Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Entamoeba histolytica | cysteine protease, putative | 0.0141 | 0.0889 | 0.2032 |
Brugia malayi | Cathepsin L-like precursor | 0.06 | 0.4374 | 0.433 |
Echinococcus multilocularis | family C2 unassigned peptidase (C02 family) | 0.0056 | 0.0244 | 0.022 |
Loa Loa (eye worm) | pyruvate kinase | 0.0034 | 0.0079 | 0.0079 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0141 | 0.0889 | 0.1886 |
Mycobacterium tuberculosis | Probable pyruvate kinase PykA | 0.0034 | 0.0079 | 0.5 |
Plasmodium vivax | serine-repeat antigen (SERA) | 0.0141 | 0.0889 | 0.1886 |
Brugia malayi | Papain family cysteine protease containing protein | 0.0327 | 0.2302 | 0.2241 |
Loa Loa (eye worm) | hypothetical protein | 0.0414 | 0.2961 | 0.2961 |
Giardia lamblia | Cathepsin B precursor | 0.0141 | 0.0889 | 0.2234 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.06 | 0.4374 | 1 |
Plasmodium vivax | serine-repeat antigen (SERA) | 0.0141 | 0.0889 | 0.1886 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.06 | 0.4374 | 0.433 |
Echinococcus granulosus | microtubule associated protein 2 | 0.0709 | 0.52 | 0.5162 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0512 | 0.3707 | 0.3657 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.06 | 0.4374 | 1 |
Plasmodium vivax | vivapain-2 | 0.06 | 0.4374 | 1 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0045 | 0.016 | 0.0082 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.06 | 0.4374 | 0.433 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0141 | 0.0889 | 0.1886 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.06 | 0.4374 | 1 |
Entamoeba histolytica | cysteine proteinase 1, putative | 0.0327 | 0.2302 | 0.5263 |
Entamoeba histolytica | cysteine protease, putative | 0.0327 | 0.2302 | 0.5263 |
Schistosoma mansoni | cathepsin s | 0.0186 | 0.1232 | 0.1162 |
Giardia lamblia | Cathepsin B precursor | 0.0141 | 0.0889 | 0.2234 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0141 | 0.0889 | 0.1886 |
Loa Loa (eye worm) | hypothetical protein | 0.0141 | 0.0889 | 0.0889 |
Echinococcus granulosus | family C2 unassigned peptidase C02 family | 0.0056 | 0.0244 | 0.0166 |
Trypanosoma cruzi | cysteine proteinase, putative | 0.0327 | 0.2302 | 0.2241 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0327 | 0.2302 | 0.5176 |
Giardia lamblia | Cysteine protease | 0.0141 | 0.0889 | 0.2234 |
Echinococcus granulosus | cathepsin l1 | 0.0414 | 0.2961 | 0.2906 |
Schistosoma mansoni | SmCL2-like peptidase (C01 family) | 0.0327 | 0.2302 | 0.2241 |
Schistosoma mansoni | microtubule-associated protein tau | 0.0709 | 0.52 | 0.5162 |
Echinococcus multilocularis | pyruvate kinase | 0.0034 | 0.0079 | 0.0055 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0327 | 0.2302 | 0.5176 |
Trypanosoma cruzi | major cysteine proteinase, putative | 0.0141 | 0.0889 | 0.0817 |
Plasmodium falciparum | cysteine proteinase falcipain 1 | 0.0327 | 0.2302 | 0.5176 |
Onchocerca volvulus | 0.06 | 0.4374 | 1 | |
Leishmania major | cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like | 0.0512 | 0.3707 | 0.8446 |
Schistosoma mansoni | tar DNA-binding protein | 0.0063 | 0.0299 | 0.0222 |
Brugia malayi | cathepsin F-like cysteine proteinase | 0.0186 | 0.1232 | 0.1162 |
Plasmodium falciparum | serine repeat antigen 5 | 0.0141 | 0.0889 | 0.1886 |
Loa Loa (eye worm) | ctsf protein | 0.06 | 0.4374 | 0.4374 |
