TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 314.379 | Formula: C18H22N2O3
H donors: 0 H acceptors: 1 LogP: 3.2 Rotable bonds: 4
Rule of 5 violations (Lipinski): 1
SMILES: COc1cc(Oc2cc(C)nc(c2)N2CCOCC2)cc(c1)C
InChi: 1S/C18H22N2O3/c1-13-8-15(21-3)11-16(9-13)23-17-10-14(2)19-18(12-17)20-4-6-22-7-5-20/h8-12H,4-7H2,1-3H3
InChiKey: MTVRVVKFPFPSMI-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Plasmodium falciparum	macrophage migration inhibitory factor	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Leishmania mexicana	macrophage migration inhibitory factor-like protein	Get druggable targets OG5_129767	All targets in OG5_129767
Leishmania infantum	macrophage migration inhibitory factor-like protein	Get druggable targets OG5_129767	All targets in OG5_129767
Plasmodium vivax	macrophage migration inhibitory factor, putative	Get druggable targets OG5_129767	All targets in OG5_129767
Plasmodium knowlesi	macrophage migration inhibitory factor, putative	Get druggable targets OG5_129767	All targets in OG5_129767
Loa Loa (eye worm)	macrophage migration inhibitory factor	Get druggable targets OG5_129767	All targets in OG5_129767
Leishmania infantum	macrophage migration inhibitory factor-like protein	Get druggable targets OG5_129767	All targets in OG5_129767
Leishmania donovani	macrophage migration inhibitory factor-like protein	Get druggable targets OG5_129767	All targets in OG5_129767
Brugia malayi	Bm-MIF-1, identical	Get druggable targets OG5_129767	All targets in OG5_129767
Leishmania donovani	macrophage migration inhibitory factor-like protein	Get druggable targets OG5_129767	All targets in OG5_129767
Plasmodium berghei	macrophage migration inhibitory factor	Get druggable targets OG5_129767	All targets in OG5_129767
Leishmania mexicana	macrophage migration inhibitory factor-like protein	Get druggable targets OG5_129767	All targets in OG5_129767
Giardia lamblia	Macrophage migration inhibitory factor	Get druggable targets OG5_129767	All targets in OG5_129767
Trichomonas vaginalis	conserved hypothetical protein	Get druggable targets OG5_129767	All targets in OG5_129767
Toxoplasma gondii	macrophage migration inhibitory factor, putative	Get druggable targets OG5_129767	All targets in OG5_129767
Neospora caninum	Macrophage migration inhibitory factor, related	Get druggable targets OG5_129767	All targets in OG5_129767
Leishmania braziliensis	macrophage migration inhibitory factor-like protein	Get druggable targets OG5_129767	All targets in OG5_129767
Plasmodium yoelii	hypothetical protein	Get druggable targets OG5_129767	All targets in OG5_129767
Leishmania major	macrophage migration inhibitory factor-like protein	Get druggable targets OG5_129767	All targets in OG5_129767
Leishmania major	macrophage migration inhibitory factor-like protein	Get druggable targets OG5_129767	All targets in OG5_129767
Entamoeba histolytica	macrophage migration inhibitory factor-like protein	Get druggable targets OG5_129767	All targets in OG5_129767
Trichomonas vaginalis	macrophage migration inhibitory factor, mif, putative	Get druggable targets OG5_129767	All targets in OG5_129767
Plasmodium falciparum	macrophage migration inhibitory factor	Get druggable targets OG5_129767	All targets in OG5_129767

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Onchocerca volvulus		0.0017	0.0032	0.0402
Brugia malayi	metabotropic glutamate receptor type 2	0.0023	0.0153	0.0153
Echinococcus granulosus	ecdysone induced protein 78C	0.0036	0.0432	0.0594
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0032	0.0032
Loa Loa (eye worm)	hypothetical protein	0.0099	0.1747	0.1747
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0036	0.0432	0.1206
Toxoplasma gondii	LsmAD domain-containing protein	0.0026	0.0222	0.0562
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0036	0.0432	0.0432
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0133	0.2441	0.2441
Brugia malayi	Nuclear hormone receptor E75	0.0017	0.0032	0.0032
Brugia malayi	conserved hypotetical protein	0.0017	0.0032	0.0032
Echinococcus multilocularis	FTZ F1 alpha	0.0036	0.0432	0.0594
Plasmodium falciparum	ataxin-2 like protein, putative	0.0026	0.0222	0.0562
Echinococcus granulosus	DNA apurinic or apyrimidinic site lyase	0.0018	0.0056	0.0077
Echinococcus multilocularis	metabotropic glutamate receptor 2	0.0039	0.0496	0.0682
