Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | beta-lactamase family protein | 0.0035 | 0.1302 | 0.2069 |
Wolbachia endosymbiont of Brugia malayi | acetylornithine transaminase protein | 0.0022 | 0.0683 | 0.5 |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.0035 | 0.1302 | 0.2069 |
Echinococcus granulosus | intermediate filament protein | 0.0026 | 0.0897 | 0.1469 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0013 | 0.0284 | 0.0414 |
Echinococcus multilocularis | lamin | 0.0026 | 0.0897 | 0.1425 |
Mycobacterium tuberculosis | Probable conserved lipoprotein | 0.0035 | 0.1302 | 0.0665 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0045 | 0.1739 | 0.2763 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0013 | 0.0284 | 0.0414 |
Echinococcus granulosus | cpg binding protein | 0.0061 | 0.2469 | 0.4042 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.1302 | 0.2069 |
Loa Loa (eye worm) | TAR-binding protein | 0.0125 | 0.5415 | 0.8603 |
Mycobacterium tuberculosis | Adenosylmethionine-8-amino-7-oxononanoate aminotransferase BioA | 0.0153 | 0.6686 | 0.6443 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0045 | 0.1739 | 0.2763 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0.0249 | 0.0396 |
Echinococcus granulosus | lamin dm0 | 0.0026 | 0.0897 | 0.1469 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0026 | 0.0897 | 0.1425 |
Echinococcus multilocularis | histone lysine N methyltransferase MLL3 | 0.0018 | 0.0502 | 0.0798 |
Trichomonas vaginalis | cat eye syndrome critical region protein 2, cscr2, putative | 0.0042 | 0.1631 | 0.243 |
Mycobacterium tuberculosis | Probable esterase/lipase LipP | 0.0035 | 0.1302 | 0.0665 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0013 | 0.0284 | 0.0414 |
Loa Loa (eye worm) | CXXC zinc finger family protein | 0.0058 | 0.2319 | 0.3685 |
Mycobacterium leprae | Probable lipase LipE | 0.0035 | 0.1302 | 0.1031 |
Echinococcus granulosus | Aminotransferase class III | 0.0022 | 0.0683 | 0.1118 |
Trichomonas vaginalis | chromodomain-helicase-DNA-binding protein, putative | 0.0013 | 0.0284 | 0.0414 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0013 | 0.0284 | 0.0414 |
Mycobacterium tuberculosis | Probable esterase LipL | 0.0035 | 0.1302 | 0.0665 |
Echinococcus multilocularis | gcn5proteinral control of amino acid synthesis | 0.0144 | 0.6294 | 1 |
Toxoplasma gondii | ABC1 family protein | 0.0035 | 0.1302 | 0.1491 |
Echinococcus multilocularis | cpg binding protein | 0.0061 | 0.2469 | 0.3923 |
Schistosoma mansoni | gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 | 0.0144 | 0.6294 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0013 | 0.0284 | 0.0414 |
Trichomonas vaginalis | bromodomain-containing protein, putative | 0.0042 | 0.1631 | 0.243 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0013 | 0.0284 | 0.0414 |
Mycobacterium tuberculosis | Probable hydrolase | 0.0035 | 0.1302 | 0.0665 |
Loa Loa (eye worm) | histone methyltransferase | 0.0018 | 0.0502 | 0.0798 |
Echinococcus multilocularis | cytoplasmic intermediate filament protein | 0.0013 | 0.0272 | 0.0432 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0045 | 0.1739 | 0.2763 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0035 | 0.1302 | 0.5 |
Mycobacterium tuberculosis | Conserved protein | 0.0035 | 0.1302 | 0.0665 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0035 | 0.1302 | 0.1938 |
Chlamydia trachomatis | glutamate-1-semialdehyde-2,1-aminomutase | 0.0022 | 0.0683 | 0.5 |
Onchocerca volvulus | 0.0035 | 0.1302 | 0.2849 | |
Trichomonas vaginalis | conserved hypothetical protein | 0.0013 | 0.0284 | 0.0414 |
Brugia malayi | TAR-binding protein | 0.0125 | 0.5415 | 0.8603 |
Loa Loa (eye worm) | intermediate filament protein | 0.0026 | 0.0897 | 0.1425 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0013 | 0.0284 | 0.0414 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.0875 | 0.139 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0013 | 0.0284 | 0.0414 |
Schistosoma mansoni | cpg binding protein | 0.0058 | 0.2319 | 0.3685 |
Mycobacterium ulcerans | fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE | 0.0035 | 0.1302 | 0.1031 |