Entamoeba histolytica | cysteine protease, putative | 0.0141 | 0.0889 | 0.2032 |
Giardia lamblia | Cysteine protease | 0.0141 | 0.0889 | 0.2234 |
Plasmodium vivax | serine-repeat antigen 2 (SERA) | 0.0141 | 0.0889 | 0.1886 |
Loa Loa (eye worm) | cysteine proteinase cathepsin Z | 0.0141 | 0.0889 | 0.0889 |
Giardia lamblia | Encystation-specific protease | 0.0141 | 0.0889 | 0.2234 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin B-like cysteine peptidase | 0.0512 | 0.3707 | 0.8446 |
Entamoeba histolytica | papain family cysteine protease domain containing protein | 0.0141 | 0.0889 | 0.2032 |
Plasmodium falciparum | serine repeat antigen 8 | 0.0141 | 0.0889 | 0.1886 |
Plasmodium falciparum | cysteine proteinase falcipain 2a | 0.06 | 0.4374 | 1 |
Loa Loa (eye worm) | cathepsin B | 0.0512 | 0.3707 | 0.3707 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.06 | 0.4374 | 1 |
Entamoeba histolytica | cysteine protease, putative | 0.0327 | 0.2302 | 0.5263 |
Schistosoma mansoni | family C2 unassigned peptidase (C02 family) | 0.0056 | 0.0244 | 0.0166 |
Giardia lamblia | Cathepsin L-like protease | 0.0141 | 0.0889 | 0.2234 |
Brugia malayi | cathepsin Z-like cysteine proteinase | 0.0141 | 0.0889 | 0.0817 |
Plasmodium vivax | serine-repeat antigen 3 (SERA) | 0.0141 | 0.0889 | 0.1886 |
Loa Loa (eye worm) | hypothetical protein | 0.0141 | 0.0889 | 0.0889 |
Brugia malayi | RNA binding protein | 0.0063 | 0.0299 | 0.0222 |
Giardia lamblia | Cathepsin B precursor | 0.0141 | 0.0889 | 0.2234 |
Echinococcus granulosus | tar DNA binding protein | 0.0063 | 0.0299 | 0.0222 |
Brugia malayi | Papain family cysteine protease containing protein | 0.06 | 0.4374 | 0.433 |
Toxoplasma gondii | cathepsin CPC1 | 0.0141 | 0.0889 | 0.1886 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0045 | 0.016 | 0.0082 |
Entamoeba histolytica | cysteine protease, putative | 0.0327 | 0.2302 | 0.5263 |
Leishmania major | cathepsin L-like protease | 0.06 | 0.4374 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.0118 | 0.0118 |
Schistosoma mansoni | SmCB2 peptidase (C01 family) | 0.1341 | 1 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0045 | 0.016 | 0.0136 |
Loa Loa (eye worm) | pyruvate kinase | 0.0034 | 0.0079 | 0.0079 |
Echinococcus granulosus | cathepsin L | 0.0327 | 0.2302 | 0.2241 |
Loa Loa (eye worm) | pyruvate kinase | 0.0034 | 0.0079 | 0.0079 |
Brugia malayi | Papain family cysteine protease containing protein | 0.0141 | 0.0889 | 0.0817 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or H-like cysteine peptidase | 0.0141 | 0.0889 | 0.1886 |
Onchocerca volvulus | Cathepsin L homolog | 0.0141 | 0.0889 | 0.1899 |
Echinococcus granulosus | cathepsin l1 | 0.06 | 0.4374 | 0.433 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0141 | 0.0889 | 0.1886 |
Entamoeba histolytica | cysteine protease, putative | 0.06 | 0.4374 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin H-like cysteine peptidase | 0.0141 | 0.0889 | 0.1886 |
Brugia malayi | Cathepsin L-like precursor | 0.0414 | 0.2961 | 0.2906 |
Schistosoma mansoni | tar DNA-binding protein | 0.0063 | 0.0299 | 0.0222 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.06 | 0.4374 | 1 |
Plasmodium falciparum | dipeptidyl aminopeptidase 2 | 0.0141 | 0.0889 | 0.1886 |
Entamoeba histolytica | cysteine protease, putative | 0.0141 | 0.0889 | 0.2032 |
Loa Loa (eye worm) | hypothetical protein | 0.0186 | 0.1232 | 0.1232 |