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0032	0.0032
Loa Loa (eye worm)	transcription factor SMAD2	0.0133	0.2462	0.2462
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0432	0.0432
Schistosoma mansoni	metabotropic glutamate receptor 2 3 (mglur group 2)	0.0053	0.079	0.2204
Echinococcus granulosus	nuclear receptor subfamily 4 group A	0.0017	0.0032	0.0043
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0036	0.0432	0.0432
Brugia malayi	TAR-binding protein	0.0133	0.2441	0.2441
Brugia malayi	hypothetical protein	0.0019	0.0075	0.0075
Echinococcus granulosus	tar DNA binding protein	0.0133	0.2441	0.3353
Brugia malayi	nuclear receptor RXR	0.0017	0.0032	0.0032
Chlamydia trachomatis	D-amino acid dehydrogenase	0.0016	0	0.5
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0036	0.0432	0.1206
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0019	0.0075	0.0208
Entamoeba histolytica	macrophage migration inhibitory factor-like protein	0.0205	0.395	1
Brugia malayi	nuclear hormone receptor	0.0017	0.0032	0.0032
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0036	0.0432	0.0432
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0036	0.0432	0.0432
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0032	0.0032
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0051	0.0742	0.2069
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0051	0.0742	0.2069
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0051	0.0742	0.1019
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0036	0.0432	0.0432
Brugia malayi	nuclear receptor NHR-67	0.0017	0.0032	0.0032
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0032	0.0032
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0032	0.0032
Schistosoma mansoni	tar DNA-binding protein	0.0133	0.2441	0.6809
Schistosoma mansoni	nuclear hormone receptor	0.0017	0.0032	0.0088
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0494	1	1
Mycobacterium leprae	PROBABLE D-AMINO ACID OXIDASE AAO	0.0187	0.3586	1
Brugia malayi	nuclear hormone receptor family member odr-7	0.0017	0.0032	0.0032
Onchocerca volvulus	Nuclear receptor subfamily 6 group A member 1 homolog	0.0017	0.0032	0.0402
Schistosoma mansoni	ecdysone-induced protein 78c (dr-78)	0.0019	0.0075	0.0208
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease, putative	0.0018	0.0056	0.0321
Echinococcus multilocularis	ecdysone induced protein 78C	0.0036	0.0432	0.0594
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.0017	0.0032	0.0043
Leishmania major	macrophage migration inhibitory factor-like protein	0.0205	0.395	1
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease	0.0018	0.0056	0.0321
Schistosoma mansoni	serine/threonine protein kinase	0.01	0.1758	0.4903
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0032	0.0032
Loa Loa (eye worm)	CMGC/DYRK/DYRK1 protein kinase	0.01	0.1758	0.1758
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0036	0.0432	0.0432
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0222	0.0222
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0036	0.0432	0.0432
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0036	0.0432	0.0432
Onchocerca volvulus		0.0052	0.076	0.965
Trypanosoma cruzi	CMGC/DYRK protein kinase, putative	0.01	0.1758	1
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.0017	0.0032	0.0043
Brugia malayi	hypothetical protein	0.0017	0.0032	0.0032
Echinococcus multilocularis	tar DNA binding protein	0.0133	0.2441	0.3353
Echinococcus multilocularis	nuclear receptor subfamily 1 group D	0.0019	0.0075	0.0102
Brugia malayi	Nuclear hormone receptor-like 1	0.0036	0.0432	0.0432
Brugia malayi	hypothetical protein	0.0017	0.0032	0.0032
Loa Loa (eye worm)	RNA binding protein	0.0133	0.2441	0.2441
Brugia malayi	Iron-sulfur cluster assembly accessory protein	0.0052	0.076	0.076
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0017	0.0032	0.0043
Treponema pallidum	exodeoxyribonuclease (exoA)	0.0018	0.0056	0.5
Brugia malayi	steroid hormone receptor	0.0036	0.0432	0.0432
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0051	0.0742	0.1019
Brugia malayi	Nuclear hormone receptor-like 1	0.0019	0.0075	0.0075
Brugia malayi	hypothetical protein	0.0019	0.0075	0.0075
Echinococcus multilocularis	nuclear receptor nhr 48	0.0017	0.0032	0.0043
Schistosoma mansoni	tar DNA-binding protein	0.0133	0.2441	0.6809
Schistosoma mansoni	thyroid hormone receptor	0.0036	0.0432	0.1206
