TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 843.852 | Formula: C38H48F3N11O8
H donors: 11 H acceptors: 8 LogP: 1.67 Rotable bonds: 15
Rule of 5 violations (Lipinski): 3
SMILES: OC(=O)C(F)(F)F.NC(=N)NCCC[C@@H]1NC(=O)[C@@H](CCCNC(=N)N)NC(=O)[C@H](NC(=O)CNC(=O)[C@@H](NC1=O)Cc1ccc2c(c1)cccc2)Cc1ccc(cc1)O
InChi: 1S/C36H47N11O6.C2HF3O2/c37-35(38)41-15-3-7-26-32(51)45-27(8-4-16-42-36(39)40)33(52)47-28(19-22-9-12-23-5-1-2-6-24(23)17-22)31(50)43-20-30(49)44-29(34(53)46-26)18-21-10-13-25(48)14-11-21;3-2(4,5)1(6)7/h1-2,5-6,9-14,17,26-29,48H,3-4,7-8,15-16,18-20H2,(H,43,50)(H,44,49)(H,45,51)(H,46,53)(H,47,52)(H4,37,38,41)(H4,39,40,42);(H,6,7)/t26-,27+,28+,29-;/m1./s1
InChiKey: CJRFPYRTUCUEQI-ICWQIYEDSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	chemokine (C-X-C motif) receptor 4	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Echinococcus multilocularis	G-protein coupled receptor, putative	chemokine (C-X-C motif) receptor 4	356 aa	332 aa	20.2 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0015	0.002	0.002
Toxoplasma gondii	ornithine aminotransferase, mitochondrial precursor, putative	0.0044	0.0419	0.1671
Brugia malayi	hypothetical protein	0.0044	0.0422	0.0559
Plasmodium falciparum	ornithine aminotransferase	0.0044	0.0419	0.9918
Echinococcus multilocularis	isocitrate dehydrogenase	0.0015	0.002	0.002
Brugia malayi	N-terminal motif family protein	0.0177	0.2286	0.3029
Onchocerca volvulus	Dipeptidyl peptidase family member 1 homolog	0.0551	0.7546	1
Onchocerca volvulus	Rap guanine nucleotide exchange factor 1 homolog	0.0177	0.2286	0.3029
Plasmodium vivax	hypothetical protein, conserved	0.0044	0.0417	0.9861
Brugia malayi	MH2 domain containing protein	0.012	0.1492	0.1977
Brugia malayi	4-aminobutyrate aminotransferase, mitochondrial precursor	0.0044	0.0419	0.0555
Loa Loa (eye worm)	hypothetical protein	0.0213	0.2787	0.3693
Leishmania major	prolyl oligopeptidase, putative,serine peptidase clan SC, family S9A, putative	0.0044	0.0417	0.1661
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0422	0.0559
Schistosoma mansoni	microtubule-associated protein tau	0.0726	1	1
Trypanosoma cruzi	oligopeptidase b	0.0044	0.0417	0.1661
Brugia malayi	isocitrate dehydrogenase	0.0015	0.002	0.0027
Trypanosoma brucei	prolyl endopeptidase	0.0044	0.0417	0.1661
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0136	0.1709	0.1709
Echinococcus multilocularis	Aminotransferase class III	0.0044	0.0419	0.0419
Schistosoma mansoni	integrin alpha-ps	0.0231	0.3044	0.3044
Trypanosoma cruzi	hypothetical protein, conserved	0.0044	0.0417	0.1661
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0015	0.002	0.002
Trypanosoma cruzi	oligopeptidase B-like protein, putative	0.0044	0.0417	0.1661
Echinococcus granulosus	integrin alpha ps	0.0213	0.2787	0.2787
Loa Loa (eye worm)	hypothetical protein	0.0177	0.2286	0.3029
Mycobacterium tuberculosis	Probable peptidase	0.0044	0.0417	0.0963
Brugia malayi	von Willebrand factor type A domain containing protein	0.0044	0.0422	0.0559
Brugia malayi	Zona pellucida-like domain containing protein	0.0044	0.0422	0.0559
Loa Loa (eye worm)	hypothetical protein	0.0231	0.3044	0.4034
Echinococcus multilocularis	voltage dependent calcium channel subunit	0.0044	0.0422	0.0422
Echinococcus multilocularis	acylamino acid releasing enzyme	0.0044	0.0417	0.0417