Onchocerca volvulus | Pyruvate kinase homolog | 0.0034 | 0.0079 | 0.0016 |
Plasmodium vivax | serine-repeat antigen (SERA), putative | 0.0141 | 0.0889 | 0.1886 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.06 | 0.4374 | 0.433 |
Loa Loa (eye worm) | hypothetical protein | 0.0054 | 0.0225 | 0.0225 |
Plasmodium falciparum | cysteine proteinase falcipain 3 | 0.06 | 0.4374 | 1 |
Echinococcus multilocularis | cysteine protease | 0.06 | 0.4374 | 0.4361 |
Brugia malayi | Papain family cysteine protease containing protein | 0.0141 | 0.0889 | 0.0817 |
Entamoeba histolytica | cysteine proteinase, putative | 0.06 | 0.4374 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0045 | 0.016 | 0.0082 |
Plasmodium falciparum | serine repeat antigen 9 | 0.0141 | 0.0889 | 0.1886 |
Giardia lamblia | Hypothetical protein | 0.0141 | 0.0889 | 0.2234 |
Echinococcus multilocularis | pyruvate kinase | 0.0034 | 0.0079 | 0.0055 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0063 | 0.0299 | 0.0299 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin B-like cysteine peptidase | 0.0141 | 0.0889 | 0.1886 |
Trypanosoma cruzi | cysteine peptidase, clan CA, family C1, cathepsin L-like, putative | 0.0414 | 0.2961 | 0.2906 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.06 | 0.4374 | 1 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0063 | 0.0299 | 0.0222 |
Mycobacterium ulcerans | pyruvate kinase | 0.0034 | 0.0079 | 0.5 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0414 | 0.2961 | 0.6711 |
Giardia lamblia | Cathepsin L precursor | 0.0141 | 0.0889 | 0.2234 |
Leishmania major | cysteine peptidase A (CPA) | 0.06 | 0.4374 | 1 |
Entamoeba histolytica | cysteine protease, putative | 0.0327 | 0.2302 | 0.5263 |
Trypanosoma cruzi | cysteine proteinase, putative | 0.0327 | 0.2302 | 0.2241 |
Trypanosoma cruzi | cruzipain precursor, putative | 0.06 | 0.4374 | 0.433 |
Schistosoma mansoni | tar DNA-binding protein | 0.0063 | 0.0299 | 0.0222 |
Brugia malayi | Cathepsin L-like cysteine proteinase | 0.0414 | 0.2961 | 0.2906 |
Echinococcus multilocularis | calpain A | 0.0056 | 0.0244 | 0.022 |
Echinococcus granulosus | cathepsin L cysteine proteinase | 0.06 | 0.4374 | 0.433 |
Loa Loa (eye worm) | calpain family protein 1 | 0.0054 | 0.0225 | 0.0225 |
Entamoeba histolytica | cysteine proteinase, putative | 0.06 | 0.4374 | 1 |
Giardia lamblia | Cathepsin L precursor | 0.0141 | 0.0889 | 0.2234 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.06 | 0.4374 | 1 |
Echinococcus multilocularis | geminin | 0.0174 | 0.114 | 0.1119 |
Schistosoma mansoni | hypothetical protein | 0.0174 | 0.114 | 0.107 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0327 | 0.2302 | 0.5176 |
Entamoeba histolytica | cysteine protease, putative | 0.0327 | 0.2302 | 0.5263 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0327 | 0.2302 | 0.5263 |
Schistosoma mansoni | tar DNA-binding protein | 0.0063 | 0.0299 | 0.0222 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.06 | 0.4374 | 0.433 |
Onchocerca volvulus | Pyruvate kinase homolog | 0.0034 | 0.0079 | 0.0016 |
Giardia lamblia | Hypothetical protein | 0.0141 | 0.0889 | 0.2234 |
Giardia lamblia | Cathepsin B precursor | 0.0512 | 0.3707 | 1 |
Plasmodium vivax | serine-repeat antigen (SERA), putative | 0.0141 | 0.0889 | 0.1886 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.06 | 0.4374 | 0.433 |