Echinococcus granulosus	nuclear receptor nhr 48	0.0017	0.0032	0.0043
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0036	0.0432	0.0594
Loa Loa (eye worm)	hypothetical protein	0.0187	0.3586	0.3586
Schistosoma mansoni	retinoic acid receptor RXR	0.0036	0.0432	0.1206
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0032	0.0032
Plasmodium vivax	ataxin-2 like protein, putative	0.0026	0.0222	0.0562
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0051	0.0742	0.0742
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0075	0.0075
Echinococcus granulosus	FTZ F1 alpha	0.0036	0.0432	0.0594
Mycobacterium ulcerans	exodeoxyribonuclease III protein XthA	0.0018	0.0056	0.0157
Leishmania major	hypothetical protein, conserved	0.0026	0.0222	0.0562
Brugia malayi	hypothetical protein	0.0255	0.4998	0.4998
Schistosoma mansoni	ap endonuclease	0.0018	0.0056	0.0157
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0036	0.0432	0.0594
Echinococcus multilocularis	nuclear receptor subfamily 4 group A	0.0017	0.0032	0.0043
Entamoeba histolytica	protein kinase, putative	0.01	0.1758	0.445
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0036	0.0432	0.0432
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0032	0.0032
Loa Loa (eye worm)	glutamate receptor	0.0047	0.0656	0.0656
Schistosoma mansoni	nuclear receptor	0.0017	0.0032	0.0088
Plasmodium falciparum	macrophage migration inhibitory factor	0.0205	0.395	1
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0051	0.0742	0.1019
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0032	0.0032
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0051	0.0742	0.2069
Loa Loa (eye worm)	nuclear receptor nhr-7B	0.0017	0.0032	0.0032
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0036	0.0432	0.1206
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0036	0.0432	0.0432
Echinococcus granulosus	metabotropic glutamate receptor 2	0.0039	0.0496	0.0682
Loa Loa (eye worm)	macrophage migration inhibitory factor 2	0.0087	0.1498	0.1498
Brugia malayi	nuclear hormone receptor	0.0036	0.0432	0.0432
Brugia malayi	photoreceptor-specific nuclear receptor	0.0036	0.0432	0.0432
Entamoeba histolytica	exodeoxyribonuclease III, putative	0.0018	0.0056	0.0143
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0032	0.0032
Schistosoma mansoni	coup transcription factor	0.0036	0.0432	0.1206
Loa Loa (eye worm)	nuclear receptor NHR-67	0.0017	0.0032	0.0032
Schistosoma mansoni	survival motor neuron protein	0.0052	0.076	0.2119
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0032	0.0032
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0036	0.0432	0.0432
Trichomonas vaginalis	conserved hypothetical protein	0.0205	0.395	1
Echinococcus granulosus	dual specificity	0.01	0.1758	0.2414
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0432	0.0432
Trypanosoma brucei	PAB1-binding protein , putative	0.0026	0.0222	0.1262
Loa Loa (eye worm)	hypothetical protein	0.0255	0.4998	0.4998
Echinococcus multilocularis	retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha	0.0017	0.0032	0.0043
Trypanosoma cruzi	CMGC/DYRK protein kinase, putative	0.01	0.1758	1
Loa Loa (eye worm)	macrophage migration inhibitory factor	0.0205	0.395	0.395
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0432	0.0432
Brugia malayi	hypothetical protein	0.0017	0.0028	0.0028
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0036	0.0432	0.0594
Onchocerca volvulus		0.0053	0.0787	1
Echinococcus multilocularis	survival motor neuron protein 1	0.0255	0.4998	0.6864
Schistosoma mansoni	d-amino acid oxidase	0.0187	0.3586	1
Brugia malayi	nuclear receptor NHR-88	0.0017	0.0032	0.0032
Brugia malayi	orphan nuclear receptor NR2E1	0.0017	0.0032	0.0032
Schistosoma mansoni	nuclear receptor	0.0017	0.0032	0.0088
Mycobacterium tuberculosis	Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI)	0.0018	0.0056	0.0173
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0036	0.0432	0.1206
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0036	0.0432	0.0594
Brugia malayi	ecdysteroid receptor	0.0036	0.0432	0.0432
Schistosoma mansoni	zinc finger protein	0.0017	0.0032	0.0088
Toxoplasma gondii	exonuclease III APE	0.0018	0.0056	0.0143
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0432	0.0432
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0036	0.0432	0.0432
