Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Sus scrofa | Aminopeptidase N | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Schistosoma japonicum | ko:K01256 membrane alanyl aminopeptidase [EC3.4.11.2], putative | Get druggable targets OG5_127217 | All targets in OG5_127217 |
Loa Loa (eye worm) | peptidase family M1 containing protein | Get druggable targets OG5_127217 | All targets in OG5_127217 |
Echinococcus granulosus | aminopeptidase N | Get druggable targets OG5_127217 | All targets in OG5_127217 |
Loa Loa (eye worm) | hypothetical protein | Get druggable targets OG5_127217 | All targets in OG5_127217 |
Loa Loa (eye worm) | hypothetical protein | Get druggable targets OG5_127217 | All targets in OG5_127217 |
Onchocerca volvulus | Get druggable targets OG5_127217 | All targets in OG5_127217 | |
Brugia malayi | Peptidase family M1 containing protein | Get druggable targets OG5_127217 | All targets in OG5_127217 |
Echinococcus multilocularis | aminopeptidase N | Get druggable targets OG5_127217 | All targets in OG5_127217 |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Echinococcus multilocularis | puromycin sensitive aminopeptidase | Aminopeptidase N | 963 aa | 981 aa | 29.2 % |
Onchocerca volvulus | Aminopeptidase N | 963 aa | 893 aa | 32.0 % | |
Echinococcus granulosus | puromycin sensitive aminopeptidase | Aminopeptidase N | 963 aa | 975 aa | 29.1 % |
Echinococcus multilocularis | puromycin sensitive aminopeptidase | Aminopeptidase N | 963 aa | 988 aa | 28.5 % |
Echinococcus multilocularis | puromycin sensitive aminopeptidase | Aminopeptidase N | 963 aa | 981 aa | 28.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma brucei | carnitine O-palmitoyltransferase, putative | 0.011 | 0.0084 | 0.5 |
Schistosoma mansoni | choline o-acyltransferase | 0.011 | 0.0084 | 0.5 |
Loa Loa (eye worm) | carnitine O-palmitoyltransferase I isoform | 0.011 | 0.0084 | 0.0084 |
Onchocerca volvulus | 0.0143 | 0.0394 | 1 | |
Brugia malayi | Peptidase family M1 containing protein | 0.0143 | 0.0394 | 0.0313 |
Trypanosoma brucei | hypothetical protein, conserved | 0.011 | 0.0084 | 0.5 |
Echinococcus granulosus | carnitine O palmitoyltransferase 1 liver | 0.06 | 0.4659 | 1 |
Loa Loa (eye worm) | choline/Carnitine O-acyltransferase | 0.011 | 0.0084 | 0.0084 |
Echinococcus granulosus | aminopeptidase N | 0.0143 | 0.0394 | 0.0677 |
Leishmania major | choline/Carnitine o-acyltransferase-like protein | 0.06 | 0.4659 | 1 |
Trypanosoma cruzi | choline/carnitine O-acyltransferase, putative | 0.06 | 0.4659 | 1 |
Echinococcus multilocularis | carnitine O palmitoyltransferase 1, liver | 0.06 | 0.4659 | 1 |
Trypanosoma brucei | carnitine O-palmitoyltransferase II, putative | 0.011 | 0.0084 | 0.5 |
Schistosoma mansoni | choline o-acyltransferase | 0.011 | 0.0084 | 0.5 |
Loa Loa (eye worm) | peptidase family M1 containing protein | 0.0116 | 0.0138 | 0.0138 |
Loa Loa (eye worm) | hypothetical protein | 0.1171 | 1 | 1 |
Trypanosoma brucei | carnitine O-palmitoyltransferase II, putative | 0.011 | 0.0084 | 0.5 |
Trypanosoma brucei | carnitine O-acetyltransferase, putative | 0.011 | 0.0084 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0128 | 0.0255 | 0.0255 |
Loa Loa (eye worm) | hypothetical protein | 0.011 | 0.0084 | 0.0084 |
Trypanosoma cruzi | choline/carnitine O-acyltransferase, putative | 0.06 | 0.4659 | 1 |
Loa Loa (eye worm) | choline O-acetyltransferase | 0.011 | 0.0084 | 0.0084 |
Echinococcus multilocularis | aminopeptidase N | 0.0143 | 0.0394 | 0.0677 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 12 uM | Competitive inhibition of pig APN using L-leucine-p-nitroanilide as substrate by Dixon-plot analysis | ChEMBL. | 22796349 |
Ki (binding) | > 100 uM | Competitive inhibition of human recombinant LTA4H using alanine-p-nitroanilide as substrate by spectrophotometric analysis | ChEMBL. | 22796349 |
Ki (binding) | > 100 uM | Competitive inhibition of bovine LAPc using L-leucine-p-nitroanilide as substrate by spectrophotometric analysis | ChEMBL. | 22796349 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.