Toxoplasma gondii | preprocathepsin c precursor, putative | 0.0141 | 0.0889 | 0.1886 |
Giardia lamblia | Cathepsin B precursor | 0.0141 | 0.0889 | 0.2234 |
Entamoeba histolytica | cysteine protease, putative | 0.0327 | 0.2302 | 0.5263 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0141 | 0.0889 | 0.1886 |
Brugia malayi | Papain family cysteine protease containing protein | 0.0141 | 0.0889 | 0.0817 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0141 | 0.0889 | 0.1886 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.06 | 0.4374 | 0.4361 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.06 | 0.4374 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0414 | 0.2961 | 0.6711 |
Chlamydia trachomatis | pyruvate kinase | 0.0034 | 0.0079 | 0.5 |
Echinococcus multilocularis | cathepsin L | 0.0141 | 0.0889 | 0.0867 |
Schistosoma mansoni | hypothetical protein | 0.0174 | 0.114 | 0.107 |
Toxoplasma gondii | cathepsin B | 0.0512 | 0.3707 | 0.8446 |
Entamoeba histolytica | cysteine protease, putative | 0.0141 | 0.0889 | 0.2032 |
Giardia lamblia | Cathepsin B precursor | 0.0141 | 0.0889 | 0.2234 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.06 | 0.4374 | 1 |
Plasmodium vivax | vivapain-2 | 0.06 | 0.4374 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.06 | 0.4374 | 1 |
Loa Loa (eye worm) | cysteine protease | 0.06 | 0.4374 | 0.4374 |
Loa Loa (eye worm) | RNA binding protein | 0.0063 | 0.0299 | 0.0299 |
Brugia malayi | Cathepsin L-like precursor | 0.06 | 0.4374 | 0.433 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.06 | 0.4374 | 1 |
Brugia malayi | cahepsin L-like non-peptiedase homolog | 0.0141 | 0.0889 | 0.0817 |
Entamoeba histolytica | cysteine proteinase 2 | 0.0327 | 0.2302 | 0.5263 |
Loa Loa (eye worm) | hypothetical protein | 0.1341 | 1 | 1 |
Echinococcus multilocularis | cathepsin b | 0.1341 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0063 | 0.0299 | 0.0222 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.06 | 0.4374 | 1 |
Onchocerca volvulus | 0.0414 | 0.2961 | 0.6716 | |
Entamoeba histolytica | cysteine proteinase, putative | 0.0327 | 0.2302 | 0.5263 |
Echinococcus multilocularis | cysteine protease | 0.06 | 0.4374 | 0.4361 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0141 | 0.0889 | 0.1886 |
Trypanosoma cruzi | cysteine peptidase C (CPC), putative | 0.0512 | 0.3707 | 0.3657 |
Plasmodium vivax | dipeptidyl aminopeptidase 1, putative | 0.0141 | 0.0889 | 0.1886 |
Entamoeba histolytica | cysteine protease, putative | 0.0327 | 0.2302 | 0.5263 |
Plasmodium falciparum | dipeptidyl aminopeptidase 1 | 0.0141 | 0.0889 | 0.1886 |
Loa Loa (eye worm) | fibroinase | 0.06 | 0.4374 | 0.4374 |
Toxoplasma gondii | cathepsin CPC2 | 0.0141 | 0.0889 | 0.1886 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.06 | 0.4374 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.06 | 0.4374 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0327 | 0.2302 | 0.5176 |
Plasmodium falciparum | serine repeat antigen 2 | 0.0141 | 0.0889 | 0.1886 |
Onchocerca volvulus | Pyruvate kinase homolog | 0.0034 | 0.0079 | 0.0016 |
Toxoplasma gondii | cathepsin CPL | 0.06 | 0.4374 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.06 | 0.4374 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0141 | 0.0889 | 0.0889 |
Loa Loa (eye worm) | Papain cysteine protease/cathepsin propeptide inhibitor-containing protein | 0.06 | 0.4374 | 0.4374 |