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0417	0.0552
Plasmodium vivax	thrombospondin-related anonymous protein	0.0044	0.0422	1
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0422	0.0559
Plasmodium vivax	hypothetical protein, conserved	0.0044	0.0422	1
Mycobacterium ulcerans	L-lysine aminotransferase	0.0044	0.0419	0.0006
Echinococcus granulosus	integrin alpha ps	0.0443	0.6028	0.6028
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0136	0.1709	0.1709
Brugia malayi	prolyl oligopeptidase family protein	0.0044	0.0417	0.0552
Loa Loa (eye worm)	transcription factor SMAD2	0.012	0.1492	0.1977
Treponema pallidum	hypothetical protein	0.0044	0.0422	0.5
Onchocerca volvulus		0.0044	0.0422	0.0559
Mycobacterium tuberculosis	Adenosylmethionine-8-amino-7-oxononanoate aminotransferase BioA	0.0309	0.4136	1
Schistosoma mansoni	hypothetical protein	0.0213	0.2787	0.2787
Schistosoma mansoni	integrin alpha	0.0443	0.6028	0.6028
Brugia malayi	von Willebrand factor type A domain containing protein	0.0044	0.0422	0.0559
Trypanosoma cruzi	serine peptidase, Clan SC, Family S9B	0.0185	0.2406	1
Schistosoma mansoni	dipeptidyl-peptidase 9 (S09 family)	0.0185	0.2406	0.2406
Plasmodium falciparum	peptidase, putative	0.0044	0.0417	0.9861
Trypanosoma cruzi	dipeptidyl-peptidase 8-like serine peptidase	0.0185	0.2406	1
Trichomonas vaginalis	ubiquitin-conjugating enzyme E2, putative	0.0044	0.0422	0.0015
Loa Loa (eye worm)	pax transcription factor protein 2	0.0236	0.3113	0.4126
Loa Loa (eye worm)	isocitrate dehydrogenase	0.0015	0.002	0.0027
Loa Loa (eye worm)	prolyl oligopeptidase	0.0044	0.0417	0.0552
Brugia malayi	Integrin alpha pat-2 precursor	0.0443	0.6028	0.7989
Echinococcus granulosus	integrin alpha 3	0.0213	0.2787	0.2787
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0136	0.1709	0.1709
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0417	0.0552
Entamoeba histolytica	hypothetical protein, conserved	0.0044	0.0422	1
Echinococcus granulosus	collagen alpha 1VII chain	0.0044	0.0422	0.0422
Toxoplasma gondii	prolyl endopeptidase	0.0044	0.0417	0.1661
Echinococcus multilocularis	integrin alpha ps	0.0213	0.2787	0.2787
Treponema pallidum	76K protein	0.0044	0.0422	0.5
Brugia malayi	von Willebrand Factor	0.0044	0.0422	0.0559
Brugia malayi	prolyl oligopeptidase family protein	0.0551	0.7546	1
Mycobacterium leprae	PROBABLE GLUTAMATE-1-SEMIALDEHYDE 2,1-AMINOMUTASE HEML (GSA) (GLUTAMATE-1-SEMIALDEHYDE AMINOTRANSFERASE) (GSA-AT)	0.0044	0.0419	0.0006
Plasmodium falciparum	circumsporozoite- and TRAP-related protein	0.0044	0.0422	1
Echinococcus granulosus	prolyl endopeptidase	0.0044	0.0417	0.0417
Onchocerca volvulus		0.0044	0.0422	0.0559
Toxoplasma gondii	hypothetical protein	0.0044	0.0417	0.1661
Brugia malayi	Isocitrate dehydrogenase	0.0015	0.002	0.0027
Wolbachia endosymbiont of Brugia malayi	acetylornithine transaminase protein	0.0044	0.0419	0.5
Toxoplasma gondii	acylaminoacyl-peptidase, putative	0.0044	0.0417	0.1661
Brugia malayi	prolyl oligopeptidase family protein	0.0185	0.2406	0.3189
Trypanosoma brucei	serine peptidase, Clan SC, Family S9B	0.0185	0.2406	1
Schistosoma mansoni	acylaminoacyl-peptidase (S09 family)	0.0044	0.0417	0.0417
Brugia malayi	von Willebrand factor type A domain containing protein	0.0044	0.0422	0.0559
Mycobacterium ulcerans	acetylornithine aminotransferase	0.0044	0.0419	0.0006