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0036	0.0432	0.0432
Brugia malayi	exodeoxyribonuclease III family protein	0.0018	0.0056	0.0056
Schistosoma mansoni	tar DNA-binding protein	0.0133	0.2441	0.6809
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0036	0.0432	0.0432
Loa Loa (eye worm)	hypothetical protein	0.0053	0.0787	0.0787
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0036	0.0432	0.0432
Entamoeba histolytica	protein kinase, putative	0.01	0.1758	0.445
Schistosoma mansoni	hepatocyte nuclear factor 4-alpha (hnf-4-alpha)	0.0017	0.0032	0.0088
Onchocerca volvulus	Bile acid receptor homolog	0.0036	0.0432	0.5489
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0036	0.0432	0.0594
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0432	0.0432
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0036	0.0432	0.0594
Loa Loa (eye worm)	steroid hormone receptor	0.0036	0.0432	0.0432
Echinococcus granulosus	survival motor neuron protein 1	0.0255	0.4998	0.6864
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0036	0.0432	0.0594
Wolbachia endosymbiont of Brugia malayi	exonuclease III	0.0018	0.0056	0.5
Schistosoma mansoni	hypothetical protein	0.0052	0.076	0.2119
Entamoeba histolytica	hypothetical protein	0.01	0.1758	0.445
Echinococcus granulosus	tumor protein p63	0.0364	0.7282	1
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0036	0.0432	0.0432
Brugia malayi	metabotropic glutamate receptor subtype 5a (mGluR5a), putative	0.0043	0.0563	0.0563
Schistosoma mansoni	nuclear receptor nhr-48	0.0017	0.0032	0.0088
Brugia malayi	Protein kinase domain containing protein	0.01	0.1758	0.1758
Echinococcus granulosus	Nuclear hormone receptor HR96	0.0017	0.0032	0.0043
Schistosoma mansoni	nuclear hormone receptor superfamily protein-related	0.0017	0.0032	0.0088
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0036	0.0432	0.0594
Toxoplasma gondii	macrophage migration inhibitory factor, putative	0.0205	0.395	1
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0036	0.0432	0.1206
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0036	0.0432	0.0594
Plasmodium falciparum	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0018	0.0056	0.0143
Loa Loa (eye worm)	TAR-binding protein	0.0133	0.2441	0.2441
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0051	0.0742	0.1019
Schistosoma mansoni	tar DNA-binding protein	0.0133	0.2441	0.6809
Brugia malayi	RNA binding protein	0.0133	0.2441	0.2441
Brugia malayi	tailless protein	0.0017	0.0032	0.0032
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0036	0.0432	0.0432
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0036	0.0432	0.1206
Brugia malayi	Bm-MIF-1, identical	0.0205	0.395	0.395
Schistosoma mansoni	nuclear hormone receptor	0.0017	0.0032	0.0088
Echinococcus multilocularis	metabotropic glutamate receptor 5	0.0058	0.0883	0.1212
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0432	0.0432
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0051	0.0742	0.0742
Brugia malayi	Nuclear hormone receptor E75	0.0017	0.0032	0.0032
Schistosoma mansoni	metabotropic glutamate receptor	0.0023	0.0153	0.0425
Brugia malayi	nuclear receptor NHR-88	0.0036	0.0432	0.0432
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0032	0.0032
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0036	0.0432	0.0432
Schistosoma mansoni	metabotropic glutamate receptor	0.0039	0.0496	0.1385
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0075	0.0075
Plasmodium falciparum	ataxin-2 like protein, putative	0.0026	0.0222	0.0562
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.0036	0.0432	0.5489
Entamoeba histolytica	protein kinase domain containing protein	0.01	0.1758	0.445
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0036	0.0432	0.0432
Brugia malayi	RNA recognition motif domain containing protein	0.0133	0.2441	0.2441
Onchocerca volvulus	Nuclear receptor subfamily 6 group A member 1 homolog	0.0017	0.0032	0.0402
Brugia malayi	MH2 domain containing protein	0.0133	0.2462	0.2462
Mycobacterium ulcerans	D-amino acid oxidase Aao	0.0187	0.3586	1
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0432	0.0432
Brugia malayi	ecdysone receptor	0.0017	0.0032	0.0032
Brugia malayi	Metabotropic glutamate receptor precursor.	0.0047	0.0656	0.0656
Mycobacterium tuberculosis	Probable D-amino acid oxidase Aao	0.0172	0.3259	1