Entamoeba histolytica | papain family cysteine protease domain containing protein | 0.0141 | 0.0889 | 0.2032 |
Loa Loa (eye worm) | hypothetical protein | 0.06 | 0.4374 | 0.4374 |
Giardia lamblia | Cysteine protease | 0.0141 | 0.0889 | 0.2234 |
Echinococcus multilocularis | cathepsin b | 0.1341 | 1 | 1 |
Echinococcus multilocularis | microtubule associated protein 2 | 0.0709 | 0.52 | 0.5188 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.06 | 0.4374 | 1 |
Plasmodium vivax | vivapain-3 | 0.0327 | 0.2302 | 0.5176 |
Giardia lamblia | Dipeptidyl-peptidase I precursor | 0.0141 | 0.0889 | 0.2234 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0141 | 0.0889 | 0.1886 |
Leishmania major | cathepsin L-like protease | 0.06 | 0.4374 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.06 | 0.4374 | 1 |
Echinococcus granulosus | cathepsin l cysteine peptidase | 0.06 | 0.4374 | 0.433 |
Brugia malayi | cathepsin Z-like cysteine proteinase | 0.0141 | 0.0889 | 0.0817 |
Brugia malayi | Cathepsin L-like precursor | 0.0186 | 0.1232 | 0.1162 |
Echinococcus multilocularis | cathepsin L | 0.0327 | 0.2302 | 0.2284 |
Giardia lamblia | Cysteine protease | 0.0141 | 0.0889 | 0.2234 |
Giardia lamblia | Cathepsin B precursor | 0.0512 | 0.3707 | 1 |
Plasmodium falciparum | serine repeat antigen 4 | 0.0141 | 0.0889 | 0.1886 |
Onchocerca volvulus | 0.06 | 0.4374 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0141 | 0.0889 | 0.0889 |
Giardia lamblia | Cathepsin B precursor | 0.0512 | 0.3707 | 1 |
Echinococcus granulosus | calpain A | 0.0056 | 0.0244 | 0.0166 |
Plasmodium vivax | unspecified product | 0.0186 | 0.1232 | 0.2684 |
Trypanosoma cruzi | major cysteine proteinase, putative | 0.0141 | 0.0889 | 0.0817 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.06 | 0.4374 | 1 |
Schistosoma mansoni | subfamily C1A unassigned peptidase (C01 family) | 0.0141 | 0.0889 | 0.0817 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0141 | 0.0889 | 0.0817 |
Entamoeba histolytica | cysteine protease, putative | 0.0141 | 0.0889 | 0.2032 |
Onchocerca volvulus | Cathepsin F homolog | 0.06 | 0.4374 | 1 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0141 | 0.0889 | 0.0817 |
Onchocerca volvulus | 0.06 | 0.4374 | 1 | |
Brugia malayi | Cathepsin L-like precursor | 0.06 | 0.4374 | 0.433 |
Echinococcus granulosus | cysteine protease | 0.0327 | 0.2302 | 0.2241 |
Schistosoma mansoni | cathepsin S (C01 family) | 0.0141 | 0.0889 | 0.0817 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.06 | 0.4374 | 1 |
Echinococcus granulosus | cathepsin L cysteine protease | 0.0327 | 0.2302 | 0.2241 |
Schistosoma mansoni | cathepsin B (C01 family) | 0.0141 | 0.0889 | 0.0817 |
Brugia malayi | cathepsin L-like cysteine proteinase | 0.0141 | 0.0889 | 0.0817 |
Echinococcus granulosus | geminin | 0.0174 | 0.114 | 0.107 |
Brugia malayi | fibroinase precursor | 0.0141 | 0.0889 | 0.0817 |
Loa Loa (eye worm) | hypothetical protein | 0.0141 | 0.0889 | 0.0889 |
Brugia malayi | Cathepsin L-like precursor | 0.06 | 0.4374 | 0.433 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.06 | 0.4374 | 1 |
Brugia malayi | calpain family protein 1 | 0.0054 | 0.0225 | 0.0148 |
Schistosoma mansoni | family C2 unassigned peptidase (C02 family) | 0.0056 | 0.0244 | 0.0166 |
Onchocerca volvulus | Cathepsin L homolog | 0.06 | 0.4374 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.06 | 0.4374 | 1 |