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0422	0.0559
Trypanosoma cruzi	oligopeptidase b	0.0044	0.0417	0.1661
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0422	0.0559
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0422	0.0559
Echinococcus multilocularis	microtubule associated protein 2	0.0726	1	1
Onchocerca volvulus	Prolyl endopeptidase homolog	0.0044	0.0417	0.0552
Schistosoma mansoni	prolyl oligopeptidase (S09 family)	0.0044	0.0417	0.0417
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0136	0.1709	0.1709
Brugia malayi	von Willebrand factor type A domain containing protein	0.0044	0.0422	0.0559
Echinococcus multilocularis	dipeptidyl aminopeptidaseprotein	0.0551	0.7546	0.7546
Schistosoma mansoni	subfamily S9B unassigned peptidase (S09 family)	0.0551	0.7546	0.7546
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0422	0.0559
Loa Loa (eye worm)	prolyl oligopeptidase	0.0551	0.7546	1
Trypanosoma cruzi	hypothetical protein, conserved	0.0044	0.0417	0.1661
Onchocerca volvulus		0.0044	0.0422	0.0559
Echinococcus multilocularis	integrin alpha ps	0.0443	0.6028	0.6028
Schistosoma mansoni	dihydropyridine-sensitive l-type calcium channel	0.0044	0.0422	0.0422
Entamoeba histolytica	elongation factor-2 kinase, putative	0.0044	0.0422	1
Mycobacterium ulcerans	4-aminobutyrate aminotransferase	0.0044	0.0419	0.0006
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0422	0.0559
Leishmania major	oligopeptidase B-like protein,serine peptidase, clan SC, family S9A-like protein	0.0044	0.0417	0.1661
Mycobacterium leprae	Probable Acetylornithine aminotransferase ArgD	0.0044	0.0419	0.0006
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0422	0.0559
Brugia malayi	Integrin alpha cytoplasmic region family protein	0.0213	0.2787	0.3693
Mycobacterium ulcerans	hypothetical protein	0.0309	0.4136	1
Loa Loa (eye worm)	von Willebrand factor type A domain-containing protein	0.0044	0.0422	0.0559
Trypanosoma brucei	Dipeptidyl-peptidase 8-like, putative	0.0185	0.2406	1
Brugia malayi	hypothetical protein	0.0142	0.1792	0.2375
Schistosoma mansoni	hypothetical protein	0.0044	0.0422	0.0422
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0136	0.1709	0.2265
Mycobacterium leprae	PROBABLE ADENOSYLMETHIONINE-8-AMINO-7-OXONONANOATE AMINOTRANSFERASE BIOA	0.0309	0.4136	1
Brugia malayi	von Willebrand factor type A domain containing protein	0.0044	0.0422	0.0559
Brugia malayi	von Willebrand factor type A domain containing protein	0.0044	0.0422	0.0559
Loa Loa (eye worm)	CUTiclin family member	0.0044	0.0422	0.0559
Plasmodium falciparum	thrombospondin-related anonymous protein	0.0044	0.0422	1
Trypanosoma cruzi	serine peptidase, clan SC, family S9A-like protein, putative	0.0044	0.0417	0.1661
Brugia malayi	Pax transcription factor protein 2	0.0236	0.3113	0.4126
Mycobacterium tuberculosis	Probable L-lysine-epsilon aminotransferase Lat (L-lysine aminotransferase) (lysine 6-aminotransferase)	0.0044	0.0419	0.0969
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0422	0.0559
Loa Loa (eye worm)	hypothetical protein	0.0213	0.2787	0.3693
Echinococcus multilocularis	ornithine aminotransferase	0.0044	0.0419	0.0419
Brugia malayi	prolyl oligopeptidase family protein	0.0044	0.0417	0.0552
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0015	0.002	0.002