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0036	0.0432	0.0594
Echinococcus granulosus	Nuclear hormone receptor HR96	0.0017	0.0032	0.0043
Brugia malayi	nuclear receptor RXR	0.0019	0.0075	0.0075
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0017	0.0032	0.0043
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0036	0.0432	0.0594
Schistosoma mansoni	thyroid hormone receptor	0.0036	0.0432	0.1206
Echinococcus granulosus	metabotropic glutamate receptor 5	0.0058	0.0883	0.1212
Echinococcus granulosus	nuclear receptor subfamily 1 group D	0.0019	0.0075	0.0102
Loa Loa (eye worm)	hypothetical protein	0.0058	0.0883	0.0883
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0032	0.0032
Schistosoma mansoni	tar DNA-binding protein	0.0133	0.2441	0.6809
Schistosoma mansoni	RAR-like nuclear receptor	0.0036	0.0432	0.1206
Brugia malayi	nuclear receptor subfamily 1, group D, member 1, putative	0.0017	0.0032	0.0032
Loa Loa (eye worm)	glutamate receptor	0.0018	0.006	0.006
Plasmodium vivax	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0018	0.0056	0.0143
Brugia malayi	nuclear hormone receptor family member nhr-6	0.0017	0.0032	0.0032
Brugia malayi	Nuclear hormone receptor-like 1	0.0019	0.0075	0.0075
Schistosoma mansoni	ap endonuclease	0.0018	0.0056	0.0157
Echinococcus multilocularis	DNA (apurinic or apyrimidinic site) lyase	0.0018	0.0056	0.0077
Leishmania major	serine/threonine-protein kinase, putative,protein kinase, putative	0.01	0.1758	0.445
Leishmania major	macrophage migration inhibitory factor-like protein	0.0205	0.395	1
Onchocerca volvulus	Protein ultraspiracle homolog	0.0036	0.0432	0.5489
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0036	0.0432	0.0594
Trypanosoma brucei	CMGC/DYRK protein kinase, putative	0.01	0.1758	1
Giardia lamblia	Endonuclease/Exonuclease/phosphatase	0.0018	0.0056	0.0143
Brugia malayi	Steroid receptor seven-up type 2	0.0036	0.0432	0.0432
Plasmodium vivax	macrophage migration inhibitory factor, putative	0.0205	0.395	1
Loa Loa (eye worm)	macrophage migration inhibitory factor 2	0.0087	0.1498	0.1498
Leishmania major	apurinic/apyrimidinic endonuclease-redox protein	0.0018	0.0056	0.0143
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0036	0.0432	0.0432
Loa Loa (eye worm)	hypothetical protein	0.0099	0.1747	0.1747
Trypanosoma cruzi	PAB1-binding protein , putative	0.0026	0.0222	0.1262
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0075	0.0075
Loa Loa (eye worm)	exodeoxyribonuclease III family protein	0.0018	0.0056	0.0056
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0036	0.0432	0.0594
Onchocerca volvulus		0.0036	0.0432	0.5489
Loa Loa (eye worm)	nuclear hormone receptor	0.0017	0.0032	0.0032
Trichomonas vaginalis	macrophage migration inhibitory factor, mif, putative	0.0205	0.395	1
Onchocerca volvulus		0.0017	0.0032	0.0402
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0075	0.0075
Echinococcus multilocularis	dual specificity	0.01	0.1758	0.2414
Echinococcus granulosus	thyroid hormone receptor alpha	0.0017	0.0032	0.0043
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0036	0.0432	0.1206
Schistosoma mansoni	nuclear hormone receptor	0.0036	0.0432	0.1206
Brugia malayi	hypothetical protein	0.0026	0.0222	0.0222
Loa Loa (eye worm)	DR-78	0.0017	0.0032	0.0032
Trypanosoma cruzi	PAB1-binding protein , putative	0.0026	0.0222	0.1262
Schistosoma mansoni	cellular tumor antigen P53	0.0053	0.0787	0.2196
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0432	0.0432
Loa Loa (eye worm)	MH2 domain-containing protein	0.0133	0.2462	0.2462
Loa Loa (eye worm)	nuclear hormone receptor-like 1	0.0019	0.0075	0.0075
Echinococcus multilocularis	tumor protein p63	0.0364	0.7282	1
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0075	0.0075
Giardia lamblia	Macrophage migration inhibitory factor	0.0205	0.395	1
Trypanosoma brucei	apurinic/apyrimidinic endonuclease, putative	0.0018	0.0056	0.0321
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0036	0.0432	0.0594

Activities

Activity type	Activity value	Assay description	Source	Reference
Ki (binding)	= 1.2 uM	Inhibition of recombinant Plasmodium falciparum MIF expressed in Escherichia coli BL21 (DE3) assessed as ketonization of enol form of 4-HPP substrate after 10 mins	ChEMBL.	23067344

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL2178849

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 1719505