Echinococcus granulosus | cathepsin L | 0.0141 | 0.0889 | 0.0817 |
Echinococcus granulosus | cathepsin b | 0.1341 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.06 | 0.4374 | 1 |
Entamoeba histolytica | cysteine protease, putative | 0.0327 | 0.2302 | 0.5263 |
Loa Loa (eye worm) | calpain family protein 1 | 0.0039 | 0.0118 | 0.0118 |
Schistosoma mansoni | family C2 unassigned peptidase (C02 family) | 0.0054 | 0.0225 | 0.0148 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.06 | 0.4374 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin B-like cysteine peptidase | 0.0141 | 0.0889 | 0.1886 |
Entamoeba histolytica | cysteine protease, putative | 0.0327 | 0.2302 | 0.5263 |
Entamoeba histolytica | cysteine protease, putative | 0.0327 | 0.2302 | 0.5263 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.06 | 0.4374 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0186 | 0.1232 | 0.1232 |
Brugia malayi | cathepsin F-like cysteine proteinase | 0.0141 | 0.0889 | 0.0817 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.1341 | 1 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0045 | 0.016 | 0.0082 |
Brugia malayi | Cathepsin L-like precursor | 0.0414 | 0.2961 | 0.2906 |
Plasmodium vivax | unspecified product | 0.0141 | 0.0889 | 0.1886 |
Schistosoma mansoni | subfamily C1A non-peptidase homologue (C01 family) | 0.0141 | 0.0889 | 0.0817 |
Brugia malayi | Cathepsin L-like precursor | 0.06 | 0.4374 | 0.433 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.06 | 0.4374 | 1 |
Plasmodium vivax | dipeptidyl aminopeptidase 2, putative | 0.0141 | 0.0889 | 0.1886 |
Brugia malayi | Papain family cysteine protease containing protein | 0.0327 | 0.2302 | 0.2241 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.06 | 0.4374 | 1 |
Plasmodium falciparum | serine repeat antigen 1 | 0.0141 | 0.0889 | 0.1886 |
Echinococcus multilocularis | calpain family protein 1, d | 0.0039 | 0.0118 | 0.0094 |
Schistosoma mansoni | dipeptidyl-peptidase I (C01 family) | 0.0141 | 0.0889 | 0.0817 |
Schistosoma mansoni | SmCL2-like peptidase (C01 family) | 0.0327 | 0.2302 | 0.2241 |
Onchocerca volvulus | 0.0141 | 0.0889 | 0.1899 | |
Loa Loa (eye worm) | hypothetical protein | 0.0047 | 0.0179 | 0.0179 |
Schistosoma mansoni | subfamily C1A unassigned peptidase (C01 family) | 0.0141 | 0.0889 | 0.0817 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0186 | 0.1232 | 0.1162 |
Trypanosoma cruzi | cysteine peptidase C (CPC), putative | 0.1341 | 1 | 1 |
Leishmania major | cathepsin L-like protease | 0.06 | 0.4374 | 1 |
Entamoeba histolytica | cysteine protease, putative | 0.0327 | 0.2302 | 0.5263 |
Echinococcus granulosus | cathepsin b | 0.1341 | 1 | 1 |
Echinococcus multilocularis | tar DNA binding protein | 0.0063 | 0.0299 | 0.0276 |
Entamoeba histolytica | hypothetical protein | 0.0141 | 0.0889 | 0.2032 |
Brugia malayi | calpain family protein 1 | 0.0054 | 0.0225 | 0.0148 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0327 | 0.2302 | 0.5263 |
Giardia lamblia | Cathepsin B-like cysteine proteinase 3 precursor | 0.0141 | 0.0889 | 0.2234 |
Plasmodium vivax | vivapain-1 | 0.0327 | 0.2302 | 0.5176 |
Plasmodium vivax | unspecified product | 0.0327 | 0.2302 | 0.5176 |
Brugia malayi | Cathepsin L-like precursor | 0.06 | 0.4374 | 0.433 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0045 | 0.016 | 0.016 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0141 | 0.0889 | 0.1886 |