Schistosoma mansoni | tar DNA-binding protein | 0.0125 | 0.5415 | 0.8603 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.1302 | 0.2069 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.1302 | 0.2069 |
Brugia malayi | intermediate filament protein | 0.0026 | 0.0897 | 0.1425 |
Schistosoma mansoni | lamin | 0.0026 | 0.0897 | 0.1425 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0035 | 0.1302 | 0.1938 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0035 | 0.1302 | 0.1938 |
Schistosoma mansoni | ornithine--oxo-acid transaminase | 0.0022 | 0.0683 | 0.1085 |
Echinococcus multilocularis | histone lysine N methyltransferase MLL3 | 0.0014 | 0.0342 | 0.0543 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0035 | 0.1302 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.1302 | 0.2069 |
Brugia malayi | beta-lactamase | 0.0035 | 0.1302 | 0.2069 |
Onchocerca volvulus | 0.0035 | 0.1302 | 0.2849 | |
Echinococcus multilocularis | mixed lineage leukemia protein mll | 0.0014 | 0.0342 | 0.0543 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0013 | 0.0284 | 0.0414 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0045 | 0.1739 | 0.2763 |
Echinococcus granulosus | lamin | 0.0026 | 0.0897 | 0.1469 |
Schistosoma mansoni | cpg binding protein | 0.0061 | 0.2469 | 0.3923 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.1302 | 0.2069 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0045 | 0.1739 | 0.2763 |
Echinococcus granulosus | histone lysine N methyltransferase MLL3 | 0.0014 | 0.0342 | 0.0559 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0035 | 0.1302 | 0.2069 |
Echinococcus multilocularis | musashi | 0.0026 | 0.0897 | 0.1425 |
Echinococcus granulosus | mixed lineage leukemia protein mll | 0.0014 | 0.0342 | 0.0559 |
Toxoplasma gondii | histone lysine acetyltransferase GCN5-A | 0.0042 | 0.1631 | 0.2283 |
Loa Loa (eye worm) | hypothetical protein | 0.0013 | 0.0272 | 0.0432 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0013 | 0.0284 | 0.0414 |
Trichomonas vaginalis | esterase, putative | 0.0035 | 0.1302 | 0.1938 |
Mycobacterium ulcerans | hypothetical protein | 0.0153 | 0.6686 | 1 |
Onchocerca volvulus | 0.0058 | 0.2319 | 1 | |
Toxoplasma gondii | histone lysine methyltransferase SET1 | 0.0112 | 0.4835 | 1 |
Mycobacterium ulcerans | beta-lactamase | 0.0035 | 0.1302 | 0.1031 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0045 | 0.1739 | 0.2846 |
Mycobacterium ulcerans | adenosylmethionine-8-amino-7-oxononanoate aminotransferase | 0.0153 | 0.6686 | 1 |
Plasmodium vivax | histone acetyltransferase GCN5, putative | 0.0042 | 0.1631 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0125 | 0.5415 | 0.8603 |
Onchocerca volvulus | 0.0035 | 0.1302 | 0.2849 | |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0026 | 0.0897 | 0.1425 |
Schistosoma mansoni | tar DNA-binding protein | 0.0125 | 0.5415 | 0.8603 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0035 | 0.1302 | 0.1938 |
Schistosoma mansoni | lamin | 0.0026 | 0.0897 | 0.1425 |
Loa Loa (eye worm) | acetyltransferase | 0.0144 | 0.6294 | 1 |
Plasmodium vivax | hypothetical protein, conserved | 0.0035 | 0.1302 | 0.6533 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.0897 | 0.1425 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0013 | 0.0284 | 0.0414 |
Schistosoma mansoni | cpg binding protein | 0.0061 | 0.2469 | 0.3923 |
Echinococcus multilocularis | Aminotransferase class III | 0.0022 | 0.0683 | 0.1085 |
Trichomonas vaginalis | helicase, putative | 0.0013 | 0.0284 | 0.0414 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.0008 | 0.0065 | 0.0104 |
Mycobacterium tuberculosis | Conserved protein | 0.0035 | 0.1302 | 0.0665 |
Mycobacterium ulcerans | esterase/lipase LipP | 0.0035 | 0.1302 | 0.1031 |
Mycobacterium ulcerans | lipase LipD | 0.0035 | 0.1302 | 0.1031 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0035 | 0.1302 | 0.1938 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0045 | 0.1739 | 0.2763 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0125 | 0.5415 | 0.8603 |
Toxoplasma gondii | histone lysine acetyltransferase GCN5-B | 0.0042 | 0.1631 | 0.2283 |