Mycobacterium ulcerans	adenosylmethionine-8-amino-7-oxononanoate aminotransferase	0.0309	0.4136	1
Entamoeba histolytica	hypothetical protein, conserved	0.0044	0.0422	1
Loa Loa (eye worm)	CUTiclin-Like family member	0.0044	0.0422	0.0559
Onchocerca volvulus		0.0044	0.0422	0.0559
Trypanosoma brucei	prolyl oligopeptidase, putative	0.0044	0.0417	0.1661
Mycobacterium ulcerans	4-aminobutyrate aminotransferase	0.0044	0.0419	0.0006
Onchocerca volvulus		0.0044	0.0422	0.0559
Brugia malayi	Transmembrane cell adhesion receptor mua-3 precursor, putative	0.0044	0.0422	0.0559
Echinococcus multilocularis	ornithine aminotransferase	0.0044	0.0419	0.0419
Giardia lamblia	Alanyl dipeptidyl peptidase	0.0044	0.0417	0.5
Plasmodium vivax	dynein-related AAA-type ATPase, putative	0.0044	0.0422	1
Chlamydia trachomatis	glutamate-1-semialdehyde-2,1-aminomutase	0.0044	0.0419	0.5
Brugia malayi	Zona pellucida-like domain containing protein	0.0044	0.0422	0.0559
Echinococcus multilocularis	integrin alpha ps	0.0443	0.6028	0.6028
Mycobacterium ulcerans	ornithine aminotransferase RocD1 and RocD2	0.0044	0.0419	0.0006
Mycobacterium tuberculosis	Probable acetylornithine aminotransferase ArgD	0.0044	0.0419	0.0969
Trypanosoma brucei	oligopeptidase b	0.0044	0.0417	0.1661
Brugia malayi	prolyl oligopeptidase family protein	0.0044	0.0417	0.0552
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0136	0.1709	0.1709
Plasmodium vivax	ornithine aminotransferase, putative	0.0044	0.0419	0.9918
Loa Loa (eye worm)	von Willebrand factor domain-containing protein	0.0044	0.0422	0.0559
Echinococcus multilocularis	integrin alpha 3	0.0213	0.2787	0.2787
Mycobacterium tuberculosis	Probable glutamate-1-semialdehyde 2,1-aminomutase HemL (GSA) (glutamate-1-semialdehyde aminotransferase) (GSA-at)	0.0044	0.0419	0.0969
Plasmodium falciparum	von Willebrand factor A domain-related protein	0.0044	0.0422	1
Loa Loa (eye worm)	hypothetical protein	0.0142	0.1792	0.2375
Mycobacterium tuberculosis	Probable protease II PtrBb [second part] (oligopeptidase B)	0.0044	0.0417	0.0963
Schistosoma mansoni	hypothetical protein	0.0044	0.0422	0.0422
Echinococcus granulosus	acylamino acid releasing enzyme	0.0044	0.0417	0.0417
Echinococcus granulosus	NADP dependent isocitrate dehydrogenase	0.0015	0.002	0.002
Echinococcus granulosus	ornithine aminotransferase	0.0044	0.0419	0.0419
Echinococcus multilocularis	collagen alpha 1(VII) chain	0.0044	0.0422	0.0422
Toxoplasma gondii	microneme protein MIC2	0.0044	0.0422	0.1685
Trypanosoma brucei	serine peptidase, clan SC, family S9A-like protein	0.0044	0.0417	0.1661
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0422	0.0559
Leishmania major	dipeptidyl-peptidase 8-like serine peptidase, putative,serine peptidase, Clan SC, Family S9B	0.0185	0.2406	1
Leishmania major	oligopeptidase b	0.0044	0.0417	0.1661
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0044	0.0422	0.0559
Trichomonas vaginalis	acetylornithine aminotransferase, putative	0.0309	0.4136	1
Echinococcus granulosus	Dipeptidyl peptidase 9	0.0185	0.2406	0.2406
Mycobacterium tuberculosis	Probable ornithine aminotransferase (N-terminus part) RocD1 (ornithine--oxo-acid aminotransferase)	0.0044	0.0419	0.0969
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0422	0.0559
Echinococcus granulosus	voltage dependent calcium channel subunit	0.0044	0.0422	0.0422