Schistosoma mansoni | cathepsin C | 0.0141 | 0.0889 | 0.0817 |
Giardia lamblia | Cathepsin L precursor | 0.0141 | 0.0889 | 0.2234 |
Trypanosoma brucei | cysteine peptidase C (CPC) | 0.0512 | 0.3707 | 0.8446 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.06 | 0.4374 | 1 |
Giardia lamblia | Cathepsin L-like protease | 0.0141 | 0.0889 | 0.2234 |
Plasmodium falciparum | dipeptidyl aminopeptidase 3 | 0.0141 | 0.0889 | 0.1886 |
Plasmodium falciparum | serine repeat antigen 3 | 0.0141 | 0.0889 | 0.1886 |
Entamoeba histolytica | cysteine protease, putative | 0.0327 | 0.2302 | 0.5263 |
Brugia malayi | cathepsin L-like precursor | 0.0414 | 0.2961 | 0.2906 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase | 0.0141 | 0.0889 | 0.1886 |
Loa Loa (eye worm) | hypothetical protein | 0.0186 | 0.1232 | 0.1232 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.06 | 0.4374 | 1 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.06 | 0.4374 | 0.4361 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.06 | 0.4374 | 1 |
Leishmania major | cathepsin L-like protease | 0.06 | 0.4374 | 1 |
Onchocerca volvulus | 0.06 | 0.4374 | 1 | |
Onchocerca volvulus | 0.06 | 0.4374 | 1 | |
Plasmodium vivax | serine-repeat antigen 5 (SERA) | 0.0141 | 0.0889 | 0.1886 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0141 | 0.0889 | 0.0817 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.0072 | 0.0072 |
Leishmania major | cathepsin L-like protease | 0.06 | 0.4374 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin B-like cysteine peptidase | 0.0141 | 0.0889 | 0.1886 |
Loa Loa (eye worm) | hypothetical protein | 0.0414 | 0.2961 | 0.2961 |
Plasmodium falciparum | serine repeat antigen 7 | 0.0141 | 0.0889 | 0.1886 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0414 | 0.2961 | 0.677 |
Brugia malayi | TAR-binding protein | 0.0063 | 0.0299 | 0.0222 |
Giardia lamblia | Dipeptidyl-peptidase I precursor | 0.0141 | 0.0889 | 0.2234 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.06 | 0.4374 | 1 |
Trypanosoma cruzi | cruzipain precursor, putative | 0.0186 | 0.1232 | 0.1162 |
Giardia lamblia | Cathepsin L precursor | 0.0141 | 0.0889 | 0.2234 |
Mycobacterium leprae | Probable pyruvate kinase PykA | 0.0034 | 0.0079 | 0.5 |
Loa Loa (eye worm) | papain family cysteine protease containing protein | 0.0141 | 0.0889 | 0.0889 |
Plasmodium vivax | dipeptidyl aminopeptidase 3, putative | 0.0141 | 0.0889 | 0.1886 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.06 | 0.4374 | 1 |
Entamoeba histolytica | cysteine protease, putative | 0.0141 | 0.0889 | 0.2032 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.0079 | 0.0079 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.06 | 0.4374 | 1 |
Plasmodium vivax | serine-repeat antigen 4 (SERA) | 0.0141 | 0.0889 | 0.1886 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin B-like cysteine peptidase | 0.0141 | 0.0889 | 0.1886 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.06 | 0.4374 | 0.433 |
Loa Loa (eye worm) | papain family cysteine protease containing protein | 0.06 | 0.4374 | 0.4374 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.06 | 0.4374 | 1 |
Loa Loa (eye worm) | papain family cysteine protease containing protein | 0.0141 | 0.0889 | 0.0889 |
Leishmania major | cathepsin L-like protease | 0.06 | 0.4374 | 1 |
Onchocerca volvulus | Cathepsin L homolog | 0.06 | 0.4374 | 1 |
