ornithine aminotransferase | 0.0023 | 0.0798 | 0.1234 |
Schistosoma mansoni | bromodomain containing protein | 0.0007 | 0.0084 | 0.0127 |
Loa Loa (eye worm) | hypothetical protein | 0.0007 | 0.0084 | 0.0084 |
Toxoplasma gondii | histone lysine methyltransferase SET1 | 0.0118 | 0.5132 | 1 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0066 | 0.2773 | 0.2773 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0014 | 0.0381 | 0.0476 |
Loa Loa (eye worm) | acetyltransferase | 0.0152 | 0.6655 | 0.6655 |
Echinococcus granulosus | mixed lineage leukemia protein mll | 0.0015 | 0.0441 | 0.0683 |
Schistosoma mansoni | cpg binding protein | 0.0064 | 0.2662 | 0.4 |
Mycobacterium ulcerans | adenosylmethionine-8-amino-7-oxononanoate aminotransferase | 0.0161 | 0.7065 | 1 |
Echinococcus multilocularis | mixed lineage leukemia protein mll | 0.0015 | 0.0441 | 0.0663 |
Plasmodium vivax | histone acetyltransferase GCN5, putative | 0.0045 | 0.1787 | 1 |
Echinococcus granulosus | FAD linked sulfhydryl oxidase ALR | 0.0033 | 0.1276 | 0.1974 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0045 | 0.1781 | 0.2677 |
Schistosoma mansoni | cpg binding protein | 0.0061 | 0.2506 | 0.3765 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0014 | 0.0381 | 0.0476 |
Echinococcus multilocularis | histone lysine N methyltransferase MLL3 | 0.0015 | 0.0441 | 0.0663 |
Trypanosoma cruzi | Present in the outer mitochondrial membrane proteome 4 | 0.0033 | 0.1276 | 1 |
Trichomonas vaginalis | acetylornithine aminotransferase, putative | 0.0161 | 0.7065 | 1 |
Entamoeba histolytica | acetyltransferase, GNAT family | 0.0041 | 0.1618 | 1 |
Trichomonas vaginalis | chromodomain-helicase-DNA-binding protein, putative | 0.0007 | 0.0093 | 0.0065 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.0009 | 0.0153 | 0.023 |
Trichomonas vaginalis | cat eye syndrome critical region protein 2, cscr2, putative | 0.0045 | 0.1787 | 0.2479 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0045 | 0.1781 | 0.2677 |
Toxoplasma gondii | Erv1 / Alr family protein | 0.0033 | 0.1276 | 0.2486 |
Mycobacterium ulcerans | hypothetical protein | 0.0161 | 0.7065 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0014 | 0.0381 | 0.0476 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0014 | 0.0381 | 0.0476 |
Giardia lamblia | Histone acetyltransferase GCN5 | 0.0041 | 0.1618 | 0.5 |
Toxoplasma gondii | Erv1 / Alr family protein | 0.0033 | 0.1276 | 0.2486 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0045 | 0.1781 | 0.2677 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0014 | 0.0381 | 0.0476 |
Echinococcus multilocularis | ornithine aminotransferase | 0.0023 | 0.0798 | 0.1198 |
Echinococcus multilocularis | cpg binding protein | 0.0064 | 0.2662 | 0.4 |
Brugia malayi | TAR-binding protein | 0.0066 | 0.2773 | 0.2773 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0014 | 0.0381 | 0.0476 |
Echinococcus granulosus | histone lysine N methyltransferase MLL3 | 0.0019 | 0.0609 | 0.0942 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0014 | 0.0381 | 0.0476 |
Schistosoma mansoni | myst-related protein | 0.0007 | 0.0083 | 0.0125 |
Echinococcus multilocularis | zinc finger protein | 0.0007 | 0.0084 | 0.0127 |
Plasmodium falciparum | zinc finger protein, putative | 0.0007 | 0.0083 | 0.0512 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0014 | 0.0381 | 0.0476 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0014 | 0.0381 | 0.0476 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0014 | 0.0381 | 0.0476 |
Trypanosoma cruzi | ERV/ALR sulfhydryl oxidase domain-containing protein | 0.0033 | 0.1276 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0066 | 0.2773 | 0.4167 |