Echinococcus granulosus | beta LACTamase domain containing family member | 0.0035 | 0.1302 | 0.2132 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0045 | 0.1739 | 0.2763 |
Giardia lamblia | Histone acetyltransferase GCN5 | 0.0039 | 0.1469 | 0.5 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0035 | 0.1302 | 0.5 |
Echinococcus granulosus | ornithine aminotransferase | 0.0022 | 0.0683 | 0.1118 |
Echinococcus multilocularis | ornithine aminotransferase | 0.0022 | 0.0683 | 0.1085 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.0122 | 0.5269 | 0.8371 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0125 | 0.5415 | 0.8603 |
Trichomonas vaginalis | acetylornithine aminotransferase, putative | 0.0153 | 0.6686 | 1 |
Brugia malayi | 4-aminobutyrate aminotransferase, mitochondrial precursor | 0.0022 | 0.0683 | 0.1085 |
Echinococcus granulosus | histone acetyltransferase KAT2B | 0.014 | 0.6109 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0125 | 0.5415 | 0.8603 |
Loa Loa (eye worm) | beta-lactamase | 0.0035 | 0.1302 | 0.2069 |
Echinococcus granulosus | histone lysine N methyltransferase MLL3 | 0.0018 | 0.0502 | 0.0822 |
Echinococcus granulosus | histone acetyltransferase KAT2B | 0.0042 | 0.1631 | 0.267 |
Brugia malayi | F/Y-rich N-terminus family protein | 0.0018 | 0.0492 | 0.0781 |
Echinococcus multilocularis | beta LACTamase domain containing family member | 0.0035 | 0.1302 | 0.2069 |
Brugia malayi | acetyltransferase, GNAT family protein | 0.0144 | 0.6294 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0013 | 0.0284 | 0.0414 |
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.0035 | 0.1302 | 0.2069 |
Loa Loa (eye worm) | RNA binding protein | 0.0125 | 0.5415 | 0.8603 |
Mycobacterium tuberculosis | Possible conserved lipoprotein LpqK | 0.0035 | 0.1302 | 0.0665 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0013 | 0.0284 | 0.0414 |
Echinococcus multilocularis | tar DNA binding protein | 0.0125 | 0.5415 | 0.8603 |
Mycobacterium tuberculosis | Probable lipase LipE | 0.0035 | 0.1302 | 0.0665 |
Schistosoma mansoni | tar DNA-binding protein | 0.0125 | 0.5415 | 0.8603 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.0014 | 0.0342 | 0.0543 |
Schistosoma mansoni | intermediate filament proteins | 0.0026 | 0.0897 | 0.1425 |
Mycobacterium tuberculosis | Conserved protein | 0.0035 | 0.1302 | 0.0665 |
Mycobacterium leprae | conserved hypothetical protein | 0.0035 | 0.1302 | 0.1031 |
Brugia malayi | cytoplasmic intermediate filament protein | 0.0014 | 0.0336 | 0.0534 |
Entamoeba histolytica | acetyltransferase, GNAT family | 0.0039 | 0.1469 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0013 | 0.0284 | 0.0414 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0035 | 0.1302 | 0.2069 |
Mycobacterium tuberculosis | Probable lipase LipD | 0.0035 | 0.1302 | 0.0665 |
Mycobacterium tuberculosis | Probable aminotransferase | 0.0153 | 0.6686 | 0.6443 |
Echinococcus multilocularis | ornithine aminotransferase | 0.0022 | 0.0683 | 0.1085 |
Trichomonas vaginalis | chromodomain-helicase-DNA-binding protein, putative | 0.0013 | 0.0284 | 0.0414 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.1302 | 0.2069 |
Mycobacterium leprae | PROBABLE ADENOSYLMETHIONINE-8-AMINO-7-OXONONANOATE AMINOTRANSFERASE BIOA | 0.0153 | 0.6686 | 1 |
Brugia malayi | beta-lactamase family protein | 0.0035 | 0.1302 | 0.2069 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0045 | 0.1739 | 0.2846 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0.0249 | 0.0396 |
Echinococcus granulosus | cytoplasmic intermediate filament protein | 0.0013 | 0.0272 | 0.0445 |
Brugia malayi | RNA binding protein | 0.0125 | 0.5415 | 0.8603 |
Leishmania major | hypothetical protein, conserved | 0.0035 | 0.1302 | 0.5 |
Mycobacterium ulcerans | hypothetical protein | 0.0035 | 0.1302 | 0.1031 |
Loa Loa (eye worm) | cytoplasmic intermediate filament protein | 0.0014 | 0.0336 | 0.0534 |
Plasmodium falciparum | histone acetyltransferase GCN5 | 0.0039 | 0.1469 | 1 |
Brugia malayi | CXXC zinc finger family protein | 0.0058 | 0.2319 | 0.3685 |
Echinococcus granulosus | tar DNA binding protein | 0.0125 | 0.5415 | 0.8864 |
Echinococcus multilocularis | lamin dm0 | 0.0026 | 0.0897 | 0.1425 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.