Giardia lamblia | Cathepsin L precursor | 0.0141 | 0.0889 | 0.2234 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.06 | 0.4374 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0141 | 0.0889 | 0.0889 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.06 | 0.4374 | 1 |
Leishmania major | cathepsin L-like protease | 0.06 | 0.4374 | 1 |
Onchocerca volvulus | 0.06 | 0.4374 | 1 | |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0141 | 0.0889 | 0.1886 |
Trypanosoma cruzi | cysteine protease, putative | 0.0327 | 0.2302 | 0.2241 |
Trypanosoma cruzi | cysteine peptidase (N-terminal), putative | 0.0327 | 0.2302 | 0.2241 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.06 | 0.4374 | 0.4361 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0414 | 0.2961 | 0.2906 |
Loa Loa (eye worm) | TAR-binding protein | 0.0063 | 0.0299 | 0.0299 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.06 | 0.4374 | 0.4361 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0045 | 0.016 | 0.0082 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0141 | 0.0889 | 0.1886 |
Plasmodium falciparum | cysteine proteinase falcipain 2b | 0.06 | 0.4374 | 1 |
Leishmania major | cathepsin L-like protease | 0.06 | 0.4374 | 1 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0141 | 0.0889 | 0.0817 |
Onchocerca volvulus | 0.06 | 0.4374 | 1 | |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.06 | 0.4374 | 1 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.1341 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin F-like cysteine peptidase | 0.0141 | 0.0889 | 0.1886 |
Plasmodium falciparum | serine repeat antigen 6 | 0.0141 | 0.0889 | 0.1886 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.1341 | 1 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0045 | 0.016 | 0.0082 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0141 | 0.0889 | 0.0817 |
Loa Loa (eye worm) | papain family cysteine protease containing protein | 0.0186 | 0.1232 | 0.1232 |
Brugia malayi | cathepsin L-like cysteine proteinase, identical | 0.0186 | 0.1232 | 0.1162 |
Giardia lamblia | Cathepsin L precursor | 0.0141 | 0.0889 | 0.2234 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0327 | 0.2302 | 0.5263 |
Loa Loa (eye worm) | hypothetical protein | 0.0414 | 0.2961 | 0.2961 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0327 | 0.2302 | 0.2241 |
Schistosoma mansoni | SmCL2-like peptidase (C01 family) | 0.0327 | 0.2302 | 0.2241 |
Plasmodium vivax | serine-repeat antigen 4 (SERA), putative | 0.0141 | 0.0889 | 0.1886 |
Giardia lamblia | Dipeptidyl-peptidase I precursor | 0.0141 | 0.0889 | 0.2234 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0045 | 0.016 | 0.0136 |
Brugia malayi | cathepsin L precursor | 0.0141 | 0.0889 | 0.0817 |
Entamoeba histolytica | cysteine protease, putative | 0.0327 | 0.2302 | 0.5263 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Imax (functional) | = 98 % | Antagonist activity at human recombinant 5HT6 receptor expressed in CHO cells assessed as inhibition of 5HT-induced luciferase activity after 4 hrs by reporter gene assay relative to control | ChEMBL. | 23006002 |
Kb (functional) | = 10.3 nM | Antagonist activity at human recombinant 5HT6 receptor expressed in CHO cells assessed as inhibition of 5HT-induced luciferase activity after 4 hrs by reporter gene assay | ChEMBL. | 23006002 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.