Schistosoma mansoni | tar DNA-binding protein | 0.0066 | 0.2773 | 0.4167 |
Echinococcus multilocularis | ornithine aminotransferase | 0.0023 | 0.0798 | 0.1198 |
Echinococcus granulosus | zinc finger protein | 0.0007 | 0.0084 | 0.0131 |
Loa Loa (eye worm) | TAR-binding protein | 0.0066 | 0.2773 | 0.2773 |
Plasmodium vivax | FAD-linked sulfhydryl oxidase ERV1, putative | 0.0033 | 0.1276 | 0.7139 |
Brugia malayi | 4-aminobutyrate aminotransferase, mitochondrial precursor | 0.0023 | 0.0798 | 0.0798 |
Brugia malayi | F/Y-rich N-terminus family protein | 0.0018 | 0.0598 | 0.0598 |
Loa Loa (eye worm) | follicle stimulating hormone receptor | 0.0226 | 1 | 1 |
Toxoplasma gondii | histone lysine acetyltransferase GCN5-B | 0.0045 | 0.1787 | 0.3482 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0045 | 0.1781 | 0.2757 |
Trichomonas vaginalis | hypothetical protein | 0.0007 | 0.0093 | 0.0065 |
Schistosoma mansoni | tar DNA-binding protein | 0.0066 | 0.2773 | 0.4167 |
Schistosoma mansoni | zinc finger protein | 0.0007 | 0.0084 | 0.0127 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0045 | 0.1781 | 0.2677 |
Loa Loa (eye worm) | hypothetical protein | 0.0007 | 0.0084 | 0.0084 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0007 | 0.0084 | 0.0127 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0014 | 0.0381 | 0.0476 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0014 | 0.0381 | 0.0476 |
Brugia malayi | CXXC zinc finger family protein | 0.0061 | 0.2506 | 0.2506 |
Echinococcus multilocularis | histone lysine N methyltransferase MLL3 | 0.0019 | 0.0609 | 0.0915 |
Trichomonas vaginalis | chromodomain-helicase-DNA-binding protein, putative | 0.0014 | 0.0381 | 0.0476 |
Echinococcus granulosus | Aminotransferase class III | 0.0023 | 0.0798 | 0.1234 |
Schistosoma mansoni | ornithine--oxo-acid transaminase | 0.0023 | 0.0798 | 0.1198 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0014 | 0.0381 | 0.0476 |
Echinococcus granulosus | histone lysine N methyltransferase MLL3 | 0.0015 | 0.0441 | 0.0683 |
Schistosoma mansoni | gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 | 0.0152 | 0.6655 | 1 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0045 | 0.1781 | 0.1781 |
Leishmania major | hypothetical protein, conserved | 0.0033 | 0.1276 | 0.5 |
Trypanosoma brucei | ERV/ALR sulfhydryl oxidase domain-containing protein | 0.0033 | 0.1276 | 1 |
Trichomonas vaginalis | helicase, putative | 0.0014 | 0.0381 | 0.0476 |
Plasmodium vivax | ornithine aminotransferase, putative | 0.0023 | 0.0798 | 0.4463 |
Brugia malayi | PHD-finger family protein | 0.0007 | 0.0084 | 0.0084 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0066 | 0.2773 | 0.2773 |
Brugia malayi | Bromodomain containing protein | 0.0007 | 0.0084 | 0.0084 |
Echinococcus granulosus | histone acetyltransferase KAT2B | 0.0045 | 0.1787 | 0.2765 |
Mycobacterium leprae | PROBABLE ADENOSYLMETHIONINE-8-AMINO-7-OXONONANOATE AMINOTRANSFERASE BIOA | 0.0161 | 0.7065 | 1 |
Echinococcus multilocularis | gcn5proteinral control of amino acid synthesis | 0.0152 | 0.6655 | 1 |
Mycobacterium tuberculosis | Probable aminotransferase | 0.0161 | 0.7065 | 1 |
Schistosoma mansoni | myst-related protein | 0.0007 | 0.0083 | 0.0125 |
Mycobacterium tuberculosis | Adenosylmethionine-8-amino-7-oxononanoate aminotransferase BioA | 0.0161 | 0.7065 | 1 |
Brugia malayi | acetyltransferase, GNAT family protein | 0.0152 | 0.6655 | 0.6655 |
Brugia malayi | Augmenter of liver regeneration | 0.0033 | 0.1276 | 0.1276 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.