Onchocerca volvulus		0.0044	0.0422	0.0559
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0417	0.0552
Schistosoma mansoni	prolyl oligopeptidase (S09 family)	0.0044	0.0417	0.0417
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0422	0.0559
Trypanosoma brucei	Alpha/beta hydrolase domain-containing protein	0.0044	0.0417	0.1661
Schistosoma mansoni	integrin alpha-ps	0.0443	0.6028	0.6028
Mycobacterium leprae	Probable 4-aminobutyrate aminotransferase GabT (GAMMA-AMINO-N-BUTYRATE TRANSAMINASE) (GABA TRANSAMINASE) (GLUTAMATE:SUCCINIC SEM	0.0044	0.0419	0.0006
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0136	0.1709	0.1709
Loa Loa (eye worm)	integrin alpha pat-2	0.0443	0.6028	0.7989
Schistosoma mansoni	ornithine--oxo-acid transaminase	0.0044	0.0419	0.0419
Echinococcus granulosus	dipeptidyl aminopeptidaseprotein	0.0551	0.7546	0.7546
Echinococcus multilocularis	prolyl endopeptidase	0.0044	0.0417	0.0417
Plasmodium vivax	von Willebrand factor A domain-related protein, putative	0.0044	0.0422	1
Mycobacterium tuberculosis	Probable aminotransferase	0.0309	0.4136	1
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0422	0.0559
Echinococcus multilocularis	Dipeptidyl peptidase 9	0.0185	0.2406	0.2406
Schistosoma mansoni	NADP-specific isocitrate dehydrogenase	0.0015	0.002	0.002
Echinococcus multilocularis	isocitrate dehydrogenase 2 (NADP+)	0.0015	0.002	0.002
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0136	0.1709	0.2265
Plasmodium vivax	circumsporozoite- and TRAP-related protein, putative	0.0044	0.0422	1
Brugia malayi	von Willebrand factor type A domain containing protein	0.0044	0.0422	0.0559
Loa Loa (eye worm)	hypothetical protein	0.0231	0.3044	0.4034
Loa Loa (eye worm)	MH2 domain-containing protein	0.012	0.1492	0.1977
Giardia lamblia	Alanyl dipeptidyl peptidase	0.0044	0.0417	0.5
Toxoplasma gondii	von Willebrand factor type A domain-containing protein	0.0044	0.0422	0.1685
Echinococcus granulosus	Aminotransferase class III	0.0044	0.0419	0.0419
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0136	0.1709	0.1709
Mycobacterium ulcerans	glutamate-1-semialdehyde aminotransferase	0.0044	0.0419	0.0006
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0422	0.0559
Trypanosoma cruzi	prolyl endopeptidase	0.0044	0.0417	0.1661
Onchocerca volvulus		0.0236	0.3113	0.4126
Brugia malayi	von Willebrand factor type A domain containing protein	0.0044	0.0422	0.0559
Entamoeba histolytica	hypothetical protein	0.0044	0.0422	1
Schistosoma mansoni	prolyl oligopeptidase (S09 family)	0.0044	0.0417	0.0417
Toxoplasma gondii	dipeptidyl peptidase iv (dpp iv) n-terminal region domain-containing protein	0.0185	0.2406	1
Onchocerca volvulus		0.0044	0.0422	0.0559

Activities

Activity type	Activity value	Assay description	Source	Reference
EC50 (functional)	= 6.11	Antagonist activity against human CXCR4 expressed in COS7 cells assessed as inhibition of CXCL12-induced myo-[3H]inositol production by scintillation counting	ChEMBL.	23043442
EC50 (functional)	= 0.78 uM	Antagonist activity against human CXCR4 expressed in COS7 cells assessed as inhibition of CXCL12-induced myo-[3H]inositol production by scintillation counting	ChEMBL.	23043442

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL2180077

